SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " NPR " 4,302 found 🔀 AI-powered Shuffle
Texas health agency asks lawmakers for additional funding to address growing Medicaid, SNAP backlogs
Texas Health and Human Services is asking the state Legislature for the funding to make more than 600 temporary eligibility worker positions into permanent jobs. The ask comes as Texas' backlog of Medicaid and Supplement Nutrition Assistance Program, or SNAP, applications continues to grow.
Dallas mayor uses primetime RNC speech to thank Trump, share political transformation story
Eric Johnson, who became a Republican after he was reelected as Dallas mayor with Democratic endorsements, said his former party treats “hard-working families with shame and disdain.”
Empty seats, socialism and Trump dominate the Republican midterm convention
The two day Republican convention in Dallas showcased the party's biggest asset in trying to win competitive midterm races and its greatest obstacle: President Trump.
Empty seats, socialism and Trump dominate the Republican midterm convention
The two day Republican convention in Dallas showcased the party's biggest asset in trying to win competitive midterm races and its greatest obstacle: President Trump.
Chimp convalescence, ant amputation: the wild world of animal doctors
When people are sick, we seek out medications and treatments to help heal. For a long time, scientists thought that was a uniquely human ability. But it turns out, many other animals do a version of it too! And since the late 1980s, western researchers have been trying to get a peek behind the curtain. And aside from just cataloguing all the cool examples just to know, there’s a real hope that studying animals’ medical cabinets may be the most promising way to expand our own. We get into the weeds with freelance science journalist Mandy Nguyen.Interested in more animal stories? Email us your ideas and questions to explore at shortwave@npr.org. They may become a future episode!Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.
Washtenaw Business Lens: Older adults turning experience into innovation
Richard Brown has had a successful career as a nuclear medicine physician and professor of radiology. Now at the age of 71, he has decided to take on a completely new endeavor — as a first-time consumer product founder in Ann Arbor. On this month's "Washtenaw Business Lens," WEMU's Caroline MacGregor and Ann Arbor/Ypsilanti Regional Chamber’s Andy LaBarre shared how a first-time entrepreneur has taken a consumer product idea toward commercialization at 71.
Hawaiʻi is still 'open for business’ during hurricane season, HTA says
David Uchiyama, chief administrative officer of the Hawaiʻi Tourism Authority, shares how the state is handling the flow of visitors after Hurricane Lowell.
Oregon Sen. Jeff Merkley, U.S. Rep. Val Hoyle, raise concerns about corruption in Springfield townhall
Oregon Sen. Jeff Merkley and U.S. Rep. Val Hoyle held a “stop the corruption” town hall in Springfield Thursday. The town hall was a part of a tour focusing on concerns about corruption in politics.
Pennsylvania businesses and nonprofits face deadline on skill game machines
Businesses and nonprofits in Pennsylvania are facing uncertainty as state lawmakers prepare to decide the fate of skill game machines before an October 14 deadline.
2025-26 Record Fundraising Year for Life Sciences at UC Davis
The University of California, Davis, raised more than $676 million in philanthropic support during fiscal year 2025–26, more than doubling the university's previous giving record and marking the strongest fundraising year in its history.Donors’ unprecedented level of investment in UC Davis will expand opportunities for students, strengthen faculty excellence, accelerate discoveries that improve lives, and support new facilities and programs that elevate the university’s impact across California and beyond.
NRF: Import cargo volume peak continues into September
The National Retail Federation (NRF) has revised its outlook for U.S. container import volumes as this year remains unpredictable in large part because of global geopolitical issues. After forecasting import...
James says 'no excuse' for political violence one year after Kirk death
Republican nominee for Michigan governor John James says Democrats and Republicans need to come together to address a rise in political violence.
Former Miss Hall's science teacher pleads not guilty to sexual assault charges
A former teacher at a Pittsfield, Massachusetts, boarding school accused of sexually assaulting students in his care has pleaded not guilty to all charges.
Ebola outbreak in DR Congo expands to new health zone, bringing total to 61: WHO
6,757 confirmed cases reported in 6 provinces, with 3,267 deaths, says agency, adding case fatality ratio at 48.3% | Anadolu
A fossil feather from the age of dinosaurs may explain why only some birds survived
An extremely well preserved fossil feather could reveal why some birds survived the dinosaur-killing asteroid, and others did not.
How the WNBA became a political prop in the culture wars
Despite record viewership and attendance, and amazing talent across the league, the WNBA has been caught up in the national conversation about the culture wars. Sportswriter Sabreena Merchant says, “everything in the WNBA seems to take on a political lens far beyond what is actually happening on the court.” Merchant spoke with Fresh Air guest interviewer Sam Fragoso (host of Talk Easy) about the expansion of the WNBA, the race and gender politics consuming the narrative, and the departure of commissioner Cathy Engelbert. Merchant writes for The Athletic, from the New York Times.Also, film critic Justin Chang reviews Practical Magic 2. Subscribe to our free weekly newsletter Follow us on Instagram Subscribe to our YouTube channel Check out the Fresh Air Archives
In Good Health: The Matter Of Maternal Mental Health Care
The Lindsay Clancy murder trial captivated the American public for weeks.Prosecutors charged Clancy with murdering her three children. They say she then tried to take her own life and that her injuries left her paralyzed from the waist down. Clancy’s lawyers say she was experiencing postpartum psychosis and should not be held criminally responsible. But prosecutors say she planned the deaths.After seven days of deliberation, the jury remained deadlocked and the case ended in a mistrial.The trial has divided the nation and sparked conversations over about maternal mental health, raising questions over gaps in care for parents after giving birth. About one in five expecting or postpartum women in the U.S. experience mental health disorders. And according to a 2025 study, overall maternal mental health has dramatically dropped in the past seven years, with only 25 percent of moms reporting excellent mental health.What do we know – and don’t know – about maternal mental health care? And how can our systems be bolstered to help those who need it most after giving birth?If you are experiencing a mental health crisis or thinking of harming yourself, the 988 Suicide and Crisis Lifeline is available 24/7 by phone and text. The National Maternal Mental Health Hotline is also available 24/7. You can text, call or chat at 1-833-TLC-MAMA. The Postpartum Support International also offers a helpline at 1-800-944-4773 or you can visit postpartum.net.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Mission accomplished
After a 14-month construction mission, the “Apollo” landed at the Kelly Falls apartment complex this week with the completion of the Mark Stebbins Community Center, the culmination of a vision by the late Mark Stebbins, a long-time business leader and philanthropist.
Steuben County Public Health confirms 10th measles case since Aug. 18
On Tuesday, the Steuben County health department reported its 10th measles case in an unvaccinated resident.
Key takeaways from day one of the Republican midterm convention
The two-day convention ends tonight, but not before many other speakers address the event, including Dallas Mayor Eric Johnson. NPR's Tamara Keith joined us to break down the events.
How the WNBA became a political prop in the culture wars
Sports journalist Sabreena Merchant says culture war issues related to race and trans athletes threaten to overshadow exceptional play on the WNBA court.
How the WNBA became a political prop in the culture wars
Sports journalist Sabreena Merchant says culture war issues related to race and trans athletes threaten to overshadow exceptional play on the WNBA court.
Israeli legislative election and Netanyahu's politics of enmity
Rather than labeling his domestic rivals as outright traitors, Netanyahu frames them as the vehicles that will deliver the enemy's desired outcome. This deliberately blurs the line between legitimate political dissent and national betrayal | Anadolu
Will North Carolina's US Senate race feature any debates this year?
If you’re an undecided voter, you might want to compare the candidates side by side on a debate stage, or in sit-down interviews with your local TV station, or perhaps at public events where they make speeches. This year, you might not find any of those opportunities to get to know Roy Cooper and Michael Whatley.
University experiences unprecedented growth
More than 44,000 students are enrolled in Fall 2026 across UT San Antonio's academic and health programs, marking a record for the university.
Friends of Firefighters, nonprofit started after 9/11, provides mental health, wellness services to FDNY members
Scientists are tracking a massive algae bloom moving through the Chesapeake Bay
The bloom has “caused quite a stir” among officials who research the issue.
WA officials rush to help thousands keep health plans as Medicaid cuts loom
Washington state leaders are trying to help about 200,000 people retain their health insurance as federal changes to Medicaid are rolled out in the coming months.
Science and music come together at Oregon State University’s third Big Fish Fest
Oregon State University’s Big Fish Fest III combines live music with shark and bird dissections to teach ocean conservation and science through art.
Healthy Moms, Healthy Babies pledges $100M to cut US maternal mortality rate in half
Healthy Moms, Healthy Babies America, the bipartisan campaign founded by Olivia and Tom Walton’s nonprofit Heartland Forward, announced a $100 million pledge Thursday to make giving birth in the United States safer.
At midterm convention, Trump vows to campaign hard for Paxton after mocking his speech and looks
The president used his winding, nearly two-hour keynote address to try to boost Republicans around the country, telling his supporters to “pretend that I’m on the ballot” this fall.
How geopolitical rifts cut scientific collaboration
Researchers have measured how worsening geopolitical relations hobble scientific collaboration, at last quantifying the impact of rifts between governments on cooperation between labs. Over the last decade, a tenser world has thrown up new barriers to cross-border science. Collaboration between the US and China has dimmed as the two countries have sunk into an ever-deeper rivalry. Links between Russia and Europe have collapsed following Moscow’s full-scale invasion of Ukraine. But while a concern, the magnitude of the damage is less than might be expected. For all the geopolitical turmoil of the last decade, international scientific collaborations are near a record high. “Some part of the story is positive,” said Shreyas Gadgin Matha, a social scientist at Harvard University and an author of the new study. “Research collaborations are largely resilient.” Matha and colleagues looked at data on cross-border research papers and patents in the period 2000-23, and analysed how they were impacted by countries’ political relations, as measured by how often states voted together in the United Nations. They found that when states drift apart at the UN by the median difference in votes between all countries, joint scientific papers decline by 3.1% over the next three-year period. To put that in context, over the last decade, the US and China have diverged by around a third of that difference in votes every three years. In other words, on average, it takes quite a significant diplomatic rift even to trigger a small single-digit percentage drop in joint papers. “In the short term, even something like a 3% reduction [in joint papers] is, in some ways, not that big of a number,” said Matha. Research remains more international than ever, according to an analysis extending to 2023 released by the Organisation for Economic Cooperation and Development (OECD) in 2025. We’re still living in an era of unprecedented scientific globalisation, the analysis says, with 27% of papers in OECD countries written across borders. In 1970, just 2% of articles had authors from different countries. Longer-term damage?However, this trend towards increasing international collaboration “has lost momentum and might be partly breaking down,” the OECD analysis says, largely due to a fall in the intensity of US-China joint papers since 2018. Matha and his colleagues stressed they are not complacent about the global science system. For now, “it's pretty resilient,” said co-author Muhammed Yildirim, director of academic research at Harvard’s Growth Lab. But if links are weakened, through the denial of study visas, for example, then this could have a much longer-term effect, cascading through generations of scientists, he added. Related articlesChina becomes Russia’s biggest collaborator after war decimates science ties with the west US scientists prefer German to Chinese collaborators, study finds Horizon Europe is now truly global. But what comes next? Another finding of the study, Burning bridges or bridging divides: Geopolitics and collaboration in research and innovation, is that trust appears easier to destroy than create.The hit to scientific collaboration when countries drift apart is around three times as big as the growth in joint papers when they move closer, the paper finds. “It's far easier to break these ties than to mend them, and that that also perhaps has some larger policy lesson,” said Matha.PatentsThe results around patents were less clear cut. Some methods of analysis found a statistically significant link between a diplomatic rift and a drop in co-patenting, but others did not. According to Yildirim, patents with cross-border inventors are often developed by multinational companies, which may have invested heavily in global R&D facilities, so are less likely to change how they operate simply due to a change in the geopolitical weather. “That's why we might not be seeing the effect immediately in technology,” he said.By contrast, researchers might be more sensitive to geopolitics, because visa policies can quickly affect who meets who at academic conferences, he went on. International collaboration on patents is much lower than for academic articles, the study shows. It peaked at around 10% in 2010, and has since fallen back to around 8%. This could be because China dramatically ramped up domestic patents in the 2010s, said Yildirim, squeezing the international share.
How geopolitical rifts cut scientific collaboration
Researchers have measured how worsening geopolitical relations hobble scientific collaboration, at last quantifying the impact of rifts between governments on cooperation between labs. Over the last decade, a tenser world has thrown up new barriers to cross-border science. Collaboration between the US and China has dimmed as the two countries have sunk into an ever-deeper rivalry. Links between Russia and Europe have collapsed following Moscow’s full-scale invasion of Ukraine. But while a concern, the magnitude of the damage is less than might be expected. For all the geopolitical turmoil of the last decade, international scientific collaborations are near a record high. “Some part of the story is positive,” said Shreyas Gadgin Matha, a social scientist at Harvard University and an author of the new study. “Research collaborations are largely resilient.” Matha and colleagues looked at data on cross-border research papers and patents in the period 2000-23, and analysed how they were impacted by countries’ political relations, as measured by how often states voted together in the United Nations. They found that when states drift apart at the UN by the median difference in votes between all countries, joint scientific papers decline by 3.1% over the next three-year period. To put that in context, over the last decade, the US and China have diverged by around a third of that difference in votes every three years. In other words, on average, it takes quite a significant diplomatic rift even to trigger a small single-digit percentage drop in joint papers. “In the short term, even something like a 3% reduction [in joint papers] is, in some ways, not that big of a number,” said Matha. Research remains more international than ever, according to an analysis extending to 2023 released by the Organisation for Economic Cooperation and Development (OECD) in 2025. We’re still living in an era of unprecedented scientific globalisation, the analysis says, with 27% of papers in OECD countries written across borders. In 1970, just 2% of articles had authors from different countries. Longer-term damage?However, this trend towards increasing international collaboration “has lost momentum and might be partly breaking down,” the OECD analysis says, largely due to a fall in the intensity of US-China joint papers since 2018. Matha and his colleagues stressed they are not complacent about the global science system. For now, “it's pretty resilient,” said co-author Muhammed Yildirim, director of academic research at Harvard’s Growth Lab. But if links are weakened, through the denial of study visas, for example, then this could have a much longer-term effect, cascading through generations of scientists, he added. Related articlesChina becomes Russia’s biggest collaborator after war decimates science ties with the west US scientists prefer German to Chinese collaborators, study finds Horizon Europe is now truly global. But what comes next? Another finding of the study, Burning bridges or bridging divides: Geopolitics and collaboration in research and innovation, is that trust appears easier to destroy than create.The hit to scientific collaboration when countries drift apart is around three times as big as the growth in joint papers when they move closer, the paper finds. “It's far easier to break these ties than to mend them, and that that also perhaps has some larger policy lesson,” said Matha.PatentsThe results around patents were less clear cut. Some methods of analysis found a statistically significant link between a diplomatic rift and a drop in co-patenting, but others did not. According to Yildirim, patents with cross-border inventors are often developed by multinational companies, which may have invested heavily in global R&D facilities, so are less likely to change how they operate simply due to a change in the geopolitical weather. “That's why we might not be seeing the effect immediately in technology,” he said.By contrast, researchers might be more sensitive to geopolitics, because visa policies can quickly affect who meets who at academic conferences, he went on. International collaboration on patents is much lower than for academic articles, the study shows. It peaked at around 10% in 2010, and has since fallen back to around 8%. This could be because China dramatically ramped up domestic patents in the 2010s, said Yildirim, squeezing the international share.
Nonprofit continues to support firefighters with mental health services nearly 25 years after 9/11
When the call involves a mental health crisis, Bridgeport sends more than police
The fatal police shootings of two Hartford men during separate mental health emergencies earlier this year put a spotlight on how Connecticut law enforcement agencies respond to people in crisis and the role mental health professionals can play in those encounters.
Trump promises Americans $5K if GOP wins. And, Kirk supporters reflect on his death
President Trump tries to incentivize voters by promising $5,000 to Americans if the GOP wins the midterms. And, young conservatives reflect on the party one year after Charlie Kirk's death.
Washtenaw County Health Department issues warning after two bats discovered with rabies
The Washtenaw County Health Department has issued an information warning after two bats with rabies were discovered locally. WEMU’s Ana Longoria has the details.
After Trump promised to pay $5,000 if Republicans win, here's what to expect Thursday
President Trump promised to send every adult citizen $5,000, but only if Republicans maintain control of Congress in the midterm election, setting high expectations for the convention's final night.
Health insurance premiums estimated to increase upwards of 10%, analyses say
Health insurance premiums in Ohio are expected to increase by about 10.7%, according to an analysis from Healthinsurance.org based on health premiums in the individual market. Affordable Care Act Marketplace insurers are proposing a median premium increase of 15% in 2027, according to an analysis of insurers with publicly available filings by KFF, a nonprofit health policy research, polling, and news organization.
Health insurance premiums estimated to increased upwards of 10%, analyses say
Health insurance premiums in Ohio are expected to increase by about 10.7%, according to an analysis from Healthinsurance.org based on health premiums in the individual market. Affordable Care Act Marketplace insurers are proposing a median premium increase of 15% in 2027, according to an analysis of insurers with publicly available filings by KFF, a nonprofit health policy research, polling, and news organization.
Amount wagered in Missouri sports betting fell in July, despite World Cup in Kansas City
One sports market analyst said he was surprised that the FIFA World Cup, for which Kansas City was a host city in June and July, didn't drive more wagers.
Farmers, business owners in limbo as federal ban threatens Kentucky hemp industry
The federal ban will require many hemp-derived products to be pulled from the market.
After Trump promised to pay $5,000 if Republicans win, here's what to expect Thursday
President Trump promised to send every adult citizen $5,000, but only if Republicans maintain control of Congress in the midterm election, setting high expectations for the convention's final night.
Scientists say August was Earth's hottest month they've measured
The European climate service Copernicus said the Earth just sweltered through its hottest month on record in August. Scientists said the heat surge is mostly due to human-caused climate change.
Law Enforcement Honors Dr. John Howard and the World Trade Center Health Program Team With ‘Service Above Self’ Award on 9/11
WASHINGTON, DC, UNITED STATES, September 8, 2026 / EINPresswire.com / -- The Federal Law Enforcement Officers Foundation , in partnership with the Police Unity Tour and the National Law Enforcement Officers Memorial Fund, is proud to announce that the World Trade Center Health Program (WTCHP)
Tampa drop-in center expands to add free healthcare, dental services for underserved community
Starting Thursday morning, a pair of local nonprofits are joining forces to offer free health and dental care to underserved Tampa residents at a local drop-in center.
Fetterman, already at odds with his party, makes surprise video for GOP convention
The Pennsylvania Democrat has already had a strained relationship with many inside his party. In the video, he spoke about working with Trump but did not outright praise him.
Fetterman, already at odds with his party, makes surprise video for GOP convention
The Pennsylvania Democrat has already had a strained relationship with many inside his party. In the video, he spoke about working with Trump but did not outright praise him.
Rhode Island could see a political wipeout next week
If Governor Dan McKee, Lieutenant Governor Sabina Matos, and Mayor Brett Smiley all were to fall, it would amount to an unprecedented upending of Rhode Island’s political establishment, and a massive rebuke that could signal a significant shift in the state’s political landscape.
Brewers’ Misiorowski Reaches Unprecedented Velocity Milestone
Jacob Misiorowski shattered records by surpassing 1,000 triple-digit pitches this season, cementing his status as a dominant rotation centerpiece for the Milwaukee Brewers.
The Democracy We Must Protect Together
It can be difficult to grasp authoritarianism because it rarely arrives all at once. Instead, it often emerges through a series of actions that may seem disconnected on the surface: attacks on scientists who tell inconvenient truths, efforts to restrict voting access, attempts to punish nonprofit
Three members of the ESPN/Disney family named to Sports Broadcasting Hall of Fame Class of 2026
Three members of The Walt Disney Company/ESPN family – former Disney Chairman and CEO Robert A. Iger, Monday Night Football analyst Troy
Healthcare nonprofit breaks ground on addiction recovery campus in Roseburg
Healthcare nonprofit Adapt expects to complete the $20 million first phase in late 2027, with additional facilities for families and youths planned later.
Fold the phone: Apple's new CEO unveils a foldable iPhone
New Apple CEO John Ternus announces the iPhone Duo, which folds like a passport and is the most radical iPhone design update in nearly 20 years.
NPR reporter explains what to expect on the first day of Dallas' Republican midterm convention
NPR political reporter Stephen Fowler explains what he's looking out for and what to expect from Ken Paxton, who's running for U.S. Senate and will speak at the convention Wednesday.
INSIDE CLIMATE NEWS: NOAA Fisheries takes a ‘sharp turn away from science’
The agency’s focus on commercial interests threatens fisheries science and over one million miles of protected marine habitats. By Johnny Sturgeon, Inside Climate News This article originally appeared on Inside Climate News, a nonprofit, non-partisan news organization that covers climate, energy and the environment. Sign up for their newsletter here. In July, the Trump administration relegated endangered leatherback turtles, sea lions and whales to mere collateral damage in its race to profit from the oceans. Now, fisheries science is in […]
Why Texas Republican donors give — and why the state matters to GOP fundraising
As the Republican National Committee gathers in Dallas, Republican donors and political experts explain why Texas raises so much money.
Meeting planned on maternal health care cuts in DC
District leaders and nurses are raising concerns following the summer closure of a postpartum unit at MedStar Washington Hospital Center, the city’s largest private, nonprofit hospital. A public forum on the issue is scheduled for Wednesday night.
Oregon Democrats seek to calm voters’ election uncertainties
Oregon Democrats express faith in the upcoming vote-by-mail election despite ongoing legal battles over President Donald Trump's attempt to restrict mail ballot delivery.
New report highlights six major mental health concerns for students
Orlando nonprofit Breaking Thru unveiled a report detailing six major mental health concerns facing local students this year.
Edmond launches monthly 'Parent Café' to build community, share mental health resources
The City of Edmond is launching a new initiative to help caregivers and families build community and navigate mental health challenges.
Nonprofit health care provider to close Bangor center, cut 16 jobs
Penobscot Community Health Care plans to close its Adult Wellness Center practice in Bangor later this year and eliminate 16 jobs.
ESPN expands Women’s Sports Sundays franchise into Fall 2026, anchored by college volleyball and NWSL
ESPN is extending its marquee women’s sports summer franchise, Women’s Sports Sundays, into Fall 2026. Building on the inaugural franchise of matchups across
The Cost of Cutting American Science: How Federal Cuts Diminish Public Health Capacity
Among the federal government’s many responsibilities is the work it does to protect public health. Federal agencies monitor our food supply to ensure safety, conduct research to better understand emerging health threats, provide funding for public health programs in communities and work to detect and respond to disease outbreaks. Americans rely on these efforts every day—in a 2024 online survey, 74% of respondents said that “if the federal government issued safety guidance about food you eat regularly,” they would follow it. Changes to Federal Public Health Capacity The Trump administration’s efforts to reshape the federal government have resulted in significant impacts on our nation’s public health capacity over the past 20 months, affecting the response to health concerns such as measles, Ebola and cyclosporiasis. Agencies with core public health, food safety and disease prevention responsibilities experienced large workforce decreases during the first year of the administration. At the Centers for Disease Control and Prevention, for instance, the workforce in February 2026 was 26.7% smaller than in September 2024 before the start of the Trump administration. The Food and Drug Administration saw a similarly steep decline of 21.6%. Agencies such as the National Institutes of Health, Substance Abuse and Mental Health Services Administration and Food Safety and Inspection Service also experienced large workforce decreases. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); Changes can also be seen in crucial public health occupations. The number of federal food inspectors, for example, decreased by more than half between September 2024 and February 2026, going from 1,035 to 473. This is the lowest number of food inspectors employed by the federal government since at least 2005. By February 2026, there were also 33.3% fewer federal public health program specialists, whose work includes advising federal funding recipients on public health activities and analyzing the effectiveness of public health programs. Government’s capacity is diminished as employees with specialized knowledge and experience in protecting the public and responding to health risks depart, leaving agencies less prepared to carry out their public health missions. There also have been vacancies in critical high-level leadership positions at public health agencies, most notably at the CDC, which had a permanent Senate-confirmed director for less than a month between January 2025 and early August 2026. Although the CDC has previously been led by acting directors at the start of an administration, the nearly yearlong gap since the departure of the administration’s first permanent director in August 2025 is without precedent. As of August 2026, the FDA is also currently without a Senate-confirmed commissioner following the previous commissioner’s resignation in May 2026. Additionally, public health agencies are experiencing increased politicization of their leadership ranks. In agencies such as the CDC and Food Safety and Inspection Service, the number of individuals in the Senior Executive Service—the most senior career leaders in government—has declined significantly, while at the same time the number of political appointees has reached record levels. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); At the CDC, for example, the number of career SES decreased 42.9% between December 2024 and February 2026, while the number of non-Senate confirmed political appointees at the agency was six times larger than the agency’s historical average from 2009 and 2024. Knowledgeable career leaders are integral to the ability of public health agencies to carry out their work with scientific integrity and professional judgment, and rapid leadership turnover and increased politicization threaten agencies’ ability to make evidence-based decisions to protect our health. The upheaval and politicization in public health agencies have also negatively affected employee engagement. Strong employee engagement is crucial to the ability of agencies to carry out their mission and successfully provide essential services to the public. In the 2025 Public Service Viewpoint Survey conducted by the Partnership for Public Service, the Department of Health and Human Services—which encompasses major public health agencies such as the CDC and FDA—had an employee engagement and satisfaction score of 20.4 out of 100, one of the lowest among large agencies. Only 2.8% of HHS employees indicated trust in their political leaders and only 8.7% reported confidence that they could report a suspected violation of law or regulation without retaliation. Employees at HHS also reported that the agency’s ability to provide services to the public had suffered. Nearly half of employees at HHS, 47.5%, said their work unit was worse at delivering quality services compared to its performance in 2024. In addition, 57.8% said their work unit was performing worse at fulfilling stakeholder needs. In addition to the work done within federal agencies, the federal government also distributes significant funding for public health and disease prevention work to state and local governments, nonprofits and small businesses—funding which has been significantly disrupted. At the CDC, for example, there was a 71.9% decrease in the amount of project grant funding issued in fiscal year 2025 compared to fiscal year 2024. The FDA also issued far less funding in fiscal year 2025—a 21.3% decrease from its fiscal year 2024 funding. Changes in federal funding include the ending of grants to community organizations that worked on HIV prevention and the cancellation of funding for research into improvements to patient safety and healthcare quality. These changes go beyond federal agencies to impact the broader public health ecosystem, including the state and local health departments responsible for much of the on-the-ground public health work in their communities. About 80% of the CDC’s domestic funding is directed towards state and local partners—meaning that cuts to CDC funding can ultimately result in cuts to state and local public health capacity. Federal agencies also provide expertise and assistance to state and local health agencies as they deal with particular health challenges, but workforce cuts have resulted in fewer federal employees available to help. The Impact of Changes to Public Health Capacity These changes to federal public health capacity are not abstract concerns. Disrupted programs, reduced funding and lost expertise at public health agencies across all levels of government threaten the public’s physical well-being and safety. In some cases, this has already led to harm. The most immediate impacts of federal cuts were seen in interruptions to ongoing public health programs and crisis responses. In one instance, when CDC grants were canceled during the 2025 Texas measles outbreak—the most severe measles outbreak in 25 years—public health officials in Lubbock, Texas were forced to pause parts of their measles response work supported by the frozen funding. Lubbock’s director of public health further said that a lack of available CDC experts to reach out to for advice “definitely” impacted the department’s response to the measles crisis. Cuts to federal funding also forced Dallas County Health and Human Services to cut staff and cancel 50 community vaccination clinics during the outbreak. Public health work outside of major outbreak responses was also disrupted. For example, in April 2025, the Milwaukee Public Health Department was unexpectedly unable to reach experts on lead poisoning due to firings at the CDC when responding to concerns about lead contamination in Milwaukee public schools. Due to federal workforce cuts, several programs at the CDC, including Alzheimer’s and epilepsy programs, have also become trapped in limbo—existing on paper, but without the staff necessary to operate. More recent crises reveal how federal cuts have weakened the public health infrastructure needed to prevent and respond to dangerous new outbreaks. Internationally, cuts at the U.S. Agency for International Development eliminated funding for disease testing and contact tracing abroad, which delayed detection of and responses to the 2026 Ebola outbreak in the Democratic Republic of Congo. While international outbreaks may seem far removed, the unchecked spread of disease in any country can quickly pose a danger to economic well-being, security and health around the world. Within the United States, public health cuts inhibited responses to the summer 2026 outbreak of the food-borne parasite cyclospora. At the federal level, cuts to funding for lab equipment and for CDC staff with expertise in parasitic infections—including 9 out of 11 staff members at the lab responsible for identifying parasitic outbreaks in 2025— contributed to the largest reporting delay in outbreak cases at the CDC in 15 years. Conflicting communications from the FDA about the source of the outbreak, which followed cuts to the agency’s communications department, additionally led to confusion among the public about how to best avoid infection. At the same time, cuts to HHS funding and support for local and state public health slowed some health departments’ responses to the crisis. The exact costs of these delays, constraints and confusion in public health responses are difficult to estimate. However, their message is clear: federal cuts have already made containing threats to public health even more of a challenge. Conclusion Protecting public health—from food safety to disease prevention—is one of the federal government’s most important missions. Dramatic and haphazard cuts to federal agencies and funding have already disrupted the public health system, impacting the response to challenges such as measles, lead poisoning and cyclosporiasis. The U.S. public health system needed improvement before these disruptions. Since 2022, federal leadership and coordination in response to public health outbreaks has been on the Government Accountability Office’s High-Risk List of areas in need of attention to improve government effectiveness and efficiency. Recent cuts only compound these concerns. The chaotic dismantling of government and resulting disruptions to crucial functions like public health and disease prevention highlight the need for meaningful reform and concrete policy proposals to reimagine how government can better serve the public and be more effective, responsive and accountable. To learn more about the impact of federal cuts to public health and science more broadly, visit The Cost of Cutting American Science. Learn more For more information on the Partnership for Public Service’s government reform initiative, visit Government for a New Era. View here In line with The Cost of Cutting American Science, federal workforce data in this brief is as of February 2026
The Cost of Cutting American Science: How Federal Cuts Diminish Public Health Capacity
Among the federal government’s many responsibilities is the work it does to protect public health. Federal agencies monitor our food supply to ensure safety, conduct research to better understand emerging health threats, provide funding for public health programs in communities and work to detect and respond to disease outbreaks. Americans rely on these efforts every day—in a 2024 online survey, 74% of respondents said that “if the federal government issued safety guidance about food you eat regularly,” they would follow it. Changes to Federal Public Health Capacity The Trump administration’s efforts to reshape the federal government have resulted in significant impacts on our nation’s public health capacity over the past 20 months, affecting the response to health concerns such as measles, Ebola and cyclosporiasis. Agencies with core public health, food safety and disease prevention responsibilities experienced large workforce decreases during the first year of the administration. At the Centers for Disease Control and Prevention, for instance, the workforce in February 2026 was 26.7% smaller than in September 2024 before the start of the Trump administration. The Food and Drug Administration saw a similarly steep decline of 21.6%. Agencies such as the National Institutes of Health, Substance Abuse and Mental Health Services Administration and Food Safety and Inspection Service also experienced large workforce decreases. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); Changes can also be seen in crucial public health occupations. The number of federal food inspectors, for example, decreased by more than half between September 2024 and February 2026, going from 1,035 to 473. This is the lowest number of food inspectors employed by the federal government since at least 2005. By February 2026, there were also 33.3% fewer federal public health program specialists, whose work includes advising federal funding recipients on public health activities and analyzing the effectiveness of public health programs. Government’s capacity is diminished as employees with specialized knowledge and experience in protecting the public and responding to health risks depart, leaving agencies less prepared to carry out their public health missions. There also have been vacancies in critical high-level leadership positions at public health agencies, most notably at the CDC, which had a permanent Senate-confirmed director for less than a month between January 2025 and early August 2026. Although the CDC has previously been led by acting directors at the start of an administration, the nearly yearlong gap since the departure of the administration’s first permanent director in August 2025 is without precedent. As of August 2026, the FDA is also currently without a Senate-confirmed commissioner following the previous commissioner’s resignation in May 2026. Additionally, public health agencies are experiencing increased politicization of their leadership ranks. In agencies such as the CDC and Food Safety and Inspection Service, the number of individuals in the Senior Executive Service—the most senior career leaders in government—has declined significantly, while at the same time the number of political appointees has reached record levels. (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); (function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})(); At the CDC, for example, the number of career SES decreased 42.9% between December 2024 and February 2026, while the number of non-Senate confirmed political appointees at the agency was six times larger than the agency’s historical average from 2009 and 2024. Knowledgeable career leaders are integral to the ability of public health agencies to carry out their work with scientific integrity and professional judgment, and rapid leadership turnover and increased politicization threaten agencies’ ability to make evidence-based decisions to protect our health. The upheaval and politicization in public health agencies have also negatively affected employee engagement. Strong employee engagement is crucial to the ability of agencies to carry out their mission and successfully provide essential services to the public. In the 2025 Public Service Viewpoint Survey conducted by the Partnership for Public Service, the Department of Health and Human Services—which encompasses major public health agencies such as the CDC and FDA—had an employee engagement and satisfaction score of 20.4 out of 100, one of the lowest among large agencies. Only 2.8% of HHS employees indicated trust in their political leaders and only 8.7% reported confidence that they could report a suspected violation of law or regulation without retaliation. Employees at HHS also reported that the agency’s ability to provide services to the public had suffered. Nearly half of employees at HHS, 47.5%, said their work unit was worse at delivering quality services compared to its performance in 2024. In addition, 57.8% said their work unit was performing worse at fulfilling stakeholder needs. In addition to the work done within federal agencies, the federal government also distributes significant funding for public health and disease prevention work to state and local governments, nonprofits and small businesses—funding which has been significantly disrupted. At the CDC, for example, there was a 71.9% decrease in the amount of project grant funding issued in fiscal year 2025 compared to fiscal year 2024. The FDA also issued far less funding in fiscal year 2025—a 21.3% decrease from its fiscal year 2024 funding. Changes in federal funding include the ending of grants to community organizations that worked on HIV prevention and the cancellation of funding for research into improvements to patient safety and healthcare quality. These changes go beyond federal agencies to impact the broader public health ecosystem, including the state and local health departments responsible for much of the on-the-ground public health work in their communities. About 80% of the CDC’s domestic funding is directed towards state and local partners—meaning that cuts to CDC funding can ultimately result in cuts to state and local public health capacity. Federal agencies also provide expertise and assistance to state and local health agencies as they deal with particular health challenges, but workforce cuts have resulted in fewer federal employees available to help. The Impact of Changes to Public Health Capacity These changes to federal public health capacity are not abstract concerns. Disrupted programs, reduced funding and lost expertise at public health agencies across all levels of government threaten the public’s physical well-being and safety. In some cases, this has already led to harm. The most immediate impacts of federal cuts were seen in interruptions to ongoing public health programs and crisis responses. In one instance, when CDC grants were canceled during the 2025 Texas measles outbreak—the most severe measles outbreak in 25 years—public health officials in Lubbock, Texas were forced to pause parts of their measles response work supported by the frozen funding. Lubbock’s director of public health further said that a lack of available CDC experts to reach out to for advice “definitely” impacted the department’s response to the measles crisis. Cuts to federal funding also forced Dallas County Health and Human Services to cut staff and cancel 50 community vaccination clinics during the outbreak. Public health work outside of major outbreak responses was also disrupted. For example, in April 2025, the Milwaukee Public Health Department was unexpectedly unable to reach experts on lead poisoning due to firings at the CDC when responding to concerns about lead contamination in Milwaukee public schools. Due to federal workforce cuts, several programs at the CDC, including Alzheimer’s and epilepsy programs, have also become trapped in limbo—existing on paper, but without the staff necessary to operate. More recent crises reveal how federal cuts have weakened the public health infrastructure needed to prevent and respond to dangerous new outbreaks. Internationally, cuts at the U.S. Agency for International Development eliminated funding for disease testing and contact tracing abroad, which delayed detection of and responses to the 2026 Ebola outbreak in the Democratic Republic of Congo. While international outbreaks may seem far removed, the unchecked spread of disease in any country can quickly pose a danger to economic well-being, security and health around the world. Within the United States, public health cuts inhibited responses to the summer 2026 outbreak of the food-borne parasite cyclospora. At the federal level, cuts to funding for lab equipment and for CDC staff with expertise in parasitic infections—including 9 out of 11 staff members at the lab responsible for identifying parasitic outbreaks in 2025— contributed to the largest reporting delay in outbreak cases at the CDC in 15 years. Conflicting communications from the FDA about the source of the outbreak, which followed cuts to the agency’s communications department, additionally led to confusion among the public about how to best avoid infection. At the same time, cuts to HHS funding and support for local and state public health slowed some health departments’ responses to the crisis. The exact costs of these delays, constraints and confusion in public health responses are difficult to estimate. However, their message is clear: federal cuts have already made containing threats to public health even more of a challenge. Conclusion Protecting public health—from food safety to disease prevention—is one of the federal government’s most important missions. Dramatic and haphazard cuts to federal agencies and funding have already disrupted the public health system, impacting the response to challenges such as measles, lead poisoning and cyclosporiasis. The U.S. public health system needed improvement before these disruptions. Since 2022, federal leadership and coordination in response to public health outbreaks has been on the Government Accountability Office’s High-Risk List of areas in need of attention to improve government effectiveness and efficiency. Recent cuts only compound these concerns. The chaotic dismantling of government and resulting disruptions to crucial functions like public health and disease prevention highlight the need for meaningful reform and concrete policy proposals to reimagine how government can better serve the public and be more effective, responsive and accountable. To learn more about the impact of federal cuts to public health and science more broadly, visit The Cost of Cutting American Science. Learn more For more information on the Partnership for Public Service’s government reform initiative, visit Government for a New Era. View here In line with The Cost of Cutting American Science, federal workforce data in this brief is as of February 2026
Southern Maryland nonprofit fills financial gaps for mental health resources
Over the last 25 years, Jennifer Voorhaar of Charlotte Hall has seen how financial barriers can prevent people from prioritizing their mental health.
Prisma Health Extends Tecsys Partnership from Distribution Center to Bedside
/PRNewswire/ -- Tecsys Inc. (TSX: TCS), an industry-leading supply chain management company, today announced that Prisma Health, the largest private, nonprofit...
Recent Stanton graduate wins Humane Science Award from National Anti-Vivisection Society
Alan Alwakeel, a recent graduate of Stanton College Preparatory School in Jacksonville, Florida, was one of just five recipients of the prestigious Humane Science Award at the 2026 Regeneron International Science and Engineering Fair (ISEF). The award is presented by the National Anti-Vivisection Society (NAVS), a nonprofit devoted to the advancement of science without harming animals and the only animal advocacy group invited to award a prize at the ISEF. Each recipient received a $3,000 prize
Trump center stage at RNC in midterms gamble
President to give speeches on both days of unprecedented gathering
Fishing the Good Fight supports men facing mental health challenges
Former University of Alabama football player Jennings Hester founded the nonprofit Fishing the Good Fight to provide men with mental health support through fly fishing retreats and community activities.
GOP's first midterm convention kicks off Wednesday, putting Dallas at center of national politics
The Republican Party's first-ever midterm convention begins in Dallas as Trump and GOP leaders rally voters, while Democrats prepare their own counterprogramming ahead of November.
Edmond launches monthly 'Parent Café' to build community, share mental health resources
The City of Edmond is launching a new initiative to help caregivers and families build community and navigate mental health challenges.
New outpatient clinic focused on suicide prevention opens in Burlington
University of Vermont Health held an open house last week to celebrate the opening of the Asha Clinic, which it describes as the only program in the region focused exclusively on suicide care. The clinic's work is led by Craig Bryan, an expert in suicide treatment and research.
Nonprofits Are Helping Musicians Pay for Insurance in Austin, Texas, and Beyond
A nonprofit and a local public health agency are subsidizing marketplace health insurance for Austin music artists, even as shifting marketplace conditions make the program a more expensive proposition. It’s becoming a model for other cities and sectors.
Republicans kick off a 'Trumpapalooza' of a midterm convention Wednesday in Texas
Republicans have never held a midterm convention before. But there's also never been a president like Donald Trump. Billed as a "Trumpapalooza," the unprecedented event kicks of in Dallas Wednesday.
Students get a head start on undergraduate research in STEM fields
High school seniors and incoming UT San Antonio freshmen work alongside faculty mentors to engage in hands-on research.
Lindsay Clancy and postpartum psychosis
The trial around Lindsay Clancy may be over for now, but it still leaves us with questions. On today’s episode, we talk to psychiatrists and patients to answer them: What is postpartum psychosis, exactly? Why don’t we know more about it? And what can you do if you are worried about a postpartum loved one?Interested in more stories on mental health? Email us your question at shortwave@npr.org.Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.
49ers defensive lineman Alfred Collins' injury latest blow to largely unproven unit
San Francisco 49ers second-year defensive lineman Alfred Collins tore his patellar tendon at the team's second practice in Melbourne and will be out for the season, coach Kyle Shanahan said.
Pappas, Sununu sweep to victory in U.S. Senate primaries
Pappas, a four-term Democratic congressman, will face off against Republican and former U.S. Senator John E. Sununu.
Pappas, Sununu sweep to victory in U.S. Senate primaries
Pappas, a moderate Democrat and current Congressman in the 1st Congressional District, will face off against Republican and former U.S. Senator John E. Sununu.
Gov. Tina Kotek says she now supports a data center moratorium
The Oregon governor is escalating her stance on the facilities as they emerge as a political hot potato.
Missouri's redistricting fight in turmoil as U.S. Supreme Court and federal rulings clash
U.S. District Judge Stephen Clark last-minute order temporarily prevents Secretary of State Denny Hoskins from using any map other than the one passed in 2025 – a move that will almost certainly be appealed.
One Small Step: Sheriff and nonprofit leader discuss parenting amid political backdrop
Matt Carr and Stefani Wells recall their earliest political experiences and how that has shaped them today, as parents.
Pritzker defends Logan prison closure; pumps 5-year plan to attract new business to Lincoln
During a media appearance Tuesday in Bloomington, Pritzker said he's the most pro-economic development governor since Jim Thompson, who left office in 1991. He plans to work with Logan County officials to state properties where industry has left, including the pending closure of Logan Correctional Center.
Ohio politicians keep promise to rebuke Les Wexner by donating $200K in campaign contributions
Freedom a la Cart, a downtown Columbus cafe that employs sex trafficking survivors, was one of several organizations that politicians donated to this year.
Years before Nepal floods, scientists pitched a seismic warning system
The scientists, who are based in Europe, say the system could have triggered lifesaving alerts before floodwaters hit in Nepal. But the concept is unproven in the field.
The Villages Health’s $541 million settlement highlights the cost of ‘upcoding’
The settlement describes how The Villages Health would go back into patients' medical files months later and add diagnoses -- sometimes adding in monitoring, evaluations or treatments.
Mysterious elk deaths in Nevada could offer clues about health of herds across the West
An unusual pattern of springtime elk deaths for more than a decade in northern Nevada has scientists searching for answers. What they find could shed light on broader questions about wildlife health across the West.
Mysterious elk deaths in Nevada could offer clues about health of herds across the West
An unusual pattern of springtime elk deaths for more than a decade in northern Nevada has scientists searching for answers. What they find could shed light on broader questions about wildlife health across the West.
Health: The Fight For The Health Of 9/11 First Responders
A quarter century after 9/11, the health of those who responded to the attacks continues to be affected.Some 3,000 people died across three locations that day. An estimated 400,000 people were exposed to toxic contaminants and risked physical injury in the hours and days that followed. That’s according to data from the Centers for Disease Control and Prevention.Since the dust and debris have settled, more than 96,000 have been diagnosed with physical and mental health conditions related to 9/11.In 2010, President Barack Obama signed the James Zadroga 9/11 Health and Compensation Act, establishing the World Trade Center Health Program and reopening the 9/11 Victims Compensation Fund. Today, more than 150,000 people are enrolled in the program.But that program wouldn’t exist without the advocacy of survivors and first responders who put their bodies and lives on the line following the attacks. How did that fight for care unfold?For more information about the Rutgers WTC Health Program, click here. And to learn more about applying, click here.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Kansas City psychiatrist explores the science behind high emotional sensitivity
Dr. Sasha Hamdani's new book, "Too Sensitive," aims to provide a science-backed, empathetic framework for understanding why some people experience high emotional sensitivity. The Kansas City psychiatrist joined KCUR's Up To Date on Tuesday.
WKRC-TV adding 3 p.m. newscast, Sunday politics show
Former WXIX-TV anchor Rebecca Smith also returns to TV as Local 12’s new health reporter, filling the vacancy from the death of Liz Bonis in April.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
'Preposterous.' 6 Washingtonians on how the high cost of living affects their lives
KUOW spoke with six Washingtonians of varying income levels about how the region's high cost of living is affecting them — and potentially how they'll vote this fall.
Central Florida judge steps down amid political donation misconduct
The state Supreme Court recommended that Diana Tennis face suspension and a fine for giving to political groups while in office, rejecting an agreement with the state.
SteelSeries’ pro-grade, wireless Xbox controller sure is expensive
Two hundred and fifty nine dollars.
Vertical Aerospace’s eVTOL Can Fly. The Passenger Business Is Still Unproven
Vertical Aerospace has made real flight progress, but five years of recapitalization show why passenger economics remain the harder test.
Julio Sáenz, the 2026 Rochester Hispanic Business Person of the Year
During "Connections with Evan Dawson" on 9/8/26, Hispanic Business Person of the Year Julio Sáenz. Then, a special rebroadcast of our conversation with the man behind the "Connections" theme song.
A young Tallahassee scientist's Alzheimer's research wins national acclaim
Lily Ma, senior at Tallahassee's Chiles High School, probed the possibility of using stem cells as a vehicle to slow or even halt the degenerative process.
On 988 Day, Vibrant Emotional Health Reminds Everyone: With 988 Reasons to Reach Out, Your Reason is Reason Enough
/PRNewswire/ -- Today, September 8 (9/8), Vibrant Emotional Health (Vibrant), the nonprofit administrator of the 988 Suicide & Crisis Lifeline, joins the...