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Excessive Overtime At UConn Health Center Flagged In Audit
Auditors noted that it is best practice to schedule employees in a manner that reduces unnecessary overtime costs, when possible, but that UConn Health incurred significant overtime costs due to lack of staff and many unfilled positions.
Virginia climbs back to No. 3 in CNBC’s top states for business rankings
Virginia has climbed a spot in CNBC's annual ranking of the best states for business, a year after federal job cuts helped knock it out of the No. 1 position. The state placed third in the 2026 rankings released today (Thursday), up from fourth last year. Ohio took the top spot for the first time,
EA SPORTS™ College Football 27 Launches Worldwide, Bringing New Era of College Football to Life
Do it For U with 138 Ways to Play in Dynasty Mode, Experience NIL and Build Your Legacy In Road to Glory Electronic Arts Inc. (NASDAQ: EA) today launched EA SPORTS™ College Football 27 worldwide on PlayStation®5, Xbox Series X|S and, for the first time ever, PC and mobile. Following the record-breaking return of the franchise, College Football 27 raises the bar once again, delivering the most authentic college football experience yet. College Football 27 captures real world elements that impact gameday like never before. College Football 27 is the definitive modern college football experience. Every major change happening in the sport — from NIL and coaching movement to recruiting, player development and game day — is now reflected in the game at unprecedented scale. Built around the current college football landscape, College Football 27 introduces the biggest changes to Dynasty Mode since the game's introduction, including all-new dynamic weather, expanded Road to Glory positions
Caesars Entertainment and MGM Resorts deals display positive outlook for Las Vegas
While a change in ownership can be a scary proposition for workers, neither of the Caesars or MGM transactions, should they be finalized, are expected to bring significant job losses in Southern Nevada.
Anchorage behavioral health center funding approved despite Fairview representatives’ opposition
The $750,000 federal funding award follows two months of public discourse.
Carville blasts Dems amid Platner scandal, warning they ignored a classic rule of politics and paid the price
James Carville blasted Maine Democrats for failing to vet Platner, saying opposition research on your own candidate is the most important step.
Carbon capture continues to expand globally despite mounting opposition
Carbon capture continues to expand globally despite mounting opposition Global energy and research consulting firm Wood Mackenzie reports that carbon capture, utilization and storage, or CCUS, is expected to expand significantly, with global capacity projected to grow from roughly 91 million metric tons per year today to about 3 billion metric tons annually by 2060, […]
Trump's support for Venezuela opposition head Machado wanes
Venezuelan opposition leader and Nobel Peace laureate María Corina Machado says she wants to return to her earthquake-ravaged homeland. Yet neither Venezuela's government nor the United States thinks that's a good idea.
Over 220,000 People Petition Sony Not To Kill Physical PlayStation Game Discs
Canadian retailer PNP Games has started the Don't Kill the Disc position to change Sony's mind.
Venezuelan aftershocks: How the quakes made political change more urgent
Venezuela’s earthquakes have created a new test for its political opposition and movement leader María Corina Machado.
Jack Sawyer’s Breakout Potential Could Create Steelers Edge Rusher Logjam
If there is one position where the Pittsburgh Steelers are deep, it is on the edge. The group is headlined by the tremendous duo of Alex Highsmith and T.J. Watt. One pleasant surprise last season was fourth-round rookie Jack Sawyer out of Ohio State.
Fathom Entertainment Names Jason Brenek New CEO Following Retirement of Ray Nutt
Fathom Entertainment July 8 announced the appointment of Jason Brenek as its new CEO following the previously announced retirement of Ray Nutt. Brenek assumes the position as the company continues its transition from Fathom Events into Fathom Entertainment, a specialty theatrical distributor with major motion picture distribution capabilities. The company’s upcoming theatrical release of Wildwood, … Continue reading "Fathom Entertainment Names Jason Brenek New CEO Following Retirement of Ray Nutt"
Colts training camp battles: Evaluating competitions at safety position
With training camp nearing, we will be taking a closer look at each of the Colts positional battles. Next up is the safety position.
Onondaga County passes new bill on term limits for county executive, comptroller
The bill that passed would establish three four-year terms for the two political positions, maxing out service at 12 years.
Yankees' Austin Wells problem needs immediate fix at trade deadline
The Yankees need to make a move at the catcher's position.
2026 World Cup Odds: Books In 'Strong Position' Following USA Elimination
The fairy tale is over for the USA, putting books in a strong position when it comes to World Cup futures. Patrick Everson breaks it down.
Five Science Fiction Versions of The Odyssey
The Odyssey by the poet Homer is one of the jewels in the crown of Greek culture. It has, in the thousands of years since its composition, also become a cornerstone of world literature and, hence, has found its way into speculative subgenres great and small. For this is a story of gods and monsters, […]
As Israel becomes Democratic litmus test, Jewish progressives warn about a tilt into antisemitism
For many liberals, longtime policy priorities like universal healthcare or stopping climate change are now intertwined with opposing Israel. An ascendant faction of the left argues there’s no such thing anymore as “progressive except for Palestine” — a phrase that took off in the years following Hamas’ October 7, 2023, attack and the ensuing war in Gaza — and sees opposition to Israel as a Democratic litmus test.
Cosplaying Free Speech: How Religion And Politics Determine Campus Taboos
(ANALYSIS) I feel like I got into a debate or a disagreement with someone about politics or religion on a near daily basis when I was between the ages of 13 and 25. I would fight with anyone about anything and I would often argue positions that I completely disagreed with because I just liked the in
Why women should be at the helm of health emergency leadership
Women comprise 70% of the health workforce but hold only 25% of emergency leadership positions.
4 Cowboys’ position groups that need answers to questions
Which positions on the Cowboys roster have the biggest questions in your mind?
Tennessee Titans projected starters ranked near bottom of NFL
ESPN analysts rank the Tennessee Titans 28th, citing concerns about the team's safety position and depth.
Fincantieri Acquires Four Companies to Expand Underwater Drone Business
Fincantieri announces the agreement for the acquisition of Next Geosolutions, WSense, Graal Tech and Defcomm. These four strategic transactions in the Underwater segment significantly enhance the Group’s positioning in a domain that is becoming increasingly central to security, energy and the development of critical infrastructure.
Could Santos help solve Man Utd's midfield malaise?
Chelsea's Andrey Santos is the latest player Manchester United have taken an interest in as they look to address their problem midfield position. With Casemiro leaving after his contract expired on 30 June and Manuel Ugarte expected to be sold, United went into the summer with England's Kobbie Mainoo as their only recognised central midfielder and with the stated aim of addressing the situation as a matter of priority. In the transfer market, United have encountered more issues.
Flutter Entertainment PLC $FLUT Shares Acquired by Fjarde AP Fonden Fourth Swedish National Pension Fund
Fjarde AP Fonden Fourth Swedish National Pension Fund raised its position in Flutter Entertainment PLC (NYSE:FLUT - Free Report) by 53.3% in the 1st quarter, according to the company in its most recent 13F filing with the Securities and Exchange Commission (SEC). The institutional investor owned 6
Live Nation Entertainment, Inc. $LYV Position Raised by Fjarde AP Fonden Fourth Swedish National Pension Fund
Fjarde AP Fonden Fourth Swedish National Pension Fund grew its holdings in shares of Live Nation Entertainment, Inc. (NYSE:LYV - Free Report) by 85.5% during the first quarter, according to the company in its most recent Form 13F filing with the Securities and Exchange Commission. The fund owned 50
Buccaneers Off-Season Position Review: Running Back
How will the Buccaneers’ backfield shake out in 2026?
Shore Regional Health Cancer Center adds community outreach coordinator
EASTON — The Cancer Center at University of Maryland Shore Regional Health recently welcomed Catalina Billings as coordinator of community outreach, a new position designed to provide up-to-date cancer information
Pete Crow-Armstrong, Cubs’ All-Star, is the straw that stirs the drink at Wrigley Field
Crow-Armstrong's MVP-caliber play has helped keep the Cubs (49-40) in a playoff position during a season littered with pitching injuries.
FULL SHOW: Inside INdiana Business 7/5/26
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Y Intercept Hong Kong Ltd Boosts Position in Flutter Entertainment PLC $FLUT
Y Intercept Hong Kong Ltd grew its stake in shares of Flutter Entertainment PLC (NYSE:FLUT - Free Report) by 121.8% during the 1st quarter, according to the company in its most recent disclosure with the Securities & Exchange Commission. The firm owned 62,572 shares of the company's stock after
Lee Danner & Bass Inc. Buys New Shares in Six Flags Entertainment Corporation $FUN
Lee Danner & Bass Inc. bought a new position in shares of Six Flags Entertainment Corporation (NYSE:FUN - Free Report) during the first quarter, according to its most recent Form 13F filing with the Securities & Exchange Commission. The firm bought 117,698 shares of the company's stock, valued
NASA's Vehicle Assembly Building flag was created for a 1976 bicentennial expo
NASA's VAB flag served as a showcase during the 1976 U.S. Bicentennial Exposition on Science and Technology, which was themed "3rd Century America."
British GP Starting Grid | Ferraris look to deny Antonelli victory
Championship leader Kimi Antonelli is set to start the British Grand Prix from pole position, with the two Ferraris hoping to overtake the youngster off the line. Here is the starting grid for today's race at Silverstone.
Large fire erupts at business in Harbor Gateway, filling the air with black smoke
Firefighters moved into defensive positions as the fire burned out of control on Figueroa Street near Rosecrans Avenue and the 110 Freeway.
Bellingham’s Runs Behind: One Of England’s Dangerous Weapons
Thomas Tuchel arrived at the World Cup building his England side upon wide connections. The central midfielders, fullbacks, and wingers coordinate via wide rotations, position exchanges, and channel runs. The idea revolves around generating spaces for crosses and cutbacks. According to Opta, only Canada (82) played more crosses than England (75) until the round of […]
Derek Shelton Addresses Minnesota Twins' Ugly Night Against the Yankees
Minnesota went 1-for-12 with runners in scoring position on Friday, but the bigger picture still looks promising.
Solid Growth Prospects Assert Sphere Entertainment Co. (SPHR) as a Top Stock to Buy According to Ariel Investments
Sphere Entertainment Co. (NYSE:SPHR) is one of the top stocks to buy according to Ariel Investments. On June 18, Benchmark reiterated a Buy rating on Sphere Entertainment (NYSE:SPHR) and raised the price target to $175 from $155. The price target hike comes amid expectations that the company is well positioned to deliver a solid second […]
Vanguard Health Care vs. iShares Biotech: How Do These ETFs Stack Up?
Broad healthcare diversification or concentrated biotech growth? Compare cost, risk, and portfolio composition to find your fit.
New York Jets Flight Connections 07/04/26
Happy Independence Day, Jets fans! Below are your daily Jets links as we celebrate 250 years of our wonderful country. Bent – Jets 2026 Position Breakdown: Can the interior d-line still be a strength with Quinnen Williams gone? NY Jets – Which Young Jets Player Could Be Poised for a Breakthrough Season? Connor Long – […]
U. of C. scientists call for halt to Quantum Shore construction, citing contamination and energy concerns
A group of graduate students, research staff and scientists, many affiliated with the University of Chicago, is joining the opposition to the Illinois Quantum and Microelectronics Park, arguing that their
As Trump commands 250th stage, Democrats offer their vision of patriotism
They want to show opposition to Trump without looking like they’re unwilling to celebrate the United States.
Rams announce death of franchise great LeRoy Irvin
Irvin is one of a handful of players to make All-Pro at multiple positions
Announcement: New Leadership at the NJ Institute for Food, Nutrition, and Health (IFNH)
Announcement by Laura Lawson, SEBS Executive Dean and NJAES Executive Director I am pleased to announce new leadership for the Institute for Food, Nutrition, and Health (IFNH), positioning the institute to further advance Rutgers University’s commitment to excellence in food, nutrition, health, and community engagement. I would like to thank the faculty members whose contributions […]
Oregon Health Authority director Dr. Sejal Hathi resigns
Oregon Health Authority director Dr. Sejal Hathi resigned from her position leading one of the state's largest agencies, effective Aug. 1.
Steam Machine alternative with Ryzen 9 available for under $850
Positioned as an alternative to the Steam Machine, the Aoostar GODY is a compact gaming PC now available outside its domestic Chinese market. The system pairs a powerful AMD processor with a dedicated graphics card.
Vance and Rubio take different approaches as Iran tests their 2028 prospects
Vice President JD Vance and Secretary of State Marco Rubio appear to be staking out differing approaches to carrying out President Donald Trump’s national security agenda as the possible 2028 presidential rivals jostle for position in a divided Republican Party.
Cape Fear Valley Health cuts nearly 200 positions
Cape Fear Valley Health is eliminating approximately 200 positions as it faces declining federal reimbursements and rising healthcare costs.
Uber Shakes Up AI Data Labeling Business, Dismissing Top Leaders
Uber Technologies Inc. has dismissed two tech leaders at its nascent AI data labeling business, shaking up a key division that the ride-hail company has positioned as a key growth driver.
Examining the deepest and thinnest position groups for the 49ers
What would your choices be?
Drake University’s Zimpleman College of Business Earns High Rating for Societal Impact
Drake Achieves Level 4 ‘Transforming School’ Designation in the 2026 Positive Impact Rating Drake University and the Zimpleman College of Business have once again secured their position as a global leader in responsible education, earning the prestigious Level 4 “Transforming School” designation in the 2026 Positive Impact Rating (PIR) for business schools. The Positive Impact...
Conduent Announces Agreement to Sell Its Tolling Business to Quarterhill Inc. for $70 Million
Conduent Announces Agreement to Sell Its Tolling Business to Quarterhill Inc. for $70 Million. Conduent Bolsters Financial Position.
Conduent Announces Agreement to Sell Its Tolling Business to Quarterhill Inc. for $70 Million
FLORHAM PARK, N.J., June 30, 2026--Conduent Announces Agreement to Sell Its Tolling Business to Quarterhill Inc. for $70 Million. Conduent Bolsters Financial Position.
EDITORIAL: Bennet, Hick play politics with the judiciary
Facing spirited challenges from the left — in the final hours of races each thought would be a walk in the park — Colorado’s two Democratic U.S. senators are doing what comes naturally to politicians. Pandering. How else to explain their opposition, reported Sunday, to the pending nomination of respected and rock-solid U.S. District Judge […]
Inside the new space shuttle ‘Endeavour’ exhibit at California Science Center
NBC News’ Gadi Schwartz previews the new exhibit at the California Science Center, where visitors will soon be able to view NASA’s space shuttle Endeavour in its ready-to-launch position.
Rocket Lab expands satellite business with Iridium deal
Yahoo Finance Senior Autos Reporter Pras Subramanian joins Market Domination to discuss Rocket Labs' (RKLB) deal to purchase Iridium Communications (IRDM), how the deal expands its satellite capabilities, and whether it strengthens the company's position against SpaceX (SPCX).
Gene Off Script: Are politicians embracing socialism?
Are politicians embracing socialism? Many candidates running for elected positions are being asked if they renounce socialism.
Mets Player Meter: Position Players, June 15-28
A quick review of how the Mets’ position players fared over the past couple weeks.
Faculty in Politics, Chemistry, Biology and English Appointed to Endowed Professorships | Pomona College in Claremont, California
Four faculty members have been awarded endowed professorship positions. The Pomona College Board of Trustees voted to support these appointments during their meeting in May.
French election politics bring surrogacy back into Europe’s spotlight
The former prime minister's call to legalize surrogacy has drawn opposition from across France's political spectrum, including within his own party, with possible consequences across Europe.
The State of Politics: The Politics of Lt. Governor Position
The governor doesn't pick the lieutenant. And they often don't get along.
Behind the scenes with Jon Ossoff, the 2026 — and maybe 2028
Outside the frame of the viral clips – shot by two cameras carefully positioned on either side of the stage – were over a thousand people, hot under the tin roof of a converted ironworks on Saturday afternoon. They applauded a few times and got one “USA! USA!” chant briefly going, but mostly they sat quietly listening as Georgia Sen. Jon Ossoff spoke.
SG Americas Securities LLC Sells 866,473 Shares of Caesars Entertainment, Inc. $CZR
SG Americas Securities LLC trimmed its position in shares of Caesars Entertainment, Inc. (NASDAQ:CZR - Free Report) by 78.9% during the 1st quarter, according to its most recent 13F filing with the Securities and Exchange Commission (SEC). The firm owned 231,290 shares of the company's stock after
Jimmie Williams could be Ohio State’s most important transfer addition
After averaging more than 15 points per game at Duquesne, Jimmie Williams brings physical scoring, positional versatility, and the dependable bench offense Ohio State has lacked in recent seasons.
National City weighs business tax overhaul amid mounting budget pressures
Council to hear proposal June 30. It faces significant opposition from business community.
The Presidential Prayer Team
Each day, we invite you to join us in prayer for our national leaders. As mandated by 1 Timothy 2:1-2, we encourage prayer for those in positions of authority.
Border to Coast Pensions Partnership Ltd Takes Position in Live Nation Entertainment, Inc. $LYV
Border to Coast Pensions Partnership Ltd purchased a new position in Live Nation Entertainment, Inc. (NYSE:LYV - Free Report) during the 1st quarter, according to its most recent Form 13F filing with the Securities and Exchange Commission (SEC). The firm purchased 172,269 shares of the company's st
US Army commander used drones, C4-packed robots to clear breach
A recent drill saw dozens of drones targeting enemy weapons, sensors, and positions before soldiers attempted to approach.
In Trump’s America, two very different views of Christianity in politics emerge
Adherence to organized religion is falling in the United States, but defenders of the religious right are ascendant in positions of power in the Trump administration.
Commanders' skill positions rank among NFL's worst
The Washington Commanders' offensive skill positions rank near the bottom of the NFL.
Days Ahead to Show If Burnham Plays Politics Better Than Starmer
Standing across from Keir Starmer in the Commons chamber this week, opposition leader Kemi Badenoch drew on a particularly violent metaphor for how the Labour Party had ditched him when she conjured up an image of “400 knives stuck in the prime minister’s back.”
Trustees hear Glencoe neighbors who blast possibility of street parking near business district
Facing opposition from residents living adjacent to the Village’s business district, the Glencoe Village Board has adopted the findings of a long-in-development parking study without three areas that multiple residents spoke against during a recent Village Board meeting. In a 5-0 vote, with Trustee Dudley Onderdonk abstaining, the Glencoe Village Board on Thursday, June 18, […]
Remigration: a growing far-right movement
Once a fringe position, calls for mass deportation are spreading throughout Europe and entering mainstream politics
Commitment season looming as Ohio State staff awaits
The month of June has been a grind for Ohio State’s coaching staff. Position camps, recruiting visits, and still prioritizing their current roster, the Buckeyes have had zero time off… and that will soon change. Ryan Day and company set to be on vacation in the coming days for a well deserved break, that doesn’t […]
Proposed Changes to Grant Rules Threaten the Future of Research: Scientists Must Act Now!
The Trump administration is seeking to politicize US federal science funding, but collective action can stop this grantpocalypse from happening.
Blue state leaders erupt after Supreme Court’s decision ending TPS protections for Haitians, Syrians
Supreme Court rules 6-3 in favor of Trump administration in two key immigration cases on Temporary Protected Status and asylum, drawing opposition from blue state Democrats.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Merck KGaA to Acquire Bio-Techne for $11.3B, Expanding Life Science Tools Presence
Merck KGaA, Darmstadt, Germany, has agreed to acquire Bio-Techne for approximately $11.3 billion, the companies said today, in a deal designed to position the buyer as more of a leader across the life science value chain by expanding its presence in high-growth, next-generation life-sci markets with Bio-Techne’s tools, analytical technologies, and consumables.
Platner, Collins’ campaign spar over federal contracts
Platner released a multi-point plan he calls “a corruption crackdown,” which covers issues such as big money in politics, lobbying activities by former members of Congress, and making it more difficult for presidents to cash in on their position while in office.
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
Here’s What It Means to Be a Democratic Socialist
Universal health care, taxing the wealthy and opposition to military aid to Israel are among the movement’s key tenets.
David P. O'Brien
About five years ago, David P. O'Brien had a comfortable position at Marsh & McLennan Cos., where he held the top post at the financial giant's Louisville, Ky., office. Despite the lofty rank, Mr. O'Brien found himself longing to be at a smaller company that had to work a little harder to land business. That desire led him away from Kentucky five years ago and to Cleveland, where he serves as executive vice president at business insurance agency Oswald Cos. "I left Marsh before it was en vogue," he said, referring to layoffs and defections at Marsh over the course of this year that followed accusations of bid rigging at the big firm. Above all, Mr. O'Brien, 38, wanted to work at a company that relied on its inventiveness, rather than its name, for business. He said he has found that at Oswald. "It causes you to be more creative, to be more resourceful," Mr. O'Brien said. For instance, an Oswald client seeking to do business internationally might be directed to the network of offices abroad run by competitors such as Marsh and Aon Risk Services Inc. "We're going to use whatever access into the market that makes the most sense for our clients," he said. Of course, using such a strategy can be dangerous for Oswald if its client decides to further a business relationship with one of the firms Oswald recommended. "That's the obvious question and why it's nontraditional," he said. "I think if we're good, and if we're bringing value to the client, then there's no risk. I'm not threatened by it." Imaginative business solutions of that type made his career move to Oswald from Marsh worthwhile. "It's very much a challenge," he said. "It helps you keep your edge. I'm all for the competition." John Jacunski, currently vice president and corporate controller at York, Pa., paper company PH Gladfelter Co., met Mr. O'Brien four years ago when Mr. Jacunski was at WCI Steel Inc. in Warren. So impressed was he with Mr. O'Brien's work for WCI that Mr. Jacunski has retained the Oswald executive at PH Gladfelter. "He's a young guy for the position he has, but he's done a great job for us," Mr. Jacunski said. Among his roles at Oswald, Mr. O'Brien leads the firm's client retention efforts and also serves as director of its property and casualty group. "You don't have the same human resources," he said of the job jump to Oswald. "You don't have, obviously, the safety net a big company has." But sometimes, it can be difficult to ascertain individual contributions when working at a big company. "I wanted to be able to see the end results of my work and my efforts," Mr. O'Brien said.
Steve Zabel, throwback two-way player, dies at 78
Steve Zabel, a tight end and pass rusher who was Oklahoma's last two-way player and then played both positions in the NFL, has died at the age of 78.
Scientists discover how a single cell builds a brain with 170 billion cells
How does a single cell build a brain with billions of precisely organized neurons? Researchers suggest that brain cells use their lineage—their cellular family tree—as a kind of positional map. Cells that come from the same ancestor stay near one another, helping the brain organize itself without relying solely on chemical signals.
Senate Republicans reject war powers resolution after Trump-Cassidy clash
The late-night vote came hours after a fractious meeting that included a shouting match with President Donald Trump over some senators’ opposition to the conflict.
Space Shuttle Endeavour: California Science Center unveils vertical shuttle display
The California Science Center Wednesday provided the first public view of space shuttle Endeavour inside its permanent home -- in upright launch position with two rocket boosters and an external fuel tank.
After Jordan Kyrou trade, Blues are open for business — and positioned for a franchise-changing run
With four firsts after move, GM Doug Armstrong is preparing for a transaction marathon — "a 6-mile jog tomorrow and an 8-mile run Friday."
Mercy Helps Position St. Louis as Global Gateway for Healthcare Innovation
Mercy continues to bring innovative thought leadership to the communities it serves and beyond. Dr. Damon Broyles, Mercy vice president of clinical innovation, informatics and precision medicine, recently shared insights and helped attract new companies to St. Louis’ nationally recognized healthcare industry as part of BioSTL.
Online violence against women in politics: what shapes political party responses to technology-facilitated gender-based violence?
Political parties have a primary role to play in tackling online violence against women and gender diverse politicians. While the prevalence and impact of TFGBV, such as coordinated disinformation campaigns, deepfake image-based sexual abuse or trolling are well documented, many parties are still building their knowledge on how to respond effectively and have not put in place internal practices and policies that respond to the rapidly evolving, poorly regulated digital ecosystem. About the ReportIn order to promote and protect fair and democratic participation in politics, this ALIGN Report explores what political parties are doing in response to TFGBV and what factors shape their action. The findings, based on existing literature and interviews with gender and politics professionals, indicate there are three sets of factors which donors, civil society and practitioners should consider when designing action to support political parties to respond to TFGBV internally. These are: (1) gender norms; (2) socio-political environment; and (3) internal party factors.Key messagesUnequal gender norms are ubiquitous across politics, shaping expectations of leaders to be strong and assertive, and practices of political parties to uphold masculinist values and sustain cultures of silence. These often lead to weak response to TFGBV against women politicians.The socio-political context can incentivise or disincentivise action, depending on the salience of gender issues, which are increasingly weaponised. Electoral competitiveness, domestic laws (i.e. quota requirements), and even the political system or global normative frameworks influence political will to act.Internal party factors that shape responses will vary across countries and contexts, but include: structures to enforce codes of conduct, policies and reporting mechanisms on (TF)GBV, political ideology, extent of centralisation of leadership, and crucially the meaningful participation of women in decision-making positions, not least through internal women’s wings.Party responses can be seen as a spectrum, with actions falling between active discouragement to address TFGBV to commitment to transform unequal norms and practices within the party.About the ToolkitTogether with the report, this ALIGN toolkit offers gender professionals and others working on democratic strengthening a set of guiding questions and reflection prompts to identify which responses could be most effective and suitable in different contexts. These actions can complement other solutions to TFGBV, such as regulations promoting safety by design. The assessment spans a broad range of factors including: (1) different manifestations of gender norms, (2) the socio-political environment and (3) internal party structures.Key messagesPolitical parties are duty-bound to take action internally to respond to the significant threats posed to women members and candidates, including from their own party colleagues, affiliates and political peers.Existing party approaches to TFGBV can be assessed along a spectrum which ranges from active discouragement and passive acceptance to minimal response and transformative change.To generate effective and context-appropriate solutions to TFGBV, it is important to consider how gender norms shape leadership expectations and internal party practices, while also analysing the impact of the socio-political environment. While actions to support women to stay safe online are very common, codes of conduct and measures to strengthen women’s voice and power in the parties are proposed as most transformative solutions.
California Science Center visitors will see space shuttle Endeavour in launch position this fall
The Samuel Oschin Air and Space Center will be free to visit, just in time for the 2028 Olympics.
Caravan of Care Brings Free Health Services to Goodwill on Dearborn
From dental cleanings to ORCA card help, Evergreen Goodwill's outdoor resource fair on Dearborn aims to meet community needs in one place.
First look at the Endeavor Space Shuttle at the California Science Center
Science fans will soon get the chance to see the Space Shuttle Endeavor in its ready-to-launch position at the California Science Center in Exposition Park this November.
Fenway Sports Group wasn’t perfect, but it left the Penguins in a very good position
As the Penguins move into new hands, it's time to admit Fenway Sports Group was not the villain it was perceived by many to be.
Jaguars coach explains what makes Liam Coen special
Who would have thought Liam Coen could ascend to this position so quickly? At least one coach wasn't surprised at all.
Lakers have reportedly called Pelicans about Yves Missi
The Lakers are actively hitting the phones in an attempt to upgrade at the center position.
Trump’s midterm liabilities on display in visit to toss-up district
A campaign-style appearance in Pennsylvania revealed the delicate position of Republicans facing tough reelection fights. They still need Trump’s voters, but are increasingly cautious about embracing him too closely.
Sportico Studio’s New Video Experience Debuts at Cannes Lions
Sportico this week launched Sportico Studio, a dedicated content and creative solutions offering for brands looking to engage the sports business community. The studio, featured on a new video page on Sportico’s homepage, will leverage Sportico‘s unique position at the center of the sports business ecosystem, connecting brands with influential decision-makers across leagues, teams, media, …
Fantasy Baseball: Recapping every offensive position ahead of the midpoint of the 2026 season
Chicago’s Bike Lanes Don’t Hurt Businesses, City Report Finds
As protected bike lanes face opposition in some neighborhoods, city-backed case studies found lanes in a half-dozen corridors have not contributed to a negative impact on economic activity.