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Why does Donald Trump keep poking fun at Ken Paxton's looks?
At the midterm Republican Convention in Dallas, Trump ribbed Paxton’s style during both of his primetime addresses.
Science Agencies Pull ‘Political Interference’ Protections From Scientific Integrity Policies
NSF and the Department of Commerce have scrubbed references to the dangers of political interference in science from official agency policy documents.
New York state seeking proposals to build new prison
The state is seeking "letters of interest" to design and construct a new 3,000-plus bed correctional facility.
Green Bay Packers release WR Bo Melton: Reports
(WFRV) – The Green Bay Packers have reportedly released one of their wide receivers a few days before their season opener. According to ESPN’s Adam Schefter, the Green Bay Packers have released wide receiver Bo Melton. Melton played three seasons with the team, appearing in 38 games. He scored two touchdowns in the regular season. […]
Jalen Hurts talks about his relationship with Philadelphia
The QB opened up about the City of Philadelphia and his relationship to it.
Pete Alonso tabbed as Orioles' MVP for obvious reasons
Alonso has been Baltimore's best player in 2026.
Week 1 injury report for the Carolina Panthers
The Panthers are healthy for the most part heading into Week 1 against the Bears.
Gophers football adds new commercial logo on helmets
The Gophers athletic department has opened up a new revenue stream, via a sponsorship sticker for its football helmets this season, sources told the Pioneer Press. With a new NCAA rule allowing a few spaces for commercial logos on jerseys, apparel and equipment this year, the bottom rear “bumper” of Minnesota’s helmets will now have branding for Visible, a budget mobile phone carrier owned by ...
Mourinho: Real Madrid could have scored ‘eight goals’ against Inter
José Mourinho hits back at criticism following Real Madrid’s 2-1 win against Inter: ‘We could have scored eight goals.’Real Madrid coach Mourinho spoke again about the Merengues’ recent 2-1 w...
Elon threatens to sue over new 'Musk' doc. But festival crowd loves it
Elon Musk and Elizabeth Holmes are unwitting film fest stars as documentaries about problematic tech titans have dominated news coming out of prestigious film festivals.
Too much light at night may quietly reshape your heart
Nighttime light exposure was linked to thicker, stiffer heart chambers and early signs of reduced heart function in a study of more than 11,000 people. The findings suggest that keeping bedrooms darker could be an overlooked strategy for protecting the heart.
It’s Been 25 Years Since 9/11. Did the Terrorists Win?
It’s been 25 years since 9/11 and we are more divided, the world is less secure, and many of our bedrock principles and ideals are eroding
Iraola on team fitness, Koumas' development and Fulham
Liverpool boss Andoni Iraola has been speaking to the media before Saturday's Premier League game against Fulham at Anfield (kick-off 15:00 BST). Bradley Barcola, who was forced off during Liverpool's 2-1 victory over Atletico Madrid in the Champions League with cramp, "should be available" for Saturday's match. Iraola confirmed the team will train on Friday afternoon and then they will assess whether Cody Gakpo "is ready" to face Fulham, or if they "need to wait" until Tottenham on Tuesday in the Carabao Cup.
Looking Glass plans a secure inpatient behavioral health facility for youth in Eugene
Looking Glass is planning a secure inpatient facility for youth with severe behavioral health needs in Eugene with 12 beds.
Lancaster County public sales: Sept. 11, 2026
Tim Weaver Auction Service conducted a public auction of real estate Aug. 11 for Anna Kauffman at 34 Corner Ketch Road, Paradise. A five-bedroom house and horse barn on 2
Yankees news: Anthony Volpe makes a mighty return
Volpe back in the mix as Chisholm hits IL; Warren’s hot streak; Mo praises Bednar; a prospect breaks out
Alliance Entertainment Holding Stock Soars Over 12% After Hours — Is This Small-Cap Entertainment Play Ready for a Comeback?
Alliance Entertainment Holding Corp. (NASDAQ:AENT) shares climbed 12.52% to $6.20 after the bell on Thursday following the announcement of fiscal year results.Revenue, Margins and EBITDA All Post Solid GainsThe results, announced after the market closed on Thursday, were for the period ended June 3…
3 burning Blackhawks questions entering 2026-27 NHL season
The Chicago Blackhawks once again missed the Stanley Cup Playoffs in 2026. The Blackhawks did not reach the highs that similar teams such as the San Jose Sharks reached a year ago. But Connor Bedard and his teammates still made progress as a team in 2025-26. The Blackhawks want to turn the corner sooner rather than later. Chicago has some very […] The post 3 burning Blackhawks questions entering 2026-27 NHL season appeared first on ClutchPoints.
A.J. Brown to miss extended time
Patriots WR A.J. Brown to miss at least four weeks because of Week 1 injury
Seahawks lose player to Klint Kubiak’s Raiders in waiver claim
The Seahawks lose an offensive lineman to Klint Kubiak’s Raiders.
Some Republicans Balk at Trump’s $5,000 ‘Dividend’ Offer
The president’s call to send a $5,000 “dividend” to every American adult if Republicans win the midterms disturbed some members of his party.
Falcons QB Tua Tagovailoa leaves practice with an oblique injury
Atlanta Falcons quarterback Tua Tagovailoa left practice Thursday with an oblique injury. Tagovailoa bent over in obvious discomfort after throwing a pass during a portion of practice open to media and grabbed his right side. The Falcons listed him as a limited participant.
Angel flies into Marvel’s “X-Men” movie: “Gen V” star joins cast
Asa Germann will keep playing a supe, just not in the world of “The Boys.”
Healthcare Technology for Providers Stocks Q2 Teardown: Privia Health (NASDAQ:PRVA) Vs The Rest
Looking back on healthcare technology for providers stocks’ Q2 earnings, we examine this quarter’s best and worst performers, including Privia Health (NASDAQ:PRVA) and its peers.
College Football Over/Under Picks for Week 2
Get Chris Vasile’s college football Week 2 Over/Under picks and predictions for Oklahoma vs Michigan, Arizona vs BYU, and Arkansas vs Utah.
Overtime Extends Partnership With Adidas In Multi-Year Agreement
Overtime initially signed a multi-year deal with the global sportswear company in 2023.
Castillo Emerging as One of Rangers' Most Intriguing Prospects
Yolfran Castillo has taken a major step forward for the Texas Rangers in 2026.
What to watch: College football Week 2 viewer's guide
No. 1 Ohio State visits No. 4 Texas after beating the Longhorns in 2025.
🚨 Transfers: the announcements you missed this week
The transfer window is not closed. The free-agent market is heating up.This Thursday, Hakim Ziyech found a new club. The Moroccan star has landed at Botafogo, the historic Rio de Janeiro club.Earlier ...
The Israel Public Health Association’s bet on what comes next
Chief executive, Yasmin Nahum, is trying to meet a surge in wartime trauma, youth substance use, and prescription-opioid dependence with programs the state has not yet absorbed.
Scientists uncover 149 species new to science on ancient Indian Ocean seamounts near Australia
Researchers examining ancient underwater volcanoes identified 149 species never before described by science in the Indian Ocean near Australia.
Nonprofit continues to support firefighters with mental health services nearly 25 years after 9/11
NYU Grossman’s next psychiatry chair on expanding mental health services at Langone
This month, NYU Langone Health tapped William Gordon Frankle to chair the Department of Psychiatry at NYU Grossman School of Medicine. With experience leading psychiatry care at NYU Langone Hospital—Brooklyn, Frankle is now slated to lead services across Manhattan, Brooklyn, Long Island. In his new role, he described plans to increase NYU Langone’s suicide prevention...
Drake Maye’s epic Week 1 meltdown raises 3 major concerns for 2026 NFL season
One ugly quarter cost New England a winnable opener and exposed problems that could last much longer.
Oil Above $100 Puts US Politics and Saudi Security Under Pressure
Oil prices climbed back above $100 a barrel […]
Mariska Hargitay's 2026 has been busy. Next up is her Emmys host gig
Mariska Hargitay has been a mainstay on television as Capt. Olivia Benson on "Law & Order: Special Victims Unit." Now, she's taking on TV's biggest night as host of the 78th Emmy Awards.
The curio cabinet of medieval mental health
Saffron and ostrich liver were prescribed but so were exercise, gardens, animals, socialising, and music
The Sidemen Rep Arcade Signs Max Fosh, Friends From Work & More Ahead Of Europe’s First Creator Upfront
EXCLUSIVE: Arcade, the management company of The Sidemen, has signed a host of creators, as it relaunches as an entertainment business ahead of its first European upfront. Comedian Max Fosh, creator c...
Lafferty, Highway Outlaws like to get the crowd moving
ELOY — Popular local musician Everett D. Lafferty and his Band the Highway Outlaws return to the Eloy Fiestas Patrias stage this year, promising a lineup of dance-worthy, sing-along songs.
Fenerbahçe vs AS Roma – Match preview and team news
AS Roma and Fenerbahçe return to the UEFA Champions League after a long wait and will now face each other in their opening UCL fixture this season on Thursday at the Chobani Stadyumu in Istanbul.Fene...
Waterfront Playhouse 2026-2027 season announced
The Waterfront Playhouse has announced that tickets for its 2026-2027 Season, are now on sale.
Drake Maye unravels late in season opening loss to Seattle
Assessing Drake Maye's performance in Super Bowl rematch with the Seattle Seahawks on opening night.
What's happening in local business
Massimo’s Pizzeria in Towne Square Shopping Center has announced it will open Monday, Sept. 14. For more information, visit “Massimo’s Pizzeria” on Facebook.
‘Get This Man a Cart’ – Sports Doctor Calls Out Patriots for Making A.J. Brown Limp to Locker Room After Injury Scare
It has been a shocking start to the 2026 NFL season. A unique Wednesday night broadcast to begin the year was already going to be an adjustment.
Patriots WR A.J. Brown leaves field with injury
Patriots wide receiver A.J. Brown limped off the field after suffering an injury in Wednesday's game against the Seahawks.
Academy Sports (ASO) Rockets 14% on Solid Q2 Despite Consumer Spending Tests
Academy Sports and Outdoors Inc. (NASDAQ:ASO) saw its share price jump by 14.40 percent on Wednesday to close at $51.15 apiece after posting a strong earnings performance in the second quarter of the year despite weakness in consumer spending trends. In an earnings call on the same day, the sporting goods store chain said that […]
Fetterman appears by video at GOP convention and says he’ll work with Trump
The U.S. senator from Pennsylvania described himself during his remarks as a “common-sense Democrat” who rejected socialism.
Viewpoint: Unlocking Europe’s wildfire data
Europe is already investing in the science, technology and infrastructure needed to understand, prevent and fight wildfires. Copernicus provides satellite-based Earth observation and environmental information, while the European Forest Fire Information System provides information on fire danger and forest fires across Europe. Weather and climate systems add forecasts of heat, drought, wind and humidity; historical fire databases show where fires have occurred; and researchers generate increasingly detailed knowledge about fuels, fire behaviour, forecasting, modelling and risk management. Meanwhile, new European research projects are adding digital twins and other tools to this growing ecosystem.However, these data do not necessarily sit together, nor are they necessarily described, structured or governed in ways that allow them to be used together. Much of the information is public, but some is commercially held. Some is sensitive. Some is subject to legal, security or operational restrictions. Even when data can be legally accessed, different systems may use different formats, terminology and rules.Europe therefore faces an unusual paradox: we have vast amounts of relevant information to respond to the wildfire challenge, but not the means to bring it together. For example, a wildfire researcher or emergency service might need to ask whether a particular combination of vegetation, drought, wind and topography has historically been associated with rapid fire spread. The relevant information may exist in several institutions, using different systems and subject to different conditions of access.The challenge is to conduct an authorised analysis that interacts with these sources, combines the results and respects the rules imposed by each data custodian.An important part of the answer can be found in the Fair principles, the idea that data should be findable, accessible, interoperable and reusable. Developed more than a decade ago, these principles have become a central reference point for modern data stewardship, making it easier for people and machines to find data, understand what it means and determine whether it can be reused.Readability by machines is essential, since AI systems will be key to meeting the data challenge. Bring analysis to the dataThe proposition is not to give an AI system unrestricted access to sensitive databases. Quite the opposite. The goal is to make it possible for approved algorithms to go to the data, rather than requiring sensitive data or large datasets to be copied to wherever the analysis happens.Imagine an analysis asking a series of questions of different data stations. At one station it might examine weather and climate data; at another, historical fire records; at another, experimental measurements of fire behaviour. The algorithm does not need to download everything. It can operate within the environment permitted by each data custodian and return only the results that the rules allow to leave.This is sometimes described as data visiting, and related approaches already exist in areas such as federated analysis and federated learning.Sensitive data should therefore not be treated as a free-for-all for machines. This requires appropriate governance at multiple levels. Access needs to be authenticated and authorised. The purpose of an analysis should be defined. The code or model being run should be controlled. Data custodians should be able to specify what can be queried and what results can leave their environment. Activities should be auditable and human oversight should remain where the consequences require it.In other words, the objective is not to trust AI with the data. It is to design systems in which AI never has more access than it needs.As open as possible, as closed as necessaryFair data should also not be confused with open data. Some wildfire data should be openly available. Other information may legitimately need to remain restricted because it concerns critical infrastructure, security, commercial interests, privacy or operational capabilities. The principle should be: as open as possible, as closed as necessary.The important point is that restricted data should not automatically become unusable data. If machines can discover what information exists, understand its meaning, establish where it came from and determine the conditions under which it can be used, authorised analyses can potentially be carried out without the underlying data ever leaving the environment in which it is protected.Restricted data can still be Fair and machine-actionable.This is also an important question of data sovereignty. European institutions should not have to surrender control of their data to a handful of technology platforms in order to benefit from AI. Nor does Europe need to start again by building one giant repository for every piece of wildfire information. The better approach is to connect what already exists.This is the principle behind emerging approaches such as Tryangle, developed through the Leiden Initiative for Fair and Equitable Science. Rather than creating another centralised data warehouse, the approach seeks to provide an interoperable layer through which approved algorithms can visit distributed data sources while respecting the rules of their custodians.In this way, a data station can remain where it is. Its custodians can retain control. Existing databases and applications do not have to be abandoned. What changes is their ability to communicate with other systems through common, machine-readable descriptions, access rules and interoperability mechanisms.But approaches like this need data that meets the Fair principles. Only then can an interoperable ecosystem safely begin to turn fragmented information into collective intelligence.Data infrastructure is wildfire infrastructureThe implications of this approach are entirely practical. Firefighters could gain better intelligence about local and evolving risks. Land managers could test prevention strategies using more comprehensive information about fuels, weather and past fires. Researchers could compare evidence across ecosystems without repeatedly moving huge datasets between institutions. Smaller regions and resource-constrained teams could access analytical capabilities without having to build large data infrastructures themselves.Europe is already investing heavily in satellites, databases, research programmes, forecasting systems and scientific expertise. The question is whether we will connect those investments well enough to turn them into actionable intelligence.That requires policymakers and funders to treat data infrastructure as seriously as physical infrastructure. Data generated or supported through European public funding should be Fair, verifiable and machine actionable by design, wherever legally and ethically possible.Related articlesData Corner: Europe’s burning need for wildfire mitigation researchClimate monitoring must remain a global enterprise, experts sayIn practice, that means funding not only the production of data, but also the infrastructure that makes data usable across systems: metadata, provenance, interoperability, access mechanisms and governance. Where data must remain restricted, we should ensure that it can still be securely discovered, verified and used for authorised analysis.Initiatives such as the European Open Science Cloud offer an existing framework through which these principles can be put into practice. What is needed now is to accelerate implementation and make them a standard part of how Europe funds and builds research and innovation systems.We do not need another generation of disconnected databases. The data is already there. The opportunity is to make it work together, securely, responsibly and quickly enough to help prevent the next fire, rather than simply document the last one.Jean-Claude Burgelman is professor emeritus at the Free University of Brussels (VUB) and editor-in-chief at Frontiers Policy Lab. For more than 20 years he held leading roles in research and innovation policy at the European Commission.
Director of Philanthropy for Maui Health Foundation to speak at Rotary Club of Lahaina Sunset
The Rotary Club of Lahaina Sunset welcomes Leana Taylor, Director of Philanthropy for Maui Health Foundation on Tuesday, Sept. 15, 2026. The topic of her presentation will be “Food Is Medicine: Locally Grown, Physician Prescribed.”
Detroit Tigers and Florida Poly Collab Creates Opportunities in Sports Science
New partnership will embed Florida Poly faculty with the Tigers’ Performance Science group, driving research in data science, sport analytics, and performance science.
Majority support Fresno prosecutors carrying firearms
Most Business Journal readers support allowing prosecutors to carry firearms on the job following a targeted attack on a Fresno County prosecutor.
Henry Winkler details rift with Tom Hanks over “Turner & Hooch” firing: ‘I am still working on my perspective’
“I guess at that time, being insecure, I talked too much,” the “Happy Days” star reflected.
NFL opening game expert picks, predictions: Patriots vs. Seahawks
Expert picks and predictions for New England Patriots vs. Seattle Seahawks—the NFL season opener.
Commanders vs Eagles Wednesday Injury Report: Three players limited
Injury updates for Week 1
Apple Unveils A20 Pro as First 2nm Smartphone Chip
Apple today revealed the A20 Pro chip in the iPhone 18 Pro and iPhone 18 Pro Max, built on a brand new architecture using 2nm process technology. Apple described the A20 Pro as "an exceptional chip that sets a new bar for mobile computing". The chip has a 6-core CPU design with two new super cores that Apple says are up to 20% faster, calling them "desktop class" and "the fastest in any smartphone," alongside four new efficiency cores.
Peapack Private Expands Specialty Lending Capabilities with Launch of Yacht Financing Business
Jim Velez Jim Velez, Senior Managing Director and President of Yacht Financing at Peapack Private BEDMINSTER, N.J., Sept. 09, 2026 (GLOBE NEWSWIRE) -- Peapack-Gladstone Financial Corporation (NASDAQ Global Select Market: PGC) and Peapack Private announced today its entrance into the yacht financing business, further expanding the Bank’s suite of customized lending solutions for high-net-worth individuals, families and their advisors. As part of the launch, Peapack Private has hired industry vete
All New iPhone 18 Pro and 'iPhone Duo' Colors Leaked
Ahead of Apple's annual iPhone event at 10 a.m. Pacific Time today, Bloomberg's Mark Gurman has leaked all of the color options for the iPhone 18 Pro, iPhone 18 Pro Max, and the first-ever foldable iPhone named the iPhone Duo. iPhone 18 Pro and iPhone 18 Pro Max color options:Black Light Blue Burgundy Silver Burgundy has also been described as Dark Red or Dark Cherry.
Tarrant passes 1-year moratorium on data center business licenses
At Tuesday’s city council meeting, Tarrant city leaders passed a temporary moratorium against approving business licenses for data centers.
Arkansas, Ryan Silverfield need a downfield passing attack
It can't be dink and dunk the whole season for KJ Jackson
Oregon Democrats seek to calm voters’ election uncertainties
Oregon Democrats express faith in the upcoming vote-by-mail election despite ongoing legal battles over President Donald Trump's attempt to restrict mail ballot delivery.
Luma locks down 15-year, $410M fund for life science investments
Luma Group today announced the final close of its inaugural life sciences venture capital fund, totaling $410 million. The New York-based investment firm has had a grip on life sciences since its founding in 2023. The funds unveiled today, dubbed LumaBio Fund I, include investments that have already been made into more than 10 biotechs. They include the likes of eye disease-focused Character Biosciences, rebranded Belgian biotech Coultreon Biopharma and cellular rejuvenation company Altos Labs. The fund saw early success when one of the companies it co-founded, called Vaccine Company, was picked up by Eli Lilly earlier this year for up to $1.55 billion. The acquisition of the in vivo nanoparticle technology-focused biotech formed part of a trio of vaccine buys for the Big Pharma, which has itself been on a prolonged spending spree in 2026. Luma's fund is structured as a 15-year investment with plans to support groundbreaking science and support companies through key milestones from discovery to commercialization, Luma explained in the release. "We founded Luma Group on the belief that extraordinary science, supported by patient, long-term capital, has the power to improve millions of lives," Joshua Fink, founder and managing member of Luma Group, said in the release. "This fund represents more than capital—it is a commitment to partnering with extraordinary innovators as they translate visionary science into life-changing medicines."
Sophie Cunningham finally gets milestone birthday celebration during Fever break
Sophie Cunningham’s family delivers delayed surprise during WNBA hiatus
Arizona Cardinals Daily Links:
Jeremiyah Love is listed as the Cardinals’ backup running back behind Tyler Allgeier to begin the season.
Leaked Video Shows iPhone 18 Pro's 3-in-1 Dynamic Island in Action
A leaker has activated Apple's upcoming three-item Dynamic Island mode inside the iOS 27 simulator, offering the first video demonstration of the new iPhone 18 Pro feature. The leaker, known as pdfu, posted a video showing the Dynamic Island toggling between three simultaneous Live Activities, matching what Bloomberg's Mark Gurman described in his report earlier today. "The new Dynamic Island with 3 items is already supported in iOS 27," pdfu wrote.
Cristiano Ronaldo snubbed on 2026 Ballon d'Or finalist list
Cristiano Ronaldo’s unfortunate streak of Ballon d’Or nominations seems to continue. The ghost of a failed Ballon d’Or finalist list has again come at this time of year to haunt Ronaldo for the fourth time in a row. A winner of five Ballon d’Or awards, he has been missing from the list for the last four years and has again failed to make it this […] The post Cristiano Ronaldo snubbed on 2026 Ballon d'Or finalist list appeared first on ClutchPoints.
BBH Launches a New Technology Business, Braid, Solving for Intelligent Data Transformation
BOSTON, September 09, 2026--Brown Brothers Harriman (BBH) today announced the launch of a new technology affiliate, Braid LLC, focused on solving enterprise data transformation for financial services. Braid offers an AI-native data transformation platform that gives firms a scale solution to transform, connect, and manage their data with confidence.
HOMETOWN HEALTH: The warning signs of suicide risk in men that often go unnoticed
CDC data shows the suicide rate among men is significantly higher than it is for women.
Prisma Health Extends Tecsys Partnership from Distribution Center to Bedside
/PRNewswire/ -- Tecsys Inc. (TSX: TCS), an industry-leading supply chain management company, today announced that Prisma Health, the largest private, nonprofit...
New Eugene facility will expand Oregon’s residential behavioral health system for youth
A 12-bed secure inpatient treatment facility in Eugene will serve youth ages 10-17 with acute behavioral health needs.
Arbeloa needs 'positive support' but defence is 'comical'
Rohan: I feel as though Arbeloa has completely underestimated the physicality of the Premier League. Without signing another centre-back as a partner for Calvin Bassey, he has allowed other players to breach the right of our defence easily. Arbeloa needs to find a way to counter this so we can start picking up points.
Dutch staffing industry rates outpace wider business services
Overall revenue in the temporary staffing sector climbed 5.8% compared with the same period last year.
Tarr family opens new Snap Fitness gym in Nitro, combines with physical therapy clinic
The Tarr family, owners of Generations Physical Therapy, opened a new Snap Fitness gym location at their Nitro, West Virginia, clinic in August 2026.
Mark Wahlberg’s ‘By Any Means’ turns 2025 Atlanta into 1966 Mississippi
The civil rights-era film “By Any Means,” which stars Yahya Abdul-Mateen II and Mark Wahlberg, turned 2025 Atlanta into 1966 Mississippi.
Parkinson demands more from Wrexham after draw
Manager Phil Parkinson acknowledges Wrexham have room for improvement after they were held to a 1-1 draw at home by Burnley.
September 9, 2026: Embedded Trials in a Learning Health System, in This Week's Rethinking Clinical Trials Grand Rounds
In this Friday’s Rethinking Clinical Trials Grand Rounds, Ryan Zarychanski of the University of Manitoba will present “Embedded Trials in a Learning Health System: A Hospital Policy of Tranexamic Acid […]
Business After Hours Sponsored by Earnest Consulting
Local professionals can connect during One SouthCoast Chamber’s September Business After Hours, Thursday, Sept. 24, from 5 to 7 p.m., at Cisco Kitchen & Bar, 1482 E. Rodney French Blvd., […]
Knicks Star Reacts to Frances Tiafoe’s Stunning US Open Comeback
A Knicks star connected Frances Tiafoe’s stunning US Open comeback to New York’s unforgettable championship run. The post Knicks Star Reacts to Frances Tiafoe’s Stunning US Open Comeback appeared first on HEAVY.
ESPN insider reveals receive shocking, Warriors’ Jimmy Butler health update
The NBA season is rapidly approaching as teams are expected to report to training camp at the end of the month.
Rock Creek Entertainment District bond preparations continue after judge denies injunction
Norman’s Rock Creek Entertainment District construction and bond preparation can move forward following a four and a half hours hearing where Cleveland County District Judge Michael Tupper ruled in favor
Ray LaMontagne topples over onstage in Nashville, where the high hits 101
On Sept. 5, the 53-year-old folk singer fell while performing his popular track 'Jolene' in front of a sold-out Nashville show, according to fan footage.
Pirates Trying to Find This Balance With Konnor Griffin
The Pittsburgh Pirates need Konnor Griffin in the lineup, while also being mindful that he's still coming back from injury.
Let’s Grade That Win Over Coastal Carolina by Position Group
Hope everybody enjoyed the holiday the right way. Grill going, family around, maybe a cold drink in your hand, and a win in the books to talk about while you do it. That’s the good life. Before we get too deep into the cookout, let’s talk about what we saw Saturday, because there’s a lot […]
Detroit businesses face costly repairs after tornado tears through east side
How Michael Carter-Williams Can Help Syracuse Basketball Program
The former SU guard has a new opportunity.
Aryna Sabalenka Shuts Down Reporter Over U.S. Open Party Question
The World No. 1 pushed back after a reporter described her pre-tournament week as 'lots of parties and fun.'
❌ Sent off after provocation: E. Mbappé loses his head
In the first leg between Lille and Real Betis, Ethan Mbappé initially shone with an assist for the opening goal. After that, however, things only went according to plan to a limited extent for the Fr...
Ask 13: Why can't all 4 health systems build new hospital beds in western North Carolina?
Four healthcare systems are competing for approval to add 92 hospital beds in western North Carolina. But why does the state have to choose just one?
MAC Takes Michigan’s Hail Mary Win to the NCAA
The MAC has asked the NCAA to hand Michigan's Hail Mary win to Western Michigan. #GoBlue
Actor Says Theatre Fired Him from “Bright Star” Over His Adult Entertainment Past
An actor says he was fired from an upcoming production of Bright Star just before rehearsals began after the theatre learned about his past work in adult entertainment.
Joy Behar says Whoopi Goldberg has been on“ The View ”so long that ‘she used to be white’
Behar made the joke as she encouraged the audience to celebrate Goldberg’s 20th season at the Hot Topics table.
Roundup: Using AI to better integrate virtual modalities into care delivery
Artificial intelligence enhancements in telehealth aim to bolster care continuity while virtual nursing extends bedside care. Also, Zocdoc integrates with Google Gemini to book appointments while Sword Health is set to acquire Headspace's parent company.
Area high school girls flag football players join GN Sports to talk about event this weekend
Judi Dench’s Oscar doesn’t have her name on it: ‘Could be anyone’s’
Sir Ian McKellen, meanwhile, never got his Golden Globe engraved for a hilarious reason.
Accenture and Google Cloud are creating a joint unit to embed AI engineers in enterprises
The Accenture Gemini Enterprise Business Group will train and deploy forward-deployed engineers to help enterprises build and scale agentic AI applications
Booster group pushes to keep Downtown Pittsburgh businesses viable
The Pittsburgh Downtown Partnership has sought to bring more small businesses into the Golden Triangle in recent years — and now it’s launching a concerted effort to keep them there. Dubbed Business Boost, the initiative is meant to support small businesses and ensure they can last Downtown long-term, Pittsburgh Downtown
Dan Campbell Accidentally Leaks Tom Kennedy News
Dan Campbell accidentally revealed Tuesday that Tom Kennedy will play for the Detroit Lions in their Week 1 matchup against New Orleans.
New-to-science Amazon frog stands out for its slow ‘lazy’ song
Scientists recently described a new species of a tiny brown frog found in the Amazonian floodplain forests of Ecuador and northwestern Brazil. It looks nearly identical to related species but its slow, widely spaced out call sets it apart, researchers note in a study. “I’ve had to get into arguments because people said the frog […]
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.