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Noah Hiles: What I’m hearing on Pirates, Konnor Griffin extension talks
BRADENTON, Fla. — The Pirates reassigned Konnor Griffin to minor league camp Saturday, ending any hope that the game’s top-rated prospect would...
Meet CT’s 2026 Women in Business honorees
Hartford Business Journal’s 2026 Women in Business awards recognize top leaders who are making a significant difference within their organization and the broader community.
Fertilizer prices bring more pain for American farmers amid war in Iran
The war in Iran is pushing up prices for already-strained farmers, with higher costs for fertilizer and energy on top of last year’s tariffs. And the increasing pressure on American agriculture could lead to even bigger price tags at the grocery store.
River Cats top Giants in exhibition at Sutter Health Park as fans welcome baseball’s return
"Finally, the drought is over between football and the start of baseball."
California Politics 360 Full Episode | Sexual abuse allegations against César Chávez
Civil rights leader Dolores Huerta broke her silence, saying she was also sexually abused by Chávez. It led to the birth of two children, a secret she kept for 60 years.
A DNA test ruled him out. He was convicted of murder anyway.
Forensics has its share of high-profile problems. There’s phony “junk science,” like bogus bite-mark and blood spatter analyses that have sent innocent people to jail. And there’s the steady drumbeat of lab scandals, where analysts make up results. But there’s a subtler and more pervasive problem at work in many cases: lab analysts and lawyers who take perfectly legitimate science and twist it. Globe Opinion is exploring these distortions with a series we’re calling “Twisted Science.” And there may be no better place to start than with the case of Terrel Barros.
5 Laptops With Better Specs Than The MacBook Neo For The Same Price
The MacBook Neo starts at $600, but these five laptops deliver better RAM, storage, and larger screens for the same price or less.
Statue of Christopher Columbus installed on White House grounds
A statue of Christopher Columbus has been erected outside of an ornate federal office building on the White House grounds — the latest sign of the Trump administration’s efforts to reshape cultural and historical representations across the nation’s capital.
Wisconsin edges Ohio St., wins another title at Frozen Four
Claire Enright scored the go-ahead goal in the third period Sunday, Ava McNaughton had 34 saves, and No. 2 seed Wisconsin beat top-seeded Ohio State 3-2 at the Frozen Four to win its second consecutive national championship.
‘Project Hail Mary’ blasts off with $80.5 million, a best for Amazon MGM, and the year
Studio estimates on Sunday say Amazon MGM's “Project Hail Mary” has topped the North American box office charts with $80.5 million in ticket sales — the second biggest ever for a non-franchise film.
Federal union says 'untrained' ICE agents shouldn't replace TSA
President Donald Trump said he would tap ICE agents to run security at US airports as unpaid TSA officers stop showing up to work.
The Times' top 25 high school baseball rankings
St. John Bosco and Sherman Oaks Notre Dame remain unbeaten in high school baseball
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Southern Living names top small towns, Florida snags 5 spots
St. Augustine named best small town in the Southern United States.
Top 5 states with the highest number of safe hospitals, according to new report
Assemblywoman Alexandra Macedo says César Chávez allegations are "just the tip of the iceberg"
California lawmakers this upcoming week are set to move quickly to rename César Chávez Day to Farmworkers Day ahead of the holiday that takes place every year on March 31.
Box Office: ‘Project Hail Mary’ blasts off with $80.5 million, a best for Amazon MGM
Studio estimates on Sunday say Amazon MGM's “Project Hail Mary” has topped the North American box office charts with $80.5 million in ticket sales. It's the biggest opening for the studio and the...
Box Office: ‘Project Hail Mary’ blasts off with $80.5 million, a best for Amazon MGM
Studio estimates on Sunday say Amazon MGM's “Project Hail Mary” has topped the North American box office charts with $80.5 million in ticket sales.
This Fresh Take on Sherlock Holmes Is the Best New Show on TV RN
‘Young Sherlock’ is quickly climbing Prime Video’s Top 10 and with rave reviews and an 83% Rotten Tomatoes score, it might be your next binge.
Phillies extend Cristopher Sánchez through 2032: NL East contenders lock up top pitcher on six-year contract
The extension runs from 2027-31
Oscar-Winning Alumnus Returns to Pasadena’s ArtCenter for Entertainment Design Expo
One week after winning the Academy Award for Best Animated Feature, KPop Demon Hunters co-director Chris Appelhans returns today to ArtCenter College of Design, the Pasadena campus where he studied illustration, for the college’s third annual Entertainment Design Expo. The expo, known as ENTX, opens the Hillside Campus to the public for a full day of gallery exhibitions, game playtesting, animation screenings and interactive experiences featuring work from more than 200 ArtCenter students and alumni. General admission is free with advance registration. Two industry panels — including Appelhans’s talk — require $15 tickets. Appelhans, who graduated from ArtCenter with a bachelor of fine arts in 2002, co-directed KPop Demon Hunters with Maggie Kang. The animated film, produced by Sony Pictures Animation and released on Netflix, became the streaming platform’s most-watched film in history, according to Netflix, and swept awards season with wins at the Golden Globes, the Annie Awards and the Grammys before taking the Oscar on March 15. His talk and audience Q&A is scheduled from noon to 1 p.m. in the Ahmanson Auditorium. Doors open at 11:30 a.m. The film’s ArtCenter ties extend beyond its co-director. Art director Angela Sung, cinematographer Gary H. Lee, visual development artist Celine Kim and painter Simon Baek are all ArtCenter graduates who worked on the production, according to the college. The free portions of ENTX include a concept design showcase, a production design gallery, a model gallery, a stop motion studio preview, an alumni gallery and a KPop Demon Hunters fan art gallery. Visitors can also playtest games designed by ArtCenter students. An Animation Shorts Showcase runs from 2 to 3 p.m. and includes “Boy, I’m Scared,” a capstone short by ArtCenter graduate Lindsey Tenaglia that was named a semifinalist for the 2025 Student Academy Awards in the animation category. Also screening
Gen Z really, really loves China's trains
This is a condensed version of Business Insider Today, a newsletter that gives you a look at the week’s top stories. Sign up here to get the full Business Insider Today in your inbox every day for the top stories in markets, tech, and business.
Electron's Investment Into Good Wayland Support
For years Electron apps were notorious for continuing to depend upon X11/XWayland and not jive well with the modern Wayland experience on modern Linux desktops
The Times' final top 25 high school boys' basketball rankings
Sierra Canyon, the state Open Division champion, finishes No. 1 in The Times' final 2025-26 high school boys' basketball rankings.
Southland girls' basketball final rankings for 2025-26 seaosn
A look at the top 20 high school girls' basketball teams in the Southland, led by Open Division state champion Ontario Christian.
Flexitarian and the MIND included in top diets for a healthy brain, according to U.S. News
Discover four top diets that may support sharper focus, steadier mood, and long-term brain resilience
A Grip on Sports: In a season when Gonzaga's defense was the driving force behind its success, the Zags couldn't get the one stop they needed
A GRIP ON SPORTS • After all the flotsam and jetsam is swept away, sometimes a college basketball game, an NCAA Tournament game, comes down to making one play. Saturday night in Portland, Texas did. And Gonzaga’s season once again fell short of its ultimate goal.
Paxton Aaronson scores twice to propel Rapids to 4-1 victory over Sporting KC
Paxton Aaronson scored a goal in each half, Wayne Frederick's first career goal was the go-ahead score and the Colorado Rapids rolled to a 4-1 victory over Sporting Kansas City on Saturday night. Aaronson gave Colorado (3-2-0) the lead in the 12th minute, but Shapi Suleymanov scored for the first time this season — in the 44th — to pull Sporting KC (1-3-1) even. The tie lasted until the second minute of stoppage time when Frederick scored unassisted for a 2-1 lead at halftime.
Recap: Sporting KC suffers 4-1 loss to Colorado
Sporting Kansas City suffered a 4-1 loss to the Colorado Rapids on Saturday at Sporting Park. Shapi Suleymanov scored the lone goal for SKC in the defeat as the visitors prevailed behind a brace from Paxten Aaronson to go along with a goal from fellow Designated Player Rafael Navarro and
New Research Shows the 6 Skills You Need to Master Anything
Scientists explain why some of us benefit more than others from expert guidance.
Amanda Peet Shares Breast Cancer Diagnosis
Amanda Peet detailed her recent breast cancer diagnosis in a new essay, sharing that her health battle coincided with both of her parents' final months in hospice care.
47th annual Utica University science fair shows area students are smarter than ever
Four dozen science projects from 60 students from eight area schools competed for the top prizes at the Donohue Concourse underneath the Frank Gannett Library. Some of the topics may have changed over the years — there were no baking soda volcanoes — but the students still displayed their projects on decorated posterboard for staff, family and the judges to see. The projects were split between the junior division — 7th and 8th grades — and the senior division — 9th through 12th grades.
Top 5 states with the highest number of safest hospitals, according to new report
Healthgrades named 438 hospitals across 40 states for its 2026 Patient Safety Excellence Award, with Texas and Florida among the top-performing states.
Trump Is Finally Eyeing an Exit From Iran. But Will He Take It?
President Trump says he is considering “winding down” operations in Iran. But many of his original war goals remain unaccomplished.
Cowboys land top pass rusher in new mock draft
It feels inevitable that Dallas will take a pass rusher in the first round.
Roberson's Sam Maki leads Week 4 girls spring sports top performers
Roberson soccer's Sam Maki scored five goals to lead the list of Week 4 WNC high school spring sports girls top performers.
Top business aviation banker talks debt, profits, JetGate, EBITDAR
Jefferies' Nick Fazioli on why Wall Street loves private jets, non-GAAP financial metrics and why past results don't preclude more investment
Here’s how Va. lawmakers suggest the next state budget handle federal health care funding fallout
Spanberger will mull theirs and former Gov. Glenn Youngkin’s budget proposals ahead of a reconvened session on April 23.
Wisconsin's Caroline Harvey wins Kazmaier Award as top player
Wisconsin defender Caroline Harvey voted as the winner of the Patty Kazaier Memorial Award for college women's hockey's top player.
Apple M5 MacBook Pro and Air Review: When the Neo Isn’t Enough
Apple’s new laptops and high-end display fit the bill for the company’s most demanding customers.
Player status report, presented by Orlando Health: Orlando City SC at Nashville SC
Here is the Player Status Report, presented by Orlando Health, for Saturday's away match at Nashville SC
Billionaires, trial lawyers and unions gear up for 2026 California ballot brawls
It costs millions to qualify for the ballot and most measures fail, but that’s not stopping lots of special interest groups from trying
Woman shot at Time Out Sports Bar in Seminole, sheriff’s office says
Video: Catch up on recent top stories from across Tampa Bay SEMINOLE, Fla. (WFLA) — The Pinellas County Sheriff’s Office is investigating after a woman was found with a gunshot wound at Time …
Community's Choice Awards spotlight: Affiliated Dermatologists
Milwaukee Top Choice Community’s Choice Awards nominations are almost done. Don’t ghost your favorite local businesses.
Inside Trump’s most difficult war decision yet: whether to put boots on the ground in Iran
In near-daily briefings with top military officials at the White House, President Donald Trump has reviewed options that include sending American troops into Iran.
This tool puts ChatGPT, Gemini, Grok, and more AI models in one place
Stop wasting time switching tabs.
🗞️Today's headlines: Joan García, academy talent and much more
The call from Luis de la Fuente to Barça’s goalkeeper is one of the top stories of the day on this football-filled Saturday.A great weekend is approaching ahead of an international break, where the...
Sacramento businesses recover after string of burglaries; 1 suspect arrested
Sacramento police have arrested a man believed to be connected to 11 burglaries affecting local businesses, as authorities work to prevent further incidents.
Battling for top-six spot, Sixers face youth-driven Jazz
Earlier this week, Joel Embiid was said to be close to a return from a right oblique strain.
Mira Costa boys' volleyball defeats rival Loyola in thriller
Mira Costa, the top-ranked boys' volleyball team in the nation, defeats No. 2 Loyola in five sets behind Mateo Fuerbringer's 37-kill effort.
From Project Hail Mary to Saturday Night Live UK: your complete entertainment guide to the week ahead
Scientist Ryan Gosling is alone in deep space – or is he? – and America’s famed topical satire is given a British angle
Yankees news: Optimism at shortstop
2026 looks promising at shortstop; Carlos Lagrange was electric this spring; Michael Kay defends Judge
Spurs look to extend winning streak while hosting hapless Pacers
The San Antonio Spurs carry a four-game winning streak as they continue their hunt for the top spot in the Western Conference while hosting the hapless Indiana Pacers on Saturday.
Brewers top Mariners in Spring Breakout matchup
Luis Peña homers, four others double in prospect showcase
Thompson makes 30 stops in Capitals win over Devils
Jesper Bratt scored for the Devils, extending his point streak with three goals and four assists over his last seven games. Jake Allen stopped 26 shots. It was the third meeting between the teams and the first that didn't require extra time.
What Buffy's Nicholas Brendon Said About His Congenital Heart Defect, Cauda Equina Syndrome Before Death
Before Nicholas Brendon died on March 20 at the age of 54, the Buffy the Vampire Slayer alum and his sister had discussed his health diagnoses, including cauda equina syndrome and a heart defect.
Downtown Chico business owner voices concerns over street closures for events
A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });
Bengals hold top-30 visit with Rutgers QB Athan Kaliakmanis
Cincinnati wants a promising developmental quarterback behind Joe Burrow, and they had a visit with one recently.
Scientists just found a hidden 48-dimensional world in quantum light
A routine quantum optics technique just revealed an extraordinary secret: entangled light can carry incredibly complex topological structures. Researchers found these hidden patterns reach up to 48 dimensions, offering a vast new “alphabet” for encoding quantum information. Unlike previous assumptions, this topology can emerge from a single property of light—orbital angular momentum.
Microsoft Is Finally Ready to Make Windows 11 Less Terrible After Bloating It With AI Crap
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The mental health effects of gun violence near schools
Dr. Scott Hadland from Mass. General Brigham discusses new data that shows the amount of shootings near schools is trending downwards.
iOS 26.4: Top 10 New Features Coming to Your iPhone
iOS 26.4 isn't the major update with new Siri features that we hoped for, but there are some useful quality of life improvements, and a little bit of fun with an AI playlist generator and new emoji characters. Playlist Playground - Apple Music has a Playlist Playground option that lets you generate playlists from text-based descriptions. You can include moods, feelings, activities, or make up something entirely nonsensical and let the AI figure out what you mean.
The State That Decided to Topple a Political Giant
Phil Berger has been the most powerful person in North Carolina for 15 years. That wasn’t enough to save him from voters’ anger at incumbents and legalized gambling.
Automatic enrollment in Medicare Advantage plans under consideration, top Trump health official says
The idea could be a major win for the health insurance industry, which has seen a crackdown on Medicare Advantage in recent years.
Group tied to Emily Gregory sends race-baiting text; Dems should condemn it
The biggest problem with the texts that went out is obviously that it’s racist. But the problems don’t stop there.
Amid soaring prices, Maryland Republicans make political push for gas tax holiday
Maryland House and Senate Republicans said Thursday they will press for a 30-day gas tax holiday to ease skyrocketing gas prices spawned by the Iran war.
Why scientists can't get a laugh
Humor is hard to pull off in front of a cold audience, full stop.
2026 NCAA Men's Basketball Tournament Highlights: Round of 64
The 2026 NCAA Men’s Basketball Tournament continues on Friday, and we’re tracking every top moment of the Big Dance!
Letai: “From this point forward, it really is much more like business as usual at the NCI.”
NCI Director Anthony Letai appeared before the National Cancer Advisory Board Committee March 17 to maneuver through thorny topics while reiterating his message of reassurance: Stability. Stability. Stability. NCI is sturdy and will weather the storms. “The mission hasn’t changed at the National Cancer Institute,” Letai said in his remarks to the committee. “The resources […]
FOX5 Las Vegas Sports' Mike Davis on the state of the Raiders
FOX5 Las Vegas Sports Anchor Mike Davis wakes up with "GMFB" on the state of the Las Vegas Raiders and defensive end Maxx Crosby trade fallout.
Baffling Crimson Desert Images Have Ignited A Generative AI Controversy
Did the developers mean to depict mushy-faced warriors atop many-limbed horses, or is generative AI simply back at it again?
Apple Announces New Mac Sales Record Following MacBook Neo Launch
Apple's CEO Tim Cook today said the Mac just had its "best launch week ever for first-time Mac customers," which suggests that the new MacBook Neo has been a hit with customers buying their first laptops or switching from Windows. Apple released the MacBook Neo last Wednesday, March 11. In the U.S., pricing starts at just $599 for the general public and an even lower $499 for college students.
Scientists Don’t Know Exactly What a Shark Is
A new study analyzing the genomes of nearly 40 sharks found that skates and rays likely evolved from the shark body plan, and that some sharks are actually evolutionarily distinct.
Missouri sports betting is now live: See the best sports betting apps to claim over $5,000 in launch promos
Missouri sports betting is now live, and the top Missouri sportsbooks are offering Missouri sports betting promos
Watch live: Whole Hog Politics with Chris Stirewalt and Bill Sammon
The Hill’s senior vice president of editorial content, Bill Sammon, joins NewsNation’s Chris Stirewalt to discuss the latest political hot topics and national news in Whole Hog Politics. The show w…
Player availability report, presented by Orlando Health Orlando Health Jewett Orthopedic Institute: Orlando Pride vs Denver Summit
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Friday's home match vs Denver Summit
Abramson advancing research at intersection of health, inequality and AI
Corey Abramson's research earns him a year in residence at the Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford University.
Towards responsible AI for mental health and well-being: experts chart a way forward
On 29 January 2026, WHO‑supported experts met at a TU Delft workshop to address the rapid, largely untested use of generative AI for mental health support. Participants warned of risks to well‑being, especially for young people, and called for stronger governance.
Iran threatens to target Israeli, US officials in global ‘tourist and entertainment centers’
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How the NCAA tries to ensure game integrity amid a sports betting boom and the latest point-shaving scandal
Two months before Selection Sunday, a widespread college basketball game-fixing scandal was revealed. How can the NCAA stop it from happening again?
How did these flowers evolve to survive a megadrought?
A multi-year megadrought in the Western U.S. has claimed untold populations of wild plants. Amid the conditions, some have survived. Scientists have produced a stunningly complete picture about how populations of one particular flower – the scarlet monkeyflower – made it through. In a new study published in the journal Science, a team of scientists spent decades studying and sampling select populations of scarlet monkeyflowers in California and Oregon. Through genetic sequencing, the team discovered that the populations that did best went through genetic changes in a short time period. This is known as rapid evolution. The team found that three of the populations that recovered the BEST adapted their stomata to open less, so they could conserve more water. Stomata act like a plant’s pores, managing gas exchange and water loss. This allowed the scarlet monkeyflowers to hunker down in the drought and survive. Interested in more stories about rapid evolution? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Listen to Short Wave on Spotify and Apple Podcasts.This episode was produced by Jeffrey Pierre, Rachel Carlson and Hannah Chinn. It was edited by Christopher Intagliata and Rebecca Ramirez. Aru Nair checked the facts. The audio engineers were Becky Brown and Robert Rodriguez.
World Cup Jerseys! Did Curaçao's Kit Top Mexico, Argentina, Spain?
Did Curaçao's World Cup away jersey by adidas upstage Mexico, Argentina and Spain?
Men’s NCAA Tournament Second Round Opening Odds: TCU vs. Duke
Horned Frogs battle top overall seed Blue Devils for a spot in the Sweet 16
US Health Department official signals progress on selecting new CDC head
The top CDC job has been filled by acting directors since Trump fired then-director Susan Monarez last August, after she objected to Kennedy's proposed vaccine policy changes.
Albuquerque The Magazine Recognizes 7 UNM Health ‘Top Docs’ for 2026
UNM Health recognizes over 1,000 dedicated physicians who create advancements in medical care as they educate and develop the next generation of health care professionals and scientists. This year, UNM Health honors seven physicians recognized as 2026...
Healthcare employee health plan bridges the gap between data and action
Integrating UpToDate evidence-based clinical decision support helps health plan optimize costs and member-centered care.
Super early 2027 Oscars predictions: Will Amy Adams finally win her first Academy Award?
Early 2027 Oscars contenders are already in the running for top awards. Here are EW's super early predictions for nominees, from Tom Cruise and Amy Adams to 'The Odyssey' and 'Dune: Part 3.'
Markiplier to Microdramas: The Ankler x NAB Show’s Future of Entertainment
Share Subscribe Vegas, baby! The Ankler is heading back to NAB Show for a second year in a row — and doubling down on conversations with the smartest people in the industry. From April 18–22, we’re partnering again with the industry’s biggest media and tech gathering to break down the Business of Media and Entertainment as it’s actually evolving: faster, riskier and increasingly driven by new formats, new audiences and new power players. This curated series will bring together top creators, executives and innovators to tackle the forces reshaping the industry — from the AI disruption of Hollywood’s creative ecosystem to the rise of the creator economy, shifting audience behavior and the changing economics of production. We’ll be rolling out more programming in the coming weeks — including top speakers from leading AI studios, prediction markets and beyond — so keep an eye on the Business of Media and Entertainment hub. But first up, we’re announcing two panels about what’s actually working in Hollywood: The Scary-Smart Business of Horror A good scare has become one of the entertainment economy’s most reliable engines. With disciplined budgets, built-in fandoms and global box office upside, horror consistently outperforms. From theatrical releases to streaming-first originals and creator-driven IP, the genre is artistically flexible and financially durable — and one of the last truly communal experiences for Gen Z and Gen Alpha audiences. Join YouTube creator Mark Fischbach, aka Markiplier, whose independent feature Iron Lung earned more than $50 million at the global box office, Atomic Monster president Michael Clear and screenwriter Akela Cooper (M3GAN, Malignant) for a conversation moderated by Like & Subscribe’s Natalie Jarvey about why horror travels so effectively across platforms and borders, how studios and independents are building sustainable genre pipelines and why the next wave of breakout franchises may emerge from unexpected sources. Inside the Microdrama Boom Short-form serialized storytelling is having a major moment. Microdramas, social-native series and creator-led narratives are capturing massive audiences with low-cost, rapid production cycles and direct-to-fan distribution. What was once dismissed as niche or experimental is now attracting major platform investment. Moderated by Jarvey, this panel of microdrama creators and executives — including one of the format’s top stars and producers, Kasey Esser, and Dhar Mann Studios’ head of vertical content, Erin McFarlane — examines how format innovation, fandom dynamics and algorithmic discovery are reshaping the economics of scripted storytelling and what traditional studios can learn from these agile models. For sponsorship opportunities, contact Lynne@theankler.com Share
Louisville tops South Florida: Highlights and Postgame Videos
Feel free to watch every second of these, or turn the highlight videos off around the 9-minute mark of the second half. Either way, go ahead and soak this up. It’s been a while. Highlights: Pat Kelsey postgame from the bus: Locker room celebration:
2026 NCAA Men's Basketball Tournament Highlights: Duke Escapes Siena
The 2026 NCAA Men’s Basketball Tournament tips off today, and we’re tracking every top moment of the Big Dance!
Justice Department probe of Powell could backfire on Trump and keep Fed chair in office
President Donald Trump has for months wanted to remove Jerome Powell as chair of the Federal Reserve. But instead, an investigation by one of his own officials could end up extending Powell's time at the top of the central bank even after his term formally ends May 15.
Are You One of Those Weirdos Who Wants More Money in Politics? Move to West Virginia!
A shady new political donations law just passed, and so the age-old effort to keep the Mountain State an oligarch’s playground rolls onwards.
Tokyo Joshi Pro Wrestling celebrates idols and combat at SXSW
The women of Tokyo Joshi Pro Wrestling, making their first-ever stop in Austin during SXSW, put on an unforgettable show.
Providence looks to sell off its health insurance plan
In an internal email to staff, Chief Financial Officer Greg Hoffman said the organization’s top priority is “continuity and stability.”
Be counted among the Capital Region’s top private companies
Each year, Business Report ranks the Top 100 Private Companies in the Capital Region — one of our most anticipated and widely read features. It’s the definitive look at the companies driving growth, investment and job creation across our market. If your company is privately held and headquartered in the Capital Region, we want to […]
Warren Endorses Platner in Maine, Splitting With Schumer
The intervention by Ms. Warren is the latest instance of her embracing a candidate at odds with Mr. Schumer, the top Senate Democrat.