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Design and Early Implementation Outcomes of a Mobile Health-Enabled Social Support Intervention for Adults Living With HIV and Type 2 Diabetes in Uganda
Background: Adults living with HIV and type 2 diabetes experience complex treatment demands that affect medication-taking, clinic attendance, privacy, social support, and engagement with care. M...
Back in business: Blue and White Snack Bar owners vow to uphold tradition of Hollidaysburg mainstay
HOLLIDAYSBURG — A local Hollidaysburg landmark is back as Blue and White Snack Bar, 905 Union St., reopened for business May 12. “The Blue and White is a landmark in Hollidaysburg and really all of Blair County. To say that people are excited to see it open again is an understatement,” Mayor Chad Repko said. […]
Falcons' Sophie Cunningham meme post sparks backlash from WNBA fans
Whthe NFL and WNBA clash.
Gunnar gives back: O's shortstop surprises local kid with specialized cleats
BALTIMORE -- The story of 11-year-old Declan Lefevre’s youth baseball career is inspirational. When Declan was about 4 years old, a doctor noticed his legs were different lengths. And it wasn’t something he would grow out of, either, which is something his parents -- father Jeff Lefevre and mother Nichole
78 days till Arizona Cardinals' opener: Remembering the 1978 season
With 78 days until the Arizona Cardinals' 2026 opener, let's look back at their 1978 season.
Washington Nationals vs Baltimore Orioles Game Thread
Follow along as the Nats look to snap their 4 game losing streak and get back to .500
Trump-backed Julia Letlow faces John Fleming in Louisiana GOP Senate runoff
U.S. Rep. Julia Letlow, who was endorsed by Trump, and state Treasurer John Fleming are competing in the runoff. The two finished ahead of Sen. Bill Cassidy in the May 16 primary after Trump denounced the two-term senator, who voted to convict him following his 2021 impeachment.
Timberwolves Re-Sign Jaylen Clark to Three-Year Contract
Minnesota brings back its defensive specialist on a team-friendly deal during a summer full of roster turnover.
Spain's Williams hits out at Uruguay over World Cup injury
Spain winger Nico Williams said suffering a latest injury setback was "one of the worst days of his life" as he criticised Uruguay for lashing out in a 1-0 defeat that ended their World Cup."Today is one of the worst days of my life.
Nintendo issues June 2026 backwards compatibility fixes for Switch games on Switch 2, full list
Another set of backwards compatibility fixes for Nintendo Switch games on Switch 2 are now available. There aren’t as many heavy hitters this time around, but it’s still a solid batch. Shovel Knight: Treasure Trove is the biggest name out of the bunch – previously, Nintendo said that players may encounter audio issues in some areas. The full list of...
Is Tencent Music Entertainment Group (TME) A Bargain Following Its Sharp Pullback?
Tencent Music Entertainment Group (TME) has drawn fresh attention after recent trading left the stock down about 9% over the past month and about 11% over the past 3 months, which has sharpened the focus on its current valuation. See our latest analysis for Tencent Music Entertainment Group. At a recent share price of $8.39, Tencent Music Entertainment Group has posted a year to date share price decline of about 53% and a 1 year total shareholder return decline of about 55%. However, the 3...
Stephenson Business Center highlights local vendors, gives back to community
The Stephenson Business Center holds a community event Saturday with dozens of vendors and some giveaways for area residents.
Buffalo Bills Make Decision On Honoring O.J. Simpson
As the franchise transitions to a new stadium, officials confirm the legendary running back’s name will be scrubbed from the Wall of Fame, ending a controversial decades-long tribute.
Deals: Prime Day shopping is over, here are the best Galaxy S26 and Pixel 10 series deals
The four-day shopping bonanza ended on Friday - now we're back to the regular, no-subscription-required deals. The four days of Amazon Prime Day shopping...
World Cup schedule, live updates: England, Portugal and Argentina back in action as group play ends
WWE Files To Trademark 'Bakusai' - Fightful | WWE News, AEW News, Pro Wrestling Backstage News
On June 26, 2026, WWE filed a new trademark for 'Bakusai.' Fans can click the article to read more about this.
The fittest founder in the room got cancer. Here's how he used AI to fight back.
When confronted with cancer, Connor Christou fed everything tied tied to his regime — blood results, scan data, wearable output, journal entries — into Claude.
The war for Burnham’s ear: politicians and wonks fight for influence over a PM
There is high emotion, a deluge of policy papers and an ‘excruciating’ jostle for jobs as Labour’s probable next leader settles back into Westminster life
After decades in the business, a Staten Island owner closes his dream restaurant
After decades building his dream in Annadale—and nearly losing it during COVID—the restaurateur steps back to savor family milestones.
Some paid the ultimate price to enact voting rights. Their survivors see America turning backward
It’s been six decades since the Voting Rights Act was enacted
Louisiana Art and Science Museum took guests back in time at its annual Dino Day
BATON ROUGE — The Louisiana Art and Science Museum gave guests an opportunity to experience a time long passed at its annual Dino Day on Saturday.
Why didn’t Arsenal’s Saliba play against Norway?
France eased past Norway to top their World Cup group on Friday night, but William Saliba was unavailable for the game as he continues to manage his back injury.Photo by Darrian Traynor/Getty ImagesFr...
Trump tamped down fights over abortion and marriage. Conservative activists want to bring them back in 2028
Since returning to the White House, Trump has largely sidestepped causes long championed by the conservative faith movement
Fallout from USMNT loss to Turkey and previewing the Mbappe-Haaland clash
On today’s show, we look back at the United States’ final group stage match against Turkey and evaluate their readiness for the Round of 32. Manchester City insider Sam Lee joins us to preview the tournament’s first true superstar heavyweight clash as Kylian Mbappe and France square off against Erling Haaland and Norway in a battle for Group I supremacy. Plus, The Athletic’s Jay Harris is back in the studio to break down the latest bracketology, advancement percentages, and qualification permutations for Groups G, H, and I using The Athletic’s World Cup Tracker.
Caleb Williams Calls Out NFL, Echoes Bold George Kittle Message
Chicago Bears quarterback Caleb Williams is already a leader of his team, and now he is leading with regards to the entire NFL. The post Caleb Williams Calls Out NFL, Echoes Bold George Kittle Message appeared first on HEAVY.
Ducks move into first round, select skill in Klepov, Nordmark
Anaheim jumped back into the first-round with two picks acquired in the Mason McTavish deal, and the Ducks went for scoring punch in Nikita Klepov and Marcus Nordmark.
Yankees news: Grisham on the comeback trail
CF working back from injury; Goldy’s resurgence; the Boston boys in pinstripes
Browns Warned Over Deshaun Watson Decision
The Cleveland Browns can insist that their quarterback competition between Deshaun Watson and Shedeur Sanders will be decided on the field, but the decision will not be made in a vacuum. The post Browns Warned Over Deshaun Watson Decision appeared first on HEAVY.
No debut, but loud cheers: Belfast crowd shows love for Vaibhav Sooryavanshi
Teenage sensation Vaibhav Sooryavanshi's India debut is still pending, but the focus shifted to Ireland's historic 34-run victory in the first T20I. Despite the loss, Shreyas Iyer vowed a strong comeback. Ireland's debutants impressed, with Jai Moondra and Matt Hollard making immediate impacts, while Abhishek Sharma's quickfire fifty wasn't enough for India.
Steelers’ Drew Allar Addresses Rookie Role Behind Aaron Rodgers
Pittsburgh Steelers quarterback Drew Allar spoke out on his place behind Aaron Rodgers on the team's depth chart entering 2026 NFL training camp. The post Steelers’ Drew Allar Addresses Rookie Role Behind Aaron Rodgers appeared first on HEAVY.
🗞 Today’s back pages: Baena downs Uruguay, the Dembélé show...
Spain’s victory over Uruguay dominates the sports newspaper headlines, but let’s take a look at how the main newspapers around the world are covering it.MARCAASMundo DeportivoSPORTL'EquipeSuperdep...
How Phones Alerted Millions Before Quakes Shook Venezuela
Millions of people in Venezuela and surrounding countries received early warning alerts to their phones up to two minutes before back-to-back earthquakes on Wednesday.
Days Ahead to Show If Burnham Plays Politics Better Than Starmer
Standing across from Keir Starmer in the Commons chamber this week, opposition leader Kemi Badenoch drew on a particularly violent metaphor for how the Labour Party had ditched him when she conjured up an image of “400 knives stuck in the prime minister’s back.”
Trump-backed Letlow faces Fleming in Louisiana GOP Senate runoff
President Donald Trump’s choice for U.S. Senate in Louisiana is seeking to secure the GOP nomination and deliver another win for the president in his effort to replace Republicans who crossed him
Coldwater Creek flooding impacts business at 'Bob's Canoes' in Milton
MILTON, Fla. -- River levels are dropping back to normal in Santa Rosa County after the remnants from Tropical Storm Arthur came through.
Caitlin Clark Fans Staging Boycott For Saturday's Fever Game
This Saturday's showdown between the Indiana Fever and Los Angeles Sparks has unfortunately lost some of its appeal due to Caitlin Clark's latest injury. Clark suffered a back injury during Wednesday's loss to the Phoenix Mercury. To make matters worse, she was on the receiving end of a cheap shot ...
Dolphins Training Camp Primer: Quarterbacks
A look at the Miami Dolphins' quarterbacks and where things may be headed during the 2026 season.
Ed Norton looks back on the surprising reaction to one of his now-iconic movies
Edward Norton is reflecting on the surprising reaction to 'Fight Club,' which overcame a rocky start to become an iconic film.
Uncle Julio's Fort Worth Celebrates Grand Re-Opening Weekend with Renovated Restaurant, Expanded Patio, Live Entertainment and Exclusive Offers
Uncle Julio's is welcoming guests back to its newly refreshed Fort Worth location with a three-day Grand Re-Opening celebration packed with exclusive offers,...
The 2x playback button on YouTube and TikTok is peak brainrot
My brain is so rotted from scrolling I can't watch anything on normal speeds.
Manufacturing business cuts ribbon in Putnam County, set to bring 120 jobs to area
The operation is a joint venture between global engineering group Sandvik and mining company Alpha Metallurgical Resources.
GOP senators seem increasingly game to buck some Trump priorities
Is growing pushback from conservative corners of the upper chamber a sign that Trump’s grip on his party may be slipping?
DAVID MARCUS: In rural Maryland, petty politics takes back seat to World Cup fever
The World Cup and America 250 celebrations unite Americans beyond politics, as the Save America Act and Trump debates fade in small-town gatherings.
Phase 2 of restoration project underway at West Herr Performing Arts Center
Members of the Rochester Broadway Theatre League say this next phase of work includes expanding the theatre's Rothschild Lounge back to its original size.
As Pa. measles outbreak worsens, state health official issue strong call to action: 'We are not just sitting back and watching this virus spread'
LANCASTER, Pa. — State Health Secretary Debra Bogen on Friday issued a strong call to action in the wake of a measles outbreak not seen in Pennsylvania...
Trump Administration Shut Down Climate Website, Former NOAA Employees Have Just Brought It Back
In June 2025, Climate.gov was shut down by an executive order that implied it did not meet the current administration's standards. Climate scientists have just brought the data back.
From The Sports Desk: The U.S. lost, but also saw return of star Christian Pulisic
The Americans may have lost their final group stage. But Pulisic, who had been nursing a calf injury, returned to action. He’s back just in time for the start of the knockout round.
CBS Sports speculates that Colts’ star could be ‘one of five players to force trade’
Could Colts running back Jonathan Taylor eventually request a trade from Indianapolis?
AI Is Already Reshaping US Politics at Every Level
From data center backlash to boundless cash from tech billionaires and concerns about deepfaked campaign ads, AI is everywhere in the 2026 US elections.
Nintendo Switch 2 ends first full year in the U.S. at nearly 6 million units sold, second fastest-selling video game system
Following the latest U.S. sales report from Circana, we have information about the first full-year sales of Nintendo Switch 2. The console ended its first twelve months at 5.9 million units sold. According to Circana, it’s the second fastest-selling video game system in the U.S. with tracked history dating back to 1995. The only other platform to outdo it was...
With Rico Dowdle gone, Panthers need production from backup RBs
Carolina's run-first offense will need backups Jonathon Brooks, Trevor Etienne and AJ Dillon to support the RB1.
What New York’s primary upheaval means for Democrats: Join Friday’s Whole Hog
Democrats are still feeling the political aftershocks of New York’s primaries on Tuesday night, including New York City Mayor Zohran Mamdani-backed victories. What could it signal for the party? Pl…
5 free agent cornerback options for the Detroit Lions
Five cornerback additions the Detroit Lions should consider after Terrion Arnold’s arrest.
How Science and Music Blurred Politics One Day Back Home
What to expect when you talk and play music to people you grew up with but have not seen for decades and have different political views from you. Turns out it was fabulous.
How Science and Music Blurred Politics One Day Back Home
What to expect when you talk and play music to people you grew up with but have not seen for decades and have different political views from you. Turns out it was fabulous.
Who are Texas A&M's All-Time Quarterback recruits?
According to 247Sports, here are the top 10 ranked Texas A&M quarterbacks recruits in program history.
Trump Mobile Takes The T1 Phone Reservation Holders For A Ride, Opens Sales To The Public Without Clearing The Backlog
Those who paid Trump Mobile a $100 deposit to gain early access to the T1 Phone suddenly find themselves at the back of the proverbial queue.
New York Jets News: Geno Smith Needs Another Career Comeback
Your daily links to the New York Jets
Williams to begin Wimbledon comeback against Joint
American superstar Serena Williams will make her highly-anticipated singles comeback at Wimbledon against Australia's Maya Joint in the first round.
YouTube Shorts Nixes 'Dislikes' And Lets You Double The Playback Speed
YouTube has made several key changes to Shorts by removing dislikes and offering a clear screen mode.
Hall of Fame GM Expresses Concerns About Extending Vita Vea
As a lucrative "hold-in" intensifies, Bill Polian warns that committing massive capital to an aging nose tackle could backfire for a Tampa Bay roster already in transition.
PNC Business Credit Names Brady to Southwest Region Sales Manager
PNC Business Credit promoted Eamonn Brady to Southwest region sales manager. Based in Denver, Brady will spearhead business development efforts across both
Slotkin says Democratic Party needs 'new leadership': 'Old models are no longer working'
Sen Elissa Slotkin calls for new Democratic Party leadership, saying old models no longer work and the party must simplify its message to win back voters.
Will Red Grooms' whimsical, wonderful Tennessee Fox Trot Carousel ride again?
The Tennessee State Museum in Nashville is considering how to bring a beloved whimsical carousel back to life. The Tennessee Fox Trot Carousel was the creation of Nashville-born artist Red
Why Michelle Pfeiffer left her 'Grease 2' audition feeling 'so humiliated'
On the anniversary of 'Grease 2,' take a look back at what Michelle Pfeiffer said about her audition. It was humiliating.
What we learned as Bryce Harper caps Phillies' shocking comeback trilogy
The Phillies erased another five-run deficit, rallied late again and reached the season’s halfway point with another reminder of how much has changed.
NBA fans troll Victor Wembanyama after MVP chants in France
Victor Wembanyama is back in France after leading the San Antonio Spurs to the NBA Finals. While his team failed to win the championship, he still received a lot of love from his countrymen. The 7-foot-4 center entered a club…
Controversial billionaire tax will appear on November ballot
Proponents of a controversial billionaire tax pledge to making sure it appears on the November ballot to backfill federal healthcare funds.
Vice President JD Vance talks faith and politics in Orange County
Vance largely talked about his grandmother’s influence at the sold-out event, which came on the heels of his new memoir, “Communion: Finding My Way Back to Faith.”
All the songs on Ariana Grande's Eternal Sunshine Tour
OAKLAND, Calif. – It's been six years since Ariana Grande’s last tour, and her yellow brick road has led her back to the stage.
Ex-NFL player Doug Martin's family sue Oakland police, allege restraint asphyxia in fatal mental health crisis
Parents of former NFL running back Doug Martin file wrongful death lawsuit alleging he died from restraint asphyxia caused by Oakland police.
YouTube Shorts are getting even shorter with an update that lets you double the playback speed
YouTube Shorts is getting a makeover.
Moore links Maryland primary to Mamdani-backed wins; analysts disagree
Gov. Wes Moore says Maryland’s primary election showed voters rejected the status quo, but political analysts say the results reflect a more complicated picture.
Yankees vs Red Sox: Cam Schlittler vs Connelly Early
The Yankees are back in Boston, but the rivalry is not.
Valve Quietly Walks Back Steam Machine 4K 60 FPS Performance Claims
Valve's Steam Machine has earned more than its fair share of skeptics, thanks to performance claims and more recently its unfortunate pricing. More recently, though, Valve has seemingly taken some of this criticism to heart and silently changed some of those performance claims on the Steam Machine p...
FlashPoint: How a Christian political media network became a platform for Indiana’s Lt. Gov.
By Sydney Byerly The Indiana Citizen June 25, 2026 When Indiana Lt. Gov. Micah Beckwith called Islam a “demonic death cult” during an appearance on the Christian political program FlashPoint in May, the remarks drew swift backlash from faith leaders across Indiana. It also highlighted the growing influence of the Christian media network that amplified
Democratic socialists’ battleground test: From the Politics Desk
Plus, Pete Buttigieg is back on the campaign trail. And digging into Michael Whatley’s bio in the North Carolina Senate race.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
After wins by democratic socialists, centrist Democrats unite to push back
Thirteen Democratic House members and candidates announced their support for an initiative that commits them to centrist principles.
Colts roster preview: Can Riley Leonard secure backup QB role?
With training camp off in the distance, we will be previewing each player on the Colts' 90-man roster. Up next is QB Riley Leonard.
The Ole-Miss All-Transfer Team: Offense
Now that NIL and the transfer portal are in full swing, creating NCAA Free Agency, there has been enough time for us to be able to go back and look at who have been the most impactful transfer Rebs so far. There will be an 11 man offense and 11 man defense and maybe an […]
The Supreme Court lets Trump deport people back to war zones
Trump’s administration may ignore procedural rules governing many of the most endangered people in America.
Romeo Doubs' Exit Could Raise the Stakes for Jordan Love in Green Bay
Jordan Love and the Green Bay Packers are eyeing a bounce-back campaign in 2026. The Packers opened the 2025 season with a strong start, posting a 9-3-1 record through their first 13 games, before a flurry of injuries derailed Green Bay's Super Bowl hopes. Since taking over as Green Bay's starter under center, the Utah State product has shown flashes of a top-five signal-caller, though the team hasn't yet made it past the divisional round under his leadership.
Consumer Discretionary Stocks Drawing Institutional Rotation Into Live Entertainment Leaders
With the Federal Reserve hinting at a pause in rate hikes, stubborn inflation still in the background, and several large companies surprising on earnings, consumer discretionary stocks are back in focus for investors weighing risk and opportunity. This article looks at how that mix of easier policy signals, solid corporate reports, and ongoing geopolitical and supply chain issues could affect larger U.S. consumer-focused companies. It will walk through 3 stocks from a curated screener that...
Dating Coach Urges All Men to Avoid 'Worst' Hobby for Single Guys
A professional dating coach isn't holding back on the "F" tier hobby for single men in the United States. Blaine Anderson, a former travel industry worker who built a successful dating coach business,...
Gov. Shapiro on Mamdani-backed wins in NYC: Candidates doing ‘performative politics’ must learn ‘how to deliver results’
YouTube Shorts player adding Clear Screen mode & 2x playback, removes dislike
YouTube today announced a number of updates to the Shorts player meant to “create a more intuitive Shorts experience.”
Graham Platner backs legal maneuver using Maine law to rein in political spending
Democratic U.S. Senate nominee Graham Platner wants to overturn the landmark U.S. Supreme Court ruling that enabled corporations and other outside groups to spend unlimited money on elections by any means possible. He supports a constitutional amendment and ethics rules on the high court, which the Sullivan oyster farmer included in his latest policy rollout […]
Mamdani on election wins: New Yorkers exhausted with ‘status quo politics’
New York City Mayor Zohran Mamdani (D) said voters showed they were exhausted with “status quo politics” by backing democratic socialists in state and federal primaries on Tuesday. Three Mamdani-ba…
Ohio State–led team secures NSF award to advance to next phase of the National Quantum Virtual Laboratory program
The Ohio State University is strengthening its growing prominence in quantum science, technology, and education with a $4 million, two‑year Phase II design award from the U.S. National Science Foundation (NSF) to advance a national effort focused on next‑generation quantum sensing.The funding is helping to bring together top researchers and ...
Gilbert-backed Cosm gets $100M Sony investment as immersive theater operator expands to Detroit
A Cosm location in downtown Detroit is expected to open in September as part of Dan Gilbert’s Bedrock LLC real estate firm’s Development at Cadillac Square project.
Steve Zabel, throwback two-way player, dies at 78
Steve Zabel, a tight end and pass rusher who was Oklahoma's last two-way player and then played both positions in the NFL, has died at the age of 78.
How anti-LGBTQ policies can affect business
Despite federal backlash against corporate DEI policies, companies that invest in inclusivity know that it makes economic sense.
Looking Back on Notre Dame’s Rout of Texas in 1995
Further proof that the Texas Longhorns don’t do so well when they travel to South Bend.
Des Bishop turns a turbulent past into comedy in 'Bridge and Tunnel'
Queens-born comic Des Bishop’s new “Bridge & Tunnel” special captures his long, winding journey from Irish stardom back to New York, where he finally finds his fast-paced American voice.
Funny thing about kids, they grow if you feed them
Great thing about being the funcle, you can just hand the kids back when they get sticky or whiny.
The science behind the back-to-back earthquakes that struck northern Venezuela
NPR's Michel Martin speaks with earthquake scientist Julia Hubbard of Cornell University about the science behind the multiple earthquakes in Venezuela, Japan and northern California Wednesday.
How is Derry City's new pitch 'World Cup standard'?
Ahead of Friday's first game back at the Brandywell, BBC Sport learns how a giant sewing machine has helped put Derry City's new hybrid pitch together.
Tamworth sign duo Dyson and Bailey
National League side Tamworth sign midfielder Oliver Dyson and left-back Joshua Bailey.