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Another Planet Entertainment Contract Extension Before Board of Supes
A resolution to extend APE’s contract with the Recreation & Parks Department for three more years, with an option of extending it out further to 2035, was approved by the Budget and Appropriat…
Long Island Fidelis policy holders facing loss of in-network Northwell Health care
A deadline looms for an agreement on a new contract between Fidelis and Northwell Health.
Nikola Jokic Gives Update Every Nuggets Fans Needed Amid Contract Talks
Jokic says he's staying in Denver, and he explained exactly why he's willing to wait one more summer to make it official.
Illinois health officials warn of high rate of intestinal illness caused by contaminated foods
The intestinal illness cyclosporiasis is contracted by consuming contaminated foods. The most common symptoms of the illness are diarrhea, nausea and fatigue, according to health officials.
Spero Health Acquires CleanSlate, Doubling Footprint and Averting Shutdown
This is an exclusive BHB+ story Spero Health acquired fellow multi-state office-based opioid treatment (OBOT) provider CleanSlate Centers. The deal saves
Illinois prison healthcare still poor as state goes 1 year without long-term medical provider
The state has been extending a short-term emergency contract with Centurion Health since July 2025 after backing out of a 10-year, $4 billion contract with Wexford Health Sources. Since then, the transition from Wexford to Centurion has complicated people's health care and left at least one subcontractor for Wexford unpaid.
Illinois prison healthcare still poor as state goes 1 year without long-term medical provider
The state has been extending a short-term emergency contract with Centurion Health since July 2025 after backing out of a 10-year, $4 billion contract with Wexford Health Sources. Since then, the transition from Wexford to Centurion has complicated people's health care and left at least one subcontractor for Wexford unpaid.
Lorenzo Pellegrini’s new contract being finalized
In addition to the various signings requested by Gasperini, new sporting director Tony D’Amico is also focusing on the renewal situation. In addition to Celik and Dybala, the issue of Lorenzo Pelleg...
Trey McBride was lowballed by Arizona Cardinals in contract talks
Before Trey McBride got a $19 million per year extension, the Cardinals gave him a cheap offer.
Terrion Arnold Clears Waivers: What it Means
Former Detroit Lions cornerback Terrion Arnold has officially entered free agency. According to ESPN, Arnold cleared waivers on Monday, meaning no NFL team claimed his contract following his release by the Lions last week. He is now free to sign…
Epic Games settles lawsuit against former contractor accused of leaking unannounced Fortnite collaborations
Epic Games has settled a legal case against a former contractor accused of leaking confidential information about Fortn…
Supporters to rally after Logan Health declines to renew doctor’s contract
A contract decision involving a longtime family physician at Logan Health is fueling a growing controversy in the Flathead Valley, with union leaders warning it
Report: Quinten Post signs offer-sheet with Memphis Grizzlies
The Warriors will now have until Tuesday to match the Grizzlies contract offer.
Council to vote on Office of Public Health and Safety oversight
The proposal calls for better contract management and ethics training.
Could Santos help solve Man Utd's midfield malaise?
Chelsea's Andrey Santos is the latest player Manchester United have taken an interest in as they look to address their problem midfield position. With Casemiro leaving after his contract expired on 30 June and Manuel Ugarte expected to be sold, United went into the summer with England's Kobbie Mainoo as their only recognised central midfielder and with the stated aim of addressing the situation as a matter of priority. In the transfer market, United have encountered more issues.
Delivery firm Evri sues BBC for £1.2m over Panorama documentary
Company seeks redress for contracts it says it has lost as a result of programme’s claims about its business practices
Epic Games settles a court case against former contractor accused of leaking Fortnite collaborations
Former contractor Hayden Cohen has agreed to a judgment that bars them from "possessing, accessing, using, or disclosing any of Epic’s confidential or trade sec
Ukraine paying big for foreign fighters, longer contracts could help
Foreign fighters told Business Insider that new contracts and higher pay could fix manpower issues if soldiers stick around long enough.
Lakers have signed Chris Mañon to two-way contract
The Lakers have signed defensive specialist Chris Mañon to a two-way contract.
Mass. to end contract with Biobot for wastewater surveillance
Biobot proved waste water surveillance was valuable enough that governments now want to do it themselves.
Tobias Harris explains decision to leave Pistons, sign with Spurs
The Detroit Pistons wanted to retain Tobias Harris in free agency, but ultimately he spurned the Pistons in favor of signing with the San Antonio Spurs on a two-year, $31 million contract. In an exchange with HoopsHype, Harris provided some insight into his decision to leave Detroit for San Antonio. “The urgency to win a championship," Harris said.
Penguins Sign Ex-Capitals RFA Forward To Two-Year Contract
Penguins sign Hendrix Lapierre for two years
The Penguins reached an agreement with one of their restricted free agents on Friday getting Hendrix Lapierre to ink a two-year contract with an AAV of $1.3 million. From the team: The Pittsburgh Penguins have signed forward Hendrix Lapierre to a two-year contract, it was announced today by President of Hockey Operations and General Manager […]
Carolina Panthers' Jaelan Phillips Named NFL's Most Overpaid Edge-Rusher
The Carolina Panthers signed Jaelan Phillips to a massive four-year, $120 million contract.
NBA Fans Bracing For Blockbuster Anthony Davis, Cavaliers Trade
Anthony Davis isn't a free agent but he's still commanding a ton of attention this NBA offseason. The Washington Wizards have already said they have no interest in trading Davis, especially since he's eligible for a contract extension. Nonetheless, trade rumors involving the All-Star forward just ...
Patriots rookie shows off health progress amid contract uncertainty
Patriots rookie edge rusher Gabe Jacas is looking strong in the weight room, despite lingering health questions.
Contract details for New York Giants GM Joe Schoen revealed
Details about the contract extension given to New York Giants general manager Joe Schoen have been revealed.
How the FIFA World Cup is providing a boost for L.A. businesses
The FIFA World Cup has given L.A. businesses a lot of opportunities to find new customers, win contracts and grow their capacity.
David Sassarini is the new Inter Women coach
FC Internazionale Milano can confirm that David Sassarini has been appointed as the new head coach of Inter Women. The coach has signed a contract with the Club until 30 June 2028. Born in La Spezia o...
Russia's services downturn deepens as new business falls at fastest pace since December 2022, PMI shows
Russia's services sector contracted further in June as weaker client demand drove steeper falls in output and new orders, a business survey showed on Friday.
Why Kotek is directing Oregon to prioritize small business contracts
Oregon small businesses will get preference in state contracting, Gov. Tina Kotek announced. Here's why.
Anfernee Simons agrees to 2-year deal with Philadelphia 76ers
The Philadelphia 76ers agreed to a two-year, $12.3 million contract with guard Anfernee Simons. Simons averaged 14.3 points per game last season.
House panel explores direct health contracting to lower costs
The House Education and Workforce Subcommittee on Health, Employment, Labor and Pensions July 1 examined whether direct health care contracts between employers and providers could help address rising health care costs.
Steelers' Defensive Line Future Hinges on Keeanu Benton Contract Decision
For the first time in what feels like a very long time, the Pittsburgh Steelers are getting second deals done with their draft picks. Joey Porter Jr. is in line for his deal, Darnell Washington got his, and Nick Herbig also cashed in during the 2026 offseason. According to a Steelers insider, the team may leave 2023 second-round pick Keeanu Benton on the outside looking in.
What’s going up on Airline Highway, near Coursey Boulevard?
The first phase of construction started in May, according to a Facebook post by Centurion Construction Management, the general contractor.
IAM District 4 Members Win First Contract at Federation of American Scientists
Nearly a year after becoming the first union in the nearly 80-year history of the Federation of American Scientists (FAS), 25 IAM District 4 members have ratified their first collective bargaining agreement, securing workplace protections, greater transparency, and a stronger voice on the job. The Federation of American Scientists (FAS) was established in 1945 by scientists
Ferrari, Lewis Hamilton in ‘Decisive’ Contract Talks Amid 2027 Uncertainty
Ferrari driver Lewis Hamilton has gotten off to an amazing start to the 2026 season, marking a real turning point with the team at a pivotal stage.
Devils Sign Winger Riley Tufte to 1 Year, $850,000 Deal
In one of the more under the radar moves today, the Devils announced the signing of 28-year-old winger Riley Tufte to a one-year, one-way NHL contract. A link to the press release can be found here. A 6’6”, 245lb behemoth, Tufte has been one of the most prolific scorers in the AHL, finishing tied for […]
Mavs Free Agent Marvin Bagley III Signs Contract with Nuggets
The move is evident of the Mavericks' logjam in the frontcourt.
New requirements for sports agents in Louisiana aim to protect student-athletes
The launch of the online portal comes after a state law went into effect last month, increasing regulatory oversight of endorsement contracts and sports agents.
Red Wings Sign Backup Goaltender
The post Red Wings Sign Backup Goaltender appeared first on Detroit Hockey Now. The Detroit Red Wings have added to their goaltending stable with a contract for Daniil Tarasov. Steve Yzerman and Detroit’s […] The post Red Wings Sign Backup Goaltender appeared first on Detroit Hockey Now.
Report: Penguins sign Andrei Kuzmenko to one-year contract
The Pittsburgh Penguins keep adding, the latest is the report that winger Andrei Kuzmenko is joining the team for one year and $5.0 million. Kuzmenko has been among the NHL’s slowest skaters, but has the hands and scoring ability to cover up that deficiency. Curiously, his salary is right in the price range of Rickard […]
Judge rules for UNC in lawsuit from fired business professor
A federal judge has ruled against a former University of North Carolina business professor who sued the school for retaliation and racial discrimination after his contract was not renewed in 2024.
Tps to prevent cyclospora infection and explosive diarrhea
At least 170 Michiganders have contracted a parasitic gastrointestinal infection called cyclosporiasis. Here are the CDC's tips to prevent illness.
Center Ariel Hukporti agrees to one-year contract with Sixers
The Sixers agreed to a deal with 24-year-old center Ariel Hukporti on the second day of free agency.
Iowa's U.S. Senator Ernst holds final Small Business Expo
Iowa Senator Joni Ernst says a bill she co-sponsored has closed loopholes in two federal programs that award military contracts to small businesses that are engaged in research and development and technology. Ernst, a Republican from Red Oak, is chair of the U-S Senate Committee on Small Business and Entrepreneurship. “We’re really proud that we […]
John Collins agrees to $51 million contract with Detroit Pistons
The veteran big man strengthens the Pistons' frontline.
Rockets agree to sign veteran shooter Bogdan Bogdanović
In the opening hours of the NBA’s 2026 free agency window, the Rockets agreed to a one-year contract with veteran sharpshooter Bogdan Bogdanović.
Maple Leafs, Canadiens both 'covet' $17 million free agent
Toronto and Montreal could be in a battle for this contract.
LA sports radio host torches Lebron in blistering reaction: ‘Wasn’t a Laker’
The longtime broadcaster also suggested the split ultimately boiled down to money, saying he believes contract negotiations played a larger role than basketball considerations.
Iowa small businesses encouraged to compete for federal defense contracts
Iowa small business owners are being encouraged to compete for billions of dollars in government contracts as the federal government looks to expand its defense industrial base.
Iowa small businesses encouraged to compete for federal defense contracts
Iowa small business owners are being encouraged to compete for billions of dollars in government contracts as the federal government looks to expand its defense industrial base.
Small Businesses Snagged $273 Billion In Federal Contracts, Even As Thousands Continue To Leave Contracting Base
Even as the government meets its goals in working with small businesses, a concerning trend appears to be accelerating.
Small Businesses Could Lose Access To Billions In Contracts As New HubZONE Deadline Kicks In
Certain areas across the U.S. that were previously designated as HUBzones will see that status expire on July 1.
Contract extension marks 'fresh start' for Taylor
Midfielder Fraser Taylor is relishing a "fresh start" under new St Mirren boss Craig McLeish after signing a two-year contract extension. The 23-year-old academy graduate, whose deal now runs to summer 2028, made his first-team debut in 2022 and featured 13 times for the Buddies last season before joining Partick Thistle on loan in January. "I'm really pleased, since the new manager has come in, he spoke to me on the off-season, and his ideas really suit the way I like to play," said Taylor.
U.S. Army Contracting Command personnel recognized for streamlining small business procurement
At the FY25 Department of War and Department of the Army Small Business Awards, Army Contracting Command (ACC) was honored for strategic acquisition reforms that diversified and strengthened the defense industrial base.
Bruno Genesio agrees two-year Marseille contract
Bruno Genesio is set to put pen to paper over a two-year deal as Marseille manager, according to a report from L’Equipe. The former Lille OSC head coach was identified by Les Phocéens as the ide...
Frustrated French Quarter business owners file lawsuit: 'The Decatur project is chaotic'
"Contractors have abandoned work on some portions of this project to work on other blocks; work has been inexplicably delayed at other locations. Completion deadlines have been missed and extended."
Harry Kane likely to sign new Bayern Munich contract despite Barcelona enquiry
Barcelona made an enquiry to Kane's representatives and have been informed that the 32-year-old is happy in Munich.
TEFCA hits 1 billion as HHS invests $1.28M in network oversight
While marking TEFCA's milestone, ONC announces a new contract to enforce network compliance. Amid ongoing legal battles over alleged network misuses, Health Gorilla CEO Bob Watson emphasizes why federalizing governance is critical to trust.
Central MA Mosquito Control Project (CMMCP)
Central MA Mosquito Control Project (CMMCP) The Town of Shrewsbury is one of 44 communities who have contracted with CMMCP for mosquito mitigation. Residents can, free of charge, make a requ
Sword Health contracted to provide AI-supported physical therapy for an entire country
Portugal's National Health Service signed a deal with digital health company Sword for its AI-assisted virtual physical therapy care.
Sharks Sign Kesselring, How To Unlock His Potential?
The San Jose Sharks have signed Michael Kesselring. The Sharks signed the 26-year-old defenseman to a three-year, $13.5 million contract ($4.5 million AAV), buying up two of his UFA seasons. There were no trade protections. Kesselring was a pending RFA. The #SJSharks signed recently acquired 26 y/o RFA RD Michael Kesselring to 3 year $4.5M […] The post Sharks Sign Kesselring, How To Unlock His Potential? appeared first on San Jose Hockey Now.
Just hopes agent is 'busy' after World Cup impact
Elijah Just hopes his agent is "busy at the moment" as the New Zealand midfielder hinted at a possible summer exit from Motherwell after impressing at the World Cup. Just only joined Motherwell from Danish club Horsens a year ago and is under contract until next summer, with the Scottish Premiership club having an option of extending that by a further year. "The World Cup has given me added belief and also motivation to keep pushing," Just told the NZ Herald.
Reports: Diomande agrees PSG move from Leipzig
Ivory Coast forward Yan Diomande has decided to leave RB Leipzig for Paris Saint-Germain, according to media reports. Broadcasters Sky and RMC, as well as transfer specialist Fabrizio Romano, reported on Sunday that the 19-year-old has agreed a five-year contract with the French Champions League winners.
Phoenix Suns Could Have Intriguing Trade Chip at Center
Phoenix Suns center Mark Williams signed a contract that is "very tradeable," according to one insider.
Trump’s vision for White House park: 47 trees to mark his 47th presidency
The president has called Lafayette Square the entrance to the White House. Contractors have been renovating the park for months and are likely to miss Trump’s original goal of reopening before July 4.
Timberwolves Re-Sign Jaylen Clark to Three-Year Contract
Minnesota brings back its defensive specialist on a team-friendly deal during a summer full of roster turnover.
Lakers Have Reportedly Not Offered LeBron James a Contract Yet
With free agency set to officially open on June 30, the Los Angeles Lakers still have not put a contract offer in front of their 41-year-old star.
Arizona health officials investigate suspected pneumonic plague case
Yavapai County Community Health Services said Friday that a county resident is thought to have contracted the infection.
AI Is Helping Small Businesses Get More Done, But It’s Far From The Only Productivity-Booster Helping Them Expand
Getting more done in less time is easier than ever for solopreneurs and small business owners, thanks to the ease of hiring contractors, using QR codes, touchless technology and other affordable methods.
Mo Salah moves closer to €80m contract deal
Following a poor campaign - both individually and collectively - the Egyptian King reached an agreement to rip up his £400k per week contract one year early.The 34-year-old is currently strutting his...
National Science Foundation finds no violations in Texas A&M research security contract
U.S. Rep. John Moolenaar, a Michigan Republican who chairs the House of Representatives' select committee on China, had urged the NSF to pause funding for a project known as SECURE.
Testing gives science-based data for Fairmont lakes
FAIRMONT— A partnership between the city of Fairmont and Minnesota State University-Mankato will result in comprehensive scientific data on the Fairmont Chain of Lakes. The $25,000 contract started on April 1 and will go through Dec. 31 of this year. Fairmont’s Water Resources Coordinator, Hannah Neusch, acknowledged that while the water treatment plant in Fairmont […]
Carolina Reportedly Shopping Rookie Defenseman Alexander Nikishin
Stung by high contract demands and defensive inconsistencies, the Stanley Cup champions may trade their offensive blueliner to land a multi-time Vezina winner for the crease.
Falcons Roundtable: Kyle Pitts Extension Done, Is Bijan Robinson Next?
The Falcons continue to lock up the core of their roster for the future. This week's Falcons Roundtable breaks down Kyle Pitts' new extension, whether his deal or Drake London's is the better value, and why Bijan Robinson appears to be the next superstar in line for a record-setting contract.
Mauricio Pochettino reportedly offered contract extension to coach USMNT for another World Cup cycle, through 2030
Pacquiao and Mayweather rematch postponed indefinitely
The rematch between boxing greats Manny Pacquiao and Floyd Mayweather has been postponed indefinitely because of a host of reasons, with contract disputes the main factor.
Thunder reportedly trade Isaiah Joe to Pistons for two second-round draft picks
Isaiah Joe still has two years left on his contract.
NASA's canceled Artemis hardware contracts reached $5.9 billion, audit finds
NASA was on track to pay nearly half a billion dollars for a stage adapter. A stage adapter should not cost half a billion dollars.
Karl Stefanovic Speaks Out on Nine Exit After Tommy Robinson Scandal
The 'Today' host declares himself 'free' in a YouTube statement after Nine ends his contract following a deleted Tommy Robinson podcast episode.
Robot startup FieldAI achieves $100M milestone in revenue, contracts
FieldAI says it has crossed $100 million in revenue and contracts by building software for robots to work in mines, construction sites, and factories.
Former Illinois forward Ben Humrichous signs contract with Nets
Heading to Brooklyn.
Kawhi Leonard Seeks Extension – But Not With Current Team
Kawhi Leonard has one year left on his current contract with the Los Angeles Clippers. He’s eligible to sign an extension this summer, and sounds like he’s willing to do get that done. The one caveat: The Clippers aren’t necessarily the team he wants to sign with. Leonard, who turns 35 on June 29, ...
Palmetto Sports Daily: Hornets star Lamelo Ball traded to Minnesota, Lamont Paris talks NIL negotiations
On the latest episode of Palmetto Sports Daily, the crew discusses the blockbuster trade sending LaMelo Ball to the Minnesota Timberwolves, and SC men’s basketball coach Lamont Paris discusses NIL contracts.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
SBA’s Proposed Update to the 8(a) Business Development Program: A New Approach to Social Disadvantage
On June 11, 2026, the Small Business Administration (“SBA”) published a proposed rule that would fundamentally alter how individuals qualify as “socially
Platner, Collins’ campaign spar over federal contracts
Platner released a multi-point plan he calls “a corruption crackdown,” which covers issues such as big money in politics, lobbying activities by former members of Congress, and making it more difficult for presidents to cash in on their position while in office.
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Earlier in June, Europe’s worst fears of technological dependence were confirmed when the White House ordered the AI firm Anthropic to stop non-US citizens using its leading models. This kill-switch moment crystalised anxieties in Brussels that the continent, lagging the US on the creation of leading-edge AI models, is now a technological of vassal of Washington. The shock has specific implications for European scientists and universities. Some governments are now worried that with AI being integrated into labs, Donald Trump now has his finger hovering over an off switch for European science. “Having restrictions on this tool, it can have an impact on our own research,” said France’s research minister, Philippe Baptiste, at the VivaTech conference in Paris on June 18.Baptiste, himself a former academic, said that colleagues in mathematics had recently warned him they were now cut off from leading-edge US models, risking their work. “This model is not available anymore now because of the US restriction, and for the first time this had an impact on mathematics,” a field where large language models (LLMs) are making a significant contribution, said Baptiste. So, should European scientists avoid relying on US models in the future? Or would this be a self-harming overreaction? And how is AI being used in science, anyway? What happened?On June 12, it emerged that Washington, citing cybersecurity concerns, had ordered Anthropic to stop non-US citizens using two models: Claude Mythos 5, and Claude Fable 5, a version of Mythos but with guardrails to prevent abuse. Anthropic said Washington’s concerns were overblown. But forced to follow the order, yet with no way to check who was using the models, the company suddenly shut down access for everyone, US citizens included. There’s still no agreement on how to restore broad access. But last week, Bloomberg reported that select US companies, and the US government, still had access to Mythos despite the ban, but the EU’s cybersecurity agency Enisa had been shut out. Class division of researchersIn the longer term, access outside the US should be restored, said Marcel Salathé, co-director of the AI centre at the Federal Polytechnic School of Lausanne (EPFL), because a permanent restriction would be financially ruinous to US AI firms. “Even Trump will eventually budge to economic pressure,” he said.However, US AI firms might end up operating rather like banks, doing due diligence on users of their leading-edge AI models, he went on.European scientists are unlikely to fall foul of such checks, he said. But having a Chinese postgraduate in their lab, or doing a type of research the US disapproved of, could potentially result in access being denied. “It will create a sort of class division of researchers,” he said. More than frontier modelsHowever, successfully deploying AI in science is about far more than just having access to leading LLMs such as Mythos.Instead, many science-specific tools, most famously Alphafold, which predicts protein folding structures, require “far less” computing power to train than frontier models, well within the capabilities of European supercomputers, according to a recent analysis by the Arq Foundation, a Brussel-based AI think tank. Instead, tools such as Alphafold are possible because certain fields, like protein folding, weather prediction or astronomy, have large, clean, standardised datasets that can be used to train predictive models. Rather than compute, “data is the central constraint for AI for science,” the report says. For example, a less powerful physics model trained on CERN’s data “will be more valuable than the best model without certain data,” said Bengüsu Özcan, author of the report. European advantage?Europe could therefore steal a march by using its scientific data and infrastructure to create models US digital giants cannot. “They might actually match or go even beyond what these big [US] companies are doing,” said Özcan.Indeed, some European start-ups hope to create automated testing labs to create the kind of standardised data that could speed up the discovery of new materials. Materials scientists say there’s currently too little data to train models. AI scientistsHowever, even if the bottleneck for AI in science is often data, rather than compute, being at the mercy of the US for LLM access could still become a problem for European scientists. A new class of “AI scientists” based on leading LLMs is also emerging, Özcan’s report says.Unlike domain-specific tools like Alphafold, these try to automate day-to-day scientific work, by providing an overarching tool that coordinates specific models to synthesise existing literature, generate hypotheses or run analysis of data. The problem for Europe, however, is that these tools are sometimes based on US leading models. Google Deepmind’s AI Co-Scientist, for example, is built on Google’s Gemini LLM. Systematic failureThese scientific automation tools are still in their early stages, and still exhibit “systematic failures on scientific tasks,” Özcan’s report says. One of the problems is that the messy, day-to-day process of scientific discovery is largely not documented, meaning LLMs don’t have a good source of data to learn how scientists actually work. Meanwhile, some tasks, such as literature synthesis, don’t typically require access to leading edge models.However, the performance of AI scientific assistants could improve as companies such as Google pour resources into developing them. Rely on US“Unfortunately, for scientific assistants, there is not much we can do right now except rely on US frontier AI,” said Antoine Bosselut, a natural language processing expert based at EPFL. Chinese-built open models, which can run on local computers, lessening the risk of a shutdown, are touted as one alternative to US dependence. There’s also Mistral, once seen as Europe’s main AI hope, but the Paris-based company has seen its recent models fall behind in performance. But the Chinese alternatives are generally not as capable as US frontier AI models, said Bosselut, unless paired with fiddly, custom tools that allows them to act as independent agents. “Most scientists do not have the time,” he said. Don’t jump ship yetAlthough the kill switch moment is seen a warning shot for European scientists, it doesn’t mean labs should abandon US AI tools immediately. “I do not think the right response is simply to abandon US-based models and systems under the banner of sovereignty or independence,” said Mattias Björnmalm, secretary general of the Cesaer university association. “That would be an overreaction.”Related articlesEuropean sovereignty in AI requires ‘ugly trade-offs,’ say experts Robotic lab start-up makes case for €500M EU-funded materials testing facilityAI in science: is it useful? Instead, European researchers need to ask themselves whether they’re becoming dependent on technology that could be turned off in Washington, said Özcan. “They might not see this today, but they should really start asking this question,” she said. European researchers need a plan B, said Salathé. “I would recommend to every researcher, very proactively explore alternatives.”Own toolsIn addition, Björnmalm and others want European research institutions to develop their own scientific AI tools.Instead of signing AI deals with US digital giants, European universities should be using this money to create their own models, which may end up being superior for research, said Sabine Leonelli, an expert on the use of AI in science at the Technical University of Munich. “Universities in Europe seem to be happy to sign commercial contracts with US companies on the assumption [their AI tools] are better,” she said. But US frontier LLMs are typically opaque, and have been developed without independent scientific input, she said. “This is not good enough for science.”Last year, Swiss researchers released Apertus, an LLM designed to be completely transparent, from its development methods to its training data. The idea is that this makes scientific tools built on top of the model far more reproducible than with closed, commercial alternatives.“Europe needs more of this: serious capacity-building that gives researchers, universities and companies credible options,” said Björnmalm.
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