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Here's some of the real science behind the science fiction film ‘Project Hail Mary’
The new science fiction film adaptation leans heavily on real science done by the National Aeronautics and Space Administration, more commonly known as NASA.
Pearl Abyss boss admits the studio "could have done a better job" with Crimson Desert's totally underwhelming story
Pearl Abyss' CEO has addressed widespread disappointment with Crimson Desert's story.
The 'Healthy Choice Waiver' is not about health — it’s about controlling the poor
Regulating the behavior of those already struggling does not address public health issues.
Friday's schedule: Morocco on OneFootball, more friendlies
FRIENDLIES05:30 - Solomon Islands x Bulgaria - DAZN and FIFA+06:10 - Australia x Cameroon - DAZN and FIFA+07:00 - Venezuela x Trinidad and Tobago - DAZN and FIFA+10:00 - Indonesia x Saint Kitts and Ne...
Rescuers scramble to aid pets abandoned after ICE raids
The exact number of displaced pets is impossible to quantify
/C O R R E C T I O N -- Alliance for Creativity and Entertainment (ACE)/
The Alliance for Creativity and Entertainment (ACE), the world's leading anti‑piracy coalition, has successfully shut down AnimePlay, one of the largest illicit anime streaming applications operating in the Asia-Pacific region. The application was run out of Riau, Indonesia.
How Democrats Can Defeat Trump’s Identity Politics
Author Justin Gest says that appealing to voters’ sense of belonging and identity is essential and can’t be done with economic policy alone.
Slow roll! Islam Makhachev not fighting until August
Islam Makhachev won’t be fighting over International Fight Week, according to UFC CEO Dana White. Makhachev’s manager was on TMZ Sports yesterday discussing the No. 1 pound for pound fighter and welterweight champion’s next move. He implied a July fight was ‘a done deal,’ but that’s apparently not the case. White came out on social […]
Providing quality, access to health care in rural Indonesia | Harvard T.H. Chan School of Public Health
Leni Siagian, MPH ’26, wants to ensure care for those who face challenges getting it.
Chinese lander reveals giant 'cavity' of radiation between Earth and the moon — and it could change how lunar exploration is done
A new study using data from China's Chang'e-4 moon lander found an area of reduced radiation from cosmic rays near the moon. The findings could be used to improve the safety of lunar explorations.
Health care costs in Colorado will grow under federal policy, patient advocates say
Health care providers in Colorado expressed anxiety around high health care costs as a result of the Trump administration’s policies.
United CEO tells Congress: 'Please get the deal done soon'
United CEO Scott Kirby said that it's "unconscionable that our politicians haven't gotten this done."
Democrats throw cold water on shutdown deal, call for more ICE reforms
Senate Democrats are cautiously optimistic about a potential agreement to fund the Department of Homeland Security. But it's far from a done deal.
Ed Davey accuses Reform UK and Tories of importing ‘Trump-style divisive politics’
Lib Dems will focus on ‘rolling up their sleeves and getting things done’, leader says at launch of local election campaign
Gechter exit sealed? This Bundesliga club is his likely destination
According to a report by 'Sky', Linus Gechter's exit from Hertha is likely a done deal. The 22-year-old Berliner, who is under contract with Hertha until 2028, is reportedly on the verge of moving to ...
A mission NASA might kill is still returning fascinating science from Jupiter
We can’t quite afford to support everything that we have done in the past."
Coeur d'Alene's science guy
Ahead of his retirement in May from the teaching staff at Arizona State University, behavioral neuroscientist Brian Smith has put his focus into making science more accessible to more people. “There's a lot of misunderstanding what science is,” Smith said.
Why Have Patriots Not Done More To Address Pass Rush?
The New England Patriots had just 35 sacks last season, ranking near the bottom of the league in the regular season.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Square Enix announces it will integrate Google’s generative AI Gemini into popular online game Dragon Quest X
Square Enix has found a use for Google’s generative AI Gemini and will be putting it to use in the popular online game, Dragon Quest X. Gemini will be used in-game as a feature that allows players to…
‘The Comeback’ took on Hollywood long before ‘The Studio.’ Now, Valerie Cherish will have her curtain call
“The Comeback” was by no means the first series to hold a funhouse mirror up to the entertainment industry, but the comedy starring co-creator Lisa Kudrow, which returns for its final season on Sunday, has certainly always done it in its own navel-gazing yet endearing way.
Community's Choice Awards spotlight: Affiliated Dermatologists
Milwaukee Top Choice Community’s Choice Awards nominations are almost done. Don’t ghost your favorite local businesses.
'Not a done deal': Democrats start to sweat over Virginia's redistricting referendum
The unique nature of the April special election and the state's recent redistricting history have presented challenges for Democrats, even as they hold a financial edge in the race.
Apple to Launch More New Hardware This April
Apple isn't done yet. After announcing seven new products in March – including the iPhone 17e, iPad Air, MacBook Air, MacBook Pro, MacBook Neo, Studio Display, and Studio Display XDR – the company has one more launch on the books in the coming weeks (as far as we know, at least). AirPods Max 2 go up for pre-order on March 25, with availability beginning in early April.
2026 March Madness: What Makes an NCAA Tournament Champion?
March Madness is here, and FOX Sports Research has done a historical deep-dive into the characteristics that make up a tournament champion.
Nintendo Switch 2 handheld boost mode is great but it does impact battery life
The new addition of handheld boost on the Nintendo Switch 2 is great for when you are playing original Nintendo Switch games as the system acts as if you are playing in docked mode…
Should R.I. regulate private equity in health care after crisis at safety-net hospitals?
On the R.I. Report podcast, a Salve Regina University expert talks about what Massachusetts, Maine, and Oregon have done to control private equity and protect patients.
Forum on harnessing Artificial Intelligence for health equity
Register to this forumOver the past decade, artificial intelligence (AI) has significantly evolved in complexity, performance, and utility. Its integration across a wide range of industrial sectors has accelerated, with healthcare emerging as one of the most transformative sectors. In this sector, AI has enabled high-impact applications – from enhancing the speed and accuracy of disease diagnosis and supporting clinical decision-making, to strengthening public health initiatives such as disease surveillance and workforce optimization. Moreover, AI holds immense potential to empower individuals, enabling them to take greater control of their personal health and well-being. Yet the central question remains: Who benefits, who is at risk, and do these innovations close or widen health inequities? While the potential of AI-enabled applications is substantial, many countries have approached their adoption with caution. This hesitancy stems from concerns about risks and benefits, including model bias, data breaches, privacy violations, and the erosion of professional skills due to over-reliance on AI. Additional barriers include inadequate data infrastructure and a lack of robust evidence on the most effective forms and interfaces of AI to enhance service delivery and system performance. Moreover, the rapid rise of Generative AI has introduced a heightened urgency for the development of comprehensive governance and ethical frameworks. The Asian Development Bank (ADB) Health Practice Team and Digital Sector, in collaboration with the World Health Organization (WHO) Regional Office for the Western Pacific, are convening the Forum on Harnessing AI for Health Equity on 25–26 March at ADB Headquarters. Senior health officials from 16 developing member countries (DMCs), alongside leading researchers, innovators, and policymakers from across Asia and the Pacific, will engage in discussions on how AI can be governed, financed, and scaled to deliver healthier lives for all. The forum is funded through the High-Level Technology Fund with support from the Government of Japan. Objectives The two-day forum aims to:Identify high-impact, evidence-based health AI use cases suitable for resource-constrained settings and map out a pipeline for potential supportIntroduce and validate the WHO's policy guidance on minimum necessary ecosystem for countries and institutions to self-assess readiness for AI adoptionObtain initial commitment from participating stakeholders to join a pilot regional initiative focused on data/model sharing for a priority health challengeEndorse a prioritized set of actionable policy recommendations focusing on governance, regulation, and sustainable financing necessary to scale high-impact health AI use cases in resource-constrained settings Target participants The forum will convene participants from 16 ADB DMCs including Bangladesh, Bhutan, Cambodia, Cook Islands, Fiji, Indonesia, Lao People's Democratic Republic, Mongolia, Nepal, Palau, Papua New Guinea, Philippines, Sri Lanka, Thailand, Uzbekistan, and Viet Nam. In addition, health system leaders and practitioners, private sector technologists, academic experts, representatives from civil society organizations, development partners, and philanthropic institutions engaged in AI for Health from Australia, the People’s Republic of China, Japan, Malaysia, New Zealand, Singapore, and the Republic of Korea will also be invited. SessionsDay 1 (25 March)Session 1: AI Use Cases for the Care Continuum: Improving Access and QualitySession 2: Adopting a risk-based approach for AI use case prioritizationSession 3: Establishing the Minimum Ecosystem for Implementation Risk ManagementSession 4: Future-Ready Health Workforce: Building Competency for Human-AI CollaborationDay 2 (26 March)Session 5: The Political Economy of AI in Health: Understanding Stakeholder Interests and their Impact on EquitySession 6: AI and Health Financing: Supporting Fair Coverage and ProtectionSession 7: AI Regulation and Oversight: Pathways for Different RealitiesSession 8: The Way Forward – Building Alliances and Regional Partnership How to registerThe forum will be held in a hybrid format. In-person attendance is by invitation only, while livestreaming of the forum will be available to the public. To register, please complete this form on or before 24 March 2026.Event organizers / partnersAsian Development Bank (ADB)WHO Regional Office for the Western Pacific High-Level Technology Fund (HLTF)ContactAkihito WatabeHealth Specialist, SD3-HSDawatabe@adb.org Jae Kyoun KimHealth Specialist, SD3-HSDjkkim@adb.org
Revealed: a crypto billionaire’s political base hosting ‘anti-woke’ and rightwing activists in Westminster
Pardoned by Trump after violating US banking law, Ben Delo provides funding, networking, and podcasting space for a range of groups, including those with hardline views on migration and abortion
I moved my company from Wall Street to Florida—wish I'd done it sooner
Webull's chief of staff and head of strategic partnerships explains the benefits of moving the company's headquarters to a less saturated market.
Project SnowWork: The easiest way for business users to get work done
Today, we are announcing Project SnowWork (Research Preview), a new autonomous AI platform for business leaders and knowledge workers across finance, sales, marketing, operations and more designed to move beyond simple answers.
10,000 Corewell Health East nurses across nine Michigan hospitals vote to authorize strike
Nurses at Corewell Health East, represented by the Teamsters Local 2024 union, voted on Tuesday to authorize a strike by a nearly 90% margin. The union includes around ten-thousand nurses across nine hospitals and campuses throughout southeastern Michigan, according to a press release from the union. “This overwhelming strike vote shows that nurses are done […]
Good vibes only? The science behind optimism and manifestation
Psychologist Deepika Chopra says that optimism isn’t about being positive all the time. It’s about staying open, curious and resilient. In her new book, The Power of Real Optimism, she explains the science behind optimism and evidence-based manifestation, and how affirmations done the right way can lead to success. Follow us on Instagram: @nprlifekitSign up for our newsletter here.Have an episode idea or feedback you want to share? Email us at lifekit@npr.orgSupport the show and listen to it sponsor-free by signing up for Life Kit+ at plus.npr.org/lifekit
Southeast Asian Fuel Prices Destabilize Politics
Indonesia, for one, has a bloody history of fuel-related riots.
Plagued by early deficits, Wild turn page to meet Blackhawks
A three-game winless streak has done little to compromise the Minnesota Wild's solid playoff positioning.
Smith: politics and big oil slow nationwide year-round E15 push
A U.S. Senator from Minnesota says politics have made nationwide, year-round E15 an interesting topic of discussion in the Senate. “It’s hard to find someone who opposes it, yet you really can’t get it done.” Tina Smith tells Brownfield “let’s be honest. I think there are U.S. Senators who have big oil interests in their […]
Trump gives second wind to reforming college sports regulation
An effort to regulate the big business of college sports is receiving a second burst of energy on Capitol Hill thanks to President Trump’s insistence that more be done to curb&n…
Ronda Rousey's return likely a one-and-done deal
Former UFC women's bantamweight champion Ronda Rousey will return to competition after a decade on May 16, at the Intuit Dome in Inglewood, California. "Rowdy" will face fellow women's MMA pioneer Gina Carano under Most Valuable Promotions. Rousey, 39, last fought in December ...
Wake Forest to Play Navy in First Round of NIT
Deacs aren’t done yet
Done With Corporate Life, Black Women Are Starting Businesses in Droves
They are becoming entrepreneurs at a faster clip than any other demographic—and a chillier corporate world has a lot to do with it.
Why curbing money in Oregon politics is easier said than done
A former Oregonian/OregonLive reporter explores what's happened since his groundbreaking 2019 investigation.
Rumour: Pokemon Legends Galar to be prehistoric Pikmin-like game commanding groups of up to 30 Pokemon
The next Pokemon Legends game which is currently titled Pokemon Legends: Galar will seemingly have a Pikmin-like aspect where you can command up to thirty Pokemon in your squad. The game was leaked as…
Learning ignites at SHS science circuit
Inside Sandpoint High School’s gym, elementary school students inflated cow lungs, flinched at bowling balls and made bubble tea boba as a part of the annual Science Circuit.
Fertitta in weekend deal talks to acquire Caesars, while billionaire Carl Icahn waits in the wings
The deal, if it gets done, would not be finalized until early April and is not expected to close until 2027.
Slay the Spire 2 is a bit too familiar for its own good
Early Access impressions: New characters shine, but it feels like we've done this before.
How Waterford trained all its K-5 teachers in science of reading
The Michigan Department of Education wants all K-5 teachers to go through a training called LETRS. Waterford Public Schools has already done that.
Analyzing the Panthers needs after the start of free agency
The Carolina Panthers have made some big moves in free agency, but there is still work to be done.
White House says it’s ‘done’ with vaccines. MAHA begs to differ
As Trump political advisers try to move on from vaccine policy debates, MAHA movement insiders push back, calling RFK Jr. supporters vital to GOP's success.
Gavin Newsom promised over one hundred mental health projects — many are still abandoned
The world just smashed the emergency glass on oil prices. Now it’s up to Trump for a long-term fix
Dozens of countries have done the unprecedented, releasing an historic amount of crude from emergency reserves to prevent high oil prices from crippling the economy. If that doesn’t work, there’s only one serious option left: ending the war and opening the Strait of Hormuz.
Howard Schultz to leave Seattle as business community bristles over income tax
Even on the dreariest of days, Bob Donegan radiates optimism.
Bobby Hurley out at Arizona State but likely not done: Possible jobs he could get and who ASU's targeting next
Arizona State is moving on from Bobby Hurley after 11 seasons. Here's a look at Hurley's record in Tempe and the possible landing spots for the veteran coach.
Initial thoughts on Colts’ first free-agent moves
First wave of free-agency done, and the Colts have moved as many of us expected, which is rather surprising. It usually does not transpire like this, I was especially surprised by the Pittman and Franklin moves because I did not expect them to happen, but here are my hot opinions on what Ballard and Steichen […]
Federal officials walked back claims on leucovorin. Here’s what families should know now
The drug leucovorin was touted by the Trump administration in September as a potential treatment for thousands of children with autism. Now, some parents and guardians of children with autism say they feel abandoned by the US Food and Drug Administration’s new stance on leucovorin.
Minerva Neurosciences Reports Fourth Quarter and Fiscal Year 2025 Financial Results and Business Updates
Initiation of confirmatory Phase 3 trial with roluperidone for negative symptoms of schizophrenia is planned for Q2 2026, with topline data anticipated in 2H 2027BURLINGTON, Mass., March 11, 2026 (GLOBE NEWSWIRE) -- Minerva Neurosciences, Inc. (Nasdaq: NERV), a clinical-stage biopharmaceutical company focused on the development of therapies to treat central nervous system (CNS) disorders, today provided business updates and reported financial results for the fourth quarter and year ended Decembe
Former site of Rego Park department store acquired by Northwell Health for $235.5 million
Northwell Health has acquired a 338,000-square-foot abandoned department store at 96-05 Queens Blvd. in Rego Park for $235.5 million from Steve Roth.
Google rolls out new Gemini capabilities to Docs, Sheets, Slides, and Drive
The idea behind the new features is to make the apps more personal and capable to help users get things done faster, right within the platforms themselves.
Get Your Small Business Jobs Done With VistaPrint
Elevate your brand presence with these cost-effective print and promotional products, without stretching your budget.
Steven Roth sells former Queens department store to Northwell Health for $236M
Two of New York’s frequent real estate shoppers just made a $236 million deal on an abandoned department store in Queens.The seller was Steven Roth, who acquired the 340,000-square-foot retail property in 1995 after a battle for control with now-President Donald Trump. Roth and partners stand to reap a nearly $150 million gain from selling the building near the Long Island Expressway to Northwell Health. The deal was disclosed Monday by Alexander’s Inc., a real estate firm Roth runs that is named after the big-in-its-time department store that once operated in the building. Alexander’s filed for bankruptcy in 1992 and closed all 11 of its locations. The site later became a Sears. It has been vacant since Burlington and Marshalls moved out last year.
Politics & Threats
The prevalence of threats and violence toward public servants in the current political climate, and what's being done to address it
Caitlin Clark, Breanna Stewart Push for Marathon CBA Session
The WNBA stars want to “iron it out” and “really get it done.”
MINNEAPOLIMEDIA ENTERTAINMENT This Weekend in the Twin Cities Entertainment Guide | March 7 to March 8, 2026
Broadway, live music, Gophers hoops, dinosaurs, taiko drums and maple syrup. The Twin Cities is packed this weekend. Get out there, March 7 to 8. Winter is not done with us yet.
MINNEAPOLIMEDIA ENTERTAINMENT | This Weekend in the Twin Cities: Entertainment Guide - March 7 to March 8, 2026
Broadway, live music, Gophers hoops, dinosaurs, taiko drums and maple syrup. The Twin Cities is packed this weekend. Get out there, March 7 to 8. Winter is not done with us yet.
How is the Iran war reshaping the world and politics here at home?
For the last week, Israeli and US bombs have devastated Iran. And the conflict has widened to include multiple countries in the Gulf. How is the conflict reshaping the world order and impacting Trump’s popularity here in the United States?For sponsor-free episodes of Consider This, sign up for Consider This+ via Apple Podcasts or at plus.npr.org. Email us at considerthis@npr.org.This episode was produced by Connor Donevan, Elena Burnett, Alejandra Marquez Janse and Erika Ryan. It was edited by Barrie Hardymon, Tara Neill, Dana Farrington, Jeanette Woods and Courtney Dorning. Our executive producer is Sami Yenigun.
Democrats aren't done with Kristi Noem: From the Politics Desk
Plus, three key questions about the Iran war.
Scientists find 2 marsupial species, thought to have gone extinct 6,000 years ago, living in the forests of New Guinea
The pygmy long-fingered possum and the ring-tailed glider, two marsupials believed to have died out thousands of years ago, are still alive in Papuan Indonesia.
‘Traversal’ Review: Stories of Science and Love
An Indonesian volcano led to lousy weather in Europe. Trapped inside, Mary Shelley began to write “Frankenstein.”
Building climate-ready healthcare facilities across Indonesia
The World Health Organization (WHO), working with the Ministry of Health and partners, developed the Climate-Resilient and Environmentally Sustainable Health Care Facilities assessment tools. These were adapted from WHO's global framework and integrated into the SIKELIM platform, a digital system that maps disaster-affected facilities in real time. The tools help facilities assess vulnerabilities across systems including workforce capacity, water and sanitation WASH and waste, energy, infrastructure and technology.
American basketball player Jarred Shaw hoping for 'miracle' in Indonesian prison as health crisis worsens
American basketball player Jarred Shaw faces a health crisis while in an Indonesian prison after his May 2025 cannabis arrest, with the former star battling Crohn's disease.
Ex-college basketball player seeks release from Indonesian prison amid health crisis
Jarred Shaw is imprisoned in Indonesia for a drug offense, his health deteriorating. The former college basketball star is 'asking for sympathy.'
Six federal scientists run out by Trump talk about the work left undone
Federal data shows the NIH lost about 4,400 people — more than 20% of its workforce. Scientists say the departures harm the U.S.’ ability to respond to disease outbreaks, develop treatments for chronic illnesses, and confront the nation’s most pressing public health problems.
MAGA’s top lawyer just gave a sitting GOP senator the biggest scare of his career
No lawyer has done more in the last decade to advance a distinctly MAGA approach to the Constitution than Ken Paxton.
Crypto billionaire pardoned by Trump gives £20m to science
The London Institute for Mathematical Sciences has secured funding from the British entrepreneur Ben Delo — a major gift for a non-Oxbridge body
Trump says he'll attend White House correspondents' dinner for his first time as president
President Donald Trump says he'll attend this year's White House Correspondent Association dinner on April 25, marking the first time he's done so as commander-in-chief.
Trump pushes back on mounting criticism about his Iran war battle plan as conflict spreads
President Donald Trump is pushing back on criticism that he hasn’t done enough to explain why it was necessary to start a war with Iran now or to articulate his vision for an endgame to the escalating conflict
Emma Bloomberg could've done anything. She chose to help the underdogs
Emma Bloomberg, daughter of Michael Bloomberg, founded Murmuration to help community organizations have the tools and tech to succeed.
UK: Christopher Dring says physical sales of Resident Evil Requiem on Nintendo Switch 2 haven’t done big numbers
UK journalist Christopher Dring has stated that physical sales of Resident Evil Requiem on the Nintendo Switch 2 in the United Kingdom haven’t done huge numbers. He went on to say that Resident Evil…
Mystic & Aurora Ticket easily obtainable in Pokemon FireRed & LeafGreen on Switch
Two things which were notoriously difficult to get in the original versions of Pokemon FireRed and LeafGreen were the Mystic and Aurora Tickets which could only be obtained via limited items that were…
Pokemon FireRed & LeafGreen censor naughty names inputted by player
One of the long-standing traditions for some users is to name yourself or your rivals something naughty to provide endless amusement in the older Pokemon games. This tradition has now been brought to…
Japan: Resident Evil Requiem on Nintendo Switch 2 is sold out at three of the biggest game retailers
It seems as though Japanese gamers are lapping up the recently released Resident Evil Requiem on the Nintendo Switch 2. Reports are circulating that the latest Resident Evil game on the Nintendo…
Trump Is Attacking Climate Science. Scientists Are Fighting Back.
It’s easy, looking at the past year, to see the damage the administration has done. But researchers are also stepping up, trying to fill the gaps.
What it means if Iran’s supreme leader is dead
President Donald Trump placed a huge wager by launching a massive air assault on Iran despite having done little to prepare Americans for a new Middle East war with immense risks and years of future consequences.
WBD Done Dealt: Politics Are On Paramount’s Side
Netflix walked away from WBD not just over price, but because of politics which has favored Paramount from the get-go.
Microsoft’s “Copilot Tasks” AI uses its own computer to get things done
A copilot for your busywork.
Indonesia Raises $4.5 Billion to Rebuff Credit Outlook Concerns
Indonesia pulled off its biggest global bond sale since at least 2017, overcoming the threat of a credit rating and signaling easing investor concerns about fiscal woes in Southeast Asia’s largest economy.
Motorola teases ‘every detail’ about Razr Fold is coming next week
Motorola has done well with its flip phone Razr series in recent years, but the company revealed at CES 2026...
DLSS upscaling is coming to Fallout 4 on Nintendo Switch 2 in the future
Bethesda has confirmed that the Fallout 4: Anniversary Edition which launched yesterday on the Nintendo Switch 2 will eventually get DLSS. DLSS is a form of upscaling which should come in handy for…
Seatmate politics - Live Updates
So much for interparty solidarity. Reps. Thomas Massie (R-Ky.) and Ro Khanna (D-Calif.), who earlier in the day telegraphed plans to sit together during the State of the Union, have evidently abandoned that idea. State of the UnionMassie wrote on X before Trump’s address that he was seated on the Republican side of the chamber. Khanna is sitting next to former House Speaker Nancy Pelosi. But Reps. Mike Lawler (R-N.Y.) and Josh Gottheimer (D-N.J.), who often work together, are seated together along with some other Republicans. Mia McCarthy contributed to this report.
Bungie says 'no second chances' if you're caught cheating in Marathon
Anyone caught cheating in Marathon will receive a permanent ban from Bungie, which announced a one-and-done stance.
The challenge of the current generation of Black politicians
Black political power has reached a high point, with record numbers of Black members in the House and Senate, but Black voters are still asking what Black political power has done for them, as they…
Uniting to respond to mental health impacts of digital violence
Technology-facilitated gender-based violence (TFGBV), from doxxing and cyberstalking to cyberbullying and online harassment, is reshaping how women and girls navigate digital spaces. Globally, an estimated 23% of women have experienced digital violence. In Indonesia, reported cases of TFGBV reached 1,791 in 2024, a 40.8% increase from the previous year. Yet very few survivors seek help, leaving lasting effects on their mental health and wellbeing. As part of the multi-UN agencies UNiTE campaign for the 16 Days of Activism against Gender-Based Violence, the World Health Organization (WHO) and the Ministry of Health (MoH) co-hosted a talk show on 6 December 2025 to spotlight this urgent issue. The event brought together voices from Meta, the Indonesian Clinical Psychologist Association and Dr Vivi Syarif, a WHO Fides content creator, creating a cross-sectoral dialogue on the magnitude and mental health impact of digital violence. The talk show introduced psychological first aid as a vital initial intervention that communities can provide to survivors. This intervention aligns with the Psychological First Aid: Guide for Field Workers, a framework that has been standardized for over a decade. The "look, listen, link" approach focuses on ensuring safety and urgent needs, reassuring survivors and connecting them to appropriate services. In addition to this public health approach, Meta also outlined mechanisms to respond to digital violence and reaffirmed its commitment to building safer digital spaces by continuously updating community guidelines based on user feedback. Such collaborative discussions help connect community engagement initiatives with daily digital life. They empower audiences not only to understand how the health sector and industry are responding, but also to educate others, promote first-line support and encourage referrals to appropriate help. By fostering awareness and engagement, these dialogues strengthen collective resilience against digital violence. Written by Jessie O. Yunus, National Professional Officer (Gender, Equity, Rights and Disability Inclusion), WHO Indonesia
Nintendo offering refunds for poor Xenoblade Chronicles X Switch 2 upgrade
Nintendo has apparently started refunding those who have asked for their money back for the disappointing Xenoblade Chronicles X Definitive Edition Nintendo Switch 2 upgrade. There have been numerous…
Medical tourism: US family went to Turkey for healthcare, saved money
Amid rising US healthcare costs, Cara West found relief in medical tourism. Her family saved thousands getting tests and scans done in Turkey.
Medical tourism: US family went to Turkey for healthcare, saved money
Amid rising US healthcare costs, Cara West found relief in medical tourism. Her family saved thousands getting tests and scans done in Turkey.
On Trump, Obama, Aliens and Washington’s Latest Bombshell
Plus, a pardoned crypto king visits Mar-a-Lago and Trump’s advisers are struggling to get him to focus on the economy.
UMass Memorial Health stops surgeon from doing transgender surgeries. Why?
Alford joined the the health system in 2023, and has done more than 40 surgeries for patients 18 to 73 years old.
‘We’ve been abandoned’: Some Md. business owners say Gov. Wes Moore left them behind
When Wes Moore first ran for governor, he framed his candidacy around a simple promise: Maryland would “leave no one behind.” But some small business owners say they feel abandoned.
'We’ve been abandoned’: Some Md. business owners say Gov. Wes Moore left them behind
When Wes Moore first ran for governor, he framed his candidacy around a simple promise: Maryland would "leave no one behind."
Kenny Atkinson weighs in on the NBA’s tanking debate
The NBA is looking into fixing tanking. Doing so while satisfying all stakeholders is easier said than done.