SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " eng " 14,088 found 🔀 AI-powered Shuffle
Takeaways from arguments in the Supreme Court case that could end grace periods for mail-in ballots
The Supreme Court’s conservative majority appeared dubious of state laws that allow the counting of mail ballots that arrive at election offices after Election Day as justices heard oral arguments in a challenge to Mississippi’s five-day grace period for mail ballots.
Federal judge sides with Wisconsin in transgender health care suit
A U.S. judge ruled in favor of Wisconsin and 20 other states challenging a Trump administration declaration that tried to limit care for trans youth.
Ben White called up for England: Why Real Madrid's Trent Alexander-Arnold continues to be frozen out
Manager Thomas Tuchel has one of the most skilled right-backs in the world to call upon, but hasn't figured out a way to make him worth it
Uplifting and Not Ceding Ground on Health Equity Practice Is Critical to Strengthening Public Health and the Health of the Nation
Public health science gains in the last quarter century in the United States have been formidable due to a focus on structural and social determinants of health, thereby enhancing understanding of the role of inequitable policies in shaping health inequities and inequitable access to ameliorative resources.
Bird‑like robots promise greater flexibility and control than drones
A bird banking in a crosswind doesn't rely on spinning blades. Its wings flex, twist and respond instantly to its environment. Engineers at Rutgers University have taken a major step toward building bird-like ...
New C8 Corvette Grand Sport Makes Surprise Debut at 12 Hours of Sebring
The first mid-engined Grand Sport dons a widebody and red hashmarks, with the car's full reveal coming later this week.
The week ahead: Another big (and tough) week for Penguins
Looking at what the Pittsburgh Penguins need to do to secure their spot in the Stanley Cup Playoffs this season.
WSU launches bilingual video series to help beekeepers improve colony health
Researchers with WSU's Honey Bee and Pollinators Program have produced a new video series giving novice keepers a strong introduction to best practices and the science of apiculture, in both Spanish and English.
UNH Paul College Top Public Business School in New England for Academic Experience and Career Outcomes
UNH’s Paul College ranks No. 63 nationally in 2026 Poets&Quants rankings, leading New England public schools in academic experience and career outcomes.
Stealth BioTherapeutics Announces MRC Business Engagement Fund Grant to Advance Mitochondrial Disease Research
/PRNewswire/ -- Stealth BioTherapeutics (the "Company"), a commercial-stage biotechnology company focused on the discovery, development, and commercialization...
Starmer says ‘every lever’ will be explored to ease rising costs of living from Iran conflict
PM will chair Cobra meeting with key ministers and Bank of England on Monday, as experts warn of economic shock
Browns coach Todd Monken’s strong suit is blunt honesty without the politics
Monken's authenticity and commitment are strengths, said the Southern Miss AD who hired him for his only other head-coaching job in 2013.
Banijay Entertainment Dials Up Global Scripted with Premium Series Mania Slate
Media and entertainment powerhouse, Banijay Entertainment, today unveils its premium scripted offering for Series Mania, showcasing a broad range of high-end drama from across its global portfolio. As the number one European studio in scripted, with more than 100 titles launching each year, the company continues to demonstrate its scale, creative strength, global reach and […]
Health care advisory Chartis brings AI development engine in-house to build tools for clients
With the acquisition of artificial intelligence incubator Leap AI, Chicago-based Chartis’ health care advisers will move from making suggestions about AI to rolling up their sleeves and building custom AI solutions.
Personnel note: Tampa Electric names Ed Narain as Director of Regional Affairs
'Tampa Electric has a long history of supporting the growth and success of the communities it serves, and I look forward to helping strengthen those partnerships.'
I tested ChatGPT vs. Perplexity with the same 5 prompts — the winner surprised me
AI Madness Round 1: The Heavyweight meets the Challenger in our first round of Tom's Guide AI Madness
Power Play Primed – Hurricanes 5, Penguins 1
The Carolina Hurricanes scored three power play goals and dominated the Pittsburgh Penguins, 5-1 on Sunday afternoon in the Steel City. The Canes controlled the puck most of the game and were holding the Pens to a paltry 12 shots on goal until the Pens finally found some offense with five minutes and change to […]
At 85, I can still work out on the bars and do headstands with my wife
Peng Lin Hua, 85, says retirement didn't slow him down. He and his wife split their time between two countries.
How Obama’s Strategist Discouraged Biden From Running in 2016
In a new set of oral histories, David Plouffe, President Barack Obama’s political adviser, described how he urged Vice President Joseph R. Biden Jr. not to challenge Hillary Clinton for the nomination.
The Christian Science Monitor Daily for March 23, 2026
Rethink the news: Reducing news to hard lines and side-taking leaves a lot of the story untold. Progress comes from challenging what we hear and considering different views.
Scientists Trap Light in a Layer 1,000x Thinner Than a Hair
Scientists have found a way to trap light in an extremely thin layer, potentially reshaping how future photonic devices are built.
Scientists Open Moon Rocks Locked Away Since 1972 – and Find Something Totally Unexpected
Decades after being sealed away, Apollo-era lunar samples are revealing unexpected chemical signatures that challenge long-standing assumptions about the Moon’s composition.
The M-Trends 2026 report shows how to strengthen business cybersecurity.
Learn more about the evolving threat landscape based on Mandiant's new M-Trends 2026 cybersecurity report.
Science diplomacy, research and global health
Nature Microbiology - As a young scientist from the global south, engaging in science diplomacy has brought greater purpose and meaning to my career, writes Delfina Fernandes Hlashwayo.
Science diplomacy, research and global health
Nature Microbiology - As a young scientist from the global south, engaging in science diplomacy has brought greater purpose and meaning to my career, writes Delfina Fernandes Hlashwayo.
Google Tested AI Headlines In Discover. Now It's Testing Them In Search
Google is testing AI headline rewrites in Search using similar language to the earlier Discover test that became a feature.
Analyst reveals high expectations for 49ers after free agency spree
Could the 49ers really challenge in 2026?
Two-thirds of workers are burned out—here's what science says about how to tackle it
Burnout is at an all-time high, with some studies saying two-thirds of employees now cite job burnout as a major challenge. Overwork and chronic stress do not just drain energy, they can erode health, ...
Ducks Sign Herman Träff to Entry-Level Contract
The 20-year-old had 41 points in 51 games this season for Oskarshamn in the HockeyAllsvenskan.
Why Have Patriots Not Done More To Address Pass Rush?
The New England Patriots had just 35 sacks last season, ranking near the bottom of the league in the regular season.
Opinion | Jesse Jackson, the Prophet Who Became a Politician
He challenged black Americans in the 1960s and ’70s, then retreated into victimhood and grievance.
Two Offseason Trades Patriots Should Have Made But Didn't
Here are two trades that the New England Patriots should have pursued this offseason but ultimately passed on.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Scientists twisted a mysterious superconductor and got a shocking result
A decades-old superconducting mystery just took a surprising turn. Strontium ruthenate, a material that conducts electricity with zero resistance at low temperatures, has long puzzled scientists with hints of an exotic, complex superconducting state. But by carefully twisting and distorting ultra-thin crystals, researchers found something unexpected: the material barely reacted at all. This challenges years of assumptions and suggests its behavior may be far simpler—or far stranger—than previously thought.
I left Goldman Sachs to build a small baking business. Here's how my time at the firm is giving me a leg up.
Colorado lawmakers can pass “Alyssa’s Act” to help coaches and parents monitor mental health (Opinion)
In 2019, we lost Alyssa after she struggled with her mental health following a series of concussions. We later learned that concussions can be linked to serious mental health challenges and an increase in suicide, especially in young people.
Margaret Cho on comedy, politics, and life in Hollywood
Comedian and actress Margaret Cho discusses her penchant for tackling political themes in her performances, evident in her upcoming tour, "Choligarchy,” coming to the Englert Theatre Friday, March 27.
Game Preview: Carolina Hurricanes @ Pittsburgh Penguins 3/22/2026
Who: Carolina Hurricanes (44-19-6, 94 points, 1st place Metropolitan Division) @ Pittsburgh Penguins (35-18-16, 86 points, 2nd place Metropolitan Division) When: 3:00 p.m. eastern How to Watch: Locally broadcast on Sportsnet Pittsburgh and FDSN South, streaming on ESPN+ Pens’ Path Ahead: Quality opponents await in the next week; the Pens host Colorado on Tuesday, an Avs team […]
OPEN THREAD
The Daily Merengue is a place where you can feel free to discuss all things football. Do not be alarmed by the overt RMCF bias. It’s in the name! Shoutout to the mods who do a fantastic job Kung_Fu_Zizou, Juninho, NeRObutBlanco, Felipejack, Ezek Ix and yours truly, Valyrian Steel. Gameday!! Huge clash in the context […]
Are AI tokens the new signing bonus or just a cost of doing business?
Maybe tokens really will become the fourth pillar of engineering compensation. But engineers might want to hold the line before embracing this as a straightforward win.
The Antidote to Our Growing Crises Must Transcend Politics
Each day, the challenges in our nation pile up. In just recent weeks, there has been the ongoing war in Iran and the Middle East, and ongoing debates about the growing negative impact of the Internet, looming AI challenges, and the Epstein files. The anticipation of divisive, even ugly, midterm elec...
The Business of Football: How many players do you need to win a World Cup anyway?
The English FA and the Premier League are having another row, as the club vs country debate rages on in English football
Election in Slovenia Will Test Europe’s Political Mood
The center-left government is being challenged by a right-wing populist accused of launching a smear campaign in the final days of a close race.
Bloodstained: The Scarlet Engagement listed for Nintendo Switch, plus an unannounced 505 Games Switch 2 title
Bloodstained: The Scarlet Engagement has been listed for Nintendo Switch alongside an unannounced Switch 2 title from 505 Games. The Scarlet Engagement, a sequel to the original, was previously announced last year. Although there wasn’t any news about a Nintendo release, the latest discovery suggests that we’ll be getting it on Switch at the very least. It’d be somewhat surprising...
Teaching Health Through Food: Kayla’s Passion for Nutrition
In celebration of National Nutrition Month, Renee Dease met with Special Olympics Michigan staff member, Health Messenger, and athlete, Kayla Cornell, to talk about how she empowers Special Olympics athletes to build healthier habits through practical cooking skills and nutrition education. Check out their conversation below.
Texas turns key weakness into strength in upset of Gonzaga
Texas overcame early interior struggles to beat Gonzaga 74-68 and reach the Sweet 16. Four Longhorns scored in double figures in Sean Miller's first season.
Farmers and rural community members can access free mental health resources
KGAN CBS 2 and KFXA Fox 28 provide local news, weather forecasts, notices of events and items of interest in the community, sports and entertainment programming for Cedar Rapids and nearby towns and communities in the Corridor and throughout eastern Iowa, including Iowa City, Waterloo, Dubuque, North Liberty, Coralville, Marion, Morengo, Williamsburg, Washington, Tiffin, Tipton, Solon, Mount Vernon, Lisbon, Central City, Urbana, Independence, Manchester, Dyersville, Oelwein, Cedar Falls, Waverly, Evansdale, Guttenberg, West Union, New Hampton, Decorah, Waukon, Maquoketa, Sigourney, Fairfield, Grundy Center, La Porte City, Dysart, Fayette, Elkader, Strawberry Point and Belle Plaine.
Should you try the 75 Hard challenge? Experts warn the risks may outweigh the benefits
The 75 Hard regimen demands 75 days of strict rules covering diet, exercise and reading. Experts explain what helps, what harms and smarter, sustainable alternatives.
Engadget review recap: Lots of Apple devices, Galaxy S26, Dell XPS 16 and more
A roundup of the latest reviews from Engadget.
Denver Broncos mock draft: Post-Jaylen Waddle trade
We’re coming back to the mock draft simulator this weekend. The Denver Broncos said ‘f dem picks’ and acquired wide receiver Jaylen Waddle from the Miami Dolphins this week. That trade provided a big boost to the offense, but it will make their 2026 NFL Draft much more challenging. With the reduction in draft capital, […]
'Not a done deal': Democrats start to sweat over Virginia's redistricting referendum
The unique nature of the April special election and the state's recent redistricting history have presented challenges for Democrats, even as they hold a financial edge in the race.
Short-Term Cuts, Long-Term Costs: Investing in Health Care for All Californians
Providing health care for all Californians improves health, strengthens communities, and prevents higher long-term costs.
Bengals hold top-30 visit with Rutgers QB Athan Kaliakmanis
Cincinnati wants a promising developmental quarterback behind Joe Burrow, and they had a visit with one recently.
The biggest medieval march in English history never actually happened
A famous detail in the Battle of Hastings is based on a major misunderstanding.
Scientists turn probiotic bacteria into tumor-hunting cancer killers
Scientists have engineered probiotic bacteria to act as tumor-seeking drug factories. In mice, these bacteria infiltrated tumors and produced a cancer-fighting drug right where it was needed. This targeted approach could make treatments more effective and reduce side effects. More research is needed before it can be tested in people.
Tectonic shift: Earth was already moving 3.5 billion years ago
Scientists have uncovered the oldest direct evidence yet that Earth’s tectonic plates were on the move 3.5 billion years ago. By analyzing magnetic fingerprints in ancient rocks, they reconstructed how parts of the planet slowly drifted and even rotated over time. This challenges long-standing ideas that early Earth may have had a rigid, unmoving surface. Instead, it suggests the planet was already dynamic—and possibly setting the stage for life—much earlier than expected.
Judge sides with New York Times in challenge to Pentagon policy limiting reporters’ access
A federal judge agreed Friday to block the Trump administration from enforcing a policy limiting news reporters’ access to the Pentagon, agreeing with The New York Times that key portions of the new rules are unlawful.
Owners of Greenville pet grooming business accused of punching dogs
The Greenville Police Department reports the owners of a pet grooming business were arrested for mistreating animals on Monday.
Learning by serving: Rose fellows reflect on lessons from the field | Harvard T.H. Chan School of Public Health
The Rose Service Learning Fellowship funds community-engaged field projects around the globe.
US furiously seeks to avert potential months-long closure of Strait of Hormuz
US officials are furiously trying to avert a potential months-long closure of the Strait of Hormuz, privately acknowledging that reopening the key waterway is a problem without a clear solution and dependent at least in part on what lengths President Donald Trump is willing to go to force the Iranian regime’s hand, multiple administration and intelligence officials tell CNN.
Google confirms AI headline rewrites test in Search results
Publishers face new risk as Google tests AI-written titles in Search, rewriting tone and intent to better match queries and boost engagement.
I've been a neuroscientist for 20 years. I keep my brain strong and healthy by avoiding 6 things
UCLA professor and neuroscientist Dr. Alex Korb shares the the habits he avoids to help strengthen his brain and manage his stress.
xAI Sends Engineers to Client Sites to Win Business from OpenAI
Elon Musk’s xAI is sending engineers directly into the offices of prospective corporate clients in an attempt to claw business customers away from rivals OpenAI and Anthropic PBC.
Younger Chinese Americans are fighting to save traditions
Younger business owners are adapting to challenges their parents didn’t face: historic tariffs, dwindling adherence to tradition and lower foot traffic in a post-pandemic San Francisco.
How did these flowers evolve to survive a megadrought?
A multi-year megadrought in the Western U.S. has claimed untold populations of wild plants. Amid the conditions, some have survived. Scientists have produced a stunningly complete picture about how populations of one particular flower – the scarlet monkeyflower – made it through. In a new study published in the journal Science, a team of scientists spent decades studying and sampling select populations of scarlet monkeyflowers in California and Oregon. Through genetic sequencing, the team discovered that the populations that did best went through genetic changes in a short time period. This is known as rapid evolution. The team found that three of the populations that recovered the BEST adapted their stomata to open less, so they could conserve more water. Stomata act like a plant’s pores, managing gas exchange and water loss. This allowed the scarlet monkeyflowers to hunker down in the drought and survive. Interested in more stories about rapid evolution? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Listen to Short Wave on Spotify and Apple Podcasts.This episode was produced by Jeffrey Pierre, Rachel Carlson and Hannah Chinn. It was edited by Christopher Intagliata and Rebecca Ramirez. Aru Nair checked the facts. The audio engineers were Becky Brown and Robert Rodriguez.
Who Should Be England’s Number 10 at the World Cup?
The 2026 FIFA World Cup is fast approaching, and England manager Thomas Tuchel has some huge decisions to make. Former boss Gareth Southgate came in for major criticism from supporters for continually...
Trump’s global agenda flies into domestic headwinds
Even as US President Donald Trump calls for international support for the war in Iran, within the US there are dissenting voices, as not everyone is convinced that war is the answer. What is clear is that domestic factors will increasingly limit Trump’s foreign policy and diplomatic engagement. Academic Derek Grossman discusses the issue.
MYB This Weekend: Koufos Talks Navigating Business Challenges Through Cottage Four
On this weekend’s “Minding Your Business” on News 12+, Cottage Four President John Koufos talks with Bob Considine about his leading consultancy and
Scientists Finally Locate the Sun’s Hidden Magnetic Engine Deep Beneath Its Surface
New observations are helping scientists peer beneath the Sun’s surface, revealing where its magnetic activity may truly begin.
4 flight attendants injured on Delta flight to Sydney after plane experiences 'brief turbulence'
Four Delta Air Lines flight attendants were injured during turbulence on a flight bound for Sydney, with three hospitalized but no passengers hurt.
Judge says he will bar RFK move aimed at cutting gender-affirming care for minors
A U.S. judge on Thursday said he would block an effort by Health Secretary Robert F. Kennedy Jr that would have sharply restricted medical providers from providing gender affirming care to minors after a group of Democratic states challenged it.
Logan Wilson speaks out on retirement, Super Bowl penalty
Bengals great Logan Wilson didn't take long to speak out after his retirement.
Dothan senior breaks 75-year barrier with international science fair qualification
Alexis Saffold earned her spot in the Regeneron International Science and Engineering Fair by turning an everyday problem into a potential breakthrough.
Gov. Stein urges mental health funding following Iryna Zarutska's murder
Governor seeks mental health funds after light rail stabbing
Scientists turn CO2 into fuel using breakthrough single-atom catalyst
Researchers have created a cutting-edge catalyst that turns CO2 into methanol more efficiently than ever before. Instead of using clumps of metal atoms, they engineered a system where each single indium atom actively drives the reaction. This dramatically reduces energy needs while making the process easier to study and optimize. The result could accelerate the shift toward cleaner fuels and sustainable chemical production.
Ex-FBI agents involved in Arctic Frost probe sue for wrongful termination
Two ex-FBI agents sued the bureau to challenge their firings, which they argued was an act of politically motivated retaliation tied 'solely' to their work on the Arctic Frost probe.
Sense of belonging predicts who stays in science
New research shows that feeling connected to a scientific community may be key to reducing attrition, with professional societies positioned to strengthen belonging across disciplines.
Fusion scientists face challenges in effort to produce reliable energy source
‘Special Report’ anchor Bret Baier reports on scientific research attempting to create fusion as a source of reliable energy and how artificial intelligence could help.
Markiplier to Microdramas: The Ankler x NAB Show’s Future of Entertainment
Share Subscribe Vegas, baby! The Ankler is heading back to NAB Show for a second year in a row — and doubling down on conversations with the smartest people in the industry. From April 18–22, we’re partnering again with the industry’s biggest media and tech gathering to break down the Business of Media and Entertainment as it’s actually evolving: faster, riskier and increasingly driven by new formats, new audiences and new power players. This curated series will bring together top creators, executives and innovators to tackle the forces reshaping the industry — from the AI disruption of Hollywood’s creative ecosystem to the rise of the creator economy, shifting audience behavior and the changing economics of production. We’ll be rolling out more programming in the coming weeks — including top speakers from leading AI studios, prediction markets and beyond — so keep an eye on the Business of Media and Entertainment hub. But first up, we’re announcing two panels about what’s actually working in Hollywood: The Scary-Smart Business of Horror A good scare has become one of the entertainment economy’s most reliable engines. With disciplined budgets, built-in fandoms and global box office upside, horror consistently outperforms. From theatrical releases to streaming-first originals and creator-driven IP, the genre is artistically flexible and financially durable — and one of the last truly communal experiences for Gen Z and Gen Alpha audiences. Join YouTube creator Mark Fischbach, aka Markiplier, whose independent feature Iron Lung earned more than $50 million at the global box office, Atomic Monster president Michael Clear and screenwriter Akela Cooper (M3GAN, Malignant) for a conversation moderated by Like & Subscribe’s Natalie Jarvey about why horror travels so effectively across platforms and borders, how studios and independents are building sustainable genre pipelines and why the next wave of breakout franchises may emerge from unexpected sources. Inside the Microdrama Boom Short-form serialized storytelling is having a major moment. Microdramas, social-native series and creator-led narratives are capturing massive audiences with low-cost, rapid production cycles and direct-to-fan distribution. What was once dismissed as niche or experimental is now attracting major platform investment. Moderated by Jarvey, this panel of microdrama creators and executives — including one of the format’s top stars and producers, Kasey Esser, and Dhar Mann Studios’ head of vertical content, Erin McFarlane — examines how format innovation, fandom dynamics and algorithmic discovery are reshaping the economics of scripted storytelling and what traditional studios can learn from these agile models. For sponsorship opportunities, contact Lynne@theankler.com Share
AEO Engine Launches ’AEO Engine AI Search’ Podcast – First Show Dedicated to How AI Is Reshaping Business Discovery, Search Visibility, and Brand Trust
AEO Engine logo representing the launch of the new "AEO Engine AI Search" podcast, hosted by Aria Chen and focused on
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Recap: CCST Science & Technology Week 2026 - California Council on Science & Technology (CCST)
CCST’s 9th annual Science & Technology Week brought together policy leaders, science and technology experts, CCST champions, and our incredible network of partner institutions to discuss some of the state’s biggest challenges and opportunities
Credit Acceptance Appoints Steffen Schumann as Chief Business Officer
New Role Strengthens Enterprise Business Planning, Pricing Strategy, and Performance Management to Support Disciplined GrowthSouthfield, Michigan, March 19, 2026 (GLOBE NEWSWIRE) -- Credit Acceptance Corporation (Nasdaq: CACC) (referred to as the “Company”, “Credit Acceptance”, “we”, “our”, or “us”) today announced that Steffen Schumann has joined the Company as Chief Business Officer, reporting to Chief Executive Officer Vinayak Hegde. In this newly created role, Schumann will help drive growth
New study challenges a site that’s key to how humans got to the Americas
A new study challenges a site that's crucial to our understanding of how people got to the Americas.
A new study questions when people first reached South America
Data suggest people lived at Chile’s Monte Verde site thousands of years later than thought, challenging key “pre-Clovis” evidence. Not all agree.
Figma stock sinks after Google 'vibe design' tool gets update
Google's Stitch AI tool is the latest shot across the bow of software makers, as AI companies roll out features directly challenging their products.
Tariffs and Mitigating Actions: Focus on the Business Law Section Report with Participation of the International Section and Real Property Law Section - New York State Bar Association
The Business Law Section presents this report on tariff policy developments since February 2025. IEEPA-based tariffs have imposed rates of 10% to 50% on nearly all trading partners. Litigants have challenged the asserted authority for these tariffs in federal court, with an appellate decision invalidating that authority now on appeal before the U.S. Supreme Court.
What to watch this week in New Orleans theater: ‘Gatsby,’ ‘Streetcar,’ ‘Little Shop,’ more
Step into the Jazz Age with a lavish musical adaptation of F. Scott Fitzgerald's classic tale at the Saenger Theatre. Don't miss the chance to witness Jay Gatsby's larger-than-life story come alive on stage!
Varying your exercise routine could add years to your life
Switching up your exercise routine does more than fight boredom. Engaging in varied forms of movement may significantly boost your longevity, according to research.
Keypoint Intelligence Launches Keypoint Engage, Delivering AI-Powered Business Execution as a Service
Keypoint Intelligence today announced the launch of Keypoint Intelligence Keypoint Engage, a new suite of AI-powered execution services designed to help organizations turn trusted industry operations intelligence into measurable business results across sales, marketing, and customer service.
2026 Financial Summit: Strengthening Small Business for a Changing Economy
Read 2026 Financial Summit: Strengthening Small Business for a Changing Economy by Georgia Business Council for SaportaReport here.
The best strength training plan might be simpler than you think
New strength training guidelines emphasize that doing any resistance training is what truly matters. Based on decades of research, experts say even simple routines can increase muscle, strength, and physical function. The key is not perfection but consistency. In fact, the best workout plan is the one you can maintain long term.
German Health Minister Nina Warken and WHO Hub in Berlin highlight 2025 achievements
Germany’s Federal Minister of Health, Nina Warken, visited the WHO Hub for Pandemic and Epidemic Intelligence in Berlin today to review progress and launch its 2025 Annual Report. The report highlights advances in using artificial intelligence, data science and pathogen genomics to strengthen global preparedness for future pandemics.In 2025, the WHO Hub in Berlin worked with more than 160 Member States and over 190 partners to help countries and organizations develop new systems and tools to detect and understand new public health threats as quickly as possible, whenever and wherever they occur.BMG to confirm whether they wish to contribute a quote. “Detecting outbreaks early is one of the most effective ways to save lives and prevent epidemics from becoming global crises,” said Federal Minister of Health Nina Warken. “Germany is proud to host and support the WHO Hub for Pandemic and Epidemic Intelligence. Its work strengthens our safety at home and helps protect people worldwide.”Artificial intelligence is increasingly transforming the detection of outbreaks. In 2025, the Hub launched an upgraded version of the Epidemic Intelligence from Open Sources (EIOS) system, which uses enhanced AI functions to scan global online information in real time and help experts quickly identify unusual health events. The system is now used by 120 countries.To better anticipate health threats, countries need information beyond traditional health data. The Hub supports countries in implementing Collaborative Surveillance, which integrates data on climate, animals, travel, and population movement to provide a more comprehensive and real-time understanding of health threats.The Hub also expanded global access to pathogen genomics, which helps scientists detect new pathogens, such as viruses and bacteria, understand how they spread and how dangerous they may become. Through the International Pathogen Surveillance Network (IPSN), the WHO Hub in Berlin worked with 309 partners in 101 countries to expand access to these technologies.“We are in a new era of global health threats, and we need new tools to face tomorrow’s challenges,” said Dr Chikwe Ihekweazu, Executive Director of the WHO Health Emergencies Programme. “The WHO Hub in Berlin helps countries use data and technology more effectively so they can identify risks earlier and respond faster. No country can address these threats alone. Strong cooperation remains our best defence.”“Berlin offers an ideal environment for our work. We collaborate closely with world-leading institutions such as the Robert Koch Institute and the Charité Center for Global Health,” said Dr Oliver Morgan, Head of the WHO Hub for Pandemic and Epidemic Intelligence. “Germany has supported the WHO Hub since its establishment, and we are pleased to welcome Federal Minister Nina Warken to the Hub today. This strong partnership helps us advance innovation in pandemic and epidemic intelligence and better support countries to prepare for future health threats.”The Hub is expanding the use of advanced analytics and mathematical modelling to forecast how outbreaks may develop and to assess which response measures are most effective. Through its Collaboratory, the Hub connects modelers and analysts with governments to ensure their work addresses real public health needs. In 2025, the community grew to 1300 members from 50 countries and 200 institutions. An AI-powered pandemic simulator, currently in the prototyping phase, will help decision-makers compare outbreak scenarios and help identify effective disease control measures.
UTA strengthens its space science leadership
Award-winning physicist leaves UCLA to help lead Center for Space and Data Science
A public health professor is bringing the National Bioethics Bowl to Pitt
The competition, organized this year by Cindy McCarthy, gives students a chance to consider challenging questions about health and technology.
Just Women’s Sports and National Women’s Soccer League Extend Media Partnership | News
The premier women’s soccer league continues its partnership with the leading digital media platform in women’s sports to expand reach and deepen fan engagement.
UK health official says too soon to declare Kent meningitis outbreak contained
A British health official said on Thursday it was too soon to declare that a meningitis outbreak in southeast England has been contained, as authorities reported seven new cases of the disease that has killed two people so far.
Panthers 'embrace' Challenge Cup win
Reclaiming the Challenge Cup for the first time in a decade is a triumph Nottingham Panthers will cherish, says head coach Danny Stewart.
Denounce 'abject' Afcon decision
Caf executive committee member Augustin Senghor says the decision to strip Senegal of the 2025 Afcon title is "unacceptable, abject and we have to denounce it".
Republicans are ramping up attacks on Muslims
Past GOP leaders, including George W. Bush, spoke out against Islamophobia. Now it is going unchallenged.