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Results for " uw " 1,582 found 🔀 AI-powered Shuffle

Wisconsin adds jersey patch sponsorship with UW Health for women’s sports

Wisconsin women’s basketball, volleyball, women’s hockey and softball will have a UW Health jersey patch on their uniforms starting in 2026-27.

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Apr 2 • 8:23 AM EDT • Sports • jsonline.com
UW Health to become official jersey patch sponsor for Wisconsin women’s sports

Landmark partnership to be featured on basketball, volleyball, hockey and softball uniforms

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Apr 2 • 8:00 AM EDT • Health • uwbadgers.com
UW Health to become official jersey patch sponsor for Wisconsin women’s sports

Landmark partnership to be featured on basketball, volleyball, hockey and softball uniforms

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Apr 2 • 8:00 AM EDT • Sports • uwbadgers.com
Arts and entertainment events happening April 2nd-5th across the Mid-Ohio Valley

Joe Oliverio joins Daybreak to discuss what’s happening April 2nd-5th across the Mid-Ohio Valley!

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Apr 2 • 7:52 AM EDT • Entertainment • wtap.com
No running water, 5 dead mice: Latest Kansas City-area restaurant inspections

A food truck, Jamaican restaurant and grocery store had some of the most health code violations in the metro recently.

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Apr 2 • 6:00 AM EDT • Health • kansascity.com
Roseanne Barr, 73, fears she will 'die on the surgery table' after doctor told her she has a 'damaged' heart

Roseanne Barr says she isn't interested in getting surgery after a doctor told her she has a 'damaged' heart. The actress said she would prefer to 'just get a heart attack or a stroke' and be put in hospice care.

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Apr 1 • 1:26 PM EDT • Entertainment • ew.com
Washington Nationals vs Philadelphia Phillies Game Thread

Follow along as the Nats and Phillies square off in an afternoon rubber match

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Apr 1 • 12:30 PM EDT • Sports • sports.yahoo.com
Top Sports Podcasts in the United States

Edison Podcast Metrics captures the top Sports podcasts among U.S. weekly podcast listeners 13+ for 2025.

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Apr 1 • 11:58 AM EDT • Sports • edisonresearch.com
Get AirPods Max 2 on Sale for Launch Day

Apple's new AirPods Max 2 launch today, and Amazon is one of the only retailers offering any sort of discount on the headphones. You can get the Midnight color option for $529.00 on Amazon, down from $549.00. Note: MacRumors is an affiliate partner with some of these vendors. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.

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Apr 1 • 9:46 AM EDT • Technology • macrumors.com
Live Updates: Supreme Court considers Trump's order on birthright citizenship

Every lower court to have considered the issue has found the order illegal and prevented it from taking effect. A definitive ruling by the nation’s highest court is expected by early summer.

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Apr 1 • 9:09 AM EDT • Politics • pbs.org
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Is Stephen Curry returning tonight? Warriors vs. Spurs injury report

Stephen Curry’s return remains on hold as the Warriors injury report looms in a crucial play-in push against a red-hot Spurs squad.

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Apr 1 • 8:51 AM EDT • Sports • sports.yahoo.com
Mike Krzyzewski reveals his reaction to Duke's last-second loss to UConn in Elite Eight: 'It was heartbreaking'
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Apr 1 • 8:51 AM EDT • Sports • sports.yahoo.com
'Fighting' Bob La Follette's Progressive legacy lives on in Madison

A century after Bob La Follette's death, his ideas live on at The Progressive magazine and UW-Madison's growing School of Public Affairs.

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Apr 1 • 6:01 AM EDT • Politics • jsonline.com
The 2025-2026 GametimeCT All-State Boys Ice Hockey Team

Introducing the 2025-2026 GametimeCT All-State Boys Ice Hockey team.

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Apr 1 • 6:00 AM EDT • Sports • sports.yahoo.com
Commute: Diamond sports see different fates on Tuesday

The morning commute for Wednesday, April 1st, 2026.

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Apr 1 • 6:00 AM EDT • Sports • sports.yahoo.com
Polaris, Callaway Golf Company, Compass, Sphere Entertainment, and Viking Shares Skyrocket, What You Need To Know

A number of stocks jumped in the morning session after investors priced in a potential de-escalation of the conflict in Iran alongside reassuring commentary from the Federal Reserve on interest rates.

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Mar 31 • 5:41 PM EDT • Entertainment • finance.yahoo.com
BetMGM to launch speakeasy to watch final weekend of March basketball matchups

“The Court of Legends” welcomes basketball fans to a new Bellagio speakeasy.

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Mar 31 • 3:19 PM EDT • Entertainment • fox5vegas.com
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Android Developer Verification Rollout Begins Ahead of September Enforcement

Google expands Android developer verification globally after September rollout, adding authentication and delays to sideloading to deter malware.

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Mar 31 • 2:28 PM EDT • Technology • thehackernews.com
Chicago Bears’ Mock Draft Madness: The Final Round

Vote for your favorite choice in these two-round Bears mock draft Madness brackets!

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Mar 31 • 1:30 PM EDT • Sports • sports.yahoo.com
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Comedian Trevor Wallace to Perform at UW April 3

Comedian Trevor Wallace will perform at the University of Wyoming’s Arts and Sciences auditorium Friday, April 3, during an event free and open to students and the Laramie community.

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Mar 31 • 12:08 PM EDT • Entertainment • uwyo.edu
University of West Florida sports to make jump from DII to DI, according to report

PENSACOLA, Fla. -- University of West Florida athletics will be making the move from Division II to Division I, according to a report from Yahoo Sports.UWF will

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Mar 31 • 11:33 AM EDT • Sports • weartv.com
Florida Panthers Welcome Michael White as President of Business Operations

25-year technology veteran brings wealth of innovation, hospitality and guest experience knowledge to organization

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Mar 31 • 9:00 AM EDT • Business • nhl.com
Steelers 2026 NFL Draft scouting report: QB Cade Klubnik

As the Pittsburgh Steelers prepare for the 2026 NFL Draft, here is a scouting report for quarterback Cade Klubnik of Clemson.

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Mar 31 • 8:01 AM EDT • Sports • sports.yahoo.com
Allegiant Stadium will host another Super Bowl

Las Vegas will host a 2nd Super Bowl in 5 years

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Mar 30 • 5:33 PM EDT • Sports • sports.yahoo.com
Cannabis-related health problems: WA clinical snapshot - UW Medicine

News and information for journalists

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Mar 30 • 1:53 PM EDT • Health • newsroom.uw.edu
DHS funding in limbo but TSA agents to be paid

Some airports remained clogged with hourslong delays at security

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Mar 30 • 10:50 AM EDT • Politics • theweek.com
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In The Lab: Astros Starting Pitching WAR Projections

What can we expect from the Astros rotation this season?

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Mar 30 • 9:02 AM EDT • Sports • sports.yahoo.com
Early 2026 fantasy expert consensus rankings: Dallas Cowboys edition

Heading into the 2026 season, here are the biggest Cowboys bargains based on early fantasy expert consensus rankings

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Mar 30 • 8:55 AM EDT • Sports • sports.yahoo.com
Scientists spotted female sperm whales working together during a birth to protect the calf

Scientists have captured rare footage of a sperm whale giving birth, offering a window into the large mammals' behavior.

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Mar 30 • 8:40 AM EDT • Science • wcax.com
Scientists spotted female sperm whales working together during a birth to protect the calf

Scientists have captured rare footage of a sperm whale giving birth, offering a window into the large mammals' behavior.

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Mar 30 • 8:40 AM EDT • Science • ktiv.com
AP Decision Notes: What to expect in Arkansas' primary runoff elections

Two Arkansas Republicans with competing visions on how best to implement President Donald Trump’s agenda to overhaul elections and voting will vie for their party’s nomination for the state’s top elections job on Tuesday

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Mar 30 • 8:31 AM EDT • Politics • washingtonpost.com
Send us a question about Wisconsin’s men’s, women’s basketball teams

Wisconsin basketball beat reporter John Steppe will answer your questions about the teams in our UW mailbag this week. Ask a question here.

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Mar 30 • 6:18 AM EDT • Sports • sports.yahoo.com
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NCAA tournament takeaways: UConn reaches Final Four on wild game winner over Duke; UConn and UCLA women each pull away in Elite Eight
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Mar 29 • 9:52 PM EDT • Sports • sports.yahoo.com
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‘I’m cooked’: Aurora business owner’s viral video draws customers to notorious strip

In Demi’s viral video, she claimed there were warnings against opening a business on Aurora when she did six years ago, although she didn’t listen.

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Mar 29 • 7:09 PM EDT • Business • kiro7.com
Eagles jersey number updates: Riq Woolen, Hollywood Brown, and more

Very important #JerseyNumberAnalytics news!

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Mar 29 • 1:36 PM EDT • Sports • sports.yahoo.com
Letter | UW Health must reinstate gender-affirming care immediately

Dear Editor: Thank you so much for publishing "Reverse UW Health's decision on gender-affirming care."

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Mar 29 • 8:45 AM EDT • Health • captimes.com
Cleveland Browns news (3/29): Draft season drawing nearer

The latest Cleveland Browns news and notes from around the NFL in the Sunday Dawg Chow.

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Mar 29 • 6:30 AM EDT • Sports • sports.yahoo.com
The Premier League Team of the Season, according to Opta

Deciding on a Premier League Team of the Season is no easy task, with almost every fan forming different opinion.Opta are arguably the game’s leading experts when it comes to football data and have ...

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Mar 29 • 3:40 AM EDT • Sports • sports.yahoo.com
Rob Schneider calls to reinstate U.S. military draft amid Iran war

Rob Schneider, who does not have a history of military service, called for the U.S. to reinstate a military draft for men and women amid the war with Iran.

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Mar 28 • 2:21 PM EDT • Entertainment • ew.com
Washington Nationals vs Chicago Cubs Game Thread

Follow along as the Nationals look to remain undefeated and secure a series win against the Cubs

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Mar 28 • 1:50 PM EDT • Sports • sports.yahoo.com
Jonathan Bullard signing with Cowboys on emotional day

Cowboys sign veteran defensive lineman Jonathan Bullard late in free agency to continue adding to their 2026 defense

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Mar 28 • 12:53 PM EDT • Sports • sports.yahoo.com
Apple Releasing Two New iPhone Apps This Year

Apple is expected to release two new iPhone apps this year, including an Apple Business app and a Siri app with chatbot-like functionality. With the Apple Business app, employees at businesses using the new Apple Business platform will be able to install apps for work, view contact information for colleagues, and request support. Apple Business is launching on April 14, and it replaces Apple Business Essentials, Apple Business Manager, and Apple Business Connect.

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Mar 28 • 11:00 AM EDT • Technology • macrumors.com
Happy Valley Rewind: Penn State-Iowa 2017

We continue our “Happy Valley Rewind” series by looking back at a spectacular Saquon Barkley game that ended with the heroics of Trace McSorley and Juwan Johnson. The full game can be viewed here:

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Mar 28 • 10:45 AM EDT • Sports • sports.yahoo.com
UW Huskies AD Pat Chun says state of college sports is ‘not sustainable’

UW athletics has generally performed well during Pat Chun's first two years in Seattle, but he has major concerns about the state of college athletics moving forward.

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Mar 28 • 9:00 AM EDT • Sports • yakimaherald.com
Mud Hens drop opener to Lehigh Valley

Scores, news, and notes from around the Detroit Tigers’ farm system for Friday, March27, 2026.

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Mar 28 • 8:00 AM EDT • Sports • sports.yahoo.com
Tiger Woods arrested for DUI, released from jail after rollover car crash in Florida
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Mar 27 • 11:48 PM EDT • Sports • sports.yahoo.com
Tiger Woods car accident live updates: PGA Tour legend arrested for DUI, released from jail after rollover crash near home in Jupiter Island, FL
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Mar 27 • 11:46 PM EDT • Sports • sports.yahoo.com
Michigan cools off hot-shooting Alabama, outguns Crimson Tide into Elite 8

Alabama's high-octane offense kept things interesting for a half. But Michigan dominates both sides of the floor and ultimately took the game over.

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Mar 27 • 10:04 PM EDT • Sports • sports.yahoo.com
Clayton Kershaw joins Dodgers front office as special assistant
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Mar 27 • 8:05 PM EDT • Sports • sports.yahoo.com
Science Museum of Virginia offers hands-on animal encounters and maker workshops

Visitors can explore Animal Lab exhibits and create projects in the Forge workshop space.

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Mar 27 • 5:11 PM EDT • Science • 12onyourside.com
UWO students to support small businesses through Innovation Foundry program

UWO students will provide project support to small businesses and startups through the new grant-funded Innovation Foundry program.

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Mar 27 • 3:09 PM EDT • Business • uwosh.edu
'Major disruption in Neanderthal history': 65,000 years ago, all Neanderthals in Europe died out except for one lineage

The last Neanderthals to survive in Europe came from a single lineage that survived the worst period of the ice age, ancient DNA reveals.

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Mar 27 • 7:00 AM EDT • Science • livescience.com
Texas A&M softball HC Trisha Ford previews the Texas series

Trisha Ford previews A&M’s trip to No. 1 Texas, stressing growth, lineup clarity, and embracing the rivalry’s trademark “spice.”

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Mar 26 • 8:29 PM EDT • Sports • sports.yahoo.com
Jacob Misiorowski sets Brewers Opening Day record with 11 strikeouts
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Mar 26 • 5:31 PM EDT • Sports • sports.yahoo.com
Could Markwayne Mullin’s tenure at DHS change the agency?

Homeland Security and ICE were heavily scrutinized during Kristi Noem’s term

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Mar 26 • 11:18 AM EDT • Politics • theweek.com
How are schools divvying up money between sports in modern era? Here's an inside look at Duke's approach
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Mar 26 • 11:10 AM EDT • Sports • sports.yahoo.com
Coca-Cola Bottler Raising Euro Bonds to Buy Africa Business

Coca-Cola HBC Finance BV is raising at least €1.5 billion ($1.7 billion) of debt on Thursday to help fund an acquisition of another drinks bottling firm.

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Mar 26 • 6:31 AM EDT • Business • bloomberg.com
Massachusetts hospital EDs have a mental health 'boarding' problem

Such long waits are expensive and unhelpful for patients experiencing psychiatric crises, in addition to tying up in-demand hospital beds, the report said.

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Mar 25 • 1:26 PM EDT • Health • bostonglobe.com
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Wednesday Dots: Counting Down

UW officially added an offensive assistant to the staff, and we are counting down to the start of spring football practice

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Mar 25 • 11:31 AM EDT • Sports • sports.yahoo.com
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Professor motivates students to nurture their inner entrepreneur

Mercer University professor Dr. Briana Stenard approaches teaching with a spirit that demonstrates that the best learning prioritizes confidence and ingenuity.

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Mar 25 • 8:30 AM EDT • Business • den.mercer.edu
AccuWeather is now available inside ChatGPT

Never again will you have to exit your AI app to check the forecast.

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Mar 24 • 3:26 PM EDT • Technology • engadget.com
“SNL” alum calls out cast members who break into laughter during sketches: 'It doesn't work'

Kevin Nealon doesn't seem to be a fan of the recent Ryan Gosling episode.

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Mar 24 • 1:55 PM EDT • Entertainment • yahoo.com
UW-Oshkosh nursing students among first to try new electronic health record platform from Epic

Thanks to a partnership with Epic, UW-Oshkosh nursing students are early adopters—among the very first to try a new electronic health record platform called Lyceum.

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Mar 24 • 8:41 AM EDT • Health • uwosh.edu
Using multiple AI health tools could pose reliability risks

Hundreds of AI tools for health care tout accuracy rates above 90%, but most are tested only in isolation.

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Mar 24 • 6:00 AM EDT • Health • axios.com
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Travis Kelce reportedly re-ups with Chiefs on a 3-year, $54.7 million deal, but there's a catch
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Mar 23 • 3:55 PM EDT • Sports • sports.yahoo.com
Exclusive: Kalshi to block athletes and politicians from trading on their markets

Prediction market Kalshi plans to block athletes, coaches and officials from betting on their sports and to block political candidates from trading on their campaigns, Axios has learned.

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Mar 23 • 2:57 PM EDT • Politics • axios.com
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Apple Reportedly Preparing 'Biggest Set of iPhone Revamps' Ever

Apple is working on "the biggest set of iPhone revamps in the product's history," according to the latest word from Bloomberg's Mark Gurman. Specifically, he is referring to the long-rumored foldable iPhone, as well as an ambitious 20th-anniversary iPhone with a truly "edge-to-edge" design.

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Mar 23 • 9:28 AM EDT • Technology • macrumors.com
Cowboys mock draft tracker: A trade might make sense early

How interested are you in trading back in the first round?

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Mar 23 • 9:00 AM EDT • Sports • sports.yahoo.com
10 Surprising Perimenopause Symptoms That Are More Common Than Hot Flashes, According to New Research

Think perimenopause is just about hot flashes? Check out these very common other menopause symptoms.

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Mar 23 • 8:00 AM EDT • Health • health.com
Chris Sale 2026 MLB Season Preview
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Mar 22 • 11:56 PM EDT • Sports • sports.yahoo.com
One dead after shooting at Last Call Sports Bar in Jackson

One person is dead after a shooting at Last Call Sports Bar early Sunday morning.

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Mar 22 • 10:17 PM EDT • Sports • wlbt.com
Alvaro Folgueiras hits game-winner to lift Iowa past No. 1 Florida, into first Sweet 16 since 1999

Florida's hopes at back-to-back national titles are gone.

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Mar 22 • 9:40 PM EDT • Sports • sports.yahoo.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Spring Game #28: Athletics versus Cubs Game Thread

Ready for some Friday night baseball?

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Mar 20 • 7:50 PM EDT • Sports • sports.yahoo.com
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35 photos that show what life looked like in 1973

A senior portrait so perfectly 1973 it could have been Michael Kelso's yearbook photo — the side-swept hair, the wide lapels, the expression of a guy who knows exactly how good-looking he is. The menu behind him says coffee is 15 cents.

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Mar 20 • 1:04 PM EDT • Technology • aol.com
Six avoidable factors that increase your risk of breast cancer

A healthy lifestyle without smoking, but with plenty of exercise and a healthy weight, can help avoid losing healthy years of life to breast cancer, the study led by UW scientists says.

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Mar 20 • 9:09 AM EDT • Health • seattletimes.com
A Physicist Said Heaven Has a Literal Address. The Science World Is Reacting Just Like You’d Expect.

A former Harvard physics lecturer and science communicator has said that heaven could have a physical location. And he knows exactly where it is.

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Mar 20 • 8:30 AM EDT • Science • yahoo.com
Steelers showing strong interest in talented WR draft prospect

The Pittsburgh Steelers hosted Georgia wide receiver Zachariah Branch for a pre-draft dinner ahead of the 2026 NFL Draft.

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Mar 20 • 5:09 AM EDT • Sports • sports.yahoo.com
Healthcare employee health plan bridges the gap between data and action

Integrating UpToDate evidence-based clinical decision support helps health plan optimize costs and member-centered care.

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Mar 19 • 8:00 PM EDT • Health • wolterskluwer.com
New dispute emerges around Subnautica 2’s early access release

Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.

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Mar 19 • 5:28 PM EDT • Technology • gamefile.news
Cowboys updates on George Pickens, Brandon Aubrey situations are murky

Things are reportedly the same with both Brandon Aubrey and George Pickens

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Mar 19 • 12:00 PM EDT • Sports • sports.yahoo.com
Pistons star Cade Cunningham to miss at least two weeks with collapsed lung
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Mar 19 • 10:52 AM EDT • Sports • sports.yahoo.com
Cowboys reportedly played 49ers well in Osa Odighizuwa trade

The Cowboys may have gotten the 49ers to blink on the Osa Odighizuwa trade.

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Mar 18 • 6:00 PM EDT • Sports • sports.yahoo.com
UW Health resident creates adaptive crayons for children with disabilities

MADISON, Wis. — A physical medicine and rehabilitation resident at UW Health is reimagining crayons by creating adaptive crayons for people with developmental disabilities, stemming from her past experiences.

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Mar 18 • 5:49 PM EDT • Health • channel3000.com
Georgia's Union City will get a medical center affiliated with Grady Health Systems

Grady is partnering with the Fulton-DeKalb Hospital Authority to add a more than $1 billion hospital facility to Union City

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Mar 18 • 4:02 PM EDT • Health • ajc.com
Dolphins officially trade WR Jaylen Waddle to Broncos in blockbuster move
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Mar 18 • 3:14 PM EDT • Sports • sports.yahoo.com
Madison influence adds to 'Our Town' universal themes

University Opera's production of Thornton Wilder's story links his Madison roots with a new generation of UW students.

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Mar 18 • 6:00 AM EDT • Entertainment • captimes.com
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Gastonia business feels squeeze as gas prices rise

A Gastonia business owner says that rising gas prices are having a direct impact on his business and may cause him to raise his prices.

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Mar 18 • 5:08 AM EDT • Business • yahoo.com
Thunder's Alex Caruso receives technical foul for using shoe to block shot in win over Magic
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Mar 17 • 9:54 PM EDT • Sports • sports.yahoo.com
Vikings agree to terms with P Johnny Hekker
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Mar 17 • 9:23 PM EDT • Sports • sports.yahoo.com
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Chelsea Handler claims RFK Jr. and Cheryl Hines sold her 'disaster' house: 'Most toxic environment'

Chelsea Handler is claiming that RFK Jr. and Cheryl Hines sold her a 'disaster' house that she still has not lived in to this day: 'The most toxic environment.'

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Mar 17 • 11:21 AM EDT • Entertainment • ew.com
'Arteta has been smart in managing Dowman'

Watch The Oberserver's Rory Smith and former Premier League striker Chris Sutton disagree on Arsenal and manager Mikel Arteta's use of youngster Max Dowman. "I don't necessarily agree with that," added Sutton.

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Mar 17 • 4:47 AM EDT • Sports • sports.yahoo.com
World Baseball Classic: Venezuela beats Italy with 3-run, 7th-inning rally to advance and face Team USA in final
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Mar 17 • 12:13 AM EDT • Sports • sports.yahoo.com
World Baseball Classic: Venezuela beats Italy with 3-run, 7th-inning rally to advance to final
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Mar 16 • 11:46 PM EDT • Sports • sports.yahoo.com
Wisconsin will lose to High Point, CBS Sports’ Clark Kellogg predicts

Should Wisconsin basketball be on upset alert in March Madness? CBS Sports’ Clark Kellogg says Badgers will lose in the first round.

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Mar 15 • 6:59 PM EDT • Sports • jsonline.com
How to watch Selection Sunday for the NCAA bracket release

Indiana enters Selection Sunday firmly on the wrong side of the bubble. Here’s how and when to watch the selection show.

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Mar 15 • 10:30 AM EDT • Sports • sports.yahoo.com
Netflix’s science fiction triumph earns 100% positive reviews in 57 countries

The internet says it's perfect. So why is one country shrugging while everyone else hits play?

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Mar 15 • 7:09 AM EDT • Science • 3dvf.com
Cowboys news: The free agent to replace Osa Odighizuwa

Your Sunday morning Cowboys news.

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Mar 15 • 7:00 AM EDT • Sports • sports.yahoo.com
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Wisconsin sets official visits with two class of 2027 lineman

A pair of lineman have set visits with the Wisconsin Badgers. Both are Class of 2027 recruits, though neither are in-state targets.

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Mar 15 • 5:05 AM EDT • Sports • sports.yahoo.com
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World Baseball Classic schedule, scores: Team USA to face Dominican Republic in semifinals; Japan vs. Venezuela concludes quarterfinals
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Mar 14 • 7:40 PM EDT • Sports • sports.yahoo.com