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Recent Chicago Cubs Player Called Up By New Team
A recent Chicago Cubs player is back in the big leagues after earning a call-up from his new National League team. The post Recent Chicago Cubs Player Called Up By New Team appeared first on HEAVY.
Wilkinsburg billboards try to attract new businesses during Parkway East detour: "Tunnel traffic is forever"
Where to Watch the TIME100 Sports Gala Red Carpet Livestream
The most influential athletes, coaches, advocates, and investors in sports will gather in New York City on July 16 for the inaugural event.
It’s not me, it’s them: Platner goes down snarling with graceless exit video
The populist Democrat nominee for Senate in Maine bowed to the inevitable but turned his farewell into a pity party
World Cup 2026: England defender Marc Guehi a serious doubt for quarter-final clash with Norway
What's next for immigrants with TPS status after Supreme Court ruling?
The legal status of nearly 1.3 million immigrants facing war or environmental disasters in their home countries is up in the air following a U.S. Supreme Court ruling on the Temporary Protected Status (TPS) program. In a 6-3 decision, the high court ruled last month that the Homeland Security secretary’s decision to grant, extend or terminate a country’s TPS designation, which lets people from eligible countries legally live and work in the U.S. for periods
Avondale's single grocery store shutting down after 1 year in business
After opening in early 2025, Avondale's single full-service grocery store announced July 9 that it will be closing its doors.
Microsoft goes all in on new AI-powered Windows security strategy - what it means for you
An elite security team at Microsoft has built an AI-powered pipeline to find vulnerabilities in Windows and get them to engineers to build fixes.
Globavend Expands Entertainment Business Through Strategic Investment in MAMAMOO 2026 WORLD TOUR <4WARD> Hong Kong, Securing Participation in Concert Economics
Investment strengthens company's live entertainment presence and advances its AI-powered digital entertainment strategy...
Arts and entertainment events happening July 9th-12th across the Mid-Ohio Valley
Jeff Dewitt joins Daybreak to discuss what’s happening July 9th-12th across the Mid-Ohio Valley.
West Atlanta organizers gather to preview Healthy Soul & Mental Health Fest Atlanta
International Business Machines (IBM) Unveils New AI Infrastructure, Is The Stock Fully Priced?
International Business Machines (IBM) stock has been in focus after a cluster of technology announcements, including quantum computing work on fusion energy, new z17 and LinuxONE 5 rack mount systems, and expanded cybersecurity partnerships. See our latest analysis for International Business Machines. Against this backdrop of quantum computing progress, new z17 and LinuxONE systems, and expanded cybersecurity partnerships, International Business Machines’ share price has moved sharply, with a...
From Our Partners: Eastside Small Businesses Can't Afford to Ignore Cybersecurity Anymore
Today, alongside familiar challenges such as inflation, workforce pressures, and economic uncertainty, small-business owners face another growing risk that is becoming increasingly difficult to ignore: cybersecurity.
Do you know where your birth certificate is? Journalist warns of new voting barriers
The rules of the midterms are being rewritten, from redistricting to campaign money. Mother Jones journalist Ari Berman explains why President Trump seems "obsessed with the mechanics of voting."
OPB’s First Look: Oregon Health Plan faces looming budget cuts
A new report gives Gov. Tina Kotek dozens of options to cut the Oregon Health Plan budget in coming years, but it offers no clear path forward. Here's your First Look at Wednesday's news.
For A Few Short Minutes Today, 99 Percent Of Humanity Will Be Bathed In Sunlight. If You Miss It, You Will Get Another Chance Tomorrow.
For a short few minutes, nearly all of humanity will experience sunlight together.
Tech, Media & Telecom Roundup: Market Talk
Find insight on SpaceX, LG Electronics, Tencent, and more in the latest Market Talks covering technology, media and telecom.
Turning Ideas Into Businesses with Keith Glines
If you’re launching your first business, dreaming about taking the leap, or curious about what it takes to turn an idea into business… listen in!
Oregon eyes $421 million in Medicaid cuts, including fewer benefits and limits on prescription drugs
Major cuts are coming to the Oregon Health Plan, the state’s free healthcare program covering 1.4 million children and low-income adults. But the group of experts Gov. Tina Kotek charged with minimizing the harm of those cuts has given her no definitive recommendations.
Williamson Health leaders say $950M Ascension St. Thomas sale will fuel hospital growth in the county
Williamson Health's board recommends a $950M sale to Ascension St. Thomas, pending Williamson County commission approval.
Samsung unveils Galaxy Z Fold 8 deal for $1,230 off ahead of July Unpacked
Samsung Unpacked will take place later this month in London, and all eyes are on the Galaxy Glasses.
Graham Platner's ruined campaign in Maine adds pressures for Democrats
Platner had entered the race as an outsider and was seen as riding a progressive, anti-establishment wave of support.
Candidates for Kentucky’s 6th Congressional District make their case to Lexington business leaders
Ralph Alvarado and Zach Dembo squared off Tuesday on topics including tariffs, immigration and federal spending
Former Notre Dame basketball legend lashes out on social media
Former Notre Dame women's basketball player Skylar Diggins took to social media to vent about her losing her starting spot.
Wisconsin Supreme Court refuses to release voter records sought by conservative activist
The case has been wending its way through the courts for years and stems from attempts by conservatives to overturn President Joe Biden’s victory in Wisconsin over President Donald Trump in 2020.
Former Panthers GM lands new exec role
A former Panthers GM has himself a new executive gig outside of the NFL.
23 confirmed cases of Legionnaires' disease on Upper East Side, health officials say
Discord accidentally banned over 8,000 people for posting grids and other ‘benign’ images
Discord blames a bug affecting its safety system.
Hastings Public Library brings Science Across America to Hastings
HASTINGS - Hastings Public Library is inviting the community to discover the excitement of scientific explorat...
Trump demands Republicans use budgetary gambit to pass voting reforms
Donald Trump's latest demand: that congressional Republicans combine voting reforms with defense spending and bring both to his desk before recess.
‘Profoundly corrupt’: The EU’s leading FIFA critic sharpens his attack - Live Updates
European lawmaker Barry Andrews savages the world football governing body after U-turn on American star's suspension.
Pascagoula mayor highlights development, flooding and youth sports
Pascagoula Mayor Jay Willis spoke last week at the Mississippi Municipal League Conference.
College Merger Sparks Athletics Lawsuit Amid Enrollment Cliff
As some colleges merge to better handle a new higher education landscape with fewer students—and thus diminished tuition, dorm and meal plan revenue—along with less federal money for research, greater restrictions on international student visas and more restrictive federal student loan caps, the athletics implications could prove confounding and litigious. Enter: a new lawsuit brought …
Do You Know Your Dementia Risk?
The risk for Alzheimer's doubles every ten years after the age of 60. Knowing your risk can potentially help you prevent dementia as you age.
Ebola outbreak containment hampered by USAID closure, experts say
Foreign aid cuts have "demonstrably worsened" the Ebola crisis, a virologist told CNBC.
Go behind the scenes of DE Museum of Nature & Science's research labs
DE Museum of Nature & Science offers behind-the-scenes tours of its Collections & Research lab, as we join the tour for a preview, July 5, 2026.
FIFA clears Folarin Balogun to play for USMNT against Belgium, FOX Sports reports
FIFA has cleared U.S. men's national team forward Folarin Balogun to play in the Americans' World Cup Round of 16 match against Belgium on Monday in Seattle, according to a FOX Sports report.
NH's Business: Increasing energy demand in New Hampshire
Fred Kocher sits down with William Hinkle with Eversource to talk about how increasing demand for energy affects affordability for customers.
Mahdi Nicoll-Jazuli commits future to Chelsea by signing scholarship terms
The central midfielder turned down many leading European clubs in favour of continuing his development at Stamford Bridge.
Small Business Tech News: Big Brands Rolling Out Robotics And Rolling Back AI
GM, Santander and other companies are expanding robotics and AI, but other companies are having doubts.
Wimbledon: Elise Mertens beats No. 2 Elena Rybakina, Alex Eala knocks out defending champion Iga Świątek
Mertens ends a six-match losing streak to the 2022 Wimbledon women's champion.
His AI startup has a literal moat: a castle for an office
Rémi Louf is the CEO of the AI startup .txt. He works out of a castle with iron gates and a moat in Bourron-Marlotte, France.
Lidstrom: Red Wings Expect Arvidsson to Play in Top Six
The post Lidstrom: Red Wings Expect Arvidsson to Play in Top Six appeared first on Detroit Hockey Now. For the first time since 2015, the Detroit Red Wings didn’t select a Swede in the NHL Entry Draft. They […] The post Lidstrom: Red Wings Expect Arvidsson to Play in Top Six appeared first on Detroit Hockey Now.
Local fireworks stand sees business surge amid firework crackdown in parts of the region
The Fourth of July is just hours away, and for people celebrating across the region, setting off fireworks is a tradition.
Class of 2028 quarterback Trey Tagliaferri commits to OU
Class of 2028 quarterback Trey Tagliaferri has committed to OU, according to On3's Hayes Fawcett.
Former NBA player, Richmond native Ed Davis indicted in federal sports gambling case
Former National Basketball Association (NBA) player and Richmond native Ed Davis is among the six defendants indicted in a federal sports gambling case, according to an indictment unsealed on Monda…
A Q&A with Graham Nash
Currently on a 2026 U.S. tour, Graham Nash performs with a talented three-piece band and incorporates classics like “Immigration Man” and “Chicago” to resonate with contemporary issues and audiences.
How the FIFA World Cup is providing a boost for L.A. businesses
The FIFA World Cup has given L.A. businesses a lot of opportunities to find new customers, win contracts and grow their capacity.
Political commentator calls CNN story on deportee caught in Venezuela earthquake 'absolutely ridiculous'
'Fox News @ Night' panelists discuss CNN's story on a deportee caught in the Venezuela earthquakes and an MS NOW guest saying Democrats have 'gone off the rails.'
LeBron James' birthplace urges NBA star, 'Come home...please'
Akron's Summa Health, birthplace of LeBron James, posted a not-so-subtle message on Instagram urging the NBA star to finish his career in Cleveland.
Pittsburgh Pirates vs. Philadelphia Phillies: Jared Jones vs. Alan Rangel
The Pirates are on the road looking to grab a win today.
What’s going up on Airline Highway, near Coursey Boulevard?
The first phase of construction started in May, according to a Facebook post by Centurion Construction Management, the general contractor.
CVS Health Foundation Invests $1 Million in Rhode Island Nonprofits Tackling Community Health Needs
Local organizations receive Hometown Fund support to expand access to health care, food, housing and essential services WOONSOCKET, RI / ACCESS Newswire / July 2, 2026 /Originally published on CVS Health Company Newsroom The CVS Health Foundation ...
Arts and entertainment events happening July 2nd-5th across the Mid-Ohio Valley
Joe Oliverio joins Daybreak to discuss what’s happening July 2nd-5th across the Mid-Ohio Valley!
Chris MacFarland explains how he's improved Nashville Predators roster
Chris MacFarland explains how he's improved Nashville Predators roster
Why Meta's cloud business would be 'very bad' for these 2 companies
D.A. Davidson head of technology research Gil Luria explains what Meta's (META) potential cloud business means for CoreWeave (CRWV) and Nebius (NBIS).
Michael Weatherly to return to 'NCIS' after cancellation of 'Tony & Ziva' spinoff
Michael Weatherly is set to reprise his role of Tony DiNozzo in a season-long arc on 'NCIS.'
Are your kids already bored this summer? Here’s a new entertainment option.
Sky Zone of Wichita is “an indoor trampoline amusement park,” as one of its owners put it, and is having a soft opening starting July 10.
Trump's new Air Force One: differences, design, cost, photos of inside
Donald Trump flew on the new Air Force One, a luxury jet gifted from Qatar, for the first time. Here's how it compares to the old presidential plane.
Apple’s iPhone 18 Pro Max eSIM Model To Pack A Mammoth 5,425mAh Battery, While Physical SIM Buyers Get Predictably Shortchanged On Battery Capacity
In keeping with the prevailing divulgatory trend, the latest tidbit has detailed the battery capacity within Apple's iPhone 18 Pro Max.
Democratic socialist Melat Kiros defeats longtime House incumbent in Colorado primary
Kiros, a 29-year-old lawyer turned doctoral student, is the latest candidate to rise from the party's left flank and boot establishment-backed candidates.
Kings County names Lisa Rogers as new behavioral health director
Kings County has appointed Dr. Lisa Rogers as its new behavioral health director, bringing more than 15 years of leadership experience.
ER visits spiked around Boyle Heights during warehouse fire, public health data shows
While some residents say the smell of rotting food is improving, we are learning that ER visits nearby tripled during the warehouse fire.
See the first look for 'Neagley,' from the world of 'Reacher,' which premieres on September 16
Maria Sten stars as a private investigator Frances Neagley in a gripping new action series set in the world of Lee Child's best-selling novels.
Xavier Worthy: 2026 fantasy football projection for Chiefs WR
Take a look at out latest outlook for Kansas City Chiefs WR Xavier Worthy's 2026 fantasy football prospects.
Push to add limits on school sports participation to Nebraska Constitution gathers 211k signatures
The push comes after the U.S. Supreme Court upheld two similar state laws; the group said it collected the most signatures in state history.
Anthropic unveils 'Claude Science' AI platform for scientific research
Anthropic on Tuesday launched Claude Science, an AI platform designed to help scientists streamline research, analyze data and manage complex computing workflows.
UNC basketball champion arrested after illegal sports betting scheme
Former Tar Heel Ed Davis was one of six arrested in the latest betting sting.
Grand Theft Auto workers seek union recognition after mass firings
Exclusive: Staff at Rockstar Games hope move can be completed before release of GTA VI scheduled for November
Duke basketball's first 2027 commit has a familiar last name
The Blue Devils get another Knueppel next year.
'House of the Dragon' star Emma D'Arcy on Rhaenyra's ascent, the scene they 'dreaded,' and that beheading
Union Pacific And Norfolk Southern: How Politics Can Have A Body Count
Advances in goods shipment must be achieved not to bring harm to the trucking industry, but to protect increasingly acquisitive Americans from death born of their wealth.
BCBSM billing change could limit access to mental health care, psychiatric offices say
A recent billing change announced by Blue Cross Blue Shield of Michigan will affect access to mental health care across the state, according to psychiatric offices. The insurance provider says the change is in line with up-to-date guidance.
Meet the worst L.A. free-agent signing ever
There have been a lot of bad free-agent signing in L.A. sports history, but this one rises, or sinks among all the others.
Ahead of the MLB trade deadline, here’s where the Yankees stand
Yankees general manager Brian Cashman is almost always aggressive when he believes in his team.
Movies, books, art and music to explore as America turns 250
As America celebrates 250 years, we size up how it’s been portrayed in, and has shaped, what we watch, listen to and read.
Running through challenges: Elite runner returns to Missoula Half Marathon after health complications
Abby Rodseth finished as the 11th woman in the Missoula Half Marathon, completing an emotional return to competitive running.
California Politics 360 full episode | What to expect on California's November ballot
KCRA 3 Political Director Ashley Zavala leads conversations on California's November ballot questions, including the proposed billionaire tax.
Greens examining how party decides policy as membership triples under Zack Polanski
Exclusive: Concerns in-person vote system is giving bigger say to organised fringe activists who can attend conference
Austrian GP: Kimi Antonelli completes Friday practice double as Mercedes team-mate George Russell struggles
Music Legend Axes Shows After Onstage Health Scare
Lionel Richie was hospitalized on the opening night of his tour with Earth, Wind & Fire after feeling dizzy on-stage.
How to get free Windows 10 security patches until October 2027 - and avoid the $30 fee
Don't want to pay to keep Windows 10 security updates? Microsoft has several workarounds, with the best deal for European users.
Trump nominates Chris Klomp as HHS second-in-command
President Donald Trump on Thursday named Medicare director and former health care executive Chris Klomp to be deputy secretary of the US Department of Health and Human Services.
Kentucky State hosts students for agriculture and health science camp
Students from across the country are at Kentucky State University for a summer program focused on agriculture, health and environmental science.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
State health officials investigate Novi death, illnesses after dialysis
Police say no evidence of foul play in death, sicknesses following dialysis at DaVita.
Senator Ron Wyden accuses US health agency of plan to deport more than 500 migrant children
Wyden says in a letter addressed to Robert F Kennedy Jr that HHS is preparing an ‘unprecedented legal framework’
19th Hole party zone brings entertainment, drinks, and live music to Wichita Open
The 19th Hole at Crestview Country Club has become one of the tournament’s signature attractions, offering live entertainment, local vendors, cocktails, games and a lively atmosphere throughout the four-day event.
Lionel Richie reportedly hospitalized after medical incident forced concert to end early
Lionel Richie has reportedly been hospitalized after a medical incident on stage forced him to sit down to sing a song on the opening night of his tour with Earth, Wind & Fire.
Could the history of Mars be set in stone? Meteorite discovery may offer clues to Red Planet's past
Garnet found in a 4.4-billion-year-old meteorite gives potential insight into the history, development and geological processes of Mars.
US says China trying to discourage states, businesses from engaging with Taiwan
China has been contacting U.S. states and private firms to discourage engagement with Taiwan and mischaracterising U.S. policy, but links with Taiwan should be expanded, three U.S. government departments said in joint letters.