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Vitalize secures $31M to scale AI-powered operating system for hospital staffing and scheduling
Hospital staffing and scheduling is unglamorous, complex and tedious work, and Veeraj Shah, Vitalize CEO and co-founder, believes it's the most valuable healthcare task to tackle. | Vitalize positions its software as an "air traffic control" system for healthcare operations, helping health systems automate staffing, forecast demand, manage capacity and reduce reliance on overtime and agency labor.
Another sign of rapidly expanding political map: Pollsters can’t keep up
Increased demand for polling has strained call centers that conduct surveys, squeezed capacity and complicated the task of getting accurate reads on public opinion, according to pollsters.
Opinion: El Paso women cannot underestimate the danger in Texas’ extreme reproductive policies
After experiencing miscarriages in El Paso and Ciudad Juárez, Rebecca Guerrero reflects on why she felt better supported across the border and urges Texans to vote for reproductive health protections.
The Harvard Crimson (@theharvardcrimson)
83 likes, 0 comments - theharvardcrimson on October 6, 2026: "Harvard’s Faculty of Arts and Sciences is launching 25 tenure-track faculty searches, FAS Dean Hopi E. Hoekstra announced in a Monday email to faculty, further loosening a University-wide hiring freeze instituted last spring as the school draws an influx of philanthropic support. The searches, which include positions across the FAS’ three divisions and the School of Engineering and Applied Sciences, come less than a week after Hoekstra announced the school would also be upping Ph.D. admissions for the upcoming admissions cycle — and as the University continues soliciting support from donors for its academic programming. Full story linked in bio. 🖋: Abigail S. Gerstein and Amann S. Mahajan 📷: Mae T. Weir".
Scientists Just Found a Strange Link Between Cats and Happiness
Countries with more cats tended to report higher happiness, while greater exposure to a common cat parasite was linked to lower scores.
Students Use Forensic Science Skills in Escape Room
Hundreds of students from across the region put their problem-solving skills to the test this week during the Regional Science Consortium’s annual Forensic Science Escape Room. Elementary school students had just a few hours to figure out how someone died as part of a forensic science escape room activity. The Regional Science Consortium partnered with Mercyhurst University for the 10th year of the event, which is taking place at the Tom Ridge Environmental Center. It began Monday and runs through Thursday.Throughout the week, more than 250 students are working to solve murder mysteries using real forensic science techniques. Students must analyze the evidence, piece together clues and solve the crime before time runs out.Organizers said the event gives students interested in pursuing forensic science in college a firsthand look at what a career in the field could entail.Sarah Skelton, Special Gifts Coordinator at Iroquois, said the activity provides students with an opportunity to develop skills that can sometimes be difficult to practice in a traditional classroom. "It really helps them to work in teams and on critical thinking skills. Which, not that they don't get these opportunities, but it's hard sometimes in the classroom to develop those higher-level thinking skills”, said Skelton.Students also get a chance to learn how forensic science is used in real-life investigations. As Skelton explained, "What are the real-life applications? What would you actually see in a crime scene? How would you handle these types of forensic investigations? So it's really cool our kids get to see what opportunities are out there and possibly a career field one day."The popular event has grown over the years, with some students returning year after year. Organizers said watching those students grow and develop their interests is one of the highlights of the program.Jeanette Schnars, the Executive Director of the Regional Science Consortium said it's rewarding to see how students' interests evolve as they get older. According to Schnars, "How they have grown and matured and where their interests are going and maybe they aren't going into forensics, but if they are going into sciences or different disciplines, so it's really fulfilling to see how they have matured."One student who continues to enjoy the event is sixth-grader Mia Harvey of Iroquois. Harvey hopes to pursue a career in medicine and says the forensic science activities are helping her explore her interests, "One day I want to become a neurologist, and learning about the bones is probably going to help me."Harvey said her favorite part of the event is the real-life application of what she's learning. "While you are trying to find the clues, they teach real stuff that you would need to know”, said Harvey.Event organizers said if students are learning while having fun, then the program is accomplishing its goal. "Not only are they learning the science, but they are having fun with it too”, said Schnars.Adults will also have a chance to take part in the experience this Saturday during an adult version of the escape room, which will feature food, drinks and entertainment. For more information, click here.The Forensic Science Escape Room has become one of the Regional Science Consortium’s most popular events, with teachers signing up their students as soon as registration opens in August.
Candlelit Concert In Eastham Will Feature Guitarist Derek Gripper
Internationally acclaimed South African guitarist Derek Gripper will play a candlelit concert at Chapel in the Pines in Eastham on Wednesday, October 14, at 7 PM. The concert is part
URI astrophysics student earns coveted Association for Computing Machinery’s SIGHPC fellowship
KINGSTON, R.I. – Oct. 6, 2026 – Ever since she was young, Genevieve Payne has always had a deep interest in nature and understanding hidden systems and patterns within it, hoping to one day study some of the universe’s most extreme and least-understood phenomena. This interest developed into a focus on gravitational wave and high-energy […]
California leaders slam Trump for saying Iran could ‘take out’ L.A. or San Diego
Officials in California condemned the president's comments as “dangerous,” after he told a Nebraska rally the war in Iran was a “small price to pay for keeping the world safe.”
Brazil: Lessons from a Disaster
By Antonio Martins (Outras Palavras) Defeats become deeper and more prolonged when we misunderstand what caused them, avoid correcting course, and embrace “solutions” that only compound our mistakes. Lula’s government and the Brazilian left suffered a disaster in Sunday’s election. Contrary to every poll, the president finished the first round 2.2 million votes behind Flávio Bolsonaro—and, more significantly, 3.4 million votes below his total four years ago, when the machinery of the state was working against him and in favor of his opponent. His vote share declined in 98 percent of Brazil’s municipalities. The PL, the main party of the far right, elected 121 deputies and 28 senators, becoming the largest caucus in both houses of Congress. The parties aligned with the Centrão—Brazil’s bloc of transactional center-right parties—were somewhat diminished, but will still hold roughly 250 seats in the Chamber of Deputies and 35 in the Senate. That will make it easier to assemble the majorities needed to amend the Constitution or impeach Supreme Federal Court justices. If elected, Flávio Bolsonaro could appoint four members of the Court, substantially altering its internal balance of power. What produced these results? How can the far right be prevented from consolidating them into a prolonged political hegemony? And what is the essential change of direction the left now needs? Explaining the Disaster Across the commercial media and the exuberant chaos of digital platforms, interpretations are multiplying. Some focus on specific episodes: Lula’s absence from the Globo debate, his very close relationship with Alexandre de Moraes, or his emphasis on issues supposedly remote from most people’s everyday concerns, such as rare earth minerals. Among the more systemic interpretations, three seem especially questionable. One argues that the principal defeat was not the left’s, since its congressional representation declined only slightly. The decisive movement captured at the ballot box, according to this view, was a shift within the right itself—from the more moderate and transactional forces of the Centrão toward the more ideological and radicalized forces of the PL and Novo. A second interpretation holds that the nature of electoral and political processes has changed. The material interests and aspirations of society, it argues, no longer play the central role they once did; they have given way to forms of subjective self-identification that the left has yet to understand. And a third concludes that, because of these two developments, we should expect a political winter: a prolonged period in which the far right and the broader right dominate Brazilian political life. There are important elements in all three interpretations. The problem lies in what they deny or leave out: Lula’s third government was a small-bore government. It offered the majorities that elected it neither a clearly better life nor reasons to believe again in politics and its power to transform society. These failures flowed from two fatal accommodations, which I will examine below. As a result, the government suffered a slow but steady erosion of support. And, as has happened in so many Western countries, it gave the far right the opportunity to present itself as anti-system and to benefit from popular frustration and distress. The interpretation that emphasizes the migration of votes from the center-right and traditional right toward the far right has been advanced, among others, by the courageous journalist Leonardo Sakamoto. In his UOL column on Monday, October 5, he highlights the miserable behavior of the traditional conservative parties. Over the past four years, they repeatedly joined forces with the “neo”-fascists, helping to “normalize” them—a criticism that could equally be directed at almost the entire corporate media. Believing they could use the far right as a stepping stone, they instead ended up partly devoured by it. This was especially true in the Senate, where the PL’s gain of 13 senators and Novo’s gain of two came at the expense of the PSD, which lost nine; the MDB, which lost two; the PSDB, which lost two; and the PP, which lost one. Sakamoto’s observation is accurate and necessary, but it leaves uncomfortable questions unanswered. Why did the erosion of the Centrão benefit the far right rather than, for example, producing growth for the left—as has happened so many times before, both in Brazil and elsewhere? The answer is not difficult. Throughout its four years in office, Lula’s third government was almost invariably associated with the Centrão. Here lies its first accommodation: accepting the limits imposed by conservative institutions; avoiding, as much as possible, any attempt to strain those limits through popular pressure; and believing only in the modest changes that could be squeezed through openings in Congress. The failure of the campaign to end the six-day workweek is emblematic. Lula could have electrified the presidential race by pairing it with a popular campaign for passage of the measure. Instead, he chose to place his hopes in the hands of Senate president Rodrigo Alcolumbre. He generated no mass mobilization, did not force his opponents onto an uncomfortable defensive, and won no victory. In September 2025, the government squandered the greatest of its many opportunities to shake up conservative power in Congress. Popular opposition to the so-called Shielding Amendment—which, if approved, would have restricted criminal proceedings against members of Congress—brought crowds into the streets, mobilized primarily by artists and social movements. This opened the possibility for a broader political education: a campaign that could begin exposing the limits and dysfunctions of Brazil’s political system while putting Bolsonaro’s movement on the defensive for its predictable support of political privilege. The amendment was defeated. But the executive branch then backed away from the fight. It remained associated with an institutional world widely seen as corrupt, elitist, and indifferent to ordinary people’s struggles. In doing so, it forfeited its credibility as a vehicle for the protest vote. On Sunday, it reaped the bitter fruits. Are We Doomed? Taking a different approach from Sakamoto, the philosopher Moysés Pinto Neto and other writers have drawn attention, in their first analyses of October 4, to the fragmentation of the public sphere produced by Big Tech platforms. Through their algorithms, these platforms present each person with a different view of social reality. As a consequence, it becomes much harder to identify common material problems and demands—for example, the fight for labor rights or for a properly funded public health system. Voters no longer embrace such demands, these authors argue, because they no longer see themselves as part of a collective. Instead, they tend to value the identities assigned to them by neoliberal subjectivity—the role of the entrepreneur, for example. On this interpretation, the left’s possible error lies in clinging to outdated illusions. Moysés’s warning is highly relevant and resonates with arguments such as Naomi Klein and Astra Taylor’s “Apocalyptic Fascism and the Billionaires’ Bet.” Unlike a century ago, the far right no longer promises a radiant future. It concentrates instead on resentment—especially that of young men. “They belong to a generation that fears it may never own a home, but compensates with the pleasure it gets from constantly provoking progressives online. Convinced their future has been stolen, they share memes romanticizing historical authoritarian regimes,” the authors write. But Moysés seems to confuse this danger with inevitability. He fails to see that the left’s answer cannot be adaptation. On the contrary, it must strengthen the possibility of politics as collective action. Nor does he recognize that precisely such a reversal is already becoming possible in some of the most promising mobilizations of the twenty-first century: the election, at the end of 2025, of the young Muslim Zohran Mamdani as mayor of New York, on a platform centered on the intensely material fight for an affordable city; the Left Party’s victory in Berlin two weeks ago, built around the demand to expropriate private real-estate corporations; and the very recent wave of demonstrations in Spain—including an occupation of Madrid’s Puerta del Sol—in which tens of thousands of young people mobilized by the Tenants’ Union have demanded limits on rents. By putting itself in the straitjacket of the “fiscal framework” in the first months of 2022, Lula’s third government adopted the second fatal accommodation of its term. Faced with conservative institutions and a country devastated by four years of Bolsonaro, increased public investment was the government’s remaining weapon for offering a more dignified life to the majority and forging an anti-conservative pact with them. The same state that disburses 1 trillion reais a year to enrich a small class of rentiers could instead spend money to extend the Family Health Strategy to every Brazilian, at a cost of 30 billion reais; provide full-day public schooling and childcare to all adolescents and children—and, especially, relief to their mothers; achieve universal sanitation while cleaning up polluted urban rivers; multiply metro systems; begin transforming the urban peripheries; and undertake many other urgently needed projects. In April 2023, an article in Outras Palavras warned that the fiscal framework could “shrink the Lula government and preserve the forces that condemn the country to inequality and regression.” A year later, another article showed that restraints on public spending were strangling policies vital to ordinary people and undermining the president’s popularity. In November 2024 came a reality check, in the form of the government’s humiliating defeat in the municipal elections. Even then, the fiscal lock was neither removed nor loosened. On the contrary: throughout the government’s four years, fiscal restraint remained central to its political narrative. The administration proudly proclaimed that it had “put the state’s accounts in order,” without grasping either how misleading that phrase was—given the payment of 1 trillion reais in interest—or how badly the message was hurting it politically. Lula finally woke up in September 2026. The increase in Bolsa Família benefits, after four years of being frozen; the announcement that anti-obesity drugs would be offered through Brazil’s public health system; and the ban on online betting showed that the state has the power to act decisively on behalf of the majority when those in government are willing to confront obstacles. The huge marches that closed the campaign in Fortaleza, Salvador, Rio de Janeiro, and São Paulo on the eve of October 4 showed how such initiatives can mobilize activists and the broader public. But it was too late—and too little to change the outcome of the first round. History has not ended The possibility of a turnaround in the three weeks leading up to November 25 cannot be ruled out. It will not be simple or easy. Lula must not only make up a deficit of 2.2 million votes; he must also offset the movement of voters who backed other right-wing candidates in the first round, most of whom are likely to move toward Flávio Bolsonaro. Pulling that off will require a broad, grassroots effort to win over voters, potentially reinforced by new initiatives from Lula. The coming hours and days will be decisive. If Bolsonaro’s movement also wins the presidency, the result will create a high-risk situation for Brazilian sovereignty and democracy. The enormous challenges posed by such an outcome would require the left to reexamine, in depth and with a genuine willingness to engage in self-criticism, its political projects—or its lack of them—and its practices. But would that mean we are condemned to the long winter of far-right hegemony that some analyses are beginning to forecast? It is far too early to say, suggests a recent text by Álvaro García Linera, the thinker who served as vice president of Bolivia under Evo Morales. His central hypothesis is that this political current will prove short-lived. At a moment when the entire world is once again talking about sovereignty and protecting national economies, the far right offers a stale, recolonizing neoliberalism. Its submission to the United States is as blatant and pathetic as Flávio and Eduardo Bolsonaro’s overtures to Donald Trump. Its project amounts to something like every man for himself: greater inequality, capitalism without limits, devastation, and supremacism. Will it work? In the United States, just two years into his second term, Trump himself is reaching record levels of unpopularity and may be on the verge of losing Republican control of both the House and Senate in November. Every new beginning is difficult. Whatever the outcome of the second round, the defeats of October 4 show how profoundly the Brazilian left will have to rethink and rebuild. But just as it would be foolish to underestimate the seriousness of its mistakes, it would be equally foolish to conclude that rebuilding a political project is no longer possible. History has not ended. The times are moving faster than ever. Originally published in Portuguese by Outras Palavras. English translation by Eric Blanc; I’ve added the subtitles. More We can’t stop the far right at home or abroad without a revitalized labor movement, which is yet another reason why you should become a sustaining supporter of the Emergency Workplace Organizing Committee (EWOC) — one of US labor’s pivotal bright spots. Relatedly, Jacobin published a short piece of mine reflecting on a decade of Bernie Sanders inspiring a whole new generation of young worker organizers.
These Are the Only Nintendo Switch 2 Discounts That Are Actually Worth Your Money in Amazon's 48-Hour Prime Sale — Save on Games, Consoles, Gift Cards, and More
Our resident shopping experts have curated the 10 absolute best Nintendo Switch 2 console bundles, games, and accessory deals for Amazon's latest 48-hour Prime sale.
“Boy Meets World” star Matthew Lawrence recalls ‘dysfunction’ on “Girl Meets World ”set: ‘It was very weird’
Lawrence spoke to EW about reprising the role of Jack on a 2015 episode of the Disney Channel spinoff.
‘Boy Meets World’ star Matthew Lawrence recalls ‘dysfunction’ on ‘Girl Meets World’
‘Boy Meets World’ star Matthew Lawrence spoke to EW about the ‘dysfunction’ on the ‘Girl Meets World’ set, and his ‘strange’ experience guest-starring on the spinoff.
Rangers Daily: Tolvanen’s ‘hockey IQ;’ Ovechkin retiring; Celebrini injury
Considered a good late-summer addition at the time, signing Eeli Tolvanen is shaping up to be a steal in the […]
Nintendo Switch Sports Resort: I’d Trade Table Tennis for Swordplay, Baseball, or Frisbee, but It’s Still Won Me Over
I’m stunned at how excited I am for Nintendo Switch Sports Resort. I plan to 100% this game, which is not something I would have said two weeks ago. I’m still not entirely thrilled with the sports lineup – I would trade Table Tennis and Volleyball for things like Swordplay, Baseball, or Frisbee – but what is here is shaping up to be really fantastic. Don’t sleep on this one: I think it’s going to be an enormous improvement on Nintendo Switch Sports and a fantastic return to one of my favorite settings in Nintendo history. I’ll see you on Wuhu Island.
Amazon Prime Big Deal Days Offers Major Discounts on AirPods, iPads, and Much More
Amazon's Prime Big Deal Days has officially kicked off, offering shoppers the first chance to save on holiday shopping from a major retailer. Similar to last year's fall Prime Day, it will last for two days, and you can find a large selection of deals across Amazon's storefront, covering savings on tech, clothing, video games, groceries, and much, much more. Note: MacRumors is an affiliate partner with Amazon.
NAACP launches voter protection hub for midterm elections
The civil rights organization is stepping up efforts in response to President Donald Trump’s push to change voting rules.
It's literally never been cheaper to buy this Wahoo indoor trainer on Amazon thanks to a whopping Prime Day discount
Shorter days, colder weather and more time indoors are coming so now is the time to upgrade your indoor trainer
Is it possible to preserve your memories before dying? The science is moving beyond science fiction
For most of history, preserving someone’s memories after death meant relying on photographs, letters, stories and the recollections of other people. Technology is now pushing that idea much further. Scientists can record parts of brain activity linked to memory, researchers are mapping the neural networks that store experiences, and digital systems can preserve enormous amounts of a person’s voice, writing, images and personal history. That still falls far short of copying a mind. No technology
How traditional Chinese medicine is shaping Kazakhstan’s health system
Partnership is latest move by Beijing to engage the resource-rich country amid expanded ties in energy, security, trade and infrastructure.
Latest bowl projection has Duke facing SEC power
Duke is hoping to reach its fifth straight bowl game for the first time in program history.
Trump, politics and lawfare take center stage in Arizona's attorney general race
Four years ago, Democratic Attorney General Kris Mayes won the office by less than 300 votes. Now, she’s hoping her track record taking on President Trump, fake electors and predatory businesses will earn her a second term in office.
Stocks making the biggest moves premarket: Constellation Energy, Option Care Health, Lennar, P&G and more
These are the stocks posting the largest moves in early trading.
On the barricades with wheelie bins and shopping trolleys: Paris students rage at politicians and police
Unprecedented protests that began in low-income banlieue are turning ugly, with investigations under way into police brutality
Miller Admits To Possibility That He Was Tipping Pitches
San Diego Padres closer Mason Miller blew a save against Milwaukee in Game 2, and there may be a reason why.
I’m an American in Denmark. I moved here excited to have a better work-life balance—but I kept resisting it
Brooke Black says moving to Denmark from the U.S. didn't cure her workaholism. It took her years to learn that rest and ambition were not mutually exclusive.
Craig Breslow Identified Red Sox’s Biggest Offseason Priority
Craig Breslow’s assessment of Boston’s offense should make the Red Sox’s offseason shopping list pretty obvious.
As Taiwan expands Arizona chip plant, China warns against developing political ties
The world's biggest chipmaker now manufactures at scale in Phoenix, as well as Taiwan. China is warning political leaders in Arizona to not get too friendly.
Fitter Kids May Grow Into Less Depressed Adults
By Dennis Thompson HealthDay ReporterTUESDAY, Oct. 6, 2026 (HealthDay News) — Kids who run and play will reap mental health benefits into middle age, a new study says. Active, fit children appear to have a lower risk of developing depression in their late 30s and 40s, researchers reported recently ...
Trilliant Health Releases Its 2026 Trends Shaping the Health Economy Report
BRENTWOOD, Tenn.--(BUSINESS WIRE)--Oct 6, 2026--
What are ‘sleeping beauties’ in the world of knowledge?
In a new book, artist David Byrne explores how important ideas are forgotten—and then remembered—over time.
Ndour on Juventus radar after firing Azzurrini to Euros
Juventus are among several clubs keeping tabs on Cher Ndour after the Fiorentina midfielder fired Italy’s Under-21s to the European Championship.According to Tuttomercatoweb, the Bianconeri see the ...
Opinion | Meta Is Crushing Small Online Retailers
Meta is crushing small online businesses by charging more for less effective ads, a sign of its extraordinary grip on the market.
Current and Historical Public Opinion on Medicare-for-All and Other National Health Plan Proposals
This chart pack summarizes KFF polling data on public opinion on Medicare-for-all and other national health plan proposals. The latest update finds that two-thirds of the public supports Medicare-for-all, while support changes drastically as respondents hear arguments from proponents and critics.
Deshaun Watson's Rollercoaster Performances for the Cleveland Browns
I'm going to focus on EPA for this piece. EPA stands for Expected Points Added, which measures the value of individual plays based on how much they increase or decrease a team's likelihood of scoring.Here is a fantastic video explaining what EPA is and why it is a measure that looks at years on NFL history rather than one person's subjective opinion on a certain play.Deshaun Watson's Current...
Escape From Tarkov’s New PvE Update Officially Makes the Game Easier for Newbies
Exfil Brothers rewards veterans for helping newcomers
Keeping up with the Bolsonaros: Flávio’s surprise first-round election win heralds rise of a political dynasty
Four members of disgraced ex-president Jair Bolsonaro’s family have been elected to office, most notably his wife and son Flávio, who won the first round of voting to be Brazil’s new president
Northwest Biotherapeutics Announces Keynote Presentation on Harnessing Immunity: A Personalized, Multi-Target Approach to Cancer At the UK National Health Service Annual Oncology Conference
/PRNewswire/ -- Northwest Biotherapeutics (OTCQB:NWBO) (the "Company" or "NWBio"), a biotechnology company developing DCVax® personalized immune therapies for...
In Business: Bemidji Woolen Mills Keeping Local Production Alive
https://youtu.be/dwmn4Xteru4 As more clothing production moves overseas, one Bemidji manufacturer is still keeping much of its work local. Behind the racks and finished products at the Bemidji Woolen Mills, much of the work here still comes down to people cutting, stitching, and sewing. In an industry where production has often…
Northern Essex’s McCarthy Joins New Small Business Advisory Council
Michael McCarthy, executive vice president and chief financial and operating officer at Northern Essex Community College, was recently appointed to the Massachusetts Small Business Development Center statewide Advisory Council, a new group of business, government, economic development and community leaders helping guide the future of small business support in the state. The Advisory Council was
LeBron James Gets Major Perk While Playing for Sixers
LeBron James won’t have to foot the bill for his unusual Sixers commute — but fans hoping to see him Monday night got different news. The post LeBron James Gets Major Perk While Playing for Sixers appeared first on HEAVY.
Two Overlooked Stars Keeping Packers Alive
The 2026 Green Bay Packers look and feel like a bad team that has miraculously beaten even worse teams. The coaching and scheme have not consistently aligned with the players’ abilities to execute, while gut-wrenching injuries have left Green Bay relying on backups across multiple position groups. And it is only Week 5. For a …
Reds May Have Stumbled Into a Valuable Piece at the Trade Deadline
By flipping rental Nate Lowe for utility prospect Juan Brito, Cincinnati may have secured a versatile switch-hitter ready to spark the 2027 roster after a blistering debut.
Padres’ Potential Game 4 Starter Comes Back from Paternity List
Walker Buehler has spent the season being one of the San Diego Padres' most valuable starting pitchers. That might not be immediately apparent from the overlying statistics, but the metrics under the surface show a different picture. San Diego will be all hands on deck after dropping both games to the Milwaukee Brewers at American …
Science starts at the dinner table: Building STEM connections with families
By inviting children, parents and grandparents to explore science together, a Hartford outreach program is helping families see research as part of everyday life.
Countries race to provide oral health care for all in 100-Day Sprint across Asia
Twenty Asian countries and areas across the WHO Western Pacific and South-East Asia regions vowed to strengthen essential oral health benefits as part of a “100-Day Sprint” initiative, during the 16th Asian Chief Dental Officers Meeting held from 27 to 29 September in Kota Kinabalu, Malaysia. The meeting marked the midpoint of the 100-day sprint bolstering support for countries to develop essential oral health benefit packages that can be integrated into national universal health coverage plans. Convened by the two WHO regional offices and the Malaysian Ministry of Health as the Secretariat, the meeting brought together national oral health leaders from 20 Asian countries, staff from all levels of WHO, WHO collaborating centres and other development partners. Participating countries and areas included: Bangladesh, Bhutan, Brunei Darussalam, Cambodia, China, Hong Kong (SAR) China, India, Indonesia, Japan, Lao People’s Democratic Republic, Malaysia, Maldives, Mongolia, Nepal, the Philippines, Singapore, Sri Lanka, Thailand, Timor-Leste and Viet Nam. Participants reviewed progress and refined proposals using the WHO Service Package Delivery and Implementation (SPDI) Platform. Countries conducted bottleneck analyses across four key areas: service delivery, workforce, access to essential medicines and health products, and health financing. They identified practical actions to address implementation challenges and refined proposed revisions to their national oral health benefit packages. “There is no health without oral health. Through the 100-Day Sprint, countries are advancing the implementation of the Western Pacific regional implementation plan on oral health and strengthening progress towards universal health coverage,” noted WHO Regional Director for the Western Pacific Dr Saia Ma'u Piukala. Participants identified bottlenecks and proposed workable solutions to strengthen access to essential oral health care through primary health care, sharing experiences and discussing how best to translate policy commitments into feasible and sustainable action at the country level. Malaysian Minister of Health Datuk Seri Dr Dzulkefly Ahmad highlighted the importance of prevention and primary health-care approaches to improve oral health: “Oral diseases can have lifelong consequences, yet many are preventable. By integrating essential oral health care into primary health care and promoting prevention in schools and communities, we can improve oral health across the life course.”The WHO team led by Dr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control of the WHO Western Pacific Region and national oral health leads from over 20 Asian countries visited the SK Pekan Putatan School, Sabah for school oral health programme including flouride mouth rinsing. © WHO / V. ChaudharyDr Huong Tran, Director of the Division of Health Promotion, Disease Prevention and Control for the WHO Western Pacific Region, emphasized key collaborative roles WHO can play. “Oral diseases are the most common noncommunicable diseases, yet many can be prevented and treated through essential oral health services delivered at the primary health-care level,” she said. “By sharing experiences and using WHO tools such as the SPDI Platform, countries are accelerating progress towards universal health coverage for oral health.” “Integrating oral health into broader health services is essential for reducing inequities, expanding access and recognizing oral health as an integral component of overall health and well-being. The 100-Day Sprint provides an important opportunity to translate this commitment into practical action and ensure that quality oral health services reach all people, especially those most in need,” said Dr Suman Rijal, Director of the WHO South-East Asia regional Department of Healthier Populations and Noncommunicable Diseases. As host of the meeting, Malaysia showcased ongoing efforts to strengthen oral health care through primary health care and prevention-focused approaches, while providing a platform for countries across the two WHO regions to exchange experiences and accelerate progress towards universal health coverage for oral health. “WHO is encouraged by Malaysia's leadership in addressing the burden of oral diseases and advancing universal health coverage for oral health through practical, country-led action,” said Dr Rabi Abeyasinghe, WHO Representative to Malaysia, Brunei Darussalam and Singapore. Countries will continue to refine and figure costs for national oral health benefits during the remaining sessions of the 100 days. These efforts support implementation of the WHO Global strategy and action plan on oral health 2023–2030, while also helping to expand access to essential oral health services through stronger and more equitable health systems across the WHO Western Pacific and South-East Asia regions.______________For more information, or to arrange media interviews, contact: WHO Regional Office for the Western Pacific: wprocom@who.int WHO Regional Office for South-East Asia: SEMediaRelations@who.int
This Weekend in Gators Sports: Tennis Wins Big, Swim and Dive Stays Perfect
Florida swimming and diving and men’s tennis posted strong results on the road over the weekend. Gators men’s tennis returned to Gainesville stamping 15 wins on the weekend at the three-day Bedford Cup hosted by UCF, while Florida men’s and women’s swim and dive remained undefeated against Kentucky 31-0 all time. Men’s Tennis: Doubles Title […]
Hunter Green Named Ray’s Eight, Punting Matchup with Iowa
Washington punter Hunter Green was named one of the “Ray’s Eight” punters of the week by the Ray Guy Award after his 310-yard punting performance at USC. Green punted six times for an average of 51.7 yards with three pinned inside the 20-yard line. Two of his punts were downed at the one-yard line. His …
Robert De Niro rips 'coward' Trump over voter suppression
Robert De Niro is ramping up his criticism of the Trump administration in the final weeks before the 2026 midterm elections.
Japan's entertainment robots diversify with AI, offer comfort
The range of home entertainment robots is becoming increasingly diverse in Japan, with some providing emotional comfort like pets, and others serving as fashion accessories due to their cute appearance. The growing use of artificial intelligence is also helping to expand the market, widely seen as having taken off with…
Oct. 8 talk to discuss building a new era of materials characterization
Pinshane Y. Huang, Racheff Faculty Scholar in the Department of Materials Science and Engineering at the University of Illinois, Urbana-Champaign, will give the talk “Building a new era of atom-by-atom materials characterization with electron ptychography” at 3:05 p.m. on Thursday, Oct. 8, in 10 Sparks Building on the University Park campus.
Long & Foster taps RE/MAX exec as new CEO
Long & Foster Cos. announced that President and CEO Patrick Bain is stepping down and that it has tapped Daniel Dennis to succeed him.
Eagles address uncertainty surrounding missing star
Will Eagles star return? Team is keeping quiet.
Tony Gilroy on Leaving the Politics of 'Andor' Behind for His 9-Composer Music Drama 'Behemoth!'
NEW YORK (AP) — Long before Tony Gilroy wrote “The Bourne Identity," made “Michael Clayton” or created “Andor,” he wanted to be a musician. After playing guitar in a string of bands, Gilroy came to Los Angeles hoping to become a studio musician. A session with some real players quickly disabused him ...
Fall Preview with Entertainment Correspondent Mike Marra
Airdate: October 5th, 2026 Leoni Township Update with Administrator Mike JesterOctober 5, 2026City Treasurer Hosting Town Hall Meeting SeriesOctober 5, 2026Tecumseh Appleumpkin Festival This WeekendOctober 5, 2026Fall Preview with Entertainment Correspondent Mike MarraOctober 5, 2026Disney’s Frozen Premieres Thursday at The SaukOctober 5, 2026Alison McGlynn & Lilly Hayworth, The Annex Collective SalonOctober 5, 2026John Spink, Nite…
California scientist wins a Nobel Prize, then makes school lunches for his kids
STANFORD, California (AP) — Dr. Karl Deisseroth spent hours fielding congratulatory calls after learning early Monday that he had won a Nobel Prize for medicine for helping to open a new field of brain science called optogenetics.
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.
California scientist wins a Nobel Prize, then makes school lunches for his kids
Dr. Karl Deisseroth spent hours fielding congratulatory calls after learning that he had won a Nobel Prize for medicine for helping to open a new field of brain science called optogenetics.
Bladen Community College to host “So You Want to Start a Small Business” class and preview Pitch It Bladen 2027
The Small Business Center at Bladen Community College invites aspiring entrepreneurs to attend “So You Want to Start a Small Business” on Tuesday, Oct. 13, 2026, from 6:00 p.m. to 8:00 p.m. in Building 14, Room 104. This class will help participants explore what it takes to become an entrepreneur and take the first steps toward turning a business idea into reality.Participants will explore the entrepreneurial mindset and consider whether they have the interests, characteristics, motivation and willingness to take on the challenges of business ownership. The class will encourage attendees to examine their personal goals, expectations, strengths and readiness to pursue entrepreneurship.Attendees will also gain insight into the realities of starting and operating a small business, including the commitment, planning, decision-making and perseverance required to build a successful venture. Whether participants are just beginning to consider business ownership or already have an idea they want to pursue, this class will provide a foundation for determining their next steps.In addition to the class instruction, attendees will receive advance information about the upcoming Pitch It Bladen 2027 Business Competition, including the application form and details about the program. Individuals who are ready to move forward may submit their applications early and have the opportunity to receive advance acceptance into the program.Pitch It Bladen helps aspiring and emerging entrepreneurs develop their business ideas through structured instruction in business planning, financial management, cash-flow projections, marketing and operations. Participants work toward completing a business plan and preparing a business pitch, with the opportunity to compete for cash prizes.Last year's Pitch It Bladen program demonstrated the value of investing in local entrepreneurs by helping participants strengthen their business knowledge, develop their business plans and prepare to present their ideas. The competition showcased the creativity and potential of Bladen County's small-business community and provided participants with practical tools to move their business goals forward.Building on that success, Pitch It Bladen 2027 will provide another opportunity for local entrepreneurs to gain knowledge, build confidence and take meaningful steps toward launching or growing a business.“The Small Business Center wants to help individuals make informed decisions about entrepreneurship before they take the leap into business ownership,” said Theresa Dennison, Small Business Center director, in a press release. “This class gives participants an opportunity to evaluate whether entrepreneurship is right for them while also introducing them to Pitch It Bladen 2027 and the resources available to help them succeed.”Registration: Visit www.ncsbc.net and search for the class by name, or contact the Small Business Center at 910-879-5572 for additional information.
Opinion: Pay for performance, not for politics
North Carolina should link teacher pay growth to hard-to-staff roles and performance, not seniority, credentials or political pressures, columnist John Hood arg...
Opinion: Pay for performance, not for politics
North Carolina should link teacher pay growth to hard-to-staff roles and performance, not seniority, credentials or political pressures, columnist John Hood arg...
Banijay Entertainment Consolidates U.S. Operations to 'Banijay America' Under CEO Ben Samek
Banijay Entertainment Oct. 5 announced it is consolidating its U.S. operations under a new moniker, Banijay America, under the direction of CEO Ben Samek, who reports to Jane Turton, deputy CEO of Banijay Entertainment. The company is restructuring its operational footprint to centralize leadership and operational support while keeping its individual production labels creatively independent. … Continue reading "Banijay Entertainment Consolidates U.S. Operations to ‘Banijay America’ Under CEO Ben Samek"
Obama to campaign with El-Sayed in Detroit as ex-president gets more involved in midterms
Obama is upping involvement in the midterm election. He taped two dozen ads last week for Democratic candidates for governor and Senate that will be released in the coming days and weeks.
Kings HC Christie 'Really Enjoying' FA Signing Simmons
The Sacramento Kings are hoping free agent pickup Ben Simmons can get back to a semblance of his old self, while giving the team a much-needed boost on the defensive end. Head coach Doug Christie has been extremely positive regarding Simmons, calling him a "special" player.
Trump is clearly trying to buy votes with taxpayer money
President Donald Trump is ramping up his efforts to use taxpayer money and resources to help Republicans win the 2026 midterm elections.
ASU designs a statewide pipeline for Arizona's anesthesia workforce
Every surgery, C-section, trauma case and cancer operation in Arizona depends on a clinician administering anesthesia and keeping the patient safe while the surgeon works. The state needs more of these clinicians.As of September, the Arizona State Board of Nursing lists 1,759 certified registered nurse anesthetists, or CRNAs, in the state. In 2023, Arizona was short 732 nurse anesthetists, and the shortage is projected to reach 868 by 2033.
OPINION: Pay for performance, not for politics
The North Carolina General Assembly approved substantial pay increases for public schoolteachers earlier this year. If a bipartisan commission has its way, teacher compensation will soar over …
CT Business Blend: Oct. 5, 2026
Hartford Business Journal’s Greg Bordonaro and WTIC’s Brian Shactman explore the people, companies and trends shaping Connecticut’s business scene every Monday at 8:30 a.m. on WTIC 1080 AM.
Karoline Leavitt joining Fox News as on-air contributor
Former White House press secretary Karoline Leavitt will become an on-air Fox News contributor next month, weeks after stepping down from her prior role to spend more time focusing on her family.
Seedy K’s Pigskin Palaver: House of Cards & Much Mo’
Ah yes, October; the pigskin campaign is morphing more fully developed. And, fully enveloping. This week, there’s a football game on every single night. Not just the more traditional Thursday, Friday, Saturday, Sunday, Monday. Because Draft Kings and Fan Duel and The World Wide Leader need content, we get Southern Miss and Troy on Tuesday, […]
NWA C-Suite: Tom Allen
Allen has been closely involved in the continued development of the Pinnacle Hills area of Rogers, including helping to lead the development and leasing efforts for The Visionaries, Hunt Ventures’...
Some mental health providers hoping to serve Lane County's Oregon Health Plan members say they’re facing barriers
Aspire is one of a few healthcare providers in Lane County that told KLCC they want to – but haven’t been able to – get a contract with Lane County's Medicaid insurer Trillium. That’s left Aspire without access to its target population, and other providers considering scaling back their services.
Jeffries says House Democrats aiming to repeat 2018 sweep by flipping Trump districts
The Democratic Party is working to expand the map by going on offense in Republican-held districts, while President Donald Trump hits the trail in a red-state sprint to boost voter enthusiasm and shore up support from his base.
Labour standards increasingly shape market access and business competitiveness
A new ILO Brief examines how labour standards and responsible business expectations are increasingly shaping market access, supply chains and business competitiveness in Asia and the Pacific. It highlights the role of employer and business membership organizations in helping companies navigate evolving requirements and promote better labour outcomes.
AirTags are on sale ahead of Amazon Prime Day. These early deals are worth shopping
Amazon Prime Day is tomorrow, but these early AirTag deals are already worth snagging.
Scientists Reveal The Optimal Amount of Sleep For Lower Dementia Risk
A huge analysis uncovered the sweet spot.
Chimpanzees steal less pineapple from their friends
The new research sheds more light on the evolutionary origins of friendship.
Star Wars Zero Company Has Received Its First Big Discount at Amazon Before Its October Prime Day Sale Begins, Dropping Below $50
Star Wars Zero Company has dropped to a new low price at Amazon ahead of the retailer's Prime Big Deal Days sale event, with a 20% discount across PS5 and Xbox Series X.
oasisVRX Expands to the Princeton Area With New Active Entertainment Virtual Reality Destination
/PRNewswire/ -- oasisVRX is expanding with the opening of its second location at Princeton North Shopping Center, 1225 Route 206 in Princeton, New Jersey....
Digital Science appoints Charlesworth as strategic sales partner of Altmetric and Dimensions in China’s scholarly publishing sector
Digital Science has appointed Charlesworth as its strategic sales partner of Altmetric and Dimensions in China’s scholarly publishing sector. This collaboration aims to support the growing demand for research data and information across this rapidly developing market.
Scientists generate identical photons at the push of a button
Researchers from different universities have teamed to generate photon pairs that are 90 percent identical, helping advance quantum communications.
Fact check: Did Newsom’s mental health court hit his goal for helping Californians?
Gov. Gavin Newsom claimed a major victory for CARE Court, his mental health treatment program. Did it really help 10,000 people?”
Instinct users say its AI agent is pushing unsolicited products
Instinct users say the AI agent sent unsolicited shopping picks, raising questions about whether it's monetizing their data.
‘An anchor’: Oakshire fans celebrate, grieve as business prepares to shut down
Oakshire Public House has been a gathering space in the Whiteaker neighborhood since 2013 and holds many individual and community memories. Oakshire as a company is closing, but it plans to transition the Public House to a new company in the next two months, keeping the location open through the process.
Universal Expands EMEA Retail and Partnerships for 'Shrek 5'
Universal builds excitement for 'Shrek 5's' summer 2027 release with new EMEA retail, events and partnerships. Donkey spin-off film set for 2028 release.
Mac Users Reclaim Storage With New Apple Intelligence Removal Tool
A new open-source tool is making waves in the Mac community by helping users reclaim valuable storage space taken up by Apple's AI models. Called "RemoveMacAI," the tool disables Apple Intelligence on macOS 27, removes its downloaded models, and prevents them from being downloaded again. In macOS 27, Apple removed the toggle to disable Apple Intelligence wholesale, and simply disabling individual features doesn't remove the models from your Mac's drive.
Meet the Houston university professor who's also a club DJ
Alex La Rotta teaches history at the University of Houston and Houston City College while also spinning at area events and flying the flag for Latino and Chicano popular music.
'Clearly not working': Sam Altman hits AI industry over political spending
In a wide-ranging interview, the OpenAI CEO criticized the flood of AI dollars swamping the midterm elections and suggested a new liability framework is needed for autonomous hacks.
‘Clearly not working’: Sam Altman hits AI industry over political spending
In a wide-ranging interview, the OpenAI CEO criticized the flood of AI dollars swamping the midterm elections and suggested a new liability framework is needed for autonomous hacks.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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