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Barton on enjoying over-60s England bubble

Ian Barton is bracing himself to go to Canada to represent England in the Over-60s World Cup.

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Jul 7 • 3:16 AM EDT • Sports • sports.yahoo.com
Grace Ueng: What stayed with me from my 35th Harvard Business School reunion

Thirty-five years after arriving at Harvard Business School as a nervous first-year student, Grace Ueng found herself standing at the front of the classroom leading a very different conversation.

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Jul 6 • 9:09 PM EDT • Business • wral.com
Windows 11 will soon be able to reinstall itself and your drivers without a USB drive via new 'Cloud Rebuild' recovery method

A new recovery option coming to Windows 11 will let you reinstall the OS and your drivers using the internet without a USB key, even when Windows itself is unbootable.

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Jul 6 • 8:18 PM EDT • Technology • windowscentral.com
Stevens courts McMorrow supporters, leans into electability pitch at small business visit

U.S. Rep. Haley Stevens, a Democratic candidate in a U.S. Senate primary that is now a two-person race, drew hard lines between herself and her primary opponent, former Wayne County Health Department executive Abdul El-Sayed, in a visit to Sea Leveaux, a Cajun boil restaurant in downtown Lansing that opened on Thursday.

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Jul 6 • 5:16 PM EDT • Business • michiganadvance.com
Graham Platner says he's "taking the time to reflect on the best path forward" as sexual assault allegation emerges

A Maine woman told Politico that Graham Platner entered her home in late 2021 and forced himself on her. Platner denies the allegation.

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Jul 6 • 4:44 PM EDT • Politics • cbsnews.com
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Bruce Springsteen explains why he calls himself a ‘patriot’ for speaking out against Donald Trump

Bruce Springsteen shares his perspective on what it means to be a patriot and how that includes going toe-to-toe with Donald Trump during his recent PBS special, ‘Bruce Springsteen: Finding America in Song.’

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Jul 6 • 2:18 PM EDT • Entertainment • ew.com
The down-ballot races that could shape Minnesota politics for years to come

Plus: Republican Senate hopeful pushes back on criticism over self-funding.

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Jul 6 • 10:00 AM EDT • Politics • startribune.com
The Weeknd Redeems Himself By Winning Over A Baddie In Persona 3

The ‘Blinding Lights’ singer famously fumbled Tae in Persona 5

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Jul 6 • 9:00 AM EDT • Technology • kotaku.com
Who is Steve Hilton? Here’s how he has rebranded himself multiple times

The GOP nominee for California governor wants to deregulate businesses and overturn environmental rules. He’s also praised liberal workplace policies and once made the British Conservative Party more green.

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Jul 6 • 8:30 AM EDT • Politics • calmatters.org
Shia LaBeouf keeps popping up in El Paso. Here’s why

Shia LaBeouf took selfies with fans at the El Paso airport over the weekend. Here's a possible reason why the actor keeps visiting the Sun City.

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Jul 6 • 7:53 AM EDT • Entertainment • elpasotimes.com
Patchwork laws challenge nationwide hog production

The newest iteration of the long-overdue Farm Bill leaves intact California’s Prop 12. There’s an obscene amount of information within the bill, but animal welfare laws have the potential to shape the food systems here in America. A country unable to feed itself is a country unable to defend itself. In terms of Prop 12, […]

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Jul 6 • 6:55 AM EDT • Politics • coloradopolitics.com
Scientists build living ‘neurobots’ that grow their own neural networks

Self-powered, entirely biological constructs injected with neural precursor cells - reveal the surprising flexibility of nervous systems.

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Jul 6 • 1:04 AM EDT • Science • advancedsciencenews.com
Africa Asserts Itself As Pandemic Agreement Talks Resume

The Pandemic Agreement talks resume at the World Health Organization’s (WHO) headquarters on Monday (7 July), kicking off immediately with a closed session on

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Jul 6 • 12:00 AM EDT • Health • healthpolicy-watch.news
Roob's Eagles Observations: Bryce Huff's hilariously misguided memory of 2024

Why Jeff Lurie is the best owner in Philadelphia sports history, Bryce blaming everyone but himself and more in Roob's Eagles Observations.

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Jul 5 • 7:00 AM EDT • Sports • nbcsportsphiladelphia.com
Scientists have now made the most comprehensive tally yet of deep-sea exploration — 43,681 dive records dating back to 1958 — and found that humans have directly seen less than 0.001% of the deep ocean floor, an area roughly the size of Rhode Island, leaving the vast seafloor across 66% of Earth’s surface essentially unobserved.

Humanity has sent cameras to the Moon, Mars, Venus and the outer planets, but on Earth itself there is still a larger frontier that has barely been looked at directly. A 2025 study in Science Advances has now put a number on that gap: since 1958, researchers have compiled 43,681 records of dives deep enough […]

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Jul 5 • 3:30 AM EDT • Science • spacedaily.com
Trump makes himself central to America’s 250th anniversary

The president has blended patriotic spectacle with campaign-style politics, reshaping a civic milestone around his leadership and worldview.

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Jul 4 • 4:08 PM EDT • Politics • washingtonpost.com
The Steam Machine Has Its Own ‘Red Ring Of Death’

History doesn’t always repeat itself, but it often rhymes, as one Steam Machine owner discovered a familiar fatal error alert

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Jul 4 • 12:30 PM EDT • Technology • kotaku.com
The Selective Frontier: The State of the American Experiment After 250 Years

Since its inception, America has revolutionized scientific research and technological advancements. Yet, in its shift away from federal research grants and “basic research,” science may find itself in an increasingly privatized and profit-driven setting.

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Jul 4 • 9:18 AM EDT • Science • theharvardpoliticalreview.com
For one small business, AI was key to a quick start and expansion

Here Now Health isn't an AI-based company, but its quick path from an idea in founder Michelle Turner's mind to an operating mental health platform for foster children relied deeply on the technology now restructuring the U.S. economy. Working from her Virginia Beach home, she used AI tools to school herself in startup culture, create a business plan and fine-tune a presentation for early-stage investors. Funding began to flow, and the company, launched in ‌January 2025, now has 16 employees and is certified in three states to provide Medicaid-funded mental health counseling for children entering the foster system, a gap in care she identified through her own experience as a foster parent.

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Jul 4 • 6:01 AM EDT • Business • finance.yahoo.com
America held a big birthday party — and a soccer extravaganza broke out

The game the rest of the world knows as football is teaching America something about itself on its 250th birthday and reminding foreigners that the nation is far more welcoming and complex than its bitter political caricature.

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Jul 4 • 12:00 AM EDT • Politics • cnn.com
Trump pokes fun at himself, roasts Obama in children's podcast

The 24-page book “Presidents Play!” features illustrations showing how presidents, despite their hectic schedule, unwind on the White House grounds

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Jul 3 • 8:34 PM EDT • Politics • usatoday.com
Yankees injuries: Rodón on IL, Grisham and McMahon activated

Two players return to the active roster, but a valuable pitcher heads to the IL himself.

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Jul 3 • 3:14 PM EDT • Sports • sports.yahoo.com
Long Reads for the Long Weekend

(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) Happy Fourth of July weekend! As has been a tradition of mine going back to the beginning of the EntStrategyGuy website, I’m sharing my favorite long reads of the last year, like I did in 2019, 2020, 2021, 2024, and 2025. Let’s dive right in! Subscribe “Different Prices for the Same Ride: How Uber and Lyft Use AI to Get More Money Out of You“ by Derek Kravitz in Consumer Reports I don’t think surveillance pricing, like the kind described in this brilliant Consumer Reports article, is long for the world—it’s toxically unpopular—but we’ll see if either party takes on this issue. If I ran a political party focused on affordability, I would focus on a few pro-consumer and pro-market policies: Banning non-compete agreements. Ending surveillance pricing Eliminating junk fees (read more here...) Ensuring “right to repair” for consumer (and military!) products Capping excessive app store fees Stopping digital/algorithmic price-fixing tools. Preventing automatic subscription price increases. And more. If you want to fight inflation, there are a lot of great ways to do it quickly. Speaking of higher prices... “Secret Documents Show Pepsi and Walmart Colluded to Raise Food Prices Across the Economy“ by Matt Stoller in BIG Again, I think a political party should focus on lowering prices for consumers. And deals like this—Walmart making a deal/forcing Pepsi to offer the lowest prices at its stores and nowhere else—hypothetically lower prices at Walmart...but raise them everywhere else. “15 DUIs, still driving: California’s failure to take repeat drunk drivers off the road“ by Robert Lewis and Lauren Hepler in CalMatters CalMatters does terrific reporting in California, something the Golden State desperately needs more of, and this article is a great example of that. “PugLips: The next insanely popular thing you’ve never heard of…” by Simon Carless in Game Discover Co I thought that this parody article (and yes, it’s a parody, but I was definitely unsure at first) was hilarious and totally nailed how much tech/business journalism feels these days. Actually, three of my favorite articles this year were on hype in the video game industry, including Georg Zoller’s “The Video Game Industries Very Dark Night”—which I linked to recently and wrote a follow-up here—and Owen Mahoney’s “Derek Zoolander, Videogame Exec”. In particular, I like Mahoney’s focus on user experience as a guide to what trends will actually grab hold of customers. “The Matrix Lies“ by Evan Shapiro in Media War & Peace Evan Shapiro’s first person account of his experience with AI was hilarious. I think LLMs capabilities have significantly grown from last summer, and yet...my editor/researcher just had an abysmal experience using an LLM to do a quite basic task (which our LLM normally does each week) and the LLM made a mistake on every single data entry...along with seven different mistakes affecting twelve of the twenty or so entries, including mistakes that are explicitly spelled out in the prompt. That’s a brutal failure rate. Again, if you use AI/LLM for data collection, you need to take a lot of extra steps to verify and check the data. “Ghosts in the Balcony: A Cross-Country Trip to 58 Theaters Fighting to Survive“ by Matthew Frank in The Ankler I thought Matthew Frank’s pitch to head across America to visit theaters sounded insane aggressive at the time—at least it felt that way to someone a decade older than him; man, to be in your twenties again, am I right?—but I knew the result would be great. And it was, a terrific feature by a great young writer. Also, I loved Matthew’s recent article on who’s getting the precious few entry level jobs in Hollywood. (Hint: nepotism.) “Disney erased FiveThirtyEight“ and “Did Las Vegas get too greedy?” by Nate Silver in Silver Bulletin I love media history and analysis, and there’s no one better to get the history of FiveThirtyEight than from Nate Silver, who wrote about his personal experience in one of my favorite pieces from this year. I also loved Nate’s breakdown of what’s causing Vegas’ woes, but I’ll offer one criticism, summarized as “Might I suggest antitrust?” Many centrists/center-right/libertarian thinkers (Nate is self-described as the latter) often don’t consider consolidation or antitrust as factors in policy issues like housing, America’s military readiness, or, in this case, Las Vegas. Even if libertarians want to debunk antitrust/consolidation concerns, I’d love to read that debunking. In this case, Vegas is incredibly consolidated (though it also has been for a long time) and I’d have loved to read Nate at least contending with this factor, since he addresses almost every other potential factor for Vegas’ decline. “Why Microsoft’s Carbon Removal Pullback Is Such a Big Deal“ by Robinson Meyer in Heatmap News I’m a big supporter of carbon removal efforts, but this nascent industry faces a lot of headwinds, including this big move most recently. I think it’s clear that solar panels and batteries should be able to get the world to its carbon footprint goals, but effective carbon renewal remains necessary to prevent the worst impacts of global warming. “AI is killing the cheap smartphone“ by David Oks LLMs and AI will impact the world in ways we’re not ready for, and already, third world countries are seeing the prices of cheap cellphones skyrocket due to the cost of chips skyrocketing. This article by David Oks is a terrific breakdown. “100 Days of Madness: Netflix, Paramount, Warner and the Future of Hollywood“ by Wade Major at Hollywood Heretic Wade Major dove deep into Hollywood/streaming’s financials in this must read piece. Not that I agree with everything in this article (read my take on Warner Bros./Paramount here) but the analysis is top notch. I think many people discount how quality thinking, regardless of the argument/conclusion, will make you a better thinker. “Erased by the UFC: Frank Shamrock, The MMA GOAT of the 20th Century“ by Nate Wilcox in The MMA Draw Newsletter Growing up playing the UFC fighting game on the Dreamcast, Frank Shamrock was my favorite MMA fighter, and this history/tribute to him was great. Other Fun Reads “The Hardest Part Of History To Tell Is How It Felt“ by Craig Fehrman at Defector “Unmasking the Sea Star Killer“ by Craig Welch at bioGraphic “What Could Save the Industry? Fin-Syn“ by Richard Rushfield in The Ankler Alex Rollins Berg in Underexposed on movie bumpers, pillow shots, Disney trash cinema, cult films, and Casablanca. David H. Montgomery in YouGov’s The Surveyor on punctuation marks, condiments, dinosaurs, and comic strips and kids media. “How Medium finally pivoted its way to profitability“ and “Why the best journalists on YouTube are all former Vox employees“ by Simon Owens in Simon Owens’s Media Newsletter “It’s Not Just You, Netflix Shows Have Gotten Slightly Shorter: Here’s What the Data Says“ by Kasey Moore at What’s on Netflix “Numlock Awards: How Diane Warren became the biggest loser in Oscar history“ by Nathaniel Rakich and “Numlock Awards: The Oscar Bait era is over. The Oscar Chum era is here.” by Walt Hickey & Michael Domanico at Numlock Awards

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Jul 3 • 2:38 PM EDT • Entertainment • entertainment.substack.com
Trump reads a children's book on second lady Usha Vance's podcast, then riffs on past presidents and himself

The president read "Presidents Play!" a children's book from the White House Historical Association that features illustrations of the presidents enjoying sports and using the White House and its grounds for recreation.

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Jul 3 • 1:17 PM EDT • Politics • pbs.org
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The United States at 250: Who gets to tell a nation's story?

As the US marks 250 years of independence, debates over how the nation's history should be told have become part of the anniversary itself. President Donald Trump says America should tell a more patriotic story.

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Jul 3 • 1:14 PM EDT • Politics • dw.com
What we know about Trump’s July Fourth fireworks event

President Donald Trump’s celebration for America’s 250th anniversary will culminate Saturday with a record-breaking fireworks show on the National Mall amid scorching temperatures and controversy over his efforts to put himself at the center of the commemoration.

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Jul 3 • 10:48 AM EDT • Politics • cnn.com
Strengthen Your Business With Lifetime Cybersecurity Training for $53

Get self-paced courses on CISSP, ethical hacking, and GRC through one lifetime membership.

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Jul 3 • 9:00 AM EDT • Business • entrepreneur.com
How Trump Made America's 250th Anniversary About Himself

Donald Trump is trying to make America's 250th anniversary about himself, from putting his face on federal building to the celebration itself.

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Jul 3 • 9:00 AM EDT • Politics • rollingstone.com
The Supreme Court can no longer explain itself

The justices don’t speak a common language, even with each other.

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Jul 3 • 6:45 AM EDT • Politics • vox.com
Trump refashions America's 250th as a celebration of himself

Historians say the nation's 250th anniversary has become a politicized spectacle, a celebration of an imperial presidency.

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Jul 3 • 6:00 AM EDT • Politics • latimes.com
Roma, Basel reach agreement over Calafiori’s resale clause

Riccardo Calafiori is one of the players who emerged from Roma’s youth system and has managed to establish himself on the big stage. The former Giallorossi defender won the Premier League with Arsen...

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Jul 3 • 3:25 AM EDT • Sports • sports.yahoo.com
Scientists make quantum time flow backward in stunning physics breakthrough

Researchers have created quantum control techniques that can make a system appear to run backward in time. By precisely managing quantum measurements, they can reshape the system's arrow of time and even harvest energy from the measurement process itself. The breakthrough could lead to more powerful quantum computers, quantum batteries, and other advanced technologies.

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Jul 2 • 8:00 PM EDT • Science • sciencedaily.com
Galaxy S27 Pro and Ultra leak hints at a big shake-up for the selfie camera

Samsung has kept the same front camera for the Galaxy S series since the S23. But a new leak suggests a change is coming.

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Jul 2 • 2:37 PM EDT • Technology • androidauthority.com
Sports Help Shape Young Lives. Trans Kids Deserve That Chance.

By Lambda Legal Senior Content Manager Lake Geslani When Becky Pepper-Jackson laced up her running shoes, she wasn’t thinking about court cases or political debates. Like countless young athletes across the country, she simply wanted to be part of a team, compete alongside her friends, and proudly represent her school. Instead, Becky found herself at...

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Jul 2 • 2:33 PM EDT • Sports • lambdalegal.org
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Bonus 236: A Term of Self-Inflicted Wounds

Within minutes of the Supreme Court handing down the birthright citizenship ruling on Tuesday and rising for its summer recess, its defenders were pointing to that decision (alongside the late-arriving mail-in ballots ruling on Monday and the tariffs ruling from February) as decisive proof that the Court really is “above politics,” and that criticisms of the justices for behaving more like politicians in robes than like judges are thus unfair. For a particularly thoughtful version of this claim, see Professor Will Baude’s opening response to the latest New York Times written roundtable about the Court with Baude, Professor Kate Shaw, and me. In that roundtable, I already offered one of the two major arguments against this thesis—that it’s an assessment of the numerator without regard to the denominator, and that a full account of the Court’s behavior throughout OT2025 suggests that the Court behaved even more politically during the current term than during even the previous (highly politicized) one. Just to take one of many data points, last term (OT2024), there were six rulings in argued cases in which all six Republican-appointed justices were in the majority and all three of the Democratic appointees were in dissent (along with a slew of such rulings on the emergency docket). This term, there were … 13. (Along with two 6-3 summary reversals and 10 rulings on the emergency docket from which the three Democratic appointees all dissented.) Today’s bonus issue addresses the flip side of that coin. In particular, below the fold, I identify four different moments in which the justices could have acted in ways to specifically defuse charges of political behavior—and opted instead to lean all the way in. As much as end-of-term narratives focus on what the Court did, and on the takeaways from individual rulings, consider today’s post an attempt to identify opportunities that the Court missed, as well. At least in the examples discussed below, by opting for the outcome that made the Court look more transparently political, the Court inflicted a series of (unnecessary) credibility wounds on itself. For those who aren’t paid subscribers, we’ll be back Monday with our regular coverage of the Court. For those who are, please read on.

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Jul 2 • 7:15 AM EDT • Politics • stevevladeck.com
Going outside in this heat? Follow these guidelines to stay safe

Man, it's a hot one! Don't go out in this summer's heat wave before you arm yourself with these tips and a really big water bottle.

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Jul 2 • 6:00 AM EDT • Health • npr.org
High-Signal Publisher
A Nation Larger Than Its Politics

As America approaches its 250th birthday, I find myself wondering whether we have lost sight of something that earlier generations understood instinctively.Americans have never agreed on politics.We have argued over wars, taxes, immigration, religion, civil rights, economic policy, and the proper ro...

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Jul 2 • 12:50 AM EDT • Politics • thefulcrum.us
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Boleslaw Wyslouch steps down as director of Laboratory for Nuclear Science

After more than 10 years at the helm of the Laboratory for Nuclear Science (LNS), Boleslaw “Bolek” Wyslouch will step down to continue research in nuclear physics as director of the Bates Research and Engineering Center, a subgroup of LNS. “LNS scientists, including Bolek himself, are world leaders in particle and nuclear physics,” says Nergis […]

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Jul 1 • 5:30 PM EDT • Science • physics.mit.edu
Operations workforce powers ORNL’s autonomous science future

Behind every self-driving laboratory at the Department of Energy’s Oak Ridge National Laboratory is a team people most never see. Facilities and Operations workers are building and maintaining the infrastructure that makes autonomous science possible. More than a dozen self-driving labs operate at ORNL, placing the Tennessee national lab among the first research institutions in the world to create this autonomous laboratory model at scale.

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Jul 1 • 4:44 PM EDT • Science • eurekalert.org
Operations workforce powers ORNL’s autonomous science future

Behind every self-driving laboratory at the Department of Energy’s Oak Ridge National Laboratory is a team most people never see. Facilities and Operations (F&O) workers are building and maintaining the infrastructure that makes autonomous science possible.

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Jul 1 • 10:35 AM EDT • Science • newswise.com
Melat Kiros is the first political star truly formed by the 2020s

What’s behind her shocking victory against a 30-year incumbent in Colorado — according to the candidate herself.

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Jul 1 • 10:10 AM EDT • Politics • vox.com
Preparing your business for new shipping, packaging requirements

Any business using packaging and shipping material in Maine should familiarize itself with new compliance obligations and fees on the horizon, our guest contributor recommends.

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Jul 1 • 9:15 AM EDT • Business • mainebiz.biz
Sony will cease production of discs for new PlayStation games in 2028

New games sold for PlayStation consoles will only be available digitally and won’t be sold on discs effective January 2028, Sony has announced. The move applies to all PlayStation games released from that point on, including those made by Sony and those released by third parties. The PlayStation group calls the change “a natural direction for Sony Interactive Entertainment to adapt to consumer trends as the general preference for digital media significantly outpaces physical discs,” according to a PlayStation blog post reviewed by Game File in advance of its publication. As movies, TV and music have shifted from physical media to an age of downloads and streaming, Sony’s move could speed the demise of physical media in a gaming. The industry has offered consumers games via cartridges, cassettes, floppy discs, CDs, DVDs and Blu-Rays across a 50-year stretch. Sony has been reporting to investors in recent years that PlayStation games have been increasingly purchased as downloads, not as discs. The most recent figures show nearly four in five purchases of full games for PlayStation 4 and PlayStation 5 were purchased digitally in the past year. Stats like that may cause today’s news to carry an air of the inevitable. But Sony’s declaration for 2028 is still likely to produce a shock, as the biggest gaming platform on the planet that uses game discs leaves them behind. Discs going away, but the fate of game boxes is unknown Sony is committing to still selling games in physical retailers even after they drop discs in 2028. Just how those games will be sold—in boxes with codes inside, as cards marked with digital redemption codes—is unclear. Digital games will also continue to be sold in the online PlayStation Store. New games released for PlayStation consoles prior to January 2028 will be unaffected by the policy change, Sony says. That means the PS5 games of 2027, be they a new Madden, a new God of War, a new Call of Duty, a new Sly Cooper (one can dream?), would still potentially be offered on disc. PlayStation 6 implications Sony’s timeline for a transition to a no-disc era will also spin up more speculation about the timing and configuration of Sony’s next-generation console, the probable PlayStation 6. “This pretty much guarantees that PS6 won’t arrive until 2028 at the earliest,” Piers Harding-Rolls, senior games research analyst at Ampere Analysis tells Game File. Harding-Rolls also concludes from today’s news that “the base version of a PS6 will not include a physical media drive,” as Sony looks to keep costs down on the device. Sony itself is saying nothing about the PS6 today: not its timing, nor how it might or might not support internal or external disc drives in order to run disc-based PS4 and PS5 games, should the console be backwards compatible. The many signs this was coming Industry support for games being released on physical media has been waning. As has consumer interest in them. PC games effectively went all-digital years ago, thanks to the popularity of playing games through Steam and other digital storefronts. The Covid-19 pandemic and the lockdowns that kept much of the global population home helped shift shopping patterns toward downloads. Sony’s own data shows PlayStation game downloads being an uncommon consumer choice a decade ago and now becoming the norm. On consoles, physical media has been in such decline that Sony and Microsoft both launched their current gen Xbox Series and PS5 consoles in 2020 with cheaper versions that lacked disc drives. In early 2024, Phil Spencer, then head of Xbox, told me that ““[w]e ship games physically and digitally, and we’re really just following what the customers are doing.” He added that the game industry had become an outlier in still supporting disc-based entertainment, even as movies and TV have bailed on discs in favor of downloads and steaming: “Gaming consoles themselves have kind of become the last consumer electronic device that has a drive. And this is a real issue, just in terms of the number of manufacturers that are actually building drives and the cost associated with those. And when you think about cogs that we’re going to go put in a console—and as you have fewer suppliers and fewer buyers—the cost of the drive does have an impact.” Last year, the Nintendo’s Switch 2, which uses cartridges rather than discs, introduced the concept of game-key cards, which are physical media that contain no game, just a prompt for a download. Even disc-based games aren’t what they once were, now frequently containing just stubs of games rather than the whole thing. The website Does It Play has tested over 3000 games and found that, for example, that the disc version of this year’s hit 007: First Light, only contained the game’s first mission, with the rest needing to be downloaded. Beyond all that, last week brought the news that Grand Theft Auto VI, likely the biggest game launch this decade, will debut for PS5 and Xbox Series without a disc-based version. Today’s big news comes to you for free. Game File is a reader-supported publication. To receive new posts and ensure more of my work is possible, please consider becoming a free or paid subscriber. Subscribe Discs helped define PlayStation However the trends in entertainment may be going, it is still remarkable to see PlayStation ditch discs given their importance in PlayStation history: In the late 1990s, the first PlayStation’s support for games on relatively cheap CD-ROMs instead of traditional game cartridges allowed the upstart console to outmaneuver cartridge-based systems from Nintendo and Sega, as it drove down game prices down in the process. (The cheaper disc format even prompted Final Fantasy VII maker Square to taunt Nintendo in a magazine ad, saying that if the game was “available on cartridge, it’d retail for around $1200.”) PlayStation devices often doubled as machines for watching movies and TV on the latest disc-based formats. In the late 2000s, for example, Sony’s pricy PS3 gained traction as a go-to device for playing then-novel Blu-Ray discs. In 2013, Sony effectively roasted the digital game-sharing restrictions proposed by rival Microsoft for its upcoming Xbox One console by showing how games could be shared for the then-upcoming PS4. In a 21-second clip that has over 20 million views on YouTube, one PlayStation executive simply handed a game box—presumably with disc inside—to another, who said “thanks.” Sony’s possible motivations The PlayStation announcement today cites “consumer preferences” and a shift away from discs among “the broader entertainment industry,” but does not delve into the decision-making process that brought Sony to this point. Sony is not discussing the economics of this move (I asked!), but there are a number of potential factors: Abandoning discs will spare Sony the cost of manufacturing and shipping them, which analysts and industry veterans I spoke to said could account for $1 or so of a game’s retail price. For first-party games, that’s direct savings for Sony, though the amount is limited by the winnowing percentage of people who were even buying the disc-based versions. For third-party games, Sony could pass the savings on to partners or just retain the better profit margin for themselves. As the 2024 comments from Phil Spencer alluded to, leaving discs behind could mean leaving disc-drives behind, allowing Sony to produce consoles more cheaply. Switching to digital-only for games could diminish the risks of copies of new games leaking. It would also seemingly make second-hand sales of used games impossible, pushing more people to buy their own copies of games. These economic benefits for Sony could be boons for the games industry overall, Ampere analyst Piers Harding-Rolls tells Game File. Among other things, it could free publishers and retailers from having to worry about securing an inventory of game discs when trying to sell games, he noted. “If there is a way to streamline the business of games retail, I generally think it’s a good thing for the industry as it removes unnecessary costs,” Harding-Rolls said. “This will help offset pressure on margins from other directions – development and staffing costs for example.” Should the industry shift from game boxes that contain discs to smaller, cheaper game cards, Harding-Rolls said, that reduces pressure on publishers and retailers. “The advantage of everything going digital for the industry is that sales can be tracked much more easily and there is less commercial risk for publishers wanting to continue selling via retail,” he said. The shift to no discs will also likely impact game development timelines, as developers will no longer face the same urgency to have a build ready to submit to PlayStation for the production of a disc, as industry experts noted around GTA VI’s no-disc news last week. Instead, projects may gain weeks of development time, in the event delivery deadlines for platform approval move closer to release date. Preservationists’ likely worries While millions of gamers have shifted to digital, there are still people who associate game discs—and only game discs—with actual ownership of PlayStation games. That portion of the gaming community spoke up last week about wanting to buy a version of GTA VI that they could hold in their hands, could lend to a friend and could potentially pop into a well-preserved PS5 console three decades from now and still see it run. Such gamers didn’t want to worry that they’d merely purchased a digital copy that could lose access to the game if, say, the company behind the game someday turns of the servers that transmit downloadable copies. Digital copies of games are inherently less long-lasting, because consumers aren’t actually buying a game (on a disc), just buying access to the game. The fine print in online gaming shops notes this, as does a recent law that went on the books in California in 2025. That lasw requires game publishers doing business in the state to refrain from words like “sell” when offering digital copies of games, unless they explicitly tell consumers that what’s being sold isn’t the game itself but a potentially revocable license to access it. A Sony spokesperson noted to Game File that “[w]ith all digital content, including games, movies, and music, players are purchasing a personal license for non-commercial use.” Regarding the fears of PlayStation games being lost to time in an all-digital era, the rep also noted that Sony remains “committed to delivering experiences from past generations to the new platforms our players are using.” They noted that PlayStation has used emulation and remasters to keep offering its classic games to modern gamers. It’s true that many consumers have become accustomed to not having physical copies of new music albums or movies, but the relative precariousness of digital copies of games is in fact being highlighted today by…. Sony’s other big announcement: the upcoming closure of the PS3 and PS Vita online stores Sony said today that it will be closing the online marketplaces for its PlayStation 3 console and PS Vita handheld in most countries in July 2027 (sooner elsewhere: August 2026 for the PS3 store Mexico, Honduras and Nicaragua; late 2026 for PS3 in other Latin American countries and the Middle East). “We know this news may be disappointing to PS3 and PS Vita players who hold a special place in their hearts for this generation of gaming,” Sony said in its announcement, saying the move “was not an easy decision for us to make.” Sony said that PS3 and Vita marketplaces “are no longer able” to support modern commerce systems, prompting a “need” to close the shops and focus on more modern PlayStation platform stores. The news may spark some deja vu. Sony announced back in March 2021 that it planned to take the PS3, Vita and PlayStation Portable marketplaces offline that summer. The move would have caused some 2,000 digital-only games to become unavailable for new purchasers, according to a VGC analysis at the time. Fans complained loudly. By April 2021, Sony walked back the PS3 and Vita shop closures, with then PlayStation boss Jim Ryan saying “it’s clear that we made the wrong decision here.” This time around, Sony is giving a longer notice period in most regions. The closure of those stores is still likely to cut off access to new purchases of digital-only PS3 and Vita games. The current PlayStation 5 marketplace sells PS5 and PS4 games, as well as a selection of PS1 and PS2 games. It does not sell PS3 games, because games for that platform can’t run on the system (some are offered via a PlayStation Plus streaming option). Vita games also aren’t sold via PS5. Sony says digitally purchased PS3 and Vita games will be downloadable after the stores’ shutdowns “for the foreseeable future.” Sony’s move contrasts with Microsoft’s Xbox platform, which continues to sell and support games from all four Xbox console generations. But it puts it in line with Nintendo, which disabled purchases in the marketplace for its Wii console (a contemporary of the PS3) in 2019. Nintendo discontinued purchases in the online shop for its 3DS portable (a contemporary of the Vita) in 2023. The big questions about Sony’s 2028 post-disc era Will Microsoft follow suit, ending support for new disc-based games on Xbox platforms and therefore all game consoles, too? Whether Microsoft does or not, will third-parties that can no longer release games on discs for PlayStation, simply ditch the disc options across the board? Given the GTA VI no-disc experiment launching this November, will more game publishers decide to forgo disc-based offerings even in 2027? How will no-disc PS5/6 games be packaged and sold in brick-and-mortar retail stores? What becomes of game sharing in an all-digital era? Will Sony modify its current set-up, which currently allows some sharing of digital games across a pair of consoles, to allow more casual lending? (See for example, Nintendo’s year-old system of letting players lend a digital game to another player in a “family group” for up to 14 days.) Will there be a version of a PS6 with a disc drive? Or will a drive be offered as an add-on? And how will gamers who want to retain access to PS4/PS5 disc-based games react to whichever configurations Sony chooses to offer? What will the final disc-based PlayStation game be?

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Jul 1 • 8:00 AM EDT • Technology • gamefile.news
Wales rugby quiz: Test your summer tour knowledge

Test yourself with our quiz on Wales' men's past five summer tours.

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Jul 1 • 1:53 AM EDT • Sports • sports.yahoo.com
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Scranton woman charged with stealing funds from federal health care programs

A Scranton woman stole checks, some of which came from federal health insurance programs, and used them on herself, federal authorities say

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Jun 30 • 3:27 PM EDT • Health • thetimes-tribune.com
Blake Lively is seeking $8.04 million in legal fees from Justin Baldoni amid 'It Ends With Us' settlement

Blake Lively is asking a judge to award her over $8 million in attorneys' fees and litigation costs for having defended herself against Justin Baldoni's now-dismissed defamation lawsuit.

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Jun 30 • 11:55 AM EDT • Entertainment • ew.com
Building the Valley: Young Springdale man keeping lawns at bay as business grows

When Justin Burrell started landscaping in 2022, the then-14-year-old wasn’t old enough to drive himself to clients’ houses so he enlisted help from his parents. At first, he mowed lawns for some extra pocket change. Now, at 18, Burrell is working toward turn his Burrell Grounds and Services business into

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Jun 30 • 6:00 AM EDT • Business • triblive.com
Jalen Brunson receives praise from Knicks fans for offseason work

Jalen Brunson is wasting no time keeping himself in shape this offseason. He led the New York Knicks to the 2026 NBA championship on June 13, and the superstar guard is already working out 16 days later. A video of…

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Jun 29 • 10:33 PM EDT • Sports • sports.yahoo.com
8-year Cowboys team leader retires after 12 NFL seasons

The Cowboys special teams ace has made a name for himself among the club's fans.

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Jun 29 • 6:00 PM EDT • Sports • sports.yahoo.com
George Gresham, Health Care Union Powerhouse, Dies at 71

Until he lost an election last year amid accusations of self-enrichment, he was a longtime influential force in Democratic politics in New York.

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Jun 29 • 4:21 PM EDT • Health • nytimes.com
Lizzo slams 'Khia Asylum' meme for 'flopping' pop stars: 'Weapon that targets only women'

Lizzo slammed the 'Khia Asylum' meme often use for 'flopping' pop stars: 'A tool to bully artists,' she said, calling the title itself 'backhanded' for mocking a 'pillar in the Black community.'

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Jun 29 • 11:04 AM EDT • Entertainment • ew.com
Scientists discover an unexpected way to make pancreatic cancer cells self-destruct

Researchers tested experimental PCAI compounds against pancreatic cancer cells and found they had powerful anticancer effects. One leading compound blocked more than 90% of cancer cell migration, suggesting it could help prevent the spread of tumors. Rather than suppressing cancer signaling, the treatment hyperactivated key pathways until the cells essentially self-destructed.

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Jun 29 • 8:00 AM EDT • Science • sciencedaily.com
Careers That Shaped Biology

Every great scientific career begins with a question no one has been able to answer — and a scientist stubborn enough to keep asking it. This series looks back at the careers of some of HHMI’s most distinguished scientists — people whose contributions have changed what we know about life itself, and whose stories reflect the best of what science, and scientists, can be.

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Jun 29 • 8:00 AM EDT • Science • hhmi.org
A $1000 PlayStation 6 No Longer Sounds Crazy, As Sony Doesn’t Intend To Sell Hardware At Significant Losses

The PlayStation 6 is set to launch at one of the most challenging times for consumer tech, if not the most challenging. With the rising prices of components, RAM and SSDs above all, manufacturers are having an extremely hard time keeping costs down, and with a bill of materials that is now close to $1000, there's a very high chance the system will cost way more than most anticipated. Adding fuel to the fires of speculation is Sony itself, as the company heavily suggested in a recent investor Q&A session that it won't heavily subsidize the system. "We regard hardware as the base […]

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Jun 29 • 7:40 AM EDT • Technology • wccftech.com
Mental health medications can cause heat sensitivity

Some drugs can impair the body’s ability to cool itself and require extra self-care.

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Jun 29 • 7:02 AM EDT • Health • wbay.com
Micro moments of self-care for your mental health
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Jun 29 • 6:57 AM EDT • Health • cbsnews.com
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Comcast plans to split into two public companies by spinning of NBCUniversal and Sky

Comcast is planning to split itself into two separate publicly traded companies by spinning off NBCUniversal and Sky

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Jun 29 • 6:29 AM EDT • Business • abcnews.com
The ERs that can turn patients away

The hospital operator Nutex enriched itself by exploiting loopholes in laws meant to protect patients, STAT found.

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Jun 29 • 4:30 AM EDT • Health • statnews.com
FIFA Let Politics Win Over Football, Iran Paid The Price For Political Hypocrisy

Football's governing body has long sold itself as apolitical - like the IOC - an organisation above borders, above diplomacy, above conflict. But this World Cup has challenged that idea and changed perceptions about FIFA.

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Jun 29 • 3:33 AM EDT • Politics • ndtv.com
I'm a stay-at-home mom of 2. My 4 side gigs help me pay off debt.

Lana Ng left her marketing job in 2023 to take care of her children. Now, her four side gigs help her not lose herself in motherhood.

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Jun 28 • 8:00 PM EDT • Business • businessinsider.com
CD Projekt is rebranding as CD Projekt Red, but confusingly, CD Projekt Red is still CD Projekt Red

CD Projekt has rebranded itself as CD Projekt Red – or CD Projekt Red Spółka Akcyjna, to be precise.

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Jun 28 • 3:55 PM EDT • Technology • eurogamer.net
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial

Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to

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Jun 28 • 3:45 PM EDT • Health • astrazeneca-us.com
El Niño Is Back—and It Could Cost Businesses Trillions. What Smart Leaders Are to Prepare

Dartmouth research makes the duration of the damage clear: economic losses from major El Niño events persist for five years after the event itself.

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Jun 28 • 10:34 AM EDT • Business • inc.com
Govee's smart nugget ice maker makes every iced drink feel like a luxury

For some people, the ice in a beverage is almost as important as the drink itself. That's the audience Govee had in mind when designing its latest ice

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Jun 28 • 10:00 AM EDT • Technology • techcrunch.com
AWS CEO says replacing young employees with AI is ‘one of the dumbest ideas’—and bad for business: ‘At some point the whole thing explodes on itself’

Amazon laid off 14,000 employees this fall, but CEO Andy Jassy denied the reductions were related to AI.

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Jun 28 • 7:36 AM EDT • Business • fortune.com
The Politics of the Instagram Story

Drive yourself crazy for the low price of $3.99 a month!

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Jun 28 • 7:31 AM EDT • Politics • theatlantic.com
4 Marketing Lessons Every Business Can Learn From the 2026 FIFA World Cup

Nike, Adidas, Home Depot, and FIFA itself offer a powerful reminder: marketing success depends on far more than how much you spend.

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Jun 28 • 5:00 AM EDT • Business • inc.com
GM hires talent from rivals to solve self-driving car problem

GM has made several key executive hires since 2025 and brought back Cruise alums to ramp up its self-driving tech development in personal cars.

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Jun 28 • 4:41 AM EDT • Business • businessinsider.com
Burcum: Sanford Health got what it wanted. Now comes the moment of truth.

From columnist Jill Burcum: The South Dakota health system has spent a decade trying to crack the Twin Cities health care market. With the North Memorial deal, it now has a chance to prove itself.

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Jun 27 • 2:30 PM EDT • Health • startribune.com
Andy Burnham distanced himself from UK Prime Minister Starmer, but may be stuck with his policies

Burnham, the former mayor of Greater Manchester who was sworn into Parliament hours after Starmer announced his resignation on Monday, will be constrained by the platform the center-left Labour Party was elected on that decisively ended 14 years of Conservative rule in 2024.

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Jun 27 • 11:44 AM EDT • Politics • pbs.org
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Andy Burnham distanced himself from UK Prime Minister Starmer, but may be stuck with his policies

Andy Burnham has set himself apart from the man he expects to replace as British prime minister

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Jun 27 • 12:36 AM EDT • Politics • washingtonpost.com
Trump posts new passport rendering — featuring a memorable photo of himself

President Donald Trump unveiled a new rendering of a special commemorative US passport bearing his likeness Friday, debuting a limited-edition passport to mark America’s 250th anniversary this year.

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Jun 26 • 6:02 PM EDT • Politics • cnn.com
Vance Downplays Watergate and Compares Himself to Nixon

The vice president said that the scandal that ended Richard Nixon’s presidency would be “like a 12-hour news story” if it happened today and that the “deep state” had taken down Nixon.

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Jun 26 • 10:56 AM EDT • Politics • nytimes.com
Karl Stefanovic Speaks Out on Nine Exit After Tommy Robinson Scandal

The 'Today' host declares himself 'free' in a YouTube statement after Nine ends his contract following a deleted Tommy Robinson podcast episode.

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Jun 26 • 6:44 AM EDT • Entertainment • variety.com
JD Vance claims Diddy is 'not a Christian' after federal conviction

Sean "Diddy" Combs might have scored a reference in Vice President JD Vance's new book, but the politician is not eager to associate himself with the imprisoned music mogul.

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Jun 25 • 7:37 PM EDT • Entertainment • centraloregondaily.com
Making Our Own Luck

We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.

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Jun 25 • 4:48 PM EDT • Science • goodscience.substack.com
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David P. O'Brien

About five years ago, David P. O'Brien had a comfortable position at Marsh & McLennan Cos., where he held the top post at the financial giant's Louisville, Ky., office. Despite the lofty rank, Mr. O'Brien found himself longing to be at a smaller company that had to work a little harder to land business. That desire led him away from Kentucky five years ago and to Cleveland, where he serves as executive vice president at business insurance agency Oswald Cos. "I left Marsh before it was en vogue," he said, referring to layoffs and defections at Marsh over the course of this year that followed accusations of bid rigging at the big firm. Above all, Mr. O'Brien, 38, wanted to work at a company that relied on its inventiveness, rather than its name, for business. He said he has found that at Oswald. "It causes you to be more creative, to be more resourceful," Mr. O'Brien said. For instance, an Oswald client seeking to do business internationally might be directed to the network of offices abroad run by competitors such as Marsh and Aon Risk Services Inc. "We're going to use whatever access into the market that makes the most sense for our clients," he said. Of course, using such a strategy can be dangerous for Oswald if its client decides to further a business relationship with one of the firms Oswald recommended. "That's the obvious question and why it's nontraditional," he said. "I think if we're good, and if we're bringing value to the client, then there's no risk. I'm not threatened by it." Imaginative business solutions of that type made his career move to Oswald from Marsh worthwhile. "It's very much a challenge," he said. "It helps you keep your edge. I'm all for the competition." John Jacunski, currently vice president and corporate controller at York, Pa., paper company PH Gladfelter Co., met Mr. O'Brien four years ago when Mr. Jacunski was at WCI Steel Inc. in Warren. So impressed was he with Mr. O'Brien's work for WCI that Mr. Jacunski has retained the Oswald executive at PH Gladfelter. "He's a young guy for the position he has, but he's done a great job for us," Mr. Jacunski said. Among his roles at Oswald, Mr. O'Brien leads the firm's client retention efforts and also serves as director of its property and casualty group. "You don't have the same human resources," he said of the job jump to Oswald. "You don't have, obviously, the safety net a big company has." But sometimes, it can be difficult to ascertain individual contributions when working at a big company. "I wanted to be able to see the end results of my work and my efforts," Mr. O'Brien said.

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Jun 25 • 9:03 AM EDT • Business • crainscleveland.com
After my divorce, I rebuilt my life, starting with friendship

After my divorce, I felt lonely and had to make new friends. I learned a lot about friendship — and myself — in the process.

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Jun 25 • 8:17 AM EDT • Business • businessinsider.com
Scientists discover how a single cell builds a brain with 170 billion cells

How does a single cell build a brain with billions of precisely organized neurons? Researchers suggest that brain cells use their lineage—their cellular family tree—as a kind of positional map. Cells that come from the same ancestor stay near one another, helping the brain organize itself without relying solely on chemical signals.

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Jun 25 • 8:00 AM EDT • Science • sciencedaily.com
How should European scientists respond to the US AI kill switch?

Earlier in June, Europe’s worst fears of technological dependence were confirmed when the White House ordered the AI firm Anthropic to stop non-US citizens using its leading models. This kill-switch moment crystalised anxieties in Brussels that the continent, lagging the US on the creation of leading-edge AI models, is now a technological of vassal of Washington. The shock has specific implications for European scientists and universities. Some governments are now worried that with AI being integrated into labs, Donald Trump now has his finger hovering over an off switch for European science. “Having restrictions on this tool, it can have an impact on our own research,” said France’s research minister, Philippe Baptiste, at the VivaTech conference in Paris on June 18.Baptiste, himself a former academic, said that colleagues in mathematics had recently warned him they were now cut off from leading-edge US models, risking their work. “This model is not available anymore now because of the US restriction, and for the first time this had an impact on mathematics,” a field where large language models (LLMs) are making a significant contribution, said Baptiste. So, should European scientists avoid relying on US models in the future? Or would this be a self-harming overreaction? And how is AI being used in science, anyway? What happened?On June 12, it emerged that Washington, citing cybersecurity concerns, had ordered Anthropic to stop non-US citizens using two models: Claude Mythos 5, and Claude Fable 5, a version of Mythos but with guardrails to prevent abuse. Anthropic said Washington’s concerns were overblown. But forced to follow the order, yet with no way to check who was using the models, the company suddenly shut down access for everyone, US citizens included. There’s still no agreement on how to restore broad access. But last week, Bloomberg reported that select US companies, and the US government, still had access to Mythos despite the ban, but the EU’s cybersecurity agency Enisa had been shut out. Class division of researchersIn the longer term, access outside the US should be restored, said Marcel Salathé, co-director of the AI centre at the Federal Polytechnic School of Lausanne (EPFL), because a permanent restriction would be financially ruinous to US AI firms. “Even Trump will eventually budge to economic pressure,” he said.However, US AI firms might end up operating rather like banks, doing due diligence on users of their leading-edge AI models, he went on.European scientists are unlikely to fall foul of such checks, he said. But having a Chinese postgraduate in their lab, or doing a type of research the US disapproved of, could potentially result in access being denied. “It will create a sort of class division of researchers,” he said. More than frontier modelsHowever, successfully deploying AI in science is about far more than just having access to leading LLMs such as Mythos.Instead, many science-specific tools, most famously Alphafold, which predicts protein folding structures, require “far less” computing power to train than frontier models, well within the capabilities of European supercomputers, according to a recent analysis by the Arq Foundation, a Brussel-based AI think tank. Instead, tools such as Alphafold are possible because certain fields, like protein folding, weather prediction or astronomy, have large, clean, standardised datasets that can be used to train predictive models. Rather than compute, “data is the central constraint for AI for science,” the report says. For example, a less powerful physics model trained on CERN’s data “will be more valuable than the best model without certain data,” said Bengüsu Özcan, author of the report. European advantage?Europe could therefore steal a march by using its scientific data and infrastructure to create models US digital giants cannot. “They might actually match or go even beyond what these big [US] companies are doing,” said Özcan.Indeed, some European start-ups hope to create automated testing labs to create the kind of standardised data that could speed up the discovery of new materials. Materials scientists say there’s currently too little data to train models. AI scientistsHowever, even if the bottleneck for AI in science is often data, rather than compute, being at the mercy of the US for LLM access could still become a problem for European scientists. A new class of “AI scientists” based on leading LLMs is also emerging, Özcan’s report says.Unlike domain-specific tools like Alphafold, these try to automate day-to-day scientific work, by providing an overarching tool that coordinates specific models to synthesise existing literature, generate hypotheses or run analysis of data. The problem for Europe, however, is that these tools are sometimes based on US leading models. Google Deepmind’s AI Co-Scientist, for example, is built on Google’s Gemini LLM. Systematic failureThese scientific automation tools are still in their early stages, and still exhibit “systematic failures on scientific tasks,” Özcan’s report says. One of the problems is that the messy, day-to-day process of scientific discovery is largely not documented, meaning LLMs don’t have a good source of data to learn how scientists actually work. Meanwhile, some tasks, such as literature synthesis, don’t typically require access to leading edge models.However, the performance of AI scientific assistants could improve as companies such as Google pour resources into developing them. Rely on US“Unfortunately, for scientific assistants, there is not much we can do right now except rely on US frontier AI,” said Antoine Bosselut, a natural language processing expert based at EPFL. Chinese-built open models, which can run on local computers, lessening the risk of a shutdown, are touted as one alternative to US dependence. There’s also Mistral, once seen as Europe’s main AI hope, but the Paris-based company has seen its recent models fall behind in performance. But the Chinese alternatives are generally not as capable as US frontier AI models, said Bosselut, unless paired with fiddly, custom tools that allows them to act as independent agents. “Most scientists do not have the time,” he said. Don’t jump ship yetAlthough the kill switch moment is seen a warning shot for European scientists, it doesn’t mean labs should abandon US AI tools immediately. “I do not think the right response is simply to abandon US-based models and systems under the banner of sovereignty or independence,” said Mattias Björnmalm, secretary general of the Cesaer university association. “That would be an overreaction.”Related articlesEuropean sovereignty in AI requires ‘ugly trade-offs,’ say experts Robotic lab start-up makes case for €500M EU-funded materials testing facilityAI in science: is it useful? Instead, European researchers need to ask themselves whether they’re becoming dependent on technology that could be turned off in Washington, said Özcan. “They might not see this today, but they should really start asking this question,” she said. European researchers need a plan B, said Salathé. “I would recommend to every researcher, very proactively explore alternatives.”Own toolsIn addition, Björnmalm and others want European research institutions to develop their own scientific AI tools.Instead of signing AI deals with US digital giants, European universities should be using this money to create their own models, which may end up being superior for research, said Sabine Leonelli, an expert on the use of AI in science at the Technical University of Munich. “Universities in Europe seem to be happy to sign commercial contracts with US companies on the assumption [their AI tools] are better,” she said. But US frontier LLMs are typically opaque, and have been developed without independent scientific input, she said. “This is not good enough for science.”Last year, Swiss researchers released Apertus, an LLM designed to be completely transparent, from its development methods to its training data. The idea is that this makes scientific tools built on top of the model far more reproducible than with closed, commercial alternatives.“Europe needs more of this: serious capacity-building that gives researchers, universities and companies credible options,” said Björnmalm.

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