SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " 777 " 2,466 found 🔀 AI-powered Shuffle
New York politicians defend thwarted meeting with Iran
The State Department quashed the engagement, with an official telling Spectrum News it was “unconscionable.”
Lakers’ Austin Reaves gives insight into Luka Doncic friendship
Austin Reaves says Luka Doncic is one of his best friends and constantly sends golf swing videos as the Lakers enter a new era without LeBron James.
Wall of Entertainment Taps Chronicle Media to Power Audience Discovery and Growth for Its First U.S. Series
SAN FRANCISCO & LONDON, July 14, 2026--How do you find the exact viewers a new show is built for and turn them into a loyal, growing audience? That question is at the heart of a new multi-series partnership announced today between UK digital entertainment studio Wall of Entertainment and audience simulation platform Chronicle Media.
New York Giants Just Spilled the Beans About Cam Skattebo
The New York Giants have revealed quite a bit about Cam Skattebo without realizing it.
Grading the progress of all 32 five-star prospects from the 2024 college football recruiting class
A complete evaluation of every five‑star prospect from the Class of 2024 -- who's exceeding expectations, who's meeting them, and who faces a pivotal 2026 season
IBM forecasts preliminary Q2 revenue below estimates as spending shifts to AI
IBM's preliminary second-quarter revenue forecast came below Wall Street estimate on Tuesday, as customers prioritized spending on AI infrastructure, including servers, storage and memory purchases, sending its shares slumping 17% in premarket trading.
Business owner says higher minimum wage would raise costs, but he supports it
Pennsylvania’s budget boosts education funding, but leaves minimum wage unchanged as business owners and lawmakers weigh the cost.
New SCCT president, a veteran cardiologist, highlights importance of listening and teamwork
New SCCT president Ronen Rubinshtein, MD, says the fields of interventional cardiology and cardiac imaging are two of his greatest interests.
Poetslife Entertainment hosting Grown & Saxy's 106 & Poetry this Saturday
Acadiana's Local News Leader -- bringing Lafayette the latest news, weather, sports and entertainment
49ers' 2017 draft pick retires after 80 games in NFL
He did his best to stick around the league.
Vikings Mailbag: QB Battle, Harrison Smith, Free-Agent Targets
After a break, VikingsTerritory has reopened the mailbag, answering questions from the masses and posting them weekly in a single […]
NFL minds rank Jake Ferguson as top half tight end
Where would you rank Jake Ferguson among NFL tight ends?
Rosie O’Donnell quit her talk show when she saw this number in her bank account
The popular daytime series ran from 1996 to 2002.
Country music world heartbroken as 3 beloved groups have split in 2026
Country music fans have seen a trio of their favorite groups hang it up in 2026.
🤬The Colombian Federation rejects threats against Campaz
Through a statement, the Colombian organization condemns the threats received by the player and his family. After Colombia’s elimination against Switzerland on penalties, player Jaminton Campaz and ...
Sarasota business owner turns construction wall into outdoor art gallery
A code enforcement complaint sparked a Sarasota business owner's idea to open his wall to local painters
49ers 1st-Round Pick Flagged After ‘Subpar’ Rookie Season
PFF's Bradley Locker put "subpar" 49ers edge rusher and 2025 1st-round pick Mykel Williams on list of players under Year 2 pressure. The post 49ers 1st-Round Pick Flagged After ‘Subpar’ Rookie Season appeared first on HEAVY.
FIFA is not an independent sporting organisation; it is a political tool.
Football fans around the world are only now finding out what Palestinians have long known.
Demolition of the New Orleans airport's old south terminal is coming. See when.
The Louis Armstrong New Orleans International Airport will tear down portions of the vacant south terminal, part of the airport's larger expansion plans.
Patriots Fans Claim Tom Brady Is Sabotaging Drake Maye
Do Tom Brady and Drake Maye have unresolved beef? New England Patriots fans certainly think so. Brady had an incredible run with the Patriots, throwing for 74,571 yards and 541 touchdowns. He's undoubtedly the best player to ever suit up for the franchise. Maye, on the other hand, was an MVP ...
Cowboys Get Good News on George Pickens Offseason
Cowboys quarterback Dak Prescott is holding pre-camp workouts, and George Pickens has been the talk of the retreat. The post Cowboys Get Good News on George Pickens Offseason appeared first on HEAVY.
Can a pro-Israel Jewish Democrat be the party’s 2028 nominee? Hear what progressive House candidate Brad Lander thinks
Mamdani’s preening arrogance will ultimately prove his downfall
The democratic socialist balloon deflated this week.
The Elder Scrolls 6 Heavily Impacted by Xbox Layoffs, Team Morale at Rock Bottom
Over 50 people working on the RPG now gone
The $80 Billion Debt Cloud Hanging Over David Ellison’s Warner Deal
The Paramount CEO has promised not to sell off assets or cut content spending.
Sam Altman arson suspect remains in custody as mental health report filed
A mental health evaluation report found Daniel Moreno Gama eligible for mental health diversion.
TV stars who have never been nominated for an Emmy Award
The nominees for the 78th Emmy Awards were announced on Wednesday, and these TV stars were snubbed yet again.
Tank Bigsby among 3 biggest NFC North RB fantasy bargains
Running backs frequently make or break fantasy seasons. Here are three of the biggest RB fantasy bargains in the NFC East based on ADP.
Pittsburgh group joins national push to fight loneliness
Pittsburgh Social Health will become the Pittsburgh Chamber of Connection.
UFC champion predicts quick KO in UFC 329 main event
Former two-division champion Conor McGregor plans to put on a 'masterpiece' performance in his UFC 329 return on Saturday. "The Notorious" takes on former featherweight champion and BMF titleholder Max Holloway in a rematch in the fight card's main event. It's been five years since the 37 year-old ...
Hornets unlikely to retain defensive-minded wing after trade
After acquiring Dorian Finney-Smith from the Houston Rockets, the Hornets are unlikely to keep the 10-year veteran.
Meta Platforms Is Entering the Neocloud Business. Here's Why CoreWeave Investors Should Not Worry.
CoreWeave stock holds competitive advantages that can solidify its business.
Rogers to Become 100% Owner of Maple Leaf Sports & Entertainment
Signs agreement to buy Kilmer Sports 25% ownership stake in MLSE New global sports and entertainment powerhouse will deliver more for fans and customers TORONTO, July 06, 2026 (GLOBE NEWSWIRE) -- Rogers Communications Inc. announced today it has signed an agreement to buy the remaining 25% ownership stake in Maple Leaf Sports & Entertainment (MLSE) from Kilmer Sports Inc. for C$4.35 billion, increasing Rogers ownership in MLSE to 100%. “This is a defining moment for Rogers. Our full ownership of
Grand View goalkeeper channels love for sports into podcast
Louis Helm helped Grand View win a national soccer championship. Now he's using his podcast to learn more about the world of sports.
Keri Hilson breaks down her viral “music can harm” tweet and weighs in on the state of the industry
Keri Hilson music can harm tweet: The “Pretty Girl Rock” singer addressed her cryptic post on X at the 2026
Real Madrid forward Rodrygo delivers hopeful recovery update
Physical issues and injuries suffered by their players has been one of the most significant problems that Real Madrid have faced in the last few years, and this problem has undoubtedly played a role i...
NCAA president Charlie Baker floats regional approach to non-football sports
Conference realignment has turned college athletics into a much more national endeavor than it ever was previously. The Big Ten stretches from Southern California to New Jersey. The ACC includes a pair of teams on the Pacific coast. And the Big 12 has members located in both the deserts of the Southwest and the mountains…
Guardians Lose 3-1 To White Sox
This was a pretty underwhelming game from the offense. They faced a good pitcher in Burke, but boy did they make him look great. A solo HR from Hedgey in the 5th is the only thing that kept this one from being a shutout. Hedges is now hitting .281 with a .756 OPS on the […]
Carlsson's Flyers offer sheet was entirely avoidable for Verbeek, Ducks
If Anaheim does match, they'll be in tight salary cap straights with much more to do. If they don't match, they'll lose their franchise center for four first-round picks. How did we get here?
Cowboys fans pick their sack leader for 2026
Cowboys fans are expecting a second year jump from this player.
The United States at 250: Who gets to tell a nation's story?
As the US marks 250 years of independence, debates over how the nation's history should be told have become part of the anniversary itself. President Donald Trump says America should tell a more patriotic story.
Yankees fans have concerns about Gerrit Cole’s form
Your latest responses made it clear that the Cole Train could use some more fuel.
US officials attempted to warn Iran of fears that Israel would assassinate mediators
US officials attempted to warn Iran of fears they had that Israel would assassinate meditators during talks this spring, two US officials said.
Prairie Business honors top industry executives
Celebrating the region’s 2026 Leaders & Legacies
Best Fourth of July Deals Under $50 on Ninja, Anker and Samsung
We've rounded up almost 100 deals on tech, home essentials and more that won't break the bank.
“It’s a Business”: NYC Landlord Facing $35K Property Tax for His Buildings Speaks Out Against Zohran Mamdani’s Rent Freeze
NYC Landlord thinks people don't understand that owning apartments is a business.
Meta Is Charging a Subscription for Smart Glasses Features. Welcome to the New Era of Consumer Tech
You bought the hardware. Now you’ll need to subscribe for “expanded access” to the most advanced features.
Cincinnati Reds' Offense Goes Quiet in Loss to Brewers
Noelvi Marte’s two-run homer was the only offense Cincinnati could muster in a 4-2 loss to Milwaukee on Wednesday night.
How cryptocurrencies are changing global politics
Despite once dismissing them, Donald Trump made over $1 billion from cryptocurrency sales last year. But the digital currencies, and their lobbyists, are having an effect on policy and politicians around the world.
Bay Area Host Committee announces plans to become permanent sports leadership commission
The Bay Area Host Committee has announced plans to become a permanent leadership commission, continuing to bring sports events to the Bay Area.
3 reasons to like Wisconsin’s new AD hire
Why should Badgers fans be optimistic about their new Athletic Director?
How the Supreme Court became a pivotal force in Trump's immigration agenda
President Donald Trump's administration looked to the Supreme Court to greenlight its sweeping hard-line immigration agenda and, by and large, it got the backing it was looking for with one key exception.
Meta pops 8% as company makes cloud push to sell excess AI compute power capacity
The new business is a welcome signal for some investors who have been uneasy about the company's infrastructure spending plans.
Anthropic debuts AI-driven pharma R&D tool, Claude Science
Anthropic launches Claude Science as big tech companies increasingly eye expansion in the wider healthcare and life sciences space.
Poll: Most Americans think the U.S. has strayed from its founding principles
Most Americans believe the country has moved away from its founding principles as the nation prepares for its big 250th anniversary, a new PBS News/NPR/Marist poll finds. Eighty-three percent of U.S. adults feel America has strayed from the ideals the country was founded on two-and-a-half centuries ago. Among them, close to half of Americans — 47% — say the U.S. has "moved far away" from these principles, joined by 36% who said America has “moved
An enormous explosion has occurred in deep space – and scientists caught it within minutes of the detonation | BBC Sky at Night Magazine
Using the Submillimeter Array observatory on Maunakea, Hawaii, astronomers zoomed in on a gamma‑ray burst within minutes of its discovery.
Germany's heat wave has a political fallout
In the wake of the heat wave, critics say the government needs to do more to adapt to climate change.
Swift Boost Mission: An opportunity for science and defense
Instead of letting a 22-year-old space telescope fall to Earth, NASA wants to rescue the Neil Gehrels Swift Observatory with a robotic spacecraft designed to boost the telescope back into higher orbit.
Will NC lawmakers oppose Trump’s funding ask without Helene money?
A number of North Carolina Republicans say they will oppose the White House's funding request because it doesn't include money for Helene recovery.
ROSES-25 A.12 HAMAQ Science Team Clarified
Hemispheric Airborne Measurements of Air Quality (HAMAQ) is a NASA-funded project under the EVS-4 program using two aircraft (NASA’s B777 & P-3B) to
France Keeps Health Emergency Plan at Highest Level in Case of Another Heatwave
PARIS, June 29 (Reuters) - French Prime Minister Sebastien Lecornu said on Monday he was keeping the country's health emergency response plan, ORSAN, at its highest level for the coming days in view of "a possible recurrence of a heatwave episode". Lecornu was speaking at the start of a ...
2026 BET Awards: The 5 biggest moments of celebration and remembrance
Family and sisterhood were on display at the 2026 BET Awards at the Peacock Theater with wins for Cardi B, SZA and Doechii, and tributes to D'Angelo and Lauryn Hill.
Ingredion plans global Benicaros prebiotic expansion across gut and immune health applications
Ingredion highlights that its recent acquisition of the Benicaros prebiotic is a strong strategic addition to its Healthful Solutions portfolio, supporting the company’s formulation versatility alongside expansion of health-forward and clean label ingredients. The company purchased the patented prebiotic fiber, made from upcycled carrot pomace, from NutriLeads earlier this month. With the deal, Ingredion obtained full ownership of all intellectual property, trademarks, human clinical trials, and know-how related to manufacturing Benicaros.
Millions drop Obamacare health coverage after subsidies expire and costs rise
Health analysts say the drop in enrollment was likely related to the Jan. 1 expiration of federal subsidies, which caused a surge in plan costs that resulted in many people being unable to pay their premiums.
Appalachian State strikes again on trolling Michigan football program
It's the gift that keeps on giving. Appalachian State trolled the Michigan football program once again for the loss in 2007.
Breakthrough could lead to ‘big leaps’ in battery performance, scientists say
Researchers studied lithium-ion batteries, which are used for electric vehicles as well as portable electronics such as mobile phones and laptops.
Arkansas Department of Health urges caution during extreme heat
Now that it is officially summer, state health officials want to make sure you're on guard against the extreme heat.
Penguins organizational outlook heading into free agency
It ended up being a mostly uneventful draft weekend for the Pittsburgh Penguins. They acquired Hendrix Lapierre for draft picks, used some of their stockpile future of picks to get extra 2026 mid-round selections and went about their business of drafting players without many fireworks going down with massive moves. The big landmark for the […]
Sen. Warnock was struck that VP Vance ‘wasted no time telling the Pope how to be the Pope.’
'All INdiana Politics'
U.S. Sen. Todd Young has said that a proposed $300 billion payment to Iran would not be funded by American taxpayers, and that any ceasefire with Iran must be contingent on the dismantlement of its nuclear program, while Indiana Senators Young and Banks have split on a housing bill now awaiting President Trump's signature.
Costs of Iran war will linger despite conflict's end, experts say
The effects of the war and other factors driving inflation are likely to stick around for months, experts say, presenting an ongoing challenge to American households.
Space elevators could one day exist, transporting us off-Earth with the push of a button. Here's how they would work | BBC Sky at Night Magazine
What is a space elevator and how would one work? We look at the science behind building an elevator to take us into space.
Robison leaves legacy of building partnerships as he accepts next public health challenge at state level
…
78 days till Arizona Cardinals' opener: Remembering the 1978 season
With 78 days until the Arizona Cardinals' 2026 opener, let's look back at their 1978 season.
3 million Americans have dropped Obamacare health coverage over past year, after Republicans let federal subsidies expire
KFF expects the total number of people in the government healthcare program to continue to decline throughout the year, potentially to a low of about 17.5 million from 19.2 million now.
The Chicago Bears are getting their own Hallmark Christmas movie
The Chicago Bears are the latest NFL franchise to get the Hallmark Christmas movie treatment. The team announced Thursday that it is partnering with Hallmark Media, the NFL, and Skydance Sports for Holiday Touchdown: A Bears Love Story, which will premiere during Hallmark Channel’s 17th annual Countdown to Christmas programming event this holiday season. “My…
Germany news: Heat soars as political reforms split opinion
As Europe's heatwave rages, Germany continues to swelter with new records expected Saturday. Elsewhere, politicians bicker over reforms and industry blames train operator DB for billions in losses. DW has the latest.
Annika Sörenstam reveals Chiefs fan Caitlin Clark's dual sport ability
During her interview with @EdEastonJr, professional golf icon Annika Sörenstam revealed Kansas City Chiefs fan Caitlin Clark's dual sport ability
"People think science is about the truth. It's not" – Why everything we know about the Universe could be mere guesswork | BBC Sky at Night Magazine
Are space science, cosmology and astronomy just guesswork? Considering the purpose of science and how we study the Universe.
White House mandates move away from overdose prevention in US health programs
Experts say move signals greater political interference into public health and will exacerbate opioid overdose crisis
Pete Buttigieg was briefly separated from his children after police say he was target of false report
Former Transportation Secretary Pete Buttigieg was the target of an anonymous report that police determined was false and that he says forced him to spend a night away from his four-year-old twins.
Pilots react to a Boeing 777 freighter's 'reckless' stunt over Texas
A Boeing 777 nearly clipped the ground during an unusually low flyover in Texas, a stunt veteran pilots called "reckless" and "stupid."
Bayer wins in US court, but at what cost to public health?
A landmark US Supreme Court ruling protects Bayer from thousands of lawsuits linked to its Roundup weedkiller. Plaintiffs alleged the German agrochemical giant failed to warn users about potential cancer risks.
CORUS ENTERTAINMENT ANNOUNCES FISCAL 2026 THIRD QUARTER RESULTS
CorusEntertainmentInc. (TSX: CJR.B) announced its third quarter financial results today.
Türkiye vs United States Highlights
Check out the full game highlights between Türkiye and United States in the 2026 FIFA World Cup™. Announced by John Strong and Stu Holden.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Misericordia University Students Earn Top Honors at Pennsylvania Academy of Science's 101st Annual Meeting
Misericordia University students earned multiple prestigious awards while showcasing undergraduate research at the 101st Annual Meeting of the Pennsylvania Academy of Science (PAS), held this year on the Misericordia University campus—the first time the statewide scientific organization has hosted its annual conference at the university.
TikTok and YouTube are reinventing sports viewership. Broadcasters are taking note
Leagues, teams and media networks are increasingly meeting younger fans on social media as platforms like TikTok, Roblox and YouTube capture most of their time.
Louisville pediatrician, nurse also federally charged in 'healthcare fraud takedown'
More Louisville health professionals have been criminally charged as a part of a federal healthcare fraud crackdown.
Creators are rethinking the exit
Founders like Clea Shearer, Hoda Kotb and Mel Robbins are prioritizing control.
Grades for every NBA Draft pick; why Brendan Sorsby cannot play in NFL this season
NBA Draft grades,Brendan Sorsby denied for NFL supplemental draft
What an abandoned heart failure trial says about 'breakthrough' devices that don’t reach patients
An abandoned heart-failure trial offers a rare window into devices that the FDA deems "breakthrough" but never reach patients.
Highland Park business faces eviction after private equity buys their building
A Highland Park small business owner faces eviction after a real estate investment company bought her building last month.
Bills legend Jim Kelly reveals he suffered stroke this spring
A Hall of Fame quarterback revealed he dealt with a health scare recently.