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Northern Essex’s McCarthy Joins New Small Business Advisory Council
Michael McCarthy, executive vice president and chief financial and operating officer at Northern Essex Community College, was recently appointed to the Massachusetts Small Business Development Center statewide Advisory Council, a new group of business, government, economic development and community leaders helping guide the future of small business support in the state. The Advisory Council was
Seiko Just Made A £510 Panda Watch With Ears For Pushers And A Tail
It started life as one of Seiko’s mad design experiments. Now 5,000 are going on sale
CREO Brings AI, Health, National Defense Into Focus for Cybersecurity Awareness Month
The Center of Excellence in Cybersecurity Research, Education and Outreach is marking Cybersecurity Awareness Month with a speaker series that runs through Oct. 29.
'Stop playing politics': Ginther, Council trade barbs over $2.5M Barack Center repairs
A fight over $2.5 million in repairs to a tornado-damaged Southside community center has escalated into a public political clash between Columbus Mayor Andrew G
New Editorial Calls for Investing in Hospital Nursing Workforce to Address Health Impacts of Extreme Heat
Hospitals should make nurse staffing and supportive nurse work environments a core part of extreme heat emergency preparedness, according to a new editorial from Penn Nursing’s Center for Health Outcomes and Policy Research (CHOPR), as record-breaking temperatures and heat-related emergency department visits continue to rise across the United States. The editorial appears in Public Health Nursing.
On the Money: Tips for starting a small business
UW-led optoelectronic center receives second round of funding from the US National Science Foundation
A University of Washington-led center for optoelectronics — technologies that combine light and electronics — brings researchers from 14 universities across the U.S. together with the mission to develop new materials to transform information technology with light. Founded in 2021, NSF IMOD has received a second round of funding from the NSF to continue its work for the next five years.
How the Trump administration's revamped healthcare price transparency rules could impact patients
Consumer advocates say the rules are an important step, but stress there's more work today to ensure full transparency.
How the Trump administration's revamped healthcare price transparency rules could impact patients
Consumer advocates say the rules are an important step, but stress there's more work today to ensure full transparency.
Columbus Councilmembers say mayor playing politics over damaged rec center
Columbus City Councilmember Nancy Day-Achauer is accusing Mayor Andrew Ginther of using Barack Recreation Center as a "political prop" after it was damaged by a tornado in August.
Columbus Councilmembers say mayor playing politics over damaged rec center
Three Columbus City Councilmembers accused Mayor Andrew Ginther of using a storm-damaged rec center as a “political prop” in a capital budget fight.
Hawaiʻi Island program bridges the gap between food and health
Through a partnership with the Hawaiʻi Island Community Health Center and the Food Basket, the initiative provided 25 patients with weekly food boxes that are completely locally sourced to measure how regular access to healthy, local foods would impact their overall health.
The science behind the Superdome’s roar during the Domecoming game
Superdome Decibels Debunked: How loud was the Dome when Steve Gleason blocked the punt?
Visalia flexes its fitness, business competition - The Sun-Gazette Newspaper
VISALIA – From fitness to business, Visalia continues to be a place for some healthy competition.
Emory & Henry, Appalachian Independence Center host inaugural Healthy Aging Fair
Southern University to lead new hub for rural La. businesses with $1.27M federal award
Southern University will use a $1.275M federal award to launch the LIFT center to support rural Louisiana businesses.
The Hunt for Consciousness Is Moving Deeper Into the Brain
A research team is using ultrasound to map the deep-brain circuits that may give rise to conscious experience.
Dysfunction rocks county health dept. at center of Michigan MAHA movement
Nurses allege a toxic workplace has taken root at the St. Clair County Health Department. But officials are shrugging off calls for an independent investigation of its anti-vaccine medical director.
Cincinnati nuisance business rules for late-night bars face fierce opposition
A proposed crackdown on Cincinnati’s so-called nuisance businesses has put City Hall at odds with some late-night bar and nightclub owners.
DHS buys 2 more detention centers in California for $950 million
WASHINGTON — The Department of Homeland Security has purchased two immigrant detention facilities in Adelanto for $950 million, according to the private prison corporation that sold them. The sale by
Top Line MN Wild Center Leaves Practice with Injury
The Minnesota Wild have another injury concern after Russian centerman Danila Yurov left Monday's practice early with a previously undisclosed injury.
Orlando Science Center returns with themed laser shows on Oct. 10
Orlando Science Center returns with Cosmic Concerts on Oct. 10, featuring laser tributes to Led Zeppelin and Elton John.
WBIR Channel 10
WBIR Channel 10 in Knoxville, Tennessee produces award-winning, community-centered content "Straight From The Heart" of East Tennessee. We strive to be good citizens, to do what is right, and to be fair and honest. We care.
He says a nearby data center made it hard to breathe
Legends Radio spotlights JB Berkow’s lifelong art passion
JB Berkow is the founder of Benzaiten Center for Creative Arts in Lake Worth Beach. LEGENDS RADIO / COURTESY PHOTO This week's Legends Radio Local Artist Spotlight shines on accomplished artist and passionate advocate for the arts, JB Berkow. For more than five decades, JB Berkow has dedicated her life not only to creating art but also to making sure art has a place to thrive. Her work has been exhibited throughout the country in galleries, museums, and universities, and is held in permanent collections, including the Vatican’s Contemporary Art Collection in Italy, Boston University, and Palm Beach International Airport. Her passion for supporting other artists began early. At age 26, Berkow founded Touchstone Gallery in Washington, D.C., which became a highly successful cooperative gallery. She later brought that same entrepreneurial spirit to South Florida, founding Frenchman’s Art Gallery and Studios in Juno Beach in 1995. She opened Rosetta Stone Fine Art Gallery in 2003. In 2015, JB took her commitment to arts education even further by founding the nonprofit Benzaiten Center for Creative Arts. The 15,000-square-foot facility in Lake Worth Beach is home to Florida’s largest publicly accessible glassblowing hot shop and offers instruction in glassblowing, fusing, flameworking, and glass casting. The center also provides free classes to approximately 1,000 underserved children and young adults with disabilities each year. Its “Fragments Reimagined” art therapy program for veterans with PTSD recently received a $100,000 Impact 100 grant. In addition to her work as an artist and advocate, Berkow has authored four books, including Shades of Love and What They Didn’t Teach You in Art School. For JB, art has always been about more than creating something beautiful. It’s about opening doors, inspiring others, and making creativity an important part of life.That is why JB Berkow is in this week’s Legends Radio Local Artist Spotlight.
Byram business owner relocates man experiencing homelessness brought into city
A Byram entrepreneur recorded himself assisting a man experiencing homelessness by offering him a ride and relocating him outside the city.
Hawkeye Women Land Athletic Center Khalia Hartwell From 2027 Class
Fans of Iowa women’s hoops should be very excited about some of the recruits that are saying yes to the black and gold in the post Caitlin Clark era. Jan Jensen has had some of the very best high school players expressing serious interest in Iowa and has convinced a few of them to commit. […]
McNeese’s College of Business Earns Reaffirmation of Accreditation
The McNeese State University College of Business has earned reaffirmation of its accreditation from AACSB International, The Association to Advance Collegiate
Voters to decide on funding West Baton Rouge Parish Health Center
West Baton Rouge Parish voters will decide next month on a 10-year renewal of the property tax that funds the West Baton Rouge Health Center.
Tony Gilroy on leaving the politics of 'Andor' behind for his 9-composer music drama 'Behemoth!'
Tony Gilroy’s “Behemoth!” premiered over the weekend as the centerpiece of the New York Film Festival. Gilroy’s first film since the Star Wars series “Andor” concluded its acclaimed two-season run,
NYC Health + Hospitals/Queens Hosts Community Health Fair as Centerpiece of Hispanic Heritage Month Celebrations
NYC Health + Hospitals/Queens hosted a comprehensive Community Health Fair on September 30, serving as the primary event in the hospital’s month-long
What hospice work taught me that politics never will
In hospice, the person comes before the politics, a lesson that could make public life more humane.
Is This A Healthcare Economy?
This analysis examines recent jobs growth in health care and how it compares to the rest of the economy. Health care employment has grown faster than other sectors of the economy, with jobs in physician offices, hospitals, outpatient care centers, home health, and other settings increasing over the past year even as the rest of the job market plateaued.
Bladen Community College to host “So You Want to Start a Small Business” class and preview Pitch It Bladen 2027
The Small Business Center at Bladen Community College invites aspiring entrepreneurs to attend “So You Want to Start a Small Business” on Tuesday, Oct. 13, 2026, from 6:00 p.m. to 8:00 p.m. in Building 14, Room 104. This class will help participants explore what it takes to become an entrepreneur and take the first steps toward turning a business idea into reality.Participants will explore the entrepreneurial mindset and consider whether they have the interests, characteristics, motivation and willingness to take on the challenges of business ownership. The class will encourage attendees to examine their personal goals, expectations, strengths and readiness to pursue entrepreneurship.Attendees will also gain insight into the realities of starting and operating a small business, including the commitment, planning, decision-making and perseverance required to build a successful venture. Whether participants are just beginning to consider business ownership or already have an idea they want to pursue, this class will provide a foundation for determining their next steps.In addition to the class instruction, attendees will receive advance information about the upcoming Pitch It Bladen 2027 Business Competition, including the application form and details about the program. Individuals who are ready to move forward may submit their applications early and have the opportunity to receive advance acceptance into the program.Pitch It Bladen helps aspiring and emerging entrepreneurs develop their business ideas through structured instruction in business planning, financial management, cash-flow projections, marketing and operations. Participants work toward completing a business plan and preparing a business pitch, with the opportunity to compete for cash prizes.Last year's Pitch It Bladen program demonstrated the value of investing in local entrepreneurs by helping participants strengthen their business knowledge, develop their business plans and prepare to present their ideas. The competition showcased the creativity and potential of Bladen County's small-business community and provided participants with practical tools to move their business goals forward.Building on that success, Pitch It Bladen 2027 will provide another opportunity for local entrepreneurs to gain knowledge, build confidence and take meaningful steps toward launching or growing a business.“The Small Business Center wants to help individuals make informed decisions about entrepreneurship before they take the leap into business ownership,” said Theresa Dennison, Small Business Center director, in a press release. “This class gives participants an opportunity to evaluate whether entrepreneurship is right for them while also introducing them to Pitch It Bladen 2027 and the resources available to help them succeed.”Registration: Visit www.ncsbc.net and search for the class by name, or contact the Small Business Center at 910-879-5572 for additional information.
Yes on Prop 2: How We Can Get Money Out of Michigan Politics!
This November, Michiganders can vote yes on Prop 2 and get corporate spending — including by the data center industry — out of our politics.
Tighter data center rules on Fort Smith Board agenda
The Fort Smith Board of Directors is set to vote Tuesday (Oct. 6) on an ordinance that would give the city more oversight of any planned data center development within...
OSU Center for Health Sciences raises more than $800K for wellness center, scholarships
Oklahoma State University Center for Health Sciences hosted its first Orange Impact event Thursday and raised more than $800,000 toward a new wellness center an
Rural and Urban Health Center Patients and Financing
This brief reports on rural and urban health center patients and financing in 2025 using national data from the Uniform Data System (UDS) and examines potential impacts of recent federal policy changes.
Enabling, Denying, and Spiking the Proverbial Political Football
ANDOVER TOWNSHIP – Republicans are claiming victory over a proposed data center. But it really isn’t that simple. As one critical observer noted on a Stop Andover Data Center social media page: It was the all-Republican township committee that “opened the door (to a data center) in the first place.” This is a local issue to be sure,[...]
Planet Fitness acquires Bakersfield’s Body Xchange Health Club locations
Body Xchange Health Clubs announced that they have been acquired by Planet Fitness.The announcement was posted on their social media pages.The company said that
Mundelein resident chosen as finalist in Advocate Health Has Talent competition
Mundelein resident Gerardo Ocampo was driving his wife and child home from the airport when he received a call from his supervisor at Advocate Condell Medical Center.
Final Family Health Festival of the year comes to Reno-Sparks Livestock Events Center Pavilion
The final Family Health Festival of the year takes place Thursday, Oct. 8.
Health conference to cover GLP-1 drugs, hormone therapy, youth sports
The Area Health Education Center (AHEC) will host its 42nd Annual Update in Medicine Conference.
WindRose Health Network Discloses Data Breach Affecting 33K Individuals
Data breaches have been announced by WindRose Health Network and Advantage Home Health Care in Indiana, Camden-on-Gauley Medical Center in West Virginia, WindRose Health Network in Indiana has reported a data breach affecting more than 33,000 individuals. Data breaches have also been reported by Advantage Home Health Care in Indiana, Camden-on-Gauley Medical Center in West Virginia, and Lakes Region Visiting Nursing Association in New Hampshire.
Your Age at Menopause May Predict Your Brain Health Years Later
Brain health experts explain.
St. Louis Prehistoric Life Show brings free fossil fun to the Science Center
The inaugural St. Louis Prehistoric Life Show invites families to crack open rocks, identify fossils, meet paleontologists, and more.
#TenYearsAgo in Health Law - Petrie-Flom Center
Since January 2026, the “10 years ago” viral trend on social media — fueled by nostalgia and literal rose-colored glasses (ok, filters) — has tried to remind us of the allegedly simpler times of 2016.
Justin Bibb’s new Blue Cities/Red States coalition seeks the ‘radical center’
Cleveland Mayor Justin Bibb is launching Blue Cities/Red States, a 15-mayor coalition aimed at showing Democrats can govern effectively even when Republicans control their statehouses.
Caring for students a priority at Health Center
A primary purpose of the Campbell University Health Center is caring for students, serving as an important resource in regard… More on this post
Health care aide charged in assault of disabled resident at Halfmoon facility
A Schenectady woman working as a health care aide has been charged after State Police said a disabled resident was assaulted at a Halfmoon care facility.
Metallica rides the lightning with Sphere residency debut
The Science Enabling a Steady Supply of Critical Minerals
Researchers are collaborating across disciplines to unlock domestic sources of valuable materials and lower costs.
ER visits from foreign-born patients fell drastically during ICE raids, study finds
Those who did visit were more likely than U.S.-born patients to require hospitalization.
DHS buys three detention centers in California for $950 million
The GEO Group, a Florida-based private prison corporation, announced Monday that it had sold the detention facilities, including the Adelanto ICE Processing Center, totaling 2,644 Beds.
UT San Antonio Health Science Center study finds elevated levels of toxicants in teeth of children with autism
UT San Antonio Health Science Center study finds elevated levels of toxicants in teeth of children with autism
CARTI encourages women to prioritize breast health
As part of its annual breast health campaign, CARTI Cancer Center shared critical information regarding the importance of early detection and debunked common misconceptions about breast cancer risk…
‘Interstellar,’ ‘Nope’ headline Great Lakes Science Center’s DOME Movies After Dark fall lineup
The series also includes "V for Vendetta." Films are presented in the science center's DOME theater, with a six-story-high screen and an 11,600-watt digital sound system.
Spain’s New Protest Movement Is Putting Class Center Stage
The occupation of Madrid’s Puerta del Sol by housing protesters has brought back memories of the anti-austerity revolt that began in 2011. But where the Indignados used generic populist language, this...
2026 Outstanding Women in Business
The 18th annual Outstanding Women in Business awards recognize a dozen well-accomplished professionals from across the region and in many industries who go above and beyond. The committee selected the winners from more than 80 nominations, all of whom were worthy. The criteria evaluated each nominee’s professional achievements, community impact, ability to break the glass ceiling and mentorship of other professionals, particularly women. In addition to profiling these women in the following pages, the Worcester Business Journal will celebrate this year’s Outstanding Women in Business at a special luncheon on Oct. 28 at the College of the Holy Cross. To join the celebration of these exceptional women, visit WBJournal.com and register. – Mark Conti, editor This Year’s Judges Worcester Business Journal considered 54 Central Massachusetts professionals for the 2026 Outstanding Women in Business awards, based on 83 nominations. These nominees were independently evaluated by two volunteer judges, who scored each on their professional achievements, community contribution and mentorship of young professionals. Samantha P. McDonald is a partner at Bowditch. She is an experienced, client-focused real estate lawyer, concentrating on business and real estate property law. She has been recognized as a WBJ Power 100 in the Class of 2026 and a “Top Women of Law” in Massachusetts Lawyers Weekly. Dr. Kavita Babu is chief medical officer and vice president of medical affairs at Heywood Healthcare, where she provides strategic and clinical leadership to advance high-quality, patient-centered care across the organization. She is also a member of the WBJ Outstanding Women in Business Class of 2025.
HEALTH MINUTE: PREVENTING DANGEROUS RSV IN INFANTS
We’re officially in respiratory virus season. The U.S. Centers for Disease Control and Prevention says it typically runs October through mid-May, and the agency expects the U.S. will see a
Is It Healthy To Drink Apple Cider All Season Long? Nutritionists Explain
Gotta get that fall flavor.
Lumos offers family entertainment at Valley Ranch Town Center in New Caney
Greg and Brigette Little opened Lumos, a 45,000-square-foot entertainment venue with laser tag, bowling and Embers Grill, at Valley Ranch Town Center.
Watch live: RFK Jr., Trump officials unveil health care price transparency push
Health and Human Services Secretary Robert F. Kennedy Jr. and Centers for Medicare and Medicaid Services Administrator Dr. Mehmet Oz will announce new efforts Monday aimed at strengthening health c…
oasisVRX Expands to the Princeton Area With New Active Entertainment Virtual Reality Destination
/PRNewswire/ -- oasisVRX is expanding with the opening of its second location at Princeton North Shopping Center, 1225 Route 206 in Princeton, New Jersey....
Tracking health misinformation helps pediatricians provide targeted patient education
Pediatric clinicians can learn useful information by tracking the health misinformation that their patients encounter, according to research presented during the American Academy of Pediatrics 2026 National Conference & Exhibition Oct. 2-6, 2026, at the San Diego Convention Center.
Delta Health Center Receives Funding
Delta Health Center, Inc. has received four awards totaling $4,660,331.59 through the Mississippi Rural Health Transformation Program, a state initiative funded by the Centers for Medicare & Medicaid Services. Governor Tate Reeves announced the four RHTP awards on September 14, as part of 167 awards totaling more than $104 million statewide. The awards announced will […]
Delta Health Center Receives Funding
Delta Health Center, Inc. has received four awards totaling $4,660,331.59 through the Mississippi Rural Health Transformation Program, a state initiative funded by the Centers for Medicare & Medicaid Services. Governor Tate Reeves announced the four RHTP awards on September 14, as part of 167 awards totaling more than $104 million statewide. The awards announced will […]
Here’s Exactly How Often to Eat Fish to Support Brain Health, According to a Dietitian
In TODAY.com’s Expert Tip of the Day, a dietitian shares how to get the brain-boosting benefits from eating fish regularly.
Bill's Prescription Center remains family business in Brandon
Bill's Prescription Center continues operating as a multi-generational family pharmacy in Brandon, maintaining its commitment to personalized care despite rapid regional growth.
The 2026 Lookout List: Health and Wellness
Are you feeling centered? This is a place where we value having aligned chakras, purposeful movement, a good gym to frequent and a good dispensary to drop into (for those that partake). For our Health and Wellness category of the Lookout List, we asked you for the best spots to drop into for yoga, mindful moments, health food and more.
Providence Opens New Rural Health Clinic in Polson
Just over a year after breaking ground on a rural health clinic in Polson, community members, donors and hospital staff gathered Sept. 30 in front of the new building just behind Providence St. Joseph Medical Center. “Over the years we’ve heard about this need over and over again,” Chief Executive for Providence Montana Krissy Petersen […]
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Top salaries at VNA Health Care 2024
VNA Health Care is an Aurora-based not-for-profit Federally Qualified Health Center that serves nearly 90,000 patients a year.
Top salaries at VNA Health Care 2024
VNA Health Care is an Aurora-based not-for-profit Federally Qualified Health Center that serves nearly 90,000 patients a year.
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UT San Antonio Health Science Center study finds elevated levels of toxicants in teeth of children with autism
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Caterpillar is a Great Business. But is CAT Stock a Great Buy?
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