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Patient enrolment begins in a scientific trial to identify the first effective treatments for Bundibugyo virus disease
In a major international effort to evaluate potential treatments for Ebola disease due to Bundibugyo virus (BVD), the PARTNERS clinical trial has opened enrolment today for patients in the Democratic Republic of the Congo.
Croatia criticised for ‘unambitious’ changes to 2022 science law
Croatia’s science ministry has been accused of a lack of ambition, and even incompetence, over proposed changes to the country’s 2022 science law. Critics say an opportunity has been missed to fix wider shortcomings in the research and universities system.“This law, like all the previous ones, will not significantly change the current state of science in Croatia,” Vlatko Silobrčić, a member of the Croatian Academy of Sciences, told Science Business. “A small shift here and there will not have a significant impact.”The 2022 law introduced multi-year block grant financing of research, based on results, and changes intended to boost employment and career progression for researchers and lecturers. But implementation of the law has been uneven. “It became apparent that certain of its provisions were subject to different interpretations by higher education institutions and scientific institutes,” the science ministry said in its proposal for change. “This caused legal uncertainty in the system, administrative difficulties in implementation and, in certain cases, unequal treatment of teachers, scientists and students.”Most of the proposed amendments deal with technicalities in hiring and promoting staff, such as extending the committee deadlines from 60 to 90 days, or allowing applicants to cite all of their achievements and not only those since their last appointment.Both the ministry and Croatian media highlighted changes that would raise the retirement age from 65 to 67 years and allow part-time students 15 year rather than 10 years to finish their studies.The change to retirement age has been criticised for reinforcing a weakness in the system. According to Matko Marušić, professor emeritus at the University of Split, this will “allow unproductive teachers to advance and work longer, while hindering and discouraging productive ones.”A longtime campaigner for excellence-based meritocracy, he sees little hope in the new legislation. “I am not optimistic that things will improve,” he told Science Business. “As recent changes to the law in Croatia show, the legal framework is becoming increasingly hypocritical and harmful.”For Marušić, who analyses Croatia's university system in a recently published book, the situation is “unfavourable and constantly deteriorating” due to the criteria used for academic advancement.“The key criterion for advancement should be scientific productivity,” he said. “In Croatia [. . .] scientific criteria are increasingly lowered, and ineffective and absurd criteria such as waiting times for promotion and age limits for remaining in a job are promoted.” He would also like to see better criteria for the quality of teaching at universities. “In practice, teaching is not monitored or evaluated,” he said, estimating that up to a third of teaching simply does not take place. “Under the guise of university autonomy and bad laws, universities and faculties are allowed to earn additional money by increasing enrolment quotas that have nothing to do with the needs of the labour market.” Lack of ambitionDora Kršul, a reporter at Telegram.hr who covers science policy in Croatia, finds the rationale for changes “bizarre.” “The ministry responsible for supervising the uniform application of the law is changing the law because it is being implemented unevenly,” she said. “This primarily speaks to the power relationship in the sphere of science and higher education in Croatia, that is, the question arises as to who actually manages this system.”Rather than raising quality, she continued, the changes appear to be designed to help vocational and applied universities who have not been complying with the law.The Independent Union of Research and Higher Education Employees of Croatia said that the changes were “unambitious” and represent a missed opportunity for more important changes. “We think some of the changes are even negative,” it said in its statement on June 25. One of these is introduction of an “assistant” job title that allows people to be hired only for the duration of a project. Related articles: Elections to top science bodies test Croatia’s gender equality in researchSlovakia revises R&D approach to increase focus on competitivenessLatvia pilots citizen engagement in research grant evaluationsThe union’s president, Tvrtko Smital, who was part of the 15-member working group tasked with drafting the changes, told the local media there was a “worrying lack of ambition” in the process, and “lack of competence” in terms of research experience and understanding the problems in the system.“There is no clear will to deal with the problems,” said Smital, an assistant professor of marine and environmental sciences at the Ruđer Bošković Institute in Zagreb. “It’s a combination of unambitiousness and incompetence,” he went on, expressing his “deep frustration” with the situation. “There is no strategy, no clear thinking, and money is not being spent optimally.”Croatia’s science ministry has not responded to requests for comment.
Philippines' 80-year bet on America
Eight decades after the US recognized Philippine independence, Manila remains closely tied to Washington through treaties, military cooperation and billions in trade. DW went to Manila and Washington to ask what this partnership delivers — and who pays the price.
American dessert taste test: McDonald's, Burger King, Wienerschnitzel
I ranked fast food desserts from McDonald's, Burger King, Krispy Kreme and Wienerschnitzel to find the best patriotic treat.
James Ransone coroner report shows actor's mental health struggles
"The Wire" actor James Ransone wanted mental health treatment before his death by suicide at 46, according to a medical examiner's report.
Congressman Tom Kean’s hospital treatment for depression may encourage men’s mental health
When a Republican, male politician spoke publicly about a leave he took to get help for his depression, the US saw something uncommon and needed, experts say.
If we lose our coverage, we lose our lives
By Thomas Buckley My oncologist asked: “Polycythemia Vera. Do you know what that means?” Earlier, I lived in blissful ignorance, unaware I potentially carried a myeloproliferative neoplasm encoded within my DNA. “Yes,” I answered, “A rare form of blood cancer, incurable, not necessarily fatal, provided it’s treated.” At 31, I thought I had life figured […]
Maryland Gov. Wes Moore: How to improve young men’s mental health
“We need to stop treating our young men and boys as problems to be solved, and start treating them as people to be invested in,” writes Gov. Wes Moore.
Treat Your Health Like A Private Equity Firm For Better Leadership
Disciplined investors have a specific way of evaluating and improving assets. Here's how executives can use that same lens to optimize their health and leadership.
Can GLP-1 medications improve health in people with Type 2 diabetes and PAD?
Research Highlights: GLP-1RA (glucagon-like peptide-1 receptor agonist) medications, which are prescribed to treat Type 2 diabetes and to help with weight loss, were found to reduce the number of deaths, amputations and hospitalizations among people...
New BioShocking attack manipulates AI browser into data theft
A new prompt injection attack dubbed "BioShocking" could trick AI-powered browsers into treating real-world risky actions as part of a fictional scenario, causing them to ignore any safety guardrails.
Records show prior mental health petition for man accused of killing grandmother in Farmington Hills
Records show a petition was filed over three years ago seeking court-ordered mental health treatment for the 34-year-old man accused of killing his grandmother inside the home they shared in Farmington Hills.
ARDS patients improve with experimental treatment
JUPITER, Fla. — Doctors have few options for patients who develop a life-threatening lung condition called acute respiratory distress syndrome, or ARDS. A…
Kathie Lee Gifford admits she 'wanted to die' after misdiagnosis and multiple surgeries for chronic pain
Kathie Lee Gifford reveals she was misdiagnosed for a year and treated for a spinal issue before doctors discovered her hip had deteriorated to "ash."
PlayStation PC Retreat Is A Mistake, As 18+ Months Late Ports Made Money Without Costing a Single Console Sale
Shawn Layden argues PlayStation’s PC port retreat is a mistake, proving late ports made cash without dropping PS5 sales
N.I.H. Announces World’s Largest Integrated Health Database
It contains more than half a million people’s genomes, paired with clinical records and wearable tech data. That gives researchers unmatched power to study both diseases and treatments.
Leading Colorado toward modern mental health solutions
By Sean Camacho America is facing a silent crisis. Millions of Americans are living with invisible illnesses like generalized anxiety disorder (GAD), major depressive disorder (MDD), and post-traumatic stress disorder (PTSD), which decrease quality of life and, amid limited treatment options, create a vicious cycle of endless medications and, for many people, hopeless therapies. This […]
Scientists cured sickle cell. Then their next challenge began.
Gene editing has delivered remarkable results against sickle cell disease. Now researchers are working to make these personalized treatments faster, cheaper, and available to far more patients.
Scientists say creatine may help fight depression
Creatine is best known as a muscle-building supplement, but scientists are now investigating whether it could also help treat depression by boosting the brain's energy supply. A new review examined five randomized clinical trials involving 238 participants and found mixed results. Two studies, both involving women with major depressive disorder, reported that adding creatine to standard treatment improved symptoms, while three others found no meaningful benefit.
Gavin Newsom signs law limiting mental health diversion for people accused of crimes
A new California law gives just more flexibility to keep defendants in jail rather than releasing them to community-based mental health treatment programs.
Cost and utilization of inpatient mental health and substance use treatment - Peterson-KFF Health System Tracker
Approximately 1 in 5 people with private health insurance have any mental illness, and 1 in 20 have a serious mental illness. This brief examines inpatient mental health and substance use treatment admissions in 2023 among adults aged 18-64 with large employer-sponsored health insurance plans. Private insurance enrollees constitute roughly a quarter (26%) of mental […]
Pierce Johnson's NSFW Reds-Pirates HR reaction gets Jomboy treatment
Reds relief pitcher Pierce Johnson had an animated, NSFW reaction to allowing an eighth-inning home run in Pittsburgh.
Connie Cepko: A Life in Science Mapping the Retina — and Working to Save It
Over a five-decade career, HHMI Investigator Connie Cepko has reshaped our understanding of how the retina develops and forged new paths toward treating blindness and inherited retinal disease. This story is part of a series exploring the careers of HHMI scientists.
FDA approves surgical device for high-risk aortic procedures
The AMDS Hybrid Prosthesis was designed to help clinicians treat DeBakey Type 1 dissections complicated by malperfusion. It works as a complement to hemiarch replacement, preserving the native arch and making reinterventions possible if needed.
Minneapolis council member taking leave for mental health treatment, cites turmoil in city
Council Member Aisha Chughtai said the city’s various challenges in recent months have taken their toll on her.
When sushi meets schools in rural Colorado, everyone wins
NATHAN YIP FOUNDATION Greenwood Village By JOANNE DAVIDSON SPECIAL TO COLORADO POLITICS News: Sushi-lovers from Denver and beyond know that they’re in for a treat when the Nathan Yip Foundation hosts its annual Sushi Party. The rush to purchase tickets begins months in advance and when the big day arrives, the event space atop The Dome at AMG is filled to capacity. […]
Scientists discover an unexpected way to make pancreatic cancer cells self-destruct
Researchers tested experimental PCAI compounds against pancreatic cancer cells and found they had powerful anticancer effects. One leading compound blocked more than 90% of cancer cell migration, suggesting it could help prevent the spread of tumors. Rather than suppressing cancer signaling, the treatment hyperactivated key pathways until the cells essentially self-destructed.
My wait for a psychiatric bed in Denver highlights this nation’s overburdened system (Opinion)
Just before my birthday, a Denver doctor placed me on an involuntary 72-hour mental health hold. What came next wasn’t treatment but a drawn-out search for a bed, as the U.S. grapples with a shortage for those in crisis.
People are taking allergy and heartburn pills for PMS. Could it work?
Can the mix really help with premenstrual woes? Theoretically, the link between histamine and hormones could explain why the trendy DIY treatment seems to help some women.
AB Science reports completion of the step 3 of phase 1, evaluating the combination of AB8939 with venetoclax for the treatment of refractory or relapsed AML
PRESS RELEASE AB SCIENCE REPORTS COMPLETION OF THE STEP 3 OF PHASE 1, EVALUATING THE COMBINATION OF AB8939 WITH VENETOCLAX FOR THE TREATMENT OF REFRACTORY OR RELAPSED ACUTE MYELOID LEUKEMIA THE COMBINATION OF AB8939 WITH VENETOCLAX GENERATED A 67% OVERALL RESPONSE RATE (ORR) AND A 100% DISEASE CONTROL RATE (DCR), WITH NO DOSE-LIMITING TOXICITIES (DLT) OBSERVED, IN A POOR-PROGNOSIS POPULATION WITH ADVERSE GENETICS TREATED IN THE SECOND - TO FOURTH-LINE RELAPSED OR REFRACTORY SETTING Paris, June 2
Lux and Samira announced for 2XKO
After the finals for 2XKO at Evo 2026 today, the developers decided to treat us to something special — namely a full reveal of the remaining characters for the game's first season.It was shown that Lux, the Lady of ...
Concerns with the Sebastian County Sheriff’s office
The recently-surfaced video showing the potential maltreatment of a Sebastian County Jail inmate, and a subsequent statement about the troubling incident from interim Sheriff Mike Conger point to the need...
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Cassidy, fresh off a blowup with Trump, blasts RFK Jr.’s policies
The GOP senator said a “foundation of lies” had shaped Kennedy's health stances. He also accused Trump of treating Congress as an "appendage."
Bill Cassidy accuses Trump of treating Congress as ‘merely an appendage’
Out-going Louisiana senator’s rebuke over Iran war is rare instance of a Republican politician standing up to Trump
What science tells us about the algae bloom in the Lincoln Memorial Reflecting Pool
Algal blooms are not maintenance failures requiring paint or treatment with hydrogen peroxide and nanobubbles. They are ecological warning signs.
Huntsville health department hosting no-cost prostate exams
Prostate cancer can be treated and cured with early screenings, according to Dr. Thomas Moody with the Urology Health Foundation.
These tiny soil microbes could rescue crops from salty farmland
Researchers have discovered that beneficial soil bacteria give plants an unexpected survival advantage in salty soils. Instead of helping plants keep salt out, the microbes stimulate the production of lignin, a natural compound that strengthens roots and makes plants more resilient. Greenhouse and field tests showed healthier plants and higher yields in salty conditions. The findings could lead to bio-based treatments that help farmers grow crops on land once considered too salty for agriculture.
Meteor streaks across skies, causes bright flash Sunday morning
Early risers across southeast Louisiana were treated to quite a sight on Sunday morning when a brilliant flash of light streaked across the pre-dawn sky. Around 5:00 a.m., Storm Station viewers reported seeing what looked like a large, vibrant green ball with fire trailing behind it followed by a bright flash. When small space rocks (meteoroids) slam into Earth's atmosphere at high speeds, they create the light streaks we call shooting stars
Science & Medicine: Scanning the brain to improve treatment for traumatized teens
Around 20% of teens who have experienced emotional trauma don't respond to talk therapy. UT Health San Antonio is using neuroimaging to track brain changes in traumatized teens during a course of therapy to see if they can figure out why, which could lead to the development of more personalized treatments that will help more teens heal.
Texas Mental Health Program Reveals 103% Increase in Veteran Enrollment
Emory University treatment is expanding throughout the state at no cost, but many veterans remain unaware of their services.
Patients can save thousands with drug coupons, but only if insurers honor them
Patients who rely on co-pay assistance from drugmakers are typically heavy users of health care for whom delays in treatment or worsening conditions can lead to higher costs, according to patient advocates.
Could 'humanmaxxing' actually help you live longer? Here's what experts say
Humanmaxxing is the latest wellness trend focused on maximizing human potential through biohacking, longevity science and advanced medical treatments.
Could 'humanmaxxing' actually help you live longer? Here's what experts say
Humanmaxxing is the latest wellness trend focused on maximizing human potential through biohacking, longevity science and advanced medical treatments.
Design and Early Implementation Outcomes of a Mobile Health-Enabled Social Support Intervention for Adults Living With HIV and Type 2 Diabetes in Uganda
Background: Adults living with HIV and type 2 diabetes experience complex treatment demands that affect medication-taking, clinic attendance, privacy, social support, and engagement with care. M...
The Chicago Bears are getting their own Hallmark Christmas movie
The Chicago Bears are the latest NFL franchise to get the Hallmark Christmas movie treatment. The team announced Thursday that it is partnering with Hallmark Media, the NFL, and Skydance Sports for Holiday Touchdown: A Bears Love Story, which will premiere during Hallmark Channel’s 17th annual Countdown to Christmas programming event this holiday season. “My…
Valleywise Health acquires system to better treat premature and critically ill infants
Valleywise Health has a new system to better treat premature and critically ill infants, becoming the first Arizona hospital to implement it.
Tony Goldwyn recalls Hollywood 'people that were mean' changing their attitude toward him after this hit film
Tony Goldwyn said that Hollywood colleagues treated him as if he 'had the plague' when he was an unemployed actor, and those same 'mean' people changed their tune after this hit movie.
UNC Health Talk: Why do I still get pimples?
Are you asking why you get acne well past puberty? Dermatologist Margaret Coates has the do's and dont's for treating adult acne.
Your health insurer shouldn’t decide your treatment plan. That’s what your doctor (and possibly AI) should be doing.
With a digital health record, clinicians and AI-driven diagnostic tools would be able to see your full health history — and then make better decisions.
Eat, Sip, Shop: New businesses bring unique products, services to Bethlehem’s Main Street
Whether you’re shopping for toys, games and puzzles or jewelry, home decor and pet treats and accessories, a variety of new retailers on downtown Bethlehem’s Main Street have you covered.
Israel’s Vance problem is bigger than JD Vance
Vice President JD Vance has become the face of a Washington that no longer treats Israel as the exception to "America First."
New vitamin B12 therapy shows promise against deadly brain cancer
Researchers have identified a vitamin B12–based compound that can cross the blood-brain barrier and home in on glioblastoma tumors. In animal studies, the compound accumulated preferentially in tumor tissue and delivered sustained nitric oxide directly to cancer cells. It also worked synergistically with existing glioblastoma treatments, significantly enhancing their tumor-fighting effects.
Scientists discover what triggers belly fat as we age
Aging may trigger the appearance of specialized stem cells that supercharge the body's ability to create new belly fat. The discovery reveals a potential biological driver of middle-age weight gain and a promising target for future anti-obesity treatments.
Testing gives science-based data for Fairmont lakes
FAIRMONT— A partnership between the city of Fairmont and Minnesota State University-Mankato will result in comprehensive scientific data on the Fairmont Chain of Lakes. The $25,000 contract started on April 1 and will go through Dec. 31 of this year. Fairmont’s Water Resources Coordinator, Hannah Neusch, acknowledged that while the water treatment plant in Fairmont […]
Scientists infected a 'vagina on a chip' with gonorrhea — then cured it with a new antibiotic found by AI
To sift through 6 million molecules in pursuit of new gonorrhea treatments, researchers trained AI to select the best drug candidate and then tested it in a "vagina on a chip."
Medical miracles that changed how we treat disease
We've come a long way since \
OHSU advances massive leap in medical science with cellular therapies
Patients are benefiting from CAR-T to treat neurodegenerative diseases, cancer, lupus and other autoimmune conditions.
Shockwave Medical announces new studies evaluating carotid IVL platform
Carotid artery disease causes up to 30% of all strokes, but severely calcified lesions can make treatment quite complex. The hope is that IVL can be as successful in this area as it has been in the treatment of coronary and peripheral artery disease.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Dolly Parton surprises fans at opening of her new travel stop amid ongoing health battle
Parton had to cancel her Las Vegas residency after announcing she was being treated for an undisclosed health issue.
UT Health San Antonio identifies the first potential probiotic treatment for lupus
Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu Content provided by Claire Kowalick SAN ANTONIO, June 25, 2026 – Scientists at UT Health San Antonio, the academic health center of The University of Texas at San Antonio, found a link between a bacterium in the gut microbiome, or ecosystem, and lupus, which could lead to more effective […]
Governor Mills Celebrates Groundbreaking for Youth Mental Health Treatment Facility in Saco
Saco, MAINE-- Governor Janet Mills today participated in a groundbreaking ceremony for Sweetser's new youth psychiatric residential treatment facility. Governor Mills and the Legislature secured more than $5 million to help build the treatment facility.
This startup is using AI to close gaps in women’s healthcare
Xella Health’s precision health platform combines biomarker testing, clinical guidance, and AI analysis to help women get earlier answers about hard-to-diagnose conditions.
Federal officials plan to offload some warehouses purchased for immigrant detention
U.S. Immigration and Customs Enforcement is retreating from a plan to use warehouses to hold up to 10,000 people on a single site, dropping a key piece of former Homeland Security Secretary Kristi Noem’s $38-billion plan to rapidly expand detention capacity this year.
New Guidebook Helps Puget Sound Beneficiaries Navigate Their Health Care
Great news for military communities and TRICARE beneficiaries across the Pacific Northwest: navigating military healthcare just got easier. The recently released Puget Sound Patient Guidebook is a comprehensive resource designed for local TRICARE beneficiaries throughout the region. Inside, beneficiaries can find information on enrolling in the Defense Enrollment Eligibility Reporting System, understanding TRICARE plans, locating a Military Treatment Facility (MTF), scheduling appointments, accessing online services, ordering medications and much more.
Helping people stay in treatment starts with the basics
SouthLight's Social Determinants of Health team helps patients connect to housing, transportation and other resources to support recovery.
Jeremy Clarkson's health dilemma 'common among farmers'
The TV star shared his worried treatment would overlap with a busy period for his Cotswolds farm.
Most IVF ‘add-on’ treatments have no effect on fertility or remain unproven, study says
Review shows majority of procedures offered alongside standard IVF not backed by reliable evidence
Boys & Girls Club Teen Mental Health Retreat Helps Teens Grow Stronger Together
Discover how one Boys & Girls Club is helping teens take control of their mental health — and bringing that impact nationwide.
Former NOAA Employees Revive Climate Web Site
The database of federal global warming research recreates a website that was closed amid the administration’s broad retreat from climate science.
More psychiatric beds alone won’t fix San Antonio’s mental health challenges, experts say
San Antonio’s mental health challenges are bigger than needing more inpatient psychiatric capacity, according to experts.
Johnson County cancer survivor's business helping others got her two tickets to the World Cup
The Balm Box include items like blankets, underarm pillows, cuticle oil, and lip balm — products designed to address the real side effects of cancer treatment.
Yes, Dusty May to the NBA should be added to the pile of college sports red flags
May is more than a great coach now. He’s a symptom, and only the willfully ignorant would try to claim there’s no illness to treat.
Could less caffeine be the smarter performance enhancer? Scientists find a surprising sweet spot
Think of an athlete eyeing the finish line—could a single shot of caffeine be the difference between a podium finish and a personal best? For decades, runners and cyclists have treated the stimulant as ...
Finnish scientist Wickström awarded Körber Prize for cell research
Finnish researcher Sara Wickström has been awarded the Körber European Science Prize for discovering that cells sense physical forces, a finding that might open new possibilities for the treatment of ...
National Family Planning & Reproductive Health Association et al. v. Robert F. Kennedy, Jr. et al.
The National Family Planning & Reproductive Health Association (NFPRHA) and its member, the Family Health Council of Central Pennsylvania (FHCCP), sued the Trump administration to protect the integrity of the Title X family planning program. Title X is the country’s only dedicated federal program for family planning services. For more than 55 years, the program has provided access to effective contraceptive methods, cancer screenings, testing and treatment for STIs, and other preventive services, with priority given to patients with low incomes.
Digital Health Tools Are Reshaping Healthcare in the United States
/PRNewswire/ -- At least 12 percent of Americans now communicate with their healthcare providers about appointments, test results, and ongoing treatments via...
This emerging treatment is helping people avoid knee replacement surgery
A minimally invasive treatment called GAE is helping people with chronic knee pain get back to gardening, cycling, and other activities without undergoing knee replacement surgery. Early studies suggest the procedure can provide years of relief by reducing inflammation inside the joint.
Rising Healthcare Costs Leave Many Americans Less Secure
By Deanna Neff HealthDay ReporterMONDAY, June 22, 2026 (HealthDay News) — A growing number of Americans are finding themselves priced out of the healthcare system. Only 49% of U.S. adults report being “cost secure,” meaning they can pay for the medical visits and treatments they need. That leaves ...
Veteran Middle East CEO says business in the region isn’t retreating—it’s resetting
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Ebola Cases Top 1,000 in Congo as Virus Infects Frontline Health Workers
Ebola cases have surpassed 1,000 in the Democratic Republic of the Congo, where health workers are becoming infected before anyone realizes they’re treating the deadly virus, exposing a dangerous weakness in efforts to contain one of the world’s fastest-growing outbreaks.
UVA Health clinical trial works to target MAC lung disease
Research at UVA is working to find new treatment opportunities for a lung disease growing in prominence around the world.
iPhone Air 2 Could Get A Hardware Downgrade That Will Seal The Fate For Apple’s Sleek Flagship Future Forever
A rumor doing the rounds claims that the iPhone Air 2 could be treated to a hardware downgrade which could put an end of sleek flagships forever
How much preventive health screening should I be getting?
Screenings can find treatable conditions before they’ve caused too much damage – but ‘overscreening’ can cause harm
Lives are being ruined by undiagnosed hypermobility and lack of treatment
Letters: Ignorance around hypermobile Ehlers-Danlos syndrome is a public health catastrophe, say readers in response to an article on how sufferers have to wait 21 years for a diagnosis
Miami-Dade Commission finally approves mental health facility over two decades after it was promised
More than two decades after voters were promised a new facility to treat people with mental illnesses, rather than warehousing them in the county jail, the Miami-Dade County Commission gave final approval on Tuesday to open the Miami Center for Mental Health and Recovery.
I started treating my dad with dementia like a customer
When my father's dementia made communication difficult, I borrowed a lesson from customer service: smile first.
Science & Medicine: A San Antonio researcher is studying magnets and money to treat alcohol use disorder
Alcohol use disorder affects millions of Americans, but treatment options remain limited, and relapse is common. A UT Health San Antonio researcher is studying two unconventional approaches that he hopes could one day be combined into a single, more effective treatment.
Here's when Rosie O'Donnell will guest host “Jimmy Kimmel Live” as a 'special treat' for Trump amid decades-long feud (exclusive)
The comedian has repeatedly sparred with the president since 2006.
Here's when Rosie O'Donnell will guest host 'Jimmy Kimmel Live' as a 'special treat' for Trump amid decades-long feud
Jimmy Kimmel announced that Rosie O'Donnell will guest host 'Jimmy Kimmel Live' as a 'special treat' for Donald Trump amid her decades-long feud with the president. Here's when she'll join the show.
Stanislaus County OKs new mental health plan, prepares for state monitoring
County officials hope the plan increases access to care and serves to reduce homelessness, relieve burden on the criminal justice system and reduce untreated mental illness.
Kustom Entertainment's Stan Ross on 30 years of Country Stampede
Country Stampede at Azura. // photo courtesy Kustom Entertainment Country Stampede takes place at Azura Amphitheater from Thursday, June 25, through Saturday, June 27, and features Rascal Flatts, Zach Top, Treaty Oak Revival, Wyatt Flores, Scotty McCreery, and Tracy Lawrence, among others. Details on the festival here. In its 30-year history, Kansas’ country music festival, Country Stampede, has steadily moved...
Scientists found a cannabis compound that relieves pain without the high
Compounds responsible for the aroma of cannabis and many other plants may offer a surprising new way to relieve chronic pain. Researchers found that several cannabis-derived terpenes significantly reduced pain in mouse models of fibromyalgia and post-surgical pain, with one terpene, geraniol, showing especially strong effects. Unlike THC, these compounds are not associated with psychoactive effects, making them a potentially attractive alternative for pain treatment.
Carrie’s Custom Confections serves up sweet treats in Umatilla
UMATILLA — Anyone suffering from chronic dry mouth should stop by Carrie’s Custom Confections in Umatilla for a mouth-watering treat. Carrie and Jenny Stamm moved into one of the business […]
Roupp still winless after late lead lost
That Landen Roupp to Sam Hentges combo is always a treat!
Ozempic changed obesity treatment, but experts say the real revolution is next
The obesity treatment landscape is changing fast, with GLP-1 drugs opening the door to more effective care than ever before. Experts now envision a future where medications, minimally invasive procedures, surgery, and precision medicine work together to deliver better long-term results.
Faecal transplant makes the brains of old mice act young again
Older mice that received a faecal microbiome transplant from younger animals went on to have improved brain plasticity, which meant their brains could overcome a neurological condition that is typically successfully treated only in childhood
TGH Behavioral Health Hospital Launches Partial Hospitalization Program, Expanding Access to Outpatient Mental Health Care
/PRNewswire/ -- Tampa General Hospital (TGH) Behavioral Health Hospital has launched its Partial Hospitalization Program, a structured daytime treatment...