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Next 48 hours to be decisive for Greenwood’s future
Gian Piero Gasperini has circled Mason Greenwood’s name in red. The English winger is a top priority for raising the level of attack ahead of next season. The 2001-born player already has an agreeme...
Comcast’s Sky to Buy ITV’s Media and Entertainment Unit for Up to $2.14 Billion
Comcast’s Sky has agreed to buy ITV’s media and entertainment business in a deal that will see ITV spin ITV Studios off into a separate London-listed business.
UK's ITV to sell media and entertainment unit to Comcast's Sky for $2.1 billion
British broadcaster ITV said on Monday it had agreed to sell its media and entertainment division to Comcast's Sky for £1.6 billion ($2.13 billion).
Continental Agrees to Sell ContiTech Business to Lone Star Funds
Continental expects the deal to generate cash proceeds of approximately 3.1 billion euros, some of which will be used to cut debt, with around 2.5 billion euros distributed to shareholders.
Thales Plans Takeover of Exail Technologies After Buying 35.51% Stake
Thales said it signed an agreement with the Gorge family for their combined stake, valuing Exail at $4.46 billion, including debt.
EasyJet Agrees in Principle to Castlelake’s Latest Takeover Offer
The latest proposal—the fifth from Castlelake—stands at £6.90 a share. This is up from a previous proposal of £6.50 a share.
Africa Asserts Itself As Pandemic Agreement Talks Resume
The Pandemic Agreement talks resume at the World Health Organization’s (WHO) headquarters on Monday (7 July), kicking off immediately with a closed session on
Oil slips after OPEC+ agrees to raise output targets
Oil prices inched lower on Monday after OPEC+ agreed to further increase its output targets from August while exports from key producers via the Strait of Hormuz are recovering, potentially adding to global supplies.
Genesis Minerals Makes Rival $3.9 Billion Bid For Vault Minerals
Genesis Minerals has made a rival bid for Vault Minerals that values the Australian gold miner at $3.9 billion, trumping an agreed merger with Regis Resources.
EasyJet agrees to £5bn takeover by US investment firm
Agreement in principle with Castlelake follows several rejected offers and means UK’s biggest low-cost carrier will be taken private
Epic Games settles a court case against former contractor accused of leaking Fortnite collaborations
Former contractor Hayden Cohen has agreed to a judgment that bars them from "possessing, accessing, using, or disclosing any of Epic’s confidential or trade sec
AI in Mental Health: Why Clinicians Need to Be in the Room
As clinicians, we learn not to be agreeable, we learn to challenge and sit in discomfort. We ask the hard questions underneath the one being asked. That is the work these tools are not yet built to do.
Everton set to sign Tyrique George from Chelsea
The two Premier League clubs have agreed a deal over the 20-year-old winger
GentleBrook to operate mobile Snapology franchise
GentleBrook has entered a franchise agreement with Unleased Brands to launch a mobile, Snapology-branded education program.
GentleBrook to operate mobile Snapology franchise
GentleBrook has entered a franchise agreement with Unleased Brands to launch a mobile, Snapology-branded education program.
Report: Arsenal star closing in on £17m summer exit
Leandro Trossard to Besiktas: Arsenal forward closes in on summer exitArsenal are moving towards the sale of Leandro Trossard, with The Athletic reporting that Besiktas have agreed a deal worth “€...
Booz Allen Hamilton (BAH) to Buy Ultra I&C Mission Solutions Business for $720 Million
Booz Allen Hamilton Holding Corp. (NYSE:BAH) is one of the 12 best industrial stocks with more than 50% upside. The company’s acquisitive growth strategy is making it a compelling investment case. On June 22, Booz Allen Hamilton Holding Corp. (NYSE:BAH) signed a definitive agreement with an Advent portfolio company, Cobham Ultra Group, to purchase its […]
These church members disagree on politics. Together they’re wiping out medical debt
Some issues, like immigration or student loans, are too divisive to unite Trinity Moravian Church.
Madison Square Garden Entertainment Corp. (MSGE) To Remain Fully Operational Amid New York Penn Station Redevelopment
Madison Square Garden Entertainment Corp. (NYSE:MSGE) is one of the top stocks to buy according to Ariel Investments. On June 9, Madison Square Garden Entertainment Corp. (NYSE:MSGE) entered into a non-binding agreement with Penn Transformation Partners for the development of the New York Penn Station. Under the terms of the agreement, Madison Square Garden will […]
Rockets lose key role player to Jazz in free agency
The Houston Rockets saw Josh Okogie depart this summer, agreeing to sign with the Utah Jazz on a two-year deal.
Poll: Americans are willing to bridge political divides at July Fourth parties, over dinner and more
But they’re sharply divided over whether they would be willing to marry or live with partners with whom they strongly disagree politically.
Penguins sign Hendrix Lapierre for two years
The Penguins reached an agreement with one of their restricted free agents on Friday getting Hendrix Lapierre to ink a two-year contract with an AAV of $1.3 million. From the team: The Pittsburgh Penguins have signed forward Hendrix Lapierre to a two-year contract, it was announced today by President of Hockey Operations and General Manager […]
Long Reads for the Long Weekend
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) Happy Fourth of July weekend! As has been a tradition of mine going back to the beginning of the EntStrategyGuy website, I’m sharing my favorite long reads of the last year, like I did in 2019, 2020, 2021, 2024, and 2025. Let’s dive right in! Subscribe “Different Prices for the Same Ride: How Uber and Lyft Use AI to Get More Money Out of You“ by Derek Kravitz in Consumer Reports I don’t think surveillance pricing, like the kind described in this brilliant Consumer Reports article, is long for the world—it’s toxically unpopular—but we’ll see if either party takes on this issue. If I ran a political party focused on affordability, I would focus on a few pro-consumer and pro-market policies: Banning non-compete agreements. Ending surveillance pricing Eliminating junk fees (read more here...) Ensuring “right to repair” for consumer (and military!) products Capping excessive app store fees Stopping digital/algorithmic price-fixing tools. Preventing automatic subscription price increases. And more. If you want to fight inflation, there are a lot of great ways to do it quickly. Speaking of higher prices... “Secret Documents Show Pepsi and Walmart Colluded to Raise Food Prices Across the Economy“ by Matt Stoller in BIG Again, I think a political party should focus on lowering prices for consumers. And deals like this—Walmart making a deal/forcing Pepsi to offer the lowest prices at its stores and nowhere else—hypothetically lower prices at Walmart...but raise them everywhere else. “15 DUIs, still driving: California’s failure to take repeat drunk drivers off the road“ by Robert Lewis and Lauren Hepler in CalMatters CalMatters does terrific reporting in California, something the Golden State desperately needs more of, and this article is a great example of that. “PugLips: The next insanely popular thing you’ve never heard of…” by Simon Carless in Game Discover Co I thought that this parody article (and yes, it’s a parody, but I was definitely unsure at first) was hilarious and totally nailed how much tech/business journalism feels these days. Actually, three of my favorite articles this year were on hype in the video game industry, including Georg Zoller’s “The Video Game Industries Very Dark Night”—which I linked to recently and wrote a follow-up here—and Owen Mahoney’s “Derek Zoolander, Videogame Exec”. In particular, I like Mahoney’s focus on user experience as a guide to what trends will actually grab hold of customers. “The Matrix Lies“ by Evan Shapiro in Media War & Peace Evan Shapiro’s first person account of his experience with AI was hilarious. I think LLMs capabilities have significantly grown from last summer, and yet...my editor/researcher just had an abysmal experience using an LLM to do a quite basic task (which our LLM normally does each week) and the LLM made a mistake on every single data entry...along with seven different mistakes affecting twelve of the twenty or so entries, including mistakes that are explicitly spelled out in the prompt. That’s a brutal failure rate. Again, if you use AI/LLM for data collection, you need to take a lot of extra steps to verify and check the data. “Ghosts in the Balcony: A Cross-Country Trip to 58 Theaters Fighting to Survive“ by Matthew Frank in The Ankler I thought Matthew Frank’s pitch to head across America to visit theaters sounded insane aggressive at the time—at least it felt that way to someone a decade older than him; man, to be in your twenties again, am I right?—but I knew the result would be great. And it was, a terrific feature by a great young writer. Also, I loved Matthew’s recent article on who’s getting the precious few entry level jobs in Hollywood. (Hint: nepotism.) “Disney erased FiveThirtyEight“ and “Did Las Vegas get too greedy?” by Nate Silver in Silver Bulletin I love media history and analysis, and there’s no one better to get the history of FiveThirtyEight than from Nate Silver, who wrote about his personal experience in one of my favorite pieces from this year. I also loved Nate’s breakdown of what’s causing Vegas’ woes, but I’ll offer one criticism, summarized as “Might I suggest antitrust?” Many centrists/center-right/libertarian thinkers (Nate is self-described as the latter) often don’t consider consolidation or antitrust as factors in policy issues like housing, America’s military readiness, or, in this case, Las Vegas. Even if libertarians want to debunk antitrust/consolidation concerns, I’d love to read that debunking. In this case, Vegas is incredibly consolidated (though it also has been for a long time) and I’d have loved to read Nate at least contending with this factor, since he addresses almost every other potential factor for Vegas’ decline. “Why Microsoft’s Carbon Removal Pullback Is Such a Big Deal“ by Robinson Meyer in Heatmap News I’m a big supporter of carbon removal efforts, but this nascent industry faces a lot of headwinds, including this big move most recently. I think it’s clear that solar panels and batteries should be able to get the world to its carbon footprint goals, but effective carbon renewal remains necessary to prevent the worst impacts of global warming. “AI is killing the cheap smartphone“ by David Oks LLMs and AI will impact the world in ways we’re not ready for, and already, third world countries are seeing the prices of cheap cellphones skyrocket due to the cost of chips skyrocketing. This article by David Oks is a terrific breakdown. “100 Days of Madness: Netflix, Paramount, Warner and the Future of Hollywood“ by Wade Major at Hollywood Heretic Wade Major dove deep into Hollywood/streaming’s financials in this must read piece. Not that I agree with everything in this article (read my take on Warner Bros./Paramount here) but the analysis is top notch. I think many people discount how quality thinking, regardless of the argument/conclusion, will make you a better thinker. “Erased by the UFC: Frank Shamrock, The MMA GOAT of the 20th Century“ by Nate Wilcox in The MMA Draw Newsletter Growing up playing the UFC fighting game on the Dreamcast, Frank Shamrock was my favorite MMA fighter, and this history/tribute to him was great. Other Fun Reads “The Hardest Part Of History To Tell Is How It Felt“ by Craig Fehrman at Defector “Unmasking the Sea Star Killer“ by Craig Welch at bioGraphic “What Could Save the Industry? Fin-Syn“ by Richard Rushfield in The Ankler Alex Rollins Berg in Underexposed on movie bumpers, pillow shots, Disney trash cinema, cult films, and Casablanca. David H. Montgomery in YouGov’s The Surveyor on punctuation marks, condiments, dinosaurs, and comic strips and kids media. “How Medium finally pivoted its way to profitability“ and “Why the best journalists on YouTube are all former Vox employees“ by Simon Owens in Simon Owens’s Media Newsletter “It’s Not Just You, Netflix Shows Have Gotten Slightly Shorter: Here’s What the Data Says“ by Kasey Moore at What’s on Netflix “Numlock Awards: How Diane Warren became the biggest loser in Oscar history“ by Nathaniel Rakich and “Numlock Awards: The Oscar Bait era is over. The Oscar Chum era is here.” by Walt Hickey & Michael Domanico at Numlock Awards
As ACA enrollment falls by millions, Trump administration and policy gurus disagree on why
Affordable Care Act marketplace enrollment has declined by 3 million people. The Trump administration points to fraud controls. Policy experts point to cost.
Roma, Basel reach agreement over Calafiori’s resale clause
Riccardo Calafiori is one of the players who emerged from Roma’s youth system and has managed to establish himself on the big stage. The former Giallorossi defender won the Premier League with Arsen...
‘Check Your Political Identities at the Door’: Lawmakers Come to UVA Darden to Practice Leadership
A select group of state legislators will gather at UVA Darden for a nonpartisan leadership program focused on productive disagreement, values-based decision-making and leading across political differences.
SBA, USDA Sign MOU to Combat Lawfare Against Farmers, Ranchers, and Small Businesses
New Partnership Gives Producers a Direct Line to Report Costly Regulations and Advance Lasting ReformWASHINGTON, July 02, 2026 (GLOBE NEWSWIRE) -- Today, the U.S. Small Business Administration (SBA) and the U.S. Department of Agriculture (USDA) signed a Memorandum of Understanding (MOU) to combat lawfare targeting farmers, ranchers, rural communities, and small businesses. The agreement gives America’s producers a direct line to report the regulations and rules driving up costs and impacting pro
Anfernee Simons agrees to 2-year deal with Philadelphia 76ers
The Philadelphia 76ers agreed to a two-year, $12.3 million contract with guard Anfernee Simons. Simons averaged 14.3 points per game last season.
Hospital affiliation to preserve health care access in Haleyville and Winston County
A new affiliation agreement between Huntsville Hospital Health System and Lakeland Community Hospital is aimed at strengthening hospital care in Haleyville and
IAM District 4 Members Win First Contract at Federation of American Scientists
Nearly a year after becoming the first union in the nearly 80-year history of the Federation of American Scientists (FAS), 25 IAM District 4 members have ratified their first collective bargaining agreement, securing workplace protections, greater transparency, and a stronger voice on the job. The Federation of American Scientists (FAS) was established in 1945 by scientists
Federal judge blocks Postal Service from carrying out Trump mail-in ballot order
A federal judge blocked the U.S. Postal Service from implementing President Donald Trump's executive order on mail-in ballots nationwide, citing a 2020 agreement.
The Iran MOU is a mess. It still might work
The 14-point “Memorandum of Understanding” is among the oddest international agreements in recent memory. Short on detail, its two pages purport to grant significant up-front American concessions to Iran in exchange for opening the Strait of Hormuz, which was already open before the war President Donald Trump started in February and now hopes to end.
A Nation Larger Than Its Politics
As America approaches its 250th birthday, I find myself wondering whether we have lost sight of something that earlier generations understood instinctively.Americans have never agreed on politics.We have argued over wars, taxes, immigration, religion, civil rights, economic policy, and the proper ro...
United sign 'calm and composed' goalkeeper Amissah
Former Ross County goalkeeper Jordan Amissah has returned to Scotland to provide a "calm and composed" presence at Dundee United, says manager Jim Goodwin. The 24-year-old has agreed a two-year deal at Tannadice following his exit from Burton Albion. Amissah impressed during a six-month spell at County before heading back south of the border.
Subnautica 2 studio Unknown Worlds' CEO resigns as Krafton agrees to pay $250m bonus
Krafton has settled its lawsuit with the former leadership team of Subnautica 2 developer, Unknown Worlds, and agreed t…
US decides not to renew USMCA trade pact, will seek separate deals with Canada, Mexico
President Trump has opted against the U.S.-Mexico-Canada Agreement (USMCA) and will instead pursue separate trade deals with the two major trading partners, FOX Business has learned.
Mountaineer sports returning to several WVRC Media radio stations
Agreement includes return of WAJR and WVAQ to Mountaineer Sports Network.
Center Ariel Hukporti agrees to one-year contract with Sixers
The Sixers agreed to a deal with 24-year-old center Ariel Hukporti on the second day of free agency.
Krafton Agrees to Pay ‘Subnautica 2’ Bonuses as Developer’s CEO Resigns
After being fired over a $250 million payout dispute and then reinstated, Unknown Worlds Entertainment boss Ted Gill is leaving again
Heritage Valley Health System Enters New Era as part of Allegheny Health Network
/PRNewswire/ -- Allegheny Health Network (AHN) and Heritage Valley Health System today announced the finalization of an affiliation agreement between the...
Norman Powell agrees to 2-year, $45 million deal with Bulls: report
Powell averaged 21.7 points per game for the Miami Heat this past season.
John Collins agrees to $51 million contract with Detroit Pistons
The veteran big man strengthens the Pistons' frontline.
Rockets agree to sign veteran shooter Bogdan Bogdanović
In the opening hours of the NBA’s 2026 free agency window, the Rockets agreed to a one-year contract with veteran sharpshooter Bogdan Bogdanović.
Mamdani and City Council agree on new housing voucher program
Mamdani promised to drop the city’s lawsuit blocking a council-backed expansion of an existing voucher program.
Getty Images Plans to End Shutterstock Deal After U.K. Imposes Conditions
Getty Images plans to terminate its merger agreement with Shutterstock after a U.K. regulator said the latter company must sell its editorial business in order for the merger to be approved.
CORUS ENTERTAINMENT PROVIDES UPDATES REGARDING CREDIT FACILITY AND SUPPORT AGREEMENT
Corus Entertainment Inc. (TSX: CJR.B) ("Corus" or the "Company") announced today that it has entered into a second amending agreement to the waiver and standstill agreement dated as of February 28, 2026, as amended by a first amending agreement dated as of May 29, 2026 (the "Waiver"), with lenders under the Company's Eighth Amended and Restated Credit Agreement (the "Credit Facility"). This second amending agreement extends the term of the Waiver from June 30, 2026 to September 1, 2026 in light
RFK Jr. wants to make it easier to get peptides. FDA scientists disagree.
The health secretary has advocated for deregulating certain peptides, but FDA scientists point to a lack of data about their safety and effectiveness. Some have not been studied in humans.
Politics: High Cost Of Healthcare And The Political Fallout
Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Politics: High Cost Of Healthcare And The Political Fallout
Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Mamdani, City Council reach agreement on $125.8 billion budget
Mamdani said the budget will help make public transit more affordable.
Conduent agrees to sell tolling business to Quarterhill for $70M
Conduent Inc. announced on June 30 that it has agreed to sell its tolling business to Toronto-based Quarterhill Inc.
Supreme Court agrees to review ban on AR-style semi-automatic rifles in major Second Amendment case
The Supreme Court announced Tuesday that it will decide whether cities and states may ban people from owning AR-15 rifles and similar semiautomatic weapons, taking up a major Second Amendment dispute that it had previously declined to address.
Authentic Signs Definitive Agreement to Acquire Care Bears
Authentic Brands Group, a global brand and entertainment platform, today announced it has signed a definitive agreement to acquire the intellectual property of Care Bears, one of the world's most beloved and enduring family entertainment franchises.
Authentic Signs Definitive Agreement to Acquire Care Bears, Expanding Its Entertainment Platform Into Character IP
/PRNewswire/ -- Authentic Brands Group ("Authentic"), a global brand and entertainment platform, today announced it has signed a definitive agreement to...
Empower to Acquire Milliman’s Retirement Administration Business
Empower and Milliman, Inc. today announced they have entered into a definitive agreement for Empower to acquire Milliman’s retirement administration business...
Oregon Health Authority agrees to $630,000 settlement with ousted equity director
The sum includes more than $400,000 in back pay that the director would have received if she had remained at the agency until this year.
Nokia, SAP and Microsoft Enter Strategic Multi-Year Agreement to Advance Cloud- and AI-Driven Business Transformation
Nokia will accelerate its enterprise transformation using RISE with SAP Methodology, with SAP S/4HANA hosted on Microsoft Azure.
Conduent Announces Agreement to Sell Its Tolling Business to Quarterhill Inc. for $70 Million
Conduent Announces Agreement to Sell Its Tolling Business to Quarterhill Inc. for $70 Million. Conduent Bolsters Financial Position.
Conduent Announces Agreement to Sell Its Tolling Business to Quarterhill Inc. for $70 Million
FLORHAM PARK, N.J., June 30, 2026--Conduent Announces Agreement to Sell Its Tolling Business to Quarterhill Inc. for $70 Million. Conduent Bolsters Financial Position.
Conduent Announces Agreement to Sell Its Tolling Business to Quarterhill Inc. for $70 Million
FLORHAM PARK, N.J., June 30, 2026 — Conduent Incorporated (Nasdaq: CNDT), a global technology-driven business solutions and services provider, today announced that it has entered into a definitive agreement to sell its Tolling business (a division of...
Hormel Foods sells Brazil business
Hormel Foods has signed a definitive agreement to sell its Brazil business to “simplify and streamline its portfolio”.
These Church Members Disagree on Politics. Together They’re Wiping Out Medical Debt.
Trinity Moravian Church, a politically diverse congregation in Winston-Salem, North Carolina, has been raising money to retire medical debt in the surrounding community.
Bruno Genesio agrees two-year Marseille contract
Bruno Genesio is set to put pen to paper over a two-year deal as Marseille manager, according to a report from L’Equipe. The former Lille OSC head coach was identified by Les Phocéens as the ide...
Kristaps Porzingis remains with Warriors on two-year deal
The Golden State Warriors have reached an agreement to retain former NBA champion Kristaps Porzingis.
Private Equity-Backed IT Business TPx Files for Bankruptcy to Sell Assets
The managed information-technology services company has a restructuring agreement with its sponsor and the majority of creditors.
Hormel Foods Announces Agreement to Sell Ceratti Business in Brazil
/PRNewswire/ -- Hormel Foods Corporation (NYSE: HRL), a Fortune 500 global branded food company, today announced it has entered into a definitive agreement to...
Talawar Therapeutics and JATT II Acquisition Corp. Announce Definitive Business Combination Agreement to Create Publicly Listed Biotechnology Company Developing Potentially Best-in-Class Bispecifics for I&I Diseases
Oversubscribed $225 million concurrent private investment in public equity ("PIPE") with available cash to the combined company at closing anticipated to fund...
BT and Verizon Agree to Merge Global Business Ventures
Verizon CEO Dan Schulman says the joint venture will create an “AI-ready and secure” platform with a combined annual revenue of US$4bn
Korn Ferry Announces Definitive Agreement to Acquire AMS
Korn Ferry (NYSE: KFY), a global organizational consulting firm, today announced that it has entered into a definitive agreement with OMERS Private Equity to...
New US-Iran clashes revealed fragility of truce — and why it may work
An apparent agreement by the US and Iran to pause a fresh outburst of violence stabilized a truce that is the first step to permanently ending the war and underscored that each side has a vital national interest in doing so.
Reports: Diomande agrees PSG move from Leipzig
Ivory Coast forward Yan Diomande has decided to leave RB Leipzig for Paris Saint-Germain, according to media reports. Broadcasters Sky and RMC, as well as transfer specialist Fabrizio Romano, reported on Sunday that the 19-year-old has agreed a five-year contract with the French Champions League winners.
Miles Bridges trade details: Hornets send athletic forward to Suns, land Grayson Allen
Phoenix and Charlotte kept the NBA offseason rolling on Sunday, reportedly agreeing to a deal involving some key role players.
🚨 BREAKING: Robert Lewandowski agrees multi-year deal with Chicago Fire
Major League Soccer looks set to add another iconic veteran presence to its ranks this summer, with Polish legend Robert Lewandowski reportedly primed for a move to Chicago Fire.Per The Athletic, the ...
Suns trade Grayson Allen, Royce O'Neale for Miles Bridges
The Suns have agreed to trade two key rotation players and a 2033 first-round pick for Hornets forward Miles Bridges and future draft capital.
If USMCA is not renewed, analysts expect uncertainty for businesses
US President Donald Trump has warned he would 'rather not have' the free trade agreement ahead of its July 1 review.
Americans find common ground on healthcare
Americans agree that healthcare needs to be better, cheaper, and less complicated. Good ideas toward those goals are bubbling up around the country.
These church members disagree on politics. Together they're wiping out medical debt
Trinity Moravian Church, a politically diverse congregation in Winston-Salem, N. C., has been raising money to retire medical debt in the surrounding community.
These church members disagree on politics. Together they're wiping out medical debt
Trinity Moravian Church, a politically diverse congregation in Winston-Salem, N. C., has been raising money to retire medical debt in the surrounding community.
Israeli politicians lash out after Netanyahu announces intention of 'broad national government'
During the press conference, Netanyahu condemned unnamed forces which "want to cause a rift in the people, want to aggravate and deepen the misunderstandings and disagreements and rifts within us."
Fiorentina agreement for Beltran, but striker resists River Plate
Fiorentina have agreed to sell half of Lucas Beltran to River Plate following the loan at Valencia, but it’s reported the player wants to remain in Europe.The striker spent time in the River Plate a...
Sony is deleting over 550 purchased movies from PS5 users’ digital libraries
PlayStation says a licensing agreement means users will no longer be able to access some purchased videos…
'Godfather of SaaS' says you can't get truly rich working from home
SaaStr founder Jason Lemkin agrees with Flexport CEO Ryan Peterson's skepticism of remote work.
Mo Salah moves closer to €80m contract deal
Following a poor campaign - both individually and collectively - the Egyptian King reached an agreement to rip up his £400k per week contract one year early.The 34-year-old is currently strutting his...
140 Kauai Coffee jobs saved through new land lease agreement
The lease agreement between Kauai Coffee’s parent company, Massimo Zanetti Beverage Group, and landowner Brue Baukol Capital Partners was finalized after nearly two years of negotiations
Congress subpoenas Leon Black during interview about Jeffrey Epstein
The House Oversight Committee issued subpoenas to billionaire Leon Black after he declined to answer questions about non-disclosure agreements.
OpenAI launches limited preview of GPT-5.6 at US government's request
OpenAI said they were complying as part of its agreement with the Department of Defense, which allows the department to use its AI models.
Disagreements between Supreme Court justices bubble into public view as major rulings loom
The Supreme Court is handing down major opinions at a rapid clip, but even with some of the biggest decisions yet to come there are signs of tension between the justices.
Trump says Iran strike in Strait of Hormuz is a ‘foolish violation’ of agreement
President Donald Trump called Iran’s strike on a vessel in the Strait of Hormuz a “foolish violation” of the agreement to end the war with Tehran, but offered little indication the episode would prompt a return to active hostilities.
Ryman Hospitality Addresses Possible Sale of Opry Entertainment Group
Corporation officials say they are exploring the possible sale of a 70 percent stake in the entertainment entity, but there are no agreements in place and ‘no assurances any transaction will occur.’
HHS Expands Secure Access to Health Records Through the TEFCA® Network, Announces Milestone of One Billion Health Records Exchanged
The Office of the National Coordinator for Health IT at HHS announced new steps to strengthen the Trusted Exchange Framework and Common Agreement™ TEFCA®
Business Owners Agree: The Road to Downtown Recovery Runs Through Facts, Not Nostalgia
State Street's commercial vacancy rate is lower today than it was before the pandemic. The highest vacancy rates remain on blocks that are open to vehicle traffic.
Ex-Trump adviser John Bolton expected to plead guilty in classified information case
Bolton to plead guilty charges that he unlawfully retained sensitive national security information in agreement that includes $2.25m fine
City council members request special meeting on planned Sports and Entertainment District
San Antonio Council Districts 1, 5 and 7 want a special meeting before Aug. 7 to guide public input on the Spurs arena’s $75M Community Benefits Agreement as the city considers a $489M Sports and Entertainment District.
University, State of Utah sign agreement for proposed south valley health campus
U of U Health has secured land for a proposed health campus that will serve as the health care anchor for the 600-acre master-planned development...
Moore links Maryland primary to Mamdani-backed wins; analysts disagree
Gov. Wes Moore says Maryland’s primary election showed voters rejected the status quo, but political analysts say the results reflect a more complicated picture.
NASA, US Small Business Administration to Announce Partnership
NASA and the U.S. Small Business Administration will sign a memorandum of agreement during a ceremony at 1 p.m. EDT, Monday, June 29, at NASA Headquarters in
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Merck KGaA to Acquire Bio-Techne for $11.3B, Expanding Life Science Tools Presence
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Dave Roberts Gives Blunt Assessment on Dalton Rushing Controversy
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