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Michael Carrick Handed Fitness Boost As Lisandro Martínez Verdict Made
Matthijs de Ligt’s timely return from injury and a crucial international breather for Lisandro Martinez provide a vital defensive lifeline for Michael Carrick’s struggling backline.
Students Use Forensic Science Skills in Escape Room
Hundreds of students from across the region put their problem-solving skills to the test this week during the Regional Science Consortium’s annual Forensic Science Escape Room. Elementary school students had just a few hours to figure out how someone died as part of a forensic science escape room activity. The Regional Science Consortium partnered with Mercyhurst University for the 10th year of the event, which is taking place at the Tom Ridge Environmental Center. It began Monday and runs through Thursday.Throughout the week, more than 250 students are working to solve murder mysteries using real forensic science techniques. Students must analyze the evidence, piece together clues and solve the crime before time runs out.Organizers said the event gives students interested in pursuing forensic science in college a firsthand look at what a career in the field could entail.Sarah Skelton, Special Gifts Coordinator at Iroquois, said the activity provides students with an opportunity to develop skills that can sometimes be difficult to practice in a traditional classroom. "It really helps them to work in teams and on critical thinking skills. Which, not that they don't get these opportunities, but it's hard sometimes in the classroom to develop those higher-level thinking skills”, said Skelton.Students also get a chance to learn how forensic science is used in real-life investigations. As Skelton explained, "What are the real-life applications? What would you actually see in a crime scene? How would you handle these types of forensic investigations? So it's really cool our kids get to see what opportunities are out there and possibly a career field one day."The popular event has grown over the years, with some students returning year after year. Organizers said watching those students grow and develop their interests is one of the highlights of the program.Jeanette Schnars, the Executive Director of the Regional Science Consortium said it's rewarding to see how students' interests evolve as they get older. According to Schnars, "How they have grown and matured and where their interests are going and maybe they aren't going into forensics, but if they are going into sciences or different disciplines, so it's really fulfilling to see how they have matured."One student who continues to enjoy the event is sixth-grader Mia Harvey of Iroquois. Harvey hopes to pursue a career in medicine and says the forensic science activities are helping her explore her interests, "One day I want to become a neurologist, and learning about the bones is probably going to help me."Harvey said her favorite part of the event is the real-life application of what she's learning. "While you are trying to find the clues, they teach real stuff that you would need to know”, said Harvey.Event organizers said if students are learning while having fun, then the program is accomplishing its goal. "Not only are they learning the science, but they are having fun with it too”, said Schnars.Adults will also have a chance to take part in the experience this Saturday during an adult version of the escape room, which will feature food, drinks and entertainment. For more information, click here.The Forensic Science Escape Room has become one of the Regional Science Consortium’s most popular events, with teachers signing up their students as soon as registration opens in August.
Brazil: Lessons from a Disaster
By Antonio Martins (Outras Palavras) Defeats become deeper and more prolonged when we misunderstand what caused them, avoid correcting course, and embrace “solutions” that only compound our mistakes. Lula’s government and the Brazilian left suffered a disaster in Sunday’s election. Contrary to every poll, the president finished the first round 2.2 million votes behind Flávio Bolsonaro—and, more significantly, 3.4 million votes below his total four years ago, when the machinery of the state was working against him and in favor of his opponent. His vote share declined in 98 percent of Brazil’s municipalities. The PL, the main party of the far right, elected 121 deputies and 28 senators, becoming the largest caucus in both houses of Congress. The parties aligned with the Centrão—Brazil’s bloc of transactional center-right parties—were somewhat diminished, but will still hold roughly 250 seats in the Chamber of Deputies and 35 in the Senate. That will make it easier to assemble the majorities needed to amend the Constitution or impeach Supreme Federal Court justices. If elected, Flávio Bolsonaro could appoint four members of the Court, substantially altering its internal balance of power. What produced these results? How can the far right be prevented from consolidating them into a prolonged political hegemony? And what is the essential change of direction the left now needs? Explaining the Disaster Across the commercial media and the exuberant chaos of digital platforms, interpretations are multiplying. Some focus on specific episodes: Lula’s absence from the Globo debate, his very close relationship with Alexandre de Moraes, or his emphasis on issues supposedly remote from most people’s everyday concerns, such as rare earth minerals. Among the more systemic interpretations, three seem especially questionable. One argues that the principal defeat was not the left’s, since its congressional representation declined only slightly. The decisive movement captured at the ballot box, according to this view, was a shift within the right itself—from the more moderate and transactional forces of the Centrão toward the more ideological and radicalized forces of the PL and Novo. A second interpretation holds that the nature of electoral and political processes has changed. The material interests and aspirations of society, it argues, no longer play the central role they once did; they have given way to forms of subjective self-identification that the left has yet to understand. And a third concludes that, because of these two developments, we should expect a political winter: a prolonged period in which the far right and the broader right dominate Brazilian political life. There are important elements in all three interpretations. The problem lies in what they deny or leave out: Lula’s third government was a small-bore government. It offered the majorities that elected it neither a clearly better life nor reasons to believe again in politics and its power to transform society. These failures flowed from two fatal accommodations, which I will examine below. As a result, the government suffered a slow but steady erosion of support. And, as has happened in so many Western countries, it gave the far right the opportunity to present itself as anti-system and to benefit from popular frustration and distress. The interpretation that emphasizes the migration of votes from the center-right and traditional right toward the far right has been advanced, among others, by the courageous journalist Leonardo Sakamoto. In his UOL column on Monday, October 5, he highlights the miserable behavior of the traditional conservative parties. Over the past four years, they repeatedly joined forces with the “neo”-fascists, helping to “normalize” them—a criticism that could equally be directed at almost the entire corporate media. Believing they could use the far right as a stepping stone, they instead ended up partly devoured by it. This was especially true in the Senate, where the PL’s gain of 13 senators and Novo’s gain of two came at the expense of the PSD, which lost nine; the MDB, which lost two; the PSDB, which lost two; and the PP, which lost one. Sakamoto’s observation is accurate and necessary, but it leaves uncomfortable questions unanswered. Why did the erosion of the Centrão benefit the far right rather than, for example, producing growth for the left—as has happened so many times before, both in Brazil and elsewhere? The answer is not difficult. Throughout its four years in office, Lula’s third government was almost invariably associated with the Centrão. Here lies its first accommodation: accepting the limits imposed by conservative institutions; avoiding, as much as possible, any attempt to strain those limits through popular pressure; and believing only in the modest changes that could be squeezed through openings in Congress. The failure of the campaign to end the six-day workweek is emblematic. Lula could have electrified the presidential race by pairing it with a popular campaign for passage of the measure. Instead, he chose to place his hopes in the hands of Senate president Rodrigo Alcolumbre. He generated no mass mobilization, did not force his opponents onto an uncomfortable defensive, and won no victory. In September 2025, the government squandered the greatest of its many opportunities to shake up conservative power in Congress. Popular opposition to the so-called Shielding Amendment—which, if approved, would have restricted criminal proceedings against members of Congress—brought crowds into the streets, mobilized primarily by artists and social movements. This opened the possibility for a broader political education: a campaign that could begin exposing the limits and dysfunctions of Brazil’s political system while putting Bolsonaro’s movement on the defensive for its predictable support of political privilege. The amendment was defeated. But the executive branch then backed away from the fight. It remained associated with an institutional world widely seen as corrupt, elitist, and indifferent to ordinary people’s struggles. In doing so, it forfeited its credibility as a vehicle for the protest vote. On Sunday, it reaped the bitter fruits. Are We Doomed? Taking a different approach from Sakamoto, the philosopher Moysés Pinto Neto and other writers have drawn attention, in their first analyses of October 4, to the fragmentation of the public sphere produced by Big Tech platforms. Through their algorithms, these platforms present each person with a different view of social reality. As a consequence, it becomes much harder to identify common material problems and demands—for example, the fight for labor rights or for a properly funded public health system. Voters no longer embrace such demands, these authors argue, because they no longer see themselves as part of a collective. Instead, they tend to value the identities assigned to them by neoliberal subjectivity—the role of the entrepreneur, for example. On this interpretation, the left’s possible error lies in clinging to outdated illusions. Moysés’s warning is highly relevant and resonates with arguments such as Naomi Klein and Astra Taylor’s “Apocalyptic Fascism and the Billionaires’ Bet.” Unlike a century ago, the far right no longer promises a radiant future. It concentrates instead on resentment—especially that of young men. “They belong to a generation that fears it may never own a home, but compensates with the pleasure it gets from constantly provoking progressives online. Convinced their future has been stolen, they share memes romanticizing historical authoritarian regimes,” the authors write. But Moysés seems to confuse this danger with inevitability. He fails to see that the left’s answer cannot be adaptation. On the contrary, it must strengthen the possibility of politics as collective action. Nor does he recognize that precisely such a reversal is already becoming possible in some of the most promising mobilizations of the twenty-first century: the election, at the end of 2025, of the young Muslim Zohran Mamdani as mayor of New York, on a platform centered on the intensely material fight for an affordable city; the Left Party’s victory in Berlin two weeks ago, built around the demand to expropriate private real-estate corporations; and the very recent wave of demonstrations in Spain—including an occupation of Madrid’s Puerta del Sol—in which tens of thousands of young people mobilized by the Tenants’ Union have demanded limits on rents. By putting itself in the straitjacket of the “fiscal framework” in the first months of 2022, Lula’s third government adopted the second fatal accommodation of its term. Faced with conservative institutions and a country devastated by four years of Bolsonaro, increased public investment was the government’s remaining weapon for offering a more dignified life to the majority and forging an anti-conservative pact with them. The same state that disburses 1 trillion reais a year to enrich a small class of rentiers could instead spend money to extend the Family Health Strategy to every Brazilian, at a cost of 30 billion reais; provide full-day public schooling and childcare to all adolescents and children—and, especially, relief to their mothers; achieve universal sanitation while cleaning up polluted urban rivers; multiply metro systems; begin transforming the urban peripheries; and undertake many other urgently needed projects. In April 2023, an article in Outras Palavras warned that the fiscal framework could “shrink the Lula government and preserve the forces that condemn the country to inequality and regression.” A year later, another article showed that restraints on public spending were strangling policies vital to ordinary people and undermining the president’s popularity. In November 2024 came a reality check, in the form of the government’s humiliating defeat in the municipal elections. Even then, the fiscal lock was neither removed nor loosened. On the contrary: throughout the government’s four years, fiscal restraint remained central to its political narrative. The administration proudly proclaimed that it had “put the state’s accounts in order,” without grasping either how misleading that phrase was—given the payment of 1 trillion reais in interest—or how badly the message was hurting it politically. Lula finally woke up in September 2026. The increase in Bolsa Família benefits, after four years of being frozen; the announcement that anti-obesity drugs would be offered through Brazil’s public health system; and the ban on online betting showed that the state has the power to act decisively on behalf of the majority when those in government are willing to confront obstacles. The huge marches that closed the campaign in Fortaleza, Salvador, Rio de Janeiro, and São Paulo on the eve of October 4 showed how such initiatives can mobilize activists and the broader public. But it was too late—and too little to change the outcome of the first round. History has not ended The possibility of a turnaround in the three weeks leading up to November 25 cannot be ruled out. It will not be simple or easy. Lula must not only make up a deficit of 2.2 million votes; he must also offset the movement of voters who backed other right-wing candidates in the first round, most of whom are likely to move toward Flávio Bolsonaro. Pulling that off will require a broad, grassroots effort to win over voters, potentially reinforced by new initiatives from Lula. The coming hours and days will be decisive. If Bolsonaro’s movement also wins the presidency, the result will create a high-risk situation for Brazilian sovereignty and democracy. The enormous challenges posed by such an outcome would require the left to reexamine, in depth and with a genuine willingness to engage in self-criticism, its political projects—or its lack of them—and its practices. But would that mean we are condemned to the long winter of far-right hegemony that some analyses are beginning to forecast? It is far too early to say, suggests a recent text by Álvaro García Linera, the thinker who served as vice president of Bolivia under Evo Morales. His central hypothesis is that this political current will prove short-lived. At a moment when the entire world is once again talking about sovereignty and protecting national economies, the far right offers a stale, recolonizing neoliberalism. Its submission to the United States is as blatant and pathetic as Flávio and Eduardo Bolsonaro’s overtures to Donald Trump. Its project amounts to something like every man for himself: greater inequality, capitalism without limits, devastation, and supremacism. Will it work? In the United States, just two years into his second term, Trump himself is reaching record levels of unpopularity and may be on the verge of losing Republican control of both the House and Senate in November. Every new beginning is difficult. Whatever the outcome of the second round, the defeats of October 4 show how profoundly the Brazilian left will have to rethink and rebuild. But just as it would be foolish to underestimate the seriousness of its mistakes, it would be equally foolish to conclude that rebuilding a political project is no longer possible. History has not ended. The times are moving faster than ever. Originally published in Portuguese by Outras Palavras. English translation by Eric Blanc; I’ve added the subtitles. More We can’t stop the far right at home or abroad without a revitalized labor movement, which is yet another reason why you should become a sustaining supporter of the Emergency Workplace Organizing Committee (EWOC) — one of US labor’s pivotal bright spots. Relatedly, Jacobin published a short piece of mine reflecting on a decade of Bernie Sanders inspiring a whole new generation of young worker organizers.
Matt LaFleur Puts Packers on Notice After Week 4 Turnovers
Following a sloppy victory over the Tampa Bay Buccaneers, the Green Bay Packers' head coach threatened to bench players who fumble the football.
Who Should Bucks Look to Trade: Myles Turner or Kel'El Ware?
Milwaukee has two centers other teams would like, and only one of them fits the new timeline.
Nintendo Switch Sports Resort: I’d Trade Table Tennis for Swordplay, Baseball, or Frisbee, but It’s Still Won Me Over
I’m stunned at how excited I am for Nintendo Switch Sports Resort. I plan to 100% this game, which is not something I would have said two weeks ago. I’m still not entirely thrilled with the sports lineup – I would trade Table Tennis and Volleyball for things like Swordplay, Baseball, or Frisbee – but what is here is shaping up to be really fantastic. Don’t sleep on this one: I think it’s going to be an enormous improvement on Nintendo Switch Sports and a fantastic return to one of my favorite settings in Nintendo history. I’ll see you on Wuhu Island.
'Captaincy ends': Harmanpreet Kaur’s top five achievements as India captain
Harmanpreet Kaur has stepped down as India’s all-format captain after a landmark leadership stint. Her tenure featured India’s maiden ODI World Cup title in 2025, a record number of T20I wins as captain, four Asia Cup triumphs, the milestone of captaining 150 T20Is and a historic Test victory at Lord’s. She now returns to playing cricket.
Hot Sardines will return to Weinberg with vintage jazz
The Hot Sardines, a revivalist jazz band that emerged from Brooklyn’s underground party scene, will bring its reinvigorated take on classic jazz back to the Weinberg Center for the Arts
Purina Institute Brings Nutrition Science to the Global Veterinary Stage at World Small Animal Veterinary Association Congress 2026
Purina Institute will join WSAVA Congress in Poland to help veterinary teams turn trusted nutrition science into practical support for clients and their pets ST. LOUIS, Oct. 6, 2026 /PRNewswire/...
From Promises to Pulse: Parliamentary Power for Women's, Children's and Adolescents' Health
At the 153rd Inter-Parliamentary Union Assembly, PMNCH is calling on parliamentarians to turn commitments into measurable results for women, children and adolescents through stronger laws, protected financing, effective accountability and meaningful participation. The goal is clear: institutions that listen, respond and deliver better health and rights for all.
8 Players Withdraw from ATP Shanghai
Shanghai, the penultimate Masters 1000 of the year has, in recent years, been one of the most unpredictable. Several withdrawals are already contributing to the narrative of the tournament as it’s set to get underway soon. Which Players Have Withdrawn from Shanghai? Jannik Sinner has once again pushed back his return to the court, withdrawing …
On the barricades with wheelie bins and shopping trolleys: Paris students rage at politicians and police
Unprecedented protests that began in low-income banlieue are turning ugly, with investigations under way into police brutality
The Daily Mauling: 10/6/26
Kansas Jayhawks News The LJW has a writeup on what the return of Council means for the men’s basketball team. And it’s not paywalled! The KC Star took a close look at Darryn Peterson’s first NBA experience in this weekend’s preseason game. Should I consider DP content to be KU content? He doesn’t exactly carry […]
Folarin Balogun Speaks Out on Failed Everton Move
Monaco striker Folarin Balogun has spoken out about his failed move to Everton, and whether he could return to the Premier League.
Greg Hinz: Can the brave new world of AI be tamed?
Pritzker’s team says they’re pondering AI legislation when the General Assembly returns in November. But real solutions will require not state but federal, even international action.
Greg Hinz: Can the brave new world of AI be tamed?
Pritzker’s team says they’re pondering AI legislation when the General Assembly returns in November. But real solutions will require not state but federal, even international action.
South Florida man turns passion for healthy food into business of his own
McTominay close to Napoli return after heart procedure
Scott McTominay is on the verge of a return for Napoli after completing his recovery from a heart procedure.According to Corriere dello Sport, the Scotland international will go through his final medi...
Kenya reports first-ever Ebola death
Kenya has reported its first-ever Ebola death, the health minister announced on Tuesday, after a Kenyan man who had been living in the Democratic Republic of Congo died after returning to the country....
Nebraska kids sent out of state when they need serious mental health care
Last year, children received care in such states as Massachusetts, Alabama and Virginia that local facilities either can't or won't provide. For kids, these separations can be jarring, complicating treatment and their return home, experts say.
Kamala Harris has a 2028 opening
The former Democratic standard bearer retains considerable respect in the party, but there’s an undercurrent of anxiety about her return to the political conversation.
Serie A returns: The biggest games after the international break
Serie A resumes after a three-week international break, and Football Italia looks at the biggest matches coming up in Italy’s top flight.Three teams lead the Serie A table: Inter, Roma and Lazio are...
Countdown now on to proper football returning
When the final whistle blew on the Premier League match at Craven Cottage on Sunday 20 September, we new it was going to be tough, but this tough??? Yes, this absolutely ridiculous three week break for largely meaningless internationals, so many pointless friendlies (including the Nations League nonsense). The Premier League had only kicked off four weeks earlier and then a break of three weeks so early in the season… Please let it make sense.
De Roon to start alongside Kone vs Como
Roma returns to training today ahead of the trip to Como, scheduled for Sunday at 12:30. Gian Piero Gasperini will gradually reunite all the players who have been on international duty in recent weeks...
The Canada Super60 turned cricket into a joke. It does the sport no favours
Absurdly short boundaries, a six every other ball - what we saw in Vancouver was just not cricket
FBI Director Kash Patel and country singer Alexis Wilkins are engaged
FBI Director Kash Patel and country singer Alexis Wilkins, who is also an ambassador for Turning Point U.S.A., announced their engagement on Instagram after dating since 2023.
Trump says Super Pac will pay for taxpayer-funded ads that sparked outcry
President’s U-turn comes after Democrats and Republicans condemned use of tax dollars for pro-Trump ads
Drew Petzing Failed the Lions When They Needed Him Most
The Lions’ defense was awful, but Detroit’s offense deserves plenty of blame, too. Missed opportunities, costly penalties and questionable play-calling turned a winnable game into a brutal loss.
Chiefs' Wide Receiver Tyquan Thornton's Recovery Timeline Revealed
In this past Sunday's win against the Las Vegas Raiders, Kansas City Chiefs wide receiver Tyquan Thornton suffered a gruesome leg injury. His timetable for return has finally been revealed.
This Weekend in Gators Sports: Tennis Wins Big, Swim and Dive Stays Perfect
Florida swimming and diving and men’s tennis posted strong results on the road over the weekend. Gators men’s tennis returned to Gainesville stamping 15 wins on the weekend at the three-day Bedford Cup hosted by UCF, while Florida men’s and women’s swim and dive remained undefeated against Kentucky 31-0 all time. Men’s Tennis: Doubles Title […]
Science Must Move Faster Than Social Media
I have bought produce, cooked it, sold it, specified it, promoted it, walked fields with growers, stood in packing houses, worked with distributors and watched chefs turn raw ingredients into something people want to eat.
Local teen turns Native beading skills into business at Pueblo Collective
A 13-year-old beading artist has turned a summer program skill into a business selling earrings, bracelets and dream catchers.
Lane Johnson update: Eagles have no timetable for his return
Nick Sirianni had no update on Lane Johnson, leaving the Eagles tackle’s status uncertain before their Week 5 trip to London
City Council takes on debate over catastrophic risks of AI
AI whistleblowers and executives at top AI labs took turns testifying.
Carson Daly returning for huge “TRL” reunion special with surprises in store — and it’s not for MTV (exclusive)
EW has exclusively learned that Daly will return to reunite with major “TRL” personalities and music stars in the original Times Square studio.
Carson Daly returning for ‘TRL’ reunion special — but it’s not on MTV (exclusive)
Carson Daly will return for a ‘TRL’ reunion special recorded at the MTV Times Square studio where ‘Total Request Live’ used to air. Major surprises are in store for the Roku special.
Orlando Science Center returns with themed laser shows on Oct. 10
Orlando Science Center returns with Cosmic Concerts on Oct. 10, featuring laser tributes to Led Zeppelin and Elton John.
Lions Get Potentially Huge Brian Branch News
Lions coach Dan Campbell is hopeful Brian Branch will return to practice this week, but that doesn't guarantee he'll play against Arizona.
Heritage festival returns to Page County this weekend
Page County’s 57th annual Heritage Festival will return this Saturday.
Pittsburgh Oktoberfest returns with food, music and Ferris wheel
Pittsburgh's annual Oktoberfest celebration has officially kicked off with German-inspired food, drinks and entertainment in the heart of downtown Pittsburgh through Oct. 11.
Pittsburgh Oktoberfest returns with food, music and Ferris wheel
Pittsburgh's annual Oktoberfest celebration has officially kicked off with German-inspired food, drinks and entertainment in the heart of downtown Pittsburgh through Oct. 11.
Dr. Egnor: The “Platonic Turn” in Science
There is a “disconnect” between a physical organ of the body — the brain — and the “immortal mind,” the human spirit, that transcends it.
Eagles address uncertainty surrounding missing star
Will Eagles star return? Team is keeping quiet.
Panthers RB expected to return after Week 5 bye
The Panthers are expecting the return of one of their injured RBs after the bye.
How Close Jeffery Simmons Thinks Titans Are to Winning Football
Despite an 0-4 start, the star defensive tackle insists Tennessee is on the brink of a breakthrough if they can finally master the art of forcing turnovers.
Darko Rajakovic Reveals What’s Behind Kawhi Leonard’s Delayed Raptors Return
Toronto prioritizes long-term health over preseason minutes as the superstar ramps up his reconditioning process.
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.
City panel advances $260M settlement in wrongful-conviction cases tied to disgraced cop
The city's law department has turned to mass settlements to resolve cases sooner, resulting in significant savings if the lawsuits reach trial.
CSUN in D.C. Internship Expands Student’s Public Health Career Aspirations
For Josiah Morrow, a three-month internship in Washington, D.C., turned the nation’s capital into a classroom — and helped shape his future in healthcare.
Bladen Community College to host “So You Want to Start a Small Business” class and preview Pitch It Bladen 2027
The Small Business Center at Bladen Community College invites aspiring entrepreneurs to attend “So You Want to Start a Small Business” on Tuesday, Oct. 13, 2026, from 6:00 p.m. to 8:00 p.m. in Building 14, Room 104. This class will help participants explore what it takes to become an entrepreneur and take the first steps toward turning a business idea into reality.Participants will explore the entrepreneurial mindset and consider whether they have the interests, characteristics, motivation and willingness to take on the challenges of business ownership. The class will encourage attendees to examine their personal goals, expectations, strengths and readiness to pursue entrepreneurship.Attendees will also gain insight into the realities of starting and operating a small business, including the commitment, planning, decision-making and perseverance required to build a successful venture. Whether participants are just beginning to consider business ownership or already have an idea they want to pursue, this class will provide a foundation for determining their next steps.In addition to the class instruction, attendees will receive advance information about the upcoming Pitch It Bladen 2027 Business Competition, including the application form and details about the program. Individuals who are ready to move forward may submit their applications early and have the opportunity to receive advance acceptance into the program.Pitch It Bladen helps aspiring and emerging entrepreneurs develop their business ideas through structured instruction in business planning, financial management, cash-flow projections, marketing and operations. Participants work toward completing a business plan and preparing a business pitch, with the opportunity to compete for cash prizes.Last year's Pitch It Bladen program demonstrated the value of investing in local entrepreneurs by helping participants strengthen their business knowledge, develop their business plans and prepare to present their ideas. The competition showcased the creativity and potential of Bladen County's small-business community and provided participants with practical tools to move their business goals forward.Building on that success, Pitch It Bladen 2027 will provide another opportunity for local entrepreneurs to gain knowledge, build confidence and take meaningful steps toward launching or growing a business.“The Small Business Center wants to help individuals make informed decisions about entrepreneurship before they take the leap into business ownership,” said Theresa Dennison, Small Business Center director, in a press release. “This class gives participants an opportunity to evaluate whether entrepreneurship is right for them while also introducing them to Pitch It Bladen 2027 and the resources available to help them succeed.”Registration: Visit www.ncsbc.net and search for the class by name, or contact the Small Business Center at 910-879-5572 for additional information.
Ana Navarro addresses Rosie O’Donnell’s potential return to “The View” (exclusive)
O’Donnell previously said that she’d return for season 30, while EW later confirmed a formal ask hadn’t gone out at the time.
Ohio Democrats’ path to governor’s office runs through rural areas that have turned against party
Democrats say their nominee for governor in Ohio, Dr. Amy Acton, represents the party’s best chance in years to win that office.
The Resurrection of Gio Reyna
Once a promising prodigy, 23-year-old Gio Reyna has turned a turbulent USMNT career marked by controversy into an opportunity for mentorship. No player has benefited more from the start of the 2030 cy...
Tottenham’s International Returns For Manchester United Preparations
Tottenham’s internationals return in stages before Manchester United, leaving Roberto De Zerbi to balance training, travel and recovery at Hotspur Way.
Five Plays: NC State First Quarter
Louisville lost another football game on Saturday. They also lost another game that they should have won. Penalties had been a major issue for this team, but they replaced that issue with turnovers this time around. But the biggest issue remains, and that issue is blown coverages by the secondary. For the second straight week, […]
Supreme Court kicks off new term with major climate case
The Supreme Court returns for its new term on Monday, and oral arguments in a major case over the fate of a costly climate change lawsuit brought by Boulder County, Colorado, will kick off a term set to feature several blockbuster legal battles. Suncor Energy v. County Commissioners of Boulder County will decide whether a […]
Jordyn Tyson not close to returning
Saints WR Jordyn Tyson recovering but still weeks away from playing
Carnell Tate Not Letting First-Half Blunder Ruin Historic Day
The rookie receiver overcame a costly turnover to deliver a dominant 145-yard performance, signaling a new era of offensive consistency for Tennessee despite a narrow loss.
Team Dresch, pioneering WA punk rock band, returns with ‘Furthermore’
Team Dresch are finally putting out their third album, “Furthermore,” the long-awaited follow-up to 1996’s “Captain My Captain.”
Banijay Entertainment Unites US Operations With Banijay America Following All3Media Merger
Ben Samek will serve as the CEO of this division, which will now house Turnkey Studio Services
Banijay Entertainment Unites US Operations With Banijay America Following All3Media Merger
Ben Samek will serve as the CEO of this division, which will now house Turnkey Studio Services
Did Jaguars' Pass Rush Turn a Corner in Sunday's Victory?
The Jacksonville Jaguars had their most productive pass-rushing game of the season in Sunday's victory, with the EDGE pair of Josh Hines-Allen and Travon Walker leading the way.
Sporting KC Weekly Schedule: Oct. 7-10, 2026
Sporting Kansas City returns home to host the Portland Timbers at 7:30 p.m. CT on Saturday at Sporting Park as the club celebrates National Hispanic Heritage Month. Tickets are available on SeatGeek, including a special Latino Heritage Night ticket pack featuring an exclusive luchador mask/hat and a Corona or Coca-Cola
Holiday magic returns with sugar sparkle at holiday event
Holiday magic is getting a storybook twist when Quantum House brings back Sugar Plum Dreams.
AZ-ALBERTSONS
Returning for her third year, actress, director and mom Haylie Duff will host a special cooking demo from 1:15 p.m. to 2 p.m.
Celebrity birthdays for the week of Oct. 11-17 include Cardi B and Dominic West
Celebrities having birthdays during the week of Oct. 11-17 include rapper Cardi B, “The X-Files” creator Chris Carter and “The Wire” actor Dominic West. Rapper Eminem turns 54, singer Sammy...
Here's What Capcom Said About Using Generative AI In The RE Engine: 'AI Is Not A Replacement For Humans'
Capcom want to evolve RE Engine into an engine for the AI generation, but not turn it into an engine powered by generative AI over humans
Todd Promenade returns on Saturday, Nov. 7
TODD — The Todd CommUnity Dance organizers are pleased to announce the second Todd Promenade event, featuring an afternoon of square dance calling, flatfoot dance, and playing music for dances
50th annual Arkansas Rice Festival slated
It was 1976 and the United States was turning 200 years old. Festivities were planned in nearly every city and town across the country and one of the celebrations was...
Scientists Created a Computer Inside a Water Drop Using Billions of DNA Molecules and It Worked
You won’t believe it, but DNA molecules can turn even a tiny drop of water into a computer.
Answering Your Questions as Padres Near Disastrous End to Season
The San Diego Padres are inches away from total collapse, digging themselves into an 0-2 hole against the Milwaukee Brewers. They'll now turn home to a raucous Petco Park crowd with the hopes that they can stave off execution. The postseason allows for some insane turns of fortune. Could the Friars be the next recipient …
Michael Douglas on 'immortality,' Kirk Douglas and the memories he once avoided
Michael Douglas, the award-winning actor and producer, recently turned 82 and has released a memoir titled “One Helluva Ride.” | 830 WCCO
Michael Douglas on 'immortality,' Kirk Douglas and the memories he once avoided
Michael Douglas, the award-winning actor and producer, recently turned 82 and has released a memoir titled “One Helluva Ride.” | WWJ Newsradio 950
DeSean Bishop Is the X-Factor Arkansas Must Contain
Arkansas knows exactly where Tennessee’s offensive plan begins. It begins with DeSean Bishop. The Volunteers running back enters Fayetteville after one of the best performances in the country this season. Bishop rushed 34 times for 220 yards and three touchdowns in Tennessee’s 24-14 win over Auburn, turning a game with quarterback uncertainty into a statement …
Why your health insurance problem might not be over when you turn 65
Couples with an age gap have an extra consideration: How to continue coverage for the younger spouse who’s not yet eligible for Medicare.
Bruno Guimaraes Details Heavy Brazil Workload Ahead of Arsenal Return
Bruno Guimaraes has revealed the amount of travelling Brazil faced during a demanding international window before his return to Arsenal.
'Chicago Fire' Season 15 cast – Who's back, exiting amid premiere
Prepare to see some changes when "Chicago Fire" returns this week. The NBC series will see multiple exits amid its 15th season, set to premiere Oct. 7.
Cambridge and London Life Sciences Showcase returns during JPM Healthcare Week 2027
o2h co-discovery has announced that the Cambridge × London Life Sciences Showcase will return for its second edition during J.P. Morgan Healthcare Week 2027 in San Francisco.
Ohio Democrats’ path to the governor’s office runs through rural areas that had turned against them
Democrats say their nominee for governor in Ohio, Dr. Amy Acton, represents the party’s best chance in years to win that office.
Ohio Democrats’ path to the governor’s office runs through rural areas that had turned against them
Democrats say their nominee for governor in Ohio, Dr. Amy Acton, represents the party’s best chance in years to win that office.
KUNC's 2026 midterm election voter guide for Northern Colorado
Everything Northern Colorado voters need to know about the state’s midterm election, including major races, ballot measures, voting deadlines, how to return your ballot, and where to find trusted election resources.
'There's not a better time to turn pro'
Commonwealth Games silver medallist Connor Williams feels there is no better time to fulfil his lifelong ambition to be a professional boxer.
Millions return to The Witcher 3 as the Remastered game records another Steam personal best and sales skyrocket
CD Projekt Red's overhaul of The Witcher 3 is pulling players back in their millions, while also attracting plenty of new ones.
Orioles news: How will the O’s solve their infield logjam?
With Jordan Westburg returning next year, how will the O’s make room in the infield for him?
Morrell to join Portsmouth's coaching staff
Ex-Portsmouth and Wales midfielder Joe Morrell will be returning to his former club as a coach, joining John Mousinho's backroom staff.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
We're witnessing a critical moment for Amazon Kindles
Amazon is finally listening to Kindle fans, bringing back physical buttons and adding fresh accessories. But, there's a catch.
BagelUp Growth Lab Returns as Business Incubator for Emerging Bagel Entrepreneurs, Launching a Year-Round Partner Program
Great bagels may start with flour, water, yeast and skill, but building a successful bagel business takes much more. On Saturday, November 14th, 2026, BagelUp (which produces New York BagelFest) will present the second annual BagelUp Growth Lab, a business incubator designed to help promising bagel entrepreneurs gain the knowledge, connections and industry resources needed to turn their bagel concepts into sustainable businesses. Taking place at Loft 39 the day before New York BagelFest at Citi
From floating saunas to clinical trials: How heat might help mental health
Many people are turning to sauna because of its benefits for their mental health. While scientists have a decent understanding of how sauna — and other forms of heat exposure — exercises our cardiovascular system, they know relatively little about its impact on depression, anxiety and mood. But more studies are being done to understand this connection and why heat appears to act as a powerful antidepressant. NPR's Will Stone visits a "floating sauna village" in Oslo where a husband-wife team are conducting one of the first trials on the link between sauna and mental health — and talks to one of the leading researchers in the U.S about her efforts to study this. Morning Edition consumer health segment for October 5
Kathleen Turner Has An Iconic Response As Michael Douglas Admits To Past Affair
“What a fuss...”
Pape Gueye describes situation of former club Marseille as ‘sad’
Pape Gueye (27) has described the situation at his former club, Olympique de Marseille, as “sad”. The Villarreal midfielder returned to the Vélodrome on Sunday.Gueye featured in Senegal’s 1-0 w...
3 veteran quarterbacks Commanders could pursue after Marcus Mariota's injury
Even if Jayden Daniels returns next week, the Commanders could need another veteran, especially if Marcus Mariota is out for a while.
Soil Science and Sea Turtles: A UToledo Senior’s Case for Hands-On Learning
From clay soil to leatherback sea turtles, environmental science senior Rosalie Cufr is turning lab, field and international experience into a path toward sustainable agriculture.
'After the holidays' has arrived: The expert's recommendations for a proper return to routine
The holiday period has ended. Dr. Sigal Mazor, director of the Department of Health Education and Promotion at Clalit, provides a series of recommendations on returning to routine.
French services sector returned to growth for first time since December, PMI shows
France's dominant services sector grew in September for the first time since the end of last year, helped by a rebound in output after businesses had been impacted in August by an intense summer heatwave, a business survey showed on Monday.