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iPhone 18 Pro and Pro Max Benchmarks Reveal Speed of A20 Pro Chip
Early benchmark results for the A20 Pro chip in the iPhone 18 Pro and iPhone 18 Pro Max appeared early this morning in the Geekbench 6 database, offering us a first look at the new models' CPU and graphics performance ahead of the devices reaching customers.
City's last five meetings with Manchester United
Ahead of Sunday’s eagerly awaited Manchester derby clash away to Manchester United we look back to our most recent games against our nearest rivals. Men's Team Analysing Manchester United ahead of S...
Packers Take Notice As Harrison Smith Returns For Vikings
Christian Watson, Tucker Kraft and Matt LaFleur all acknowledged the impact Smith has on the Vikings’ defense ahead of Minnesota’s season opener against Green Bay.
Packers get clear Aaron Banks update ahead of Vikings opener
The Green Bay Packers still view Aaron Banks as the leading option at left guard for Week 1, but his availability remains uncertain because of his knee injury. Banks is set to take part in Wednesday’s practice on a limited basis after the issue restricted his involvement throughout much of training camp and the preseason. [...]
Michigan Football injury updates ahead of Oklahoma game
Michigan Football 5-star freshman edge rusher Carter Meadows is “hoping to play” against Oklahoma this weekend. Here’s the latest on that and other injuries:
Arsenal consider €80m move for Como midfielder Paz
Arsenal are considering a move to sign Como midfielder Nico Paz next summer and have expressed initial interest.Paz is on Arsenal’s radar ahead of the 2027 summer window as Mikel Arteta looks to imp...
Jets at Titans: Wednesday injury reports for both teams
Here are the injury reports for both the Jets and Titans ahead of their Week 1 game.
Bills at Texans: Wednesday injury reports for both teams
Here are the full injury reports for the Bills and Texans on Wednesday ahead of their Week 1 game.
The Sidemen Rep Arcade Signs Max Fosh, Friends From Work & More Ahead Of Europe’s First Creator Upfront
EXCLUSIVE: Arcade, the management company of The Sidemen, has signed a host of creators, as it relaunches as an entertainment business ahead of its first European upfront. Comedian Max Fosh, creator c...
Patrick Mahomes given Josh Allen warning ahead of Chiefs return
What did Mahomes say?
Students in Asia extend lead over a flagging US as AI reshapes education
High-school students across Asia are pulling ahead of their Western peers, an annual global assessment indicates, as artificial intelligence spurs a worldwide race for talent and reshapes how young people learn.
Prep sports recap for Sept. 9, 2026
PEORIA, Ill. (WMBD/WYZZ) — Dunlap senior Nolan Eccles shot a 67 to lead the Eagles to the title at the IVC Golf Invitational at Arrowhead Country Club on Wednesday. The defending state champ finished two shots ahead of Morton’s Carson Price, who’s 69 was good enough to be runner-up. Richwoods finished second while Notre Dame […]
Vikings’ Justin Jefferson Gets Blunt Over Kyler Murray Captain Decision
On Sept. 3, the Minnesota Vikings announced their captains for the 2026 NFL season, with one of them being Kyler Murray. Despite being a newcomer to the Vikings after the Arizona Cardinals cut ties with him this past offseason, the former No. 1 pick is transitioning well to Minnesota. Ahead of the Week 1 game […] The post Vikings’ Justin Jefferson Gets Blunt Over Kyler Murray Captain Decision appeared first on HEAVY.
In pictures: The first-ever Republican midterm convention
Republicans are gathering in Dallas for an unusual 2026 GOP midterm convention, an event backed by President Donald Trump and designed to energize voters, raise money and highlight key Republican candidates ahead of the elections in November.
Reince Priebus: This is all about data, science and turnout
'All-Star' panelists discuss the Republican Party's efforts to win over voters ahead of the midterm elections on 'Special Report.'
‘Trump-a-palooza’ aims to energize Republican base
Republicans gathered Wednesday night in Dallas for the first-ever Republican midterm convention, an event designed to energize voters, raise money and highlight key Republican candidates ahead of the November election. CNN’s Alayna Treene takes us through the key moments.
US says China ‘on track’ to fulfil farm purchases ahead of Xi’s Washington visit
Patriots announce two main roster elevations ahead of Seahawks matchup
The Patriots elevated running back Lan Larison and punter Mitch Wishnowsky from the practice squad ahead of their Week 1 game against the Seahawks.
Ballots discounted for late postmarks surged in Washington and Oregon after Postal Service changes
The number of ballots rejected for late postmarks has soared in the vote-by-mail states of Washington and Oregon, according to newly released data highlighting concerns about recent changes in U.S. Postal Service operations ahead of this fall's pivotal midterm election.
World Cup created a ton of momentum for our business: FanDuel president
FanDuel President Christian Genetski discusses sports betting ahead of the NFL season and New York suing Kalshi over alleged unlicensed betting on ‘The Claman Countdown.’
Cowboys Sign Former $40 Million Jets Free Agency Bust
The Dallas Cowboys have signed a former $40 million New York Jets free agency bust to a deal ahead of the season. The post Cowboys Sign Former $40 Million Jets Free Agency Bust appeared first on HEAVY.
Deshaun Watson Sends Clear Message on Jaguars Ahead of Opener
Cleveland Browns quarterback Deshaun Watson has history with the Jacksonville Jaguars. The post Deshaun Watson Sends Clear Message on Jaguars Ahead of Opener appeared first on HEAVY.
Saints’ Rookie Named ‘Future Hit’ Ahead of Week 1
The New Orleans Saints still have some questions to be answered at the wide receiver position.If Bryce Lance reaches his potential quickly, though, that could solve a lot of potential issues.And there appear to be at least some people around the league who are big believers in Lance.The Saints took Lance in the fourth round […] The post Saints’ Rookie Named ‘Future Hit’ Ahead of Week 1 appeared first on HEAVY.
Watch: Stunning save from Sam Johnstone on Celtic debut
Sam Johnstone made a stunning save to prevent Celtic from conceding on his debut. The former England Internationalist started the game ahead of Vil Sinisalo and was called into action midway through t...
With AI memes, Trump promotes mythical version of himself as challenges stack up ahead of midterms
In the real world, President Donald Trump is struggling to stop inflation, rout the Iranian government and restore American manufacturing with tariffs. It's a different story in the fantastical vision that he shares with supporters on social media.
Apple releases iOS 27 RC ahead of public launch
Apple has released the first iOS 27 release candidate for testing. The update brings Apple’s next major iPhone software release...
Washington Football Turns Focus to Short Week Against Utah State
The Washington Huskies have a lot to correct on the field, and some injuries to overcome, ahead of their matchup against Utah State.
Ja'Marr Chase trending towards playing in Week 1
Things are looking good for Ja'Marr Chase ahead of Week 1.
J.K. Dobbins listed as RB1 for Broncos
J.K. Dobbins is atop the depth chart ahead of Week 1.
ICYMI—Hagerty Joins Varney & Co. on Fox Business to Discuss Tariffs on Israel, Affordability
WASHINGTON—Today, United States Senator Bill Hagerty, (R-TN), a member of the Senate Foreign Relations, Appropriations, and Banking Committees, joined Varney & Co. on Fox Business to discuss the foreign trade restrictions on Israel and affordability ahead of the midterm election. *Click the photo above or here to watch* Partial Transcript Hagerty on foreign trade restrictions on Israel: I’m disappointed, […]
Where do Chargers stand among the AFC? NFL executives answer
See where the Chargers stand in The Athletic's AFC rankings ahead of the 2026 season.
All New iPhone 18 Pro and 'iPhone Duo' Colors Leaked
Ahead of Apple's annual iPhone event at 10 a.m. Pacific Time today, Bloomberg's Mark Gurman has leaked all of the color options for the iPhone 18 Pro, iPhone 18 Pro Max, and the first-ever foldable iPhone named the iPhone Duo. iPhone 18 Pro and iPhone 18 Pro Max color options:Black Light Blue Burgundy Silver Burgundy has also been described as Dark Red or Dark Cherry.
Brent Venables hopes elite nonconference games won’t go away
Ahead of Michigan game, OU's Brent Venables shares why he likes tough non-conference games.
NOAA is putting commercial fishing ahead of conservation
Critics say the new agenda could weaken science-based rules and marine protections.
Apple Shares Mysterious Teaser Video Before 'iPhone Duo' Event Today
Apple will be holding an event today starting at 10 a.m. Pacific Time, with the company expected to unveil new iPhones and much more. Ahead of the event, Apple's new CEO John Ternus just shared a mysterious teaser video. The short clip appears to show a beam of light that is shining onto the edge of an iPhone. The light is coming from a hexagonal shape that changes size, which could hint at the iPhone 18 Pro's rumored mechanical aperture upgrade.
Boston Celtics Get Interesting Evaluation Ahead of Training Camp
With about three weeks to go until training camp begins, ESPN sees the Celtics in a more favorable light than we do.
John Ternus posts mysterious video ahead of iPhone 18 Pro unveiling
John Ternus, ahead of his first product unveiling as Apple CEO, has posted a video teasing what may be iPhone 18 Pro’s new camera feature.
Starts and sits for fantasy football ahead of Week 1
Top starts and sits for fantasy football, including whether or not QB Matthew Stafford should be in your lineup in the season opener.
Mbappé Puts Champions League Glory Ahead of Ballon d’Or
Kylian Mbappé used his post-match remarks after Real Madrid’s 2-1 Champions League win over Inter to name the trophy as his foremost ambition at the club, according to Marca. The France internation...
Plastics treaty: Cordano presents “Aid to negotiations” but disappoints science
The document released by the INC Chair ahead of the meeting of heads of delegation in Bangkok is an even weaker version of the text already rejected at INC-5.2 a year ago
Iowa Football: Numbers To Know Ahead Of Iowa State Game
Saturday's primetime game will be just the 28th night game in Kinnick Stadium history.
Titans Unofficial Depth Chart Ahead of Season Opener vs. Jets
Cam Ward secures the starting quarterback role while Cedric Gray overcomes a concussion scare to lead the defense as Tennessee finalizes its lineup for the Week 1 clash.
Official | Auxerre loan Francisco Sierralta to Gliwice
Bought for just under €2m last summer, Francisco Sierralta (29) has joined Polish club Gliwice on a season-long loan. The deal, concluded on Wednesday, ahead of the closure of the transfer window in...
Apple’s (AAPL) “Surprise and Shine” Event Tests Its Foldable iPhone Against Huawei and Xiaomi
Wall Street sees Apple Inc. (NASDAQ:AAPL) entering a significant hardware cycle ahead of its “Surprise and Shine” event streaming live on Wednesday, September 9, 2026. Bank of America, in particular, expects a broad slate of new Apple devices led by new iPhones and a Foldable iPhone. On September 8, BofA Securities analyst Wamsi Mohan reiterated a […]
GOP's first midterm convention kicks off Wednesday, putting Dallas at center of national politics
The Republican Party's first-ever midterm convention begins in Dallas as Trump and GOP leaders rally voters, while Democrats prepare their own counterprogramming ahead of November.
Keltie Knight of E! shares a day in her life ahead of the Emmys
Emmy-winning TV host Keltie Knight juggles a busy schedule in LA, balancing show prep, podcasting, and fashion fittings ahead of the Emmys.
Schumer and Jeffries opposed a Brooklyn power play. It happened anyway.
The Brooklyn party chair rewrote the rules ahead of a leadership vote despite objections from the nation’s two most powerful Democrats, and some in the party are wondering if they could do more to stop her.
Right-back misses Liverpool training ahead of Atletico Madrid tie
Liverpool are set to open their Champions League campaign on Wednesday evening with a game against Atletico Madrid. Every year without fail, no matter which pot Liverpool and Atletico end up in, both ...
With AI memes, Trump promotes mythical version of himself as challenges stack up ahead of midterms
President Donald Trump is using memes to portray himself as powerful amid struggles with inflation and international issues.
Tucker Kraft named team captain for Packers
GREEN BAY, W.I. (KELO) — Timber Lake native and former SDSU Jackrabbit Tucker Kraft was named one of five team captains for the Green Bay Packers ahead of the 2026 season. This is Kraft’s second season as an offensive captain for the Packers. This Sunday against the Minnesota Vikings Kraft is set to make his […]
Can the 'best showman in politics' deliver again? GOP bets on Trump at historic midterm convention
Donald Trump headlines the first-ever GOP midterm convention in Dallas, aiming to energize low-propensity MAGA voters ahead of key 2026 races.
Duke Football Draws Praise From Illinois Ahead of Saturday Showdown
A certain area of the Duke Blue Devils' game against Tulane caught the eye of Illinois head coach Bret Bielema
Detroit Lions Receive Several Major Updates Ahead of Week 1
The Detroit Lions received several major updates ahead of Week 1, including encouraging injury news, a key roster decision, and an intriguing offensive line battle.
Baker Mayfield Cashes In Ahead of Browns Reunion
Former Cleveland Browns quarterback Baker Mayfield just cashed in with a massive payday. The post Baker Mayfield Cashes In Ahead of Browns Reunion appeared first on HEAVY.
Milwaukee Brewers Announce Sudden Christian Yelich Decision During Cubs Series
The Milwaukee Brewers started their series with the Chicago Cubs on Monday night with a 4-3 victory. Milwaukee will now have their ace Jacob Misiorowski on the mound for Game 2 of the series Tuesday, while Chicago will pitch lefty David Peterson. Ahead of the game, Brewers manager Pat Murphy made a few notable tweaks […] The post Milwaukee Brewers Announce Sudden Christian Yelich Decision During Cubs Series appeared first on HEAVY.
49ers catching early breaks — including avoiding Rams’ Aaron Donald
Kyle Shanahan went out of his way to avoid providing injury updates after the 49ers’ first practice in Australia, cleverly pointing out that they were a full day ahead of...
Michigan Fans Split On Bryce Underwood Ahead Of Oklahoma
Michigan fans are split on Bryce Underwood after the Western Michigan escape, with Oklahoma next. #GoBlue
Apple adds 37 hardware identifiers ahead of ‘Surprise and Shine’ event
Apple has added new hardware identifiers for iPhones, iPads, Macs, and other devices, some of which could be announced as soon as tomorrow.
Small business owners feel good now, wary about what's ahead: NFIB optimism index
Small business optimism dipped in August but stayed above its long-term average as uncertainty remained elevated, prompting some owners to delay bigger investments.
Small business owners feel good now, wary about what's ahead: NFIB optimism index
Small business optimism dipped in August but stayed above its long-term average as uncertainty remained elevated, prompting some owners to delay bigger investments.
Small business owners feel good now, wary about what's ahead: NFIB optimism index
Small business optimism dipped in August but stayed above its long-term average as uncertainty remained elevated, prompting some owners to delay bigger investments.
Small business owners feel good now, wary about what's ahead: NFIB optimism index
Small business optimism dipped in August but stayed above its long-term average as uncertainty remained elevated, prompting some owners to delay bigger investments.
Small business owners feel good now, wary about what's ahead: NFIB optimism index
Small business optimism dipped in August but stayed above its long-term average as uncertainty remained elevated, prompting some owners to delay bigger investments.
Small business owners feel good now, wary about what's ahead: NFIB optimism index
Small business optimism dipped in August but stayed above its long-term average as uncertainty remained elevated, prompting some owners to delay bigger investments.
Patriots RB TreVeyon Henderson Receives Disappointing Week 1 Update
The New England Patriots have released an injury update for running back TreVeyon Henderson ahead of Week 1.
Dueling Court Rulings Leave Missouri’s Congressional Races in Chaos
After losing in two courts and winning in another, Missouri officials said they planned to forge ahead with using a congressional map that was redrawn to benefit Republicans.
Snowflake CEO: AI is unleashing a flywheel effect on our business
Snowflake may have a few more surprising quarters ahead as customers pay for added AI services.
Microsoft patches a record 972 vulnerabilities, 112 of them critical
Security gnomes are pumping out patches ahead of an expected onslaught of AI-assisted attacks.
What Stands Out About Buccaneers' Week One Depth Chart?
The Tampa Bay Buccaneers' official depth chart had some surprises on each side of the ball. See which players have moved into starting roles ahead of Week 1.
Nebraska Stat Tracker vs Ohio, Week 1
Nebraska 49, Ohio 21 — and the offense is a long way ahead of the defense Welcome to the first statistical breakdown of the 2026 Nebraska football season. I said back in the summer that I’d track a set of numbers all year to see how this team is actually doing, and this is the […]
We redshirted our son for kindergarten. Then he skipped a grade.
We held our son back for kindergarten because of different state cutoffs. When he became bored academically, we moved him ahead a grade.
Patriots-Seahawks Betting Report: Books Need Super Bowl Middle In Opener
A rematch of SBLX will kick off the NFL season. Patrick Everson breaks down the betting action ahead SEA-NE, with books needing a specific result.
Are the Chargers being disrespected?
Are the Chargers not receiving enough support from the media ahead of the season despite back-to-back 11-win campaigns?
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
SEC sets meeting to discuss booting LSU from conference
The Tigers didn't ultimately add any NFL players to their roster ahead of Week 1, but that hasn't stopped the SEC presidents' crusade against them.
NFL media hires two veterans as new analysts
NFL Media is bolstering its ranks ahead of the 2026 season with a pair of familiar names. The league’s media arm is undergoing a transition this season with NFL Network now under the umbrella of ESPN. That arrangement is part of the equity deal that now sees the league as a minority owner in the…
Jimmy Rolder returns as Lions boast good health ahead of opener
The Detroit Lions roster is fully healthy for practice as key players return ahead of the season opener against Saints.
"The more he plays the better he gets": OU head coach Brent Venables on Cole Sullivan ahead of Michigan week
OU head coach Brent Venables and offensive coordinator Ben Arbuckle spoke to the media Tuesday following a dominant 51-0 victory over UTEP Friday night.
Pirates’ historic slump signals better days ahead
Pittsburgh’s offense dropped from first to worst in second half of 2026
Dan Campbell Gives Kerby Joseph Update Ahead of Week 1
Kerby Joseph has returned to the Detroit Lions facility as he continues recovering from the knee injury that ended his 2025 season.
Penn State HC Provides Two Injury Updates Before Temple Game
Penn State head coach Matt Campbell has revealed two injury updates ahead of Week 2.
Chinese giants Xiaomi, Huawei race to get ahead of Apple’s rumored foldable iPhone
Xiaomi and Huawei launched new foldables ahead of Apple’s event, where the company is rumored to unveil its first foldable iPhone.
Peter Krause reflects on his decades-spanning television career: ‘I like to work’
From ‘Sports Night’ to ‘Six Feet Under’ to ‘9-1-1,’ Peter Krause has been busy for the past ... several decades. The veteran actor talk to EW ahead of his new show, ‘Line of Fire.’
Watch Reacher and Neagley reunite in the opening scene of the new spinoff (exclusive)
Ahead of the “Neagley” series premiere, watch Alan Ritchson bring Reacher to the Chicago-set series.
AMID POLITICAL AD BOMBARDMENT, SAUSAGE DECLARES ITS CANDIDACY… FOR DINNER
As political advertising floods screens, phones and mailboxes ahead of the 2026 midterm elections, Johnsonville is entering the race for Dinner 2026 with a candidate of its own: Sausage. Backed by new research commissioned by Johnsonville suggesting Americans are overwhelmed by both politics and meal planning, Sausage is running on a core promise to simplify dinner decisions.
Celtic Confirm Good News Before Game vs St Johnstone
Celtic have confirmed some fantastic news ahead of their game against St Johnstone this week.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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