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Volunteer US and UK fighters in Ukraine face hidden health crises, new study suggests
Former soldiers who have served as volunteer fighters in Ukraine experience high levels of mental and physical health difficulties yet are rarely able to access the health care they need, either during ...
Luke Doncic facing suspension as Lakers oppose playoff-bound Pistons
The Los Angeles Lakers barely kept their winning streak alive on Saturday. They'll go for 10 in a row when they visit the Eastern Conference-leading Detroit Pistons on Monday.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Scientists twisted a mysterious superconductor and got a shocking result
A decades-old superconducting mystery just took a surprising turn. Strontium ruthenate, a material that conducts electricity with zero resistance at low temperatures, has long puzzled scientists with hints of an exotic, complex superconducting state. But by carefully twisting and distorting ultra-thin crystals, researchers found something unexpected: the material barely reacted at all. This challenges years of assumptions and suggests its behavior may be far simpler—or far stranger—than previously thought.
Tottenham Hotspur have chance to turn relegation narrative around against Nottingham Forest
Both sides are barely hovering above the relegation zone, Spurs boasting one point over 18th-place West Ham while Nottingham are only above the drop zone on goal differential
Friction without contact discovered as magnetic forces break a 300-year-old law
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Large Hadron Collider Discovers All-New Particle
Scientists have used CERN's Large Hadron Collider (LHC) to uncover what they say is an entirely new type of particle, dubbed Xi-cc-plus.
Large Hadron Collider Discovers All-New Particle
Scientists have used CERN's Large Hadron Collider (LHC) to uncover what they say is an entirely new type of particle, dubbed Xi-cc-plus.
iOS 26.4: Top 10 New Features Coming to Your iPhone
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WATCH: Trump says 'we don't need' Strait of Hormuz after allies won't help U.S. escort ships
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Arsenal and Manchester City lineups: James Trafford to start, Mikel Arteta dodges Kepa, David Raya question
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The Humanities: 5 Leadership Skills That Business Schools Don’t Teach
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Apple just broke launch-week records for new Mac users
Tim Cook says Apple just had a record-breaking week for brand-new Mac users. While he won't give details, it's surely the low-cost MacBook Neo that's leading the way.
Exclusive: Amazon plans smartphone comeback more than a decade after Fire Phone flop
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Here’s how Va. lawmakers suggest the next state budget handle federal health care funding fallout
More than 2 million Virginians rely on state social services like Medicaid and the Supplemental Nutrition Assistance Program, while about 400,000 Virginians get their health insurance through the state marketplace.
Maxx Crosby Trade Attempt Shows Ravens’ New Aggresive Strategy
The Baltimore Ravens rarely chase blockbuster trades, but their pursuit of Maxx Crosby suggested a different level of urgency. The trade suggested an “all in” motto from a franchise that is known for patience and draft-driven roster building. The deal ultimately fell apart before it could be finalized. Even so, the attempt revealed a willingness […] The post Maxx Crosby Trade Attempt Shows Ravens’ New Aggresive Strategy appeared first on The Lead.
Xiaomi releases new lightweight laptop with Intel Panther Lake and 120 Hz OLED display
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Trump started a war with no clear end in sight. They rarely end well for presidents
President Trump started a war with no clear end in sight. If his predecessors' experiences are an indication, conflicts don't bode well for presidential approval ratings.
Following Trump, Republicans in Congress Propose to Ban Most Voting by Mail
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Tom Brady Reveals the Sneaky Way He’s Able to Watch His Kids’ Sports Games in Person
Tom Brady shared how he avoids being recognized while cheering for his three kids at their sports games, opting to keep the focus squarely on them “where it should be.”
iPhone 18 Pro Launching Later This Year With These 12 New Features
While the iPhone 18 Pro and iPhone 18 Pro Max are not expected to launch for another six months or so, there are already plenty of rumors about the devices. It was initially reported that the iPhone 18 Pro models would have fully under-screen Face ID, with only a front camera visible in the top-left corner of the screen. However, the latest rumors indicate that only one Face ID component will be moved under the screen on the devices, which will result in merely a smaller Dynamic Island.
Tom Brady 'unlikely' to play flag football at 2028 Olympics but leaves door open: 'Never say never'
Brady did not entirely rule out an appearance on the inaugural Team USA roster
CEO Matt Upshaw Takes Ownership of Major Entertainment Marketing Agency Serino Coyne
The CEO of Serino Coyne, Matt Upshaw, has acquired ownership of the agency from its parent company. The agency will retain 100% of its executives, staff, and associates — and move into a new midtown office space.
SHOWSTOPPERS Exhibit at Helicline Fine Art Features Rarely-Seen Art Capturing Impact of Theatre and Entertainment
Helicline Fine Art’s new exhibition Showstoppers: The Art of Stage and Screen is on view through May 10. The exhibition brings together more than three dozen works capturing the impact of theatre, film, dance, opera, and popular entertainment.
A strange twist in the universe’s oldest light may be bigger than we thought
Scientists studying a mysterious effect called cosmic birefringence—a subtle twist in the polarization of the universe’s oldest light—have developed a new way to reduce uncertainty in how it’s measured. This faint rotation in the cosmic microwave background could point to entirely new physics, including hidden particles such as axions and clues about dark matter or dark energy.
Playing Politics With Scholarships Fails Families
States rarely turn down financial aid from Washington. But several Democratic governors are now doing just that, and others may join them. What’s going on? Not surprisingly, the answer involves special-interest politics.
2026 Oscar nominations full list: 'Sinners' smashes record with 16 nods as 'Wicked: For Good' is snubbed entirely
Paul Thomas Anderson's "One Battle After Another" was second with 13 while Jon M. Chu's "Wicked" sequel was completely shut out.
Leaked Samsung Galaxy Z Wide Fold specs show marginal upgrades over Galaxy Z Fold 7
The Galaxy Z Wide Fold will have to mostly rely on its wide-folding design for novelty, as the hardware isn't anything we haven't seen before.
THOR AI solves a 100-year-old physics problem in seconds
A new AI framework called THOR is transforming how scientists calculate the behavior of atoms inside materials. Instead of relying on slow simulations that take weeks of supercomputer time, the system uses tensor network mathematics and machine-learning models to solve the problem directly. The approach can compute key thermodynamic properties hundreds of times faster while preserving accuracy. Researchers say this could accelerate discoveries in materials science, physics, and chemistry.
Identity politics is seeping into economic policy
We need to support candidates who rely on logic, not labels.
ACC basketball tournament scores, schedule, results: Duke holds off Virginia to win conference title game
Duke needed to rely on its defense to close out Virginia.
Linux Finally Catches Up to Windows with a Game-Changing Performance Feature
For years, the Linux kernel’s scheduler has been world‑class at balancing loads, yet it missed a crucial, cache‑aware instinct. In modern multi‑core systems, that gap can turn into measurable latency, especially when threads bounce between cores that don’t share the same cache. A new upstream feature, often called Cache Aware Scheduling, is now set to change that equation. A cache‑savvy scheduler arrives At the heart of any OS, the scheduler decides which thread runs where and for how long. In modern CPUs, small private caches (L1 and L2) sit beside each core, while a larger Last Level Cache (LLC, typically L3) is shared among groups of cores. When a task migrates across LLC boundaries, its warm data may vanish from the cache, forcing slower trips to main memory. Cache Aware Scheduling keeps related tasks close to their shared LLC, reducing destructive migrations. By respecting cache topology, the kernel minimizes cold‑start penalties and preserves locality that many workloads desperately need. The result is less thrashing, fewer memory stalls, and more consistent throughput. "Keep tasks close to their data, and the system will keep performance close to its peak." Why this narrows the Windows gap Windows has long leaned on topology‑aware, cache‑sensitive heuristics, especially since the Windows 10 era. That advantage helped Microsoft handle hybrid designs with P‑cores and E‑cores, plus complex cluster and NUMA layouts. With cache awareness integrated upstream, Linux brings parity to this vital dimension, without sacrificing its trademark flexibility. The Linux approach remains deeply configurable, reflecting the ecosystem’s breadth across servers, desktops, and embedded devices. It layers atop existing NUMA‑balancing and energy‑aware logic, refining placement rather than reinventing the wheel. Crucially, it aligns scheduling with the hardware’s real shape, not just with abstract CPU counts. Real‑world gains and who benefits Early tests on Intel Sapphire Rapids platforms point to gains in the 30–45% range for select workloads. Those wins appear in cache‑sensitive tasks like in‑memory analytics, high‑thread compilation, and microservices with tight working‑sets. Games and latency‑bound engines can also feel steadier frame‑times, especially when threads share hot assets. The benefits extend to AMD’s 3D V‑Cache parts, where keeping threads near enlarged cache slices prevents needless misses. Hybrid x86 designs with performance and efficiency cores further profit when cache and core roles are scheduled in concert. Even handhelds running SteamOS can squeeze more out of limited power, translating cache locality into smoother play. Key advantages include: Lower end‑to‑end latency Fewer expensive misses to RAM Better multi‑socket and NUMA behavior Improved energy efficiency More predictable QoS under mixed loads Stronger scaling on dense servers Caveats, tuning, and rollout No scheduler change is purely free, and trade‑offs still exist. Favoring locality can reduce cross‑cluster balance if limits are set too tight. Likewise, fairness and utilization must remain healthy, especially under heterogeneous, bursty workloads. Linux’s implementation is designed to be measured and tunable, not a blunt instrument. It cooperates with energy‑aware scheduling for mobile efficiency, and with NUMA‑balancers on big iron. Expect architecture‑specific refinements as vendors surface richer topology hints and cache‑sharing maps. Upstream integration has begun, with broad distribution adoption likely over the next cycles. Many users will encounter the change through standard kernel updates in 2025–2026, depending on distro cadence. Server‑class kernels may enable or tune it sooner for targeted fleets where cache locality is money in the bank. How to think about performance impact Cache Aware Scheduling amplifies gains when your workload is both CPU‑bound and cache‑sensitive. Think tight inner loops, hot code paths, and datasets that fit snugly in shared LLC. It’s less dramatic for I/O‑bound services or memory‑hungry tasks that blow past cache capacity. Still, even modest locality improvements often translate into smoother tail‑latency, which is where user experience and SLAs typically break. Developers can further help by pinning related threads, batching work, and aligning data to reduce cross‑cluster chatter. The scheduler’s new awareness works best when applications expose good hints. The bottom line By understanding and honoring cache topology, Linux removes a subtle yet costly bottleneck. The kernel’s smarter placement keeps hot data hot and work near where it belongs. That narrows a long‑standing gap with Windows, while preserving the openness and tunability Linux champions. For gamers, creators, and operators, the payoff is practical: more consistent frames, faster builds, and snappier services. For the ecosystem, it’s another step toward hardware‑savvy scheduling that turns transistor complexity into real‑world speed. And for Linux itself, it’s a timely upgrade that matches today’s silicon with tomorrow’s expectations.
AMD Sees Agent Computers as the Next Step in AI PCs
AMD has published a guide for running OpenClaw locally on Windows through two distinct hardware paths it calls "RyzenClaw" and "RadeonClaw," both built around its own silicon and designed to keep AI agent workloads off the cloud entirely. The push is part of AMD's broader "Agent Computer" narrative,...
Utah measles outbreak speeds up but there are few changes to daily life
Health officials in the outbreak's epicenter are relying on social media and talk radio to reach residents. Many aren't listening.
Meet Renita Williams Thomas, Business Report’s Executive of the Year
Renita Williams Thomas had parented five children and spent years as a pediatric nurse before she understood the impossible choice facing parents of medically fragile children: Keep working or keep your child safe and healthy. That understanding came with her sixth child—Kai-Li, a baby girl born severely premature that she and her husband adopted. “When […]
Who Will Be the Packers’ Next Quarterback Redemption Story?
The Green Bay Packers have become victims of their own success. Matt LaFleur has had to rely on backup quarterback Malik Willis several times over the past two seasons. Willis stepped up impressively, leading the Packers’ offense to nine touchdowns with only one turnover in 11 games. Willis clearly benefited from working with LaFleur and the […] The post Who Will Be the Packers’ Next Quarterback Redemption Story? appeared first on The Lead.
Rapid evolution helped a wildflower survive California’s megadrought
Wild scarlet monkeyflowers in California survived a historic drought by relying on a rapid evolution, marking the first time the process has been observed in the wild.
Millions of military personnel may rely on hospitals facing financial challenges | Harvard T.H. Chan School of Public Health
A significant portion of military personnel, veterans, and their families may be relying on health care from hospitals that are on shaky financial footing, largely due to recent cuts to Medicaid, according to a new analysis.
Tim Cook kicks off Apple's 50th anniversary celebration
Apple rarely looks back, but fifty years since its founding is a milestone not to be missed and CEO Tim Cook has begun by publishing a letter celebrating it.
Microsoft’s next Xbox, Project Helix, will barely reach alpha by 2027
We’ll have to wait a while for the new Xbox.
West El Paso steakhouse receives low health inspection score: See list
A West El Paso Mexican steakhouse received a barely passing score in this week's restaurant inspections.
Business owners picking up the pieces after massive NW Miami-Dade warehouse fire
Business owners are dealing with the aftermath of a massive fire that tore through a warehouse in northwest Miami-Dade, leaving many without the equipment and inventory they rely on to make a living.
Bill Self explains Kansas star Darryn Peterson's silence amid controversy: 'Not a black-and-white situation'
Kansas' star freshman faced injuries, cramps and national scrutiny -- and his coach revealed why he rarely spoke publicly
Scientists discover molecule that stops aggressive breast cancer in its tracks
Scientists at Oregon Health & Science University have developed a new molecule that could open the door to treating triple-negative breast cancer, one of the most aggressive and difficult-to-treat forms of the disease. The compound, called SU212, targets and disables a key enzyme that cancer cells rely on to fuel their growth. In tests using humanized mouse models, the molecule caused tumors to shrink and slowed the spread of cancer by forcing the enzyme to break down.
Halfpricesoft.com Launches 2026 ezPaycheck Network Version to Empower Growing and Remote-Ready Businesses
Halfpricesoft.com announces the release of the latest 2026 ezPaycheck payroll software , now available in a powerful network version designed to support growing companies and remote teams. This enhanced edition allows businesses to securely share payroll data between multiple offices while enabling simultaneous printing of payroll checks and tax forms, streamlining operations for organizations with expanding workforces and distributed staff.
Pixel 11 Pro Fold looks barely different and just barely thinner in first leak [Gallery]
It’s already Pixel 11 leak season folks, with the first CAD-based renders of the upcoming Pixel 11 Pro Fold having...
Big Walk isn't 'friendslop,' it's an entirely new type of multiplayer game
Big Walk is a social game born of the pandemic but designed for a post-friendslop era
The “Last Mile” Problem Slowing AI Transformation
Few companies have been able to fundamentally change their operating and business models around AI. The primary obstacle to progress is rarely model quality or data availability, but rather the “last mile” of transformation where technical capability must meet organizational design. There are seven frictions that contribute to this problem: proliferation of pilots, the productivity gap, process debt, the identity problem of tribal knowledge, agentic governance, architectural complexity, and the efficiency trap. To overcome these, companies need to focus on clean-sheet process redesign, strategically capturing knowledge, and managing their new digital workforce.
Iran war sends shockwaves through African fuel market and economies
Rising global oil prices triggered by the Iran war are increasing economic pressures across Africa, where most countries rely heavily on imported petroleum products.
This Overlooked Health Condition Could Raise Your Risk of Death by 83%
A study following more than 5,000 participants for 12 years found that straightforward clinical measurements can help identify sarcopenic obesity without relying on complex imaging methods such as MRI and CT scans. Researchers from the Federal University of São Carlos (UFSCar) in Brazil, working
The Iran War Is Giving Democrats a Chance. Will They Take It?
Last week, Republicans in Congress rejected a war powers resolution and thus negated their own power. In so doing, they gave President Donald Trump free rein over the Iran conflict and tied themselves to a war that has no consistent justification, no clear end and little public support. Democrats voted largely in lockstep to curtail Trump’s power, the first move in a process that will become more substantial as the already-unpopular war continues. History shows that foreign conflicts rarely get
CMU to use coughing data from Sleep Cycle app to predict disease outbreaks
Every night, the Sleep Cycle app is recording each breath, cough and sneeze for more than a million users who rely on it to analyze their sleep. In a new...
Satellites are exposing weak bridges in America and around the world
Satellites are giving scientists a powerful new way to watch over the world’s bridges. Using radar imaging, researchers can detect millimeter-scale movements that may signal early structural problems long before inspectors notice them. The study found many bridges—especially in North America—are aging and increasingly vulnerable, but satellite monitoring could sharply reduce the number classified as high-risk. The approach could be especially valuable in regions where traditional monitoring barely exists.
Satellites are exposing weak bridges in America and around the world
Satellites are giving scientists a powerful new way to watch over the world’s bridges. Using radar imaging, researchers can detect millimeter-scale movements that may signal early structural problems long before inspectors notice them. The study found many bridges—especially in North America—are aging and increasingly vulnerable, but satellite monitoring could sharply reduce the number classified as high-risk. The approach could be especially valuable in regions where traditional monitoring barely exists.
UiPath Expands Into Healthcare AI As Valuation Lags Analyst Targets
UiPath (NYSE:PATH) has launched agentic AI automation tools tailored for healthcare providers and payers. The company is partnering with Genzeon to target data management and revenue cycle workflows. Use cases include medical records summarization, claim denial prevention, and prior authorization processing. For investors following NYSE:PATH, this move takes the company deeper into healthcare, a sector where many workflows still rely on manual processes and fragmented systems. UiPath built...
LSU sports is barely in the black financially, with uncertain financial times ahead
As LSU sports barely breaks even financially, difficult times potentially lie ahead for both its athletic teams and academic programs.
The era of Doctor AI is already here
Artificial intelligence is opening access to medical information in an entirely new way.
Scientists discover a hidden force that helps wire the brain
Growing neurons rely on chemical cues to find their targets, but new research shows that the brain’s physical properties help shape those signals. Scientists discovered that tissue stiffness can trigger the production of guidance molecules through a force-sensing protein called Piezo1. This protein not only detects mechanical forces but also helps maintain the structure of brain tissue. The discovery reveals a powerful link between the brain’s physical environment and how its wiring is built.
Amazon layoffs continue as robotics division cuts staff
Amazon's e-commerce operations rely on thousands of robots to automate warehouse operations. Still, this division hasn't avoided job cuts.
How Ludwig Göransson's Scores Became the Main Character
The 41-year-old Swedish musician is Ryan Coogler's and Christopher Nolan’s muse for a reason: His music transforms a film into something else entirely.
Workers at top 20 US low-wage firms rely on public assistance, report says
Study finds workers at 20 S&P 500 firms rely on Medicaid and Snap as CEO pay and buybacks soar
Scientists build a “periodic table” for AI
Choosing the right method for multimodal AI—systems that combine text, images, and more—has long been trial and error. Emory physicists created a unifying mathematical framework that shows many AI techniques rely on the same core idea: compress data while preserving what’s most predictive. Their “control knob” approach helps researchers design better algorithms, use less data, and avoid wasted computing power. The team believes it could pave the way for more accurate, efficient, and environmentally friendly AI.
Regulators Banning AI From Providing Mental Health Advice Could Spur Society Into A Massive Cognitive Withdrawal
Some regulators believe that there should be an outright ban on AI giving out mental health advice. A gotcha is that people already rely on AI. An AI Insider analysis.
Windows 12 release date in 2026 possible, with AI features that may force CPU upgrades
Windows 12 could be another costly upgrade for supporters of Microsoft operating systems. A new report reveals that the AI-dominated OS will require AMD and Intel CPUs with a dedicated NPU. Possibly surfacing in late 2026, the follow-up to Windows 11 may also rely on subscriptions.
Apple Accidentally Leaks 'MacBook Neo'
Apple appears to have prematurely revealed the name of its rumored lower-cost MacBook model, which is expected to be announced this Wednesday. A regulatory document for a "MacBook Neo" has appeared on Apple's website. Unfortunately, there are no further details or images available yet. Unfortunately, there are no further details or images available yet.
The Oppo Find X9 Ultra also steps outside China
Prices in Europe will surely be higher than in China.
Colorado legislature should not reverse lottery modernization
By Bill Clayton Four years ago, the Colorado General Assembly passed bipartisan legislation to modernize the state’s lottery system and strengthen funding for Colorado’s outdoor projects and open spaces. Lawmakers recognized a simple reality: consumer behavior has evolved. Most Coloradans no longer rely on cash for everyday transactions. If the lottery was to remain viable […]
Apple might use Google servers to store data for its upgraded AI Siri
The new Siri may rely on Google’s cloud.
Medicaid Coverage Supports Rural Patients, Hospitals, and Communities
One in seven Americans live in rural areas and rely on rural hospitals and health systems for the health and well-being of their communities.
Apple Discusses Google Hosting New Siri as Need for Cloud Help Grows
In January, when Apple announced an agreement to use Google’s Gemini models in Apple products, it was an admission that the iPhone maker hasn’t been able to compete in AI on its own over the past couple years. But the deal also showed that Apple is again relying on an outside company to help it ...
Vivo's X300 Ultra goes global and gets a huge 400mm Zeiss telephoto lens
Vivo barely has a presence outside of China but that seems to be changing in a big way with the company's next flagship phone.
Dodgers manager bothered by Tanner Scott quote
When the Dodgers installed Japanese-style bidets prior to the 2025 season, they were merely hoping Roki Sasaki would be part of the roster that used them. Those bidets did their job, as far as recruiting Sasaki and receiving anything he…
Forget steamy sex scenes, ‘SNL’ is Connor Storrie’s boldest move yet
Connor Storrie’s meteoric rise — which has seen him go from the world of food service to an internet-dominating television series in just a few months — has left endless possibilities open for the Texas-born actor, whose name is surely being uttered in many a Hollywood casting room these days.
Textbooks challenged by new discovery about how cells divide
Scientists have uncovered a surprising new way that giant embryonic cells divide—without relying on the classic “purse-string” ring long thought essential for splitting a cell in two. Studying zebrafish embryos, researchers found that instead of forming a fully closed contractile ring, cells use a clever “mechanical ratchet” system.
‘I rely heavily on instinct’: entertainment mogul Hassan Smith on the art he collects and why
John Legend’s manager, a prolific collector of Black post-war and contemporary art, tells us about a recent acquisition and the artists he regrets missing out on
If Bruins are buyers at trade deadline, which assets should they move?
The Bruins are barely holding on to a playoff spot in the East. If they want to reach the postseason, trade deadline reinforcements are needed.
Scientists confirm a mysterious “cosmic barcode” hidden near black holes - Futura-Sciences
It is hard to believe, but it has already been ten years since the first detection of a gravitational wave source. Named GW150914, after the date of its observation on 14 September 2015, the signal reached Earth and opened an entirely new chapter in astronomy. It marked the first direct...
Scientists compared dinosaurs to mammals for decades but missed this key difference
Baby dinosaurs weren’t coddled like lion cubs or elephant calves—they were more like prehistoric latchkey kids. New research suggests that young dinosaurs quickly struck out on their own, forming kid-only groups and surviving without much parental help, while their massive parents lived entirely different lives. Because juveniles and adults ate different foods, faced different predators, and moved through different parts of the landscape, they may have functioned almost like separate species within the same ecosystem.
Android 17 Beta 2 gives apps a way to access contacts, display color securely
Android 17 Beta 2 has officially been released by Google. Its aim seems to be privacy, as new features like...
Why top Senate Republicans are skeptical they can use a 'talking filibuster' to pass Trump's SAVE America Act
Senate Majority Leader John Thune said the conference isn't "unified" on using the rarely used tool as he faces increased pressure from the right.
Premier League chief, union boss warn of threat to star players over expanding football calendar
The 2026 World Cup is just around the corner, and PL chief executive Richard Masters said the sport 'cannot rely' on star players to maintain their level with the current calendar
Mar-a-Lago shooting: NC man shot, killed never interested in politics, guns, family says
Austin Tucker Martin rarely, if ever, talked about politics, seemed afraid of guns, and came from a family of Trump supporters, according to a cousin.
Mar-a-Lago shooting: NC man shot, killed never interested in politics, guns, family says
Austin Tucker Martin rarely, if ever, talked about politics, seemed afraid of guns, and came from a family of Trump supporters, according to a cousin.
Mar-a-Lago shooting: NC man shot, killed never interested in politics, guns, family says
Austin Tucker Martin rarely, if ever, talked about politics, seemed afraid of guns, and came from a family of Trump supporters, according to a cousin.
Galaxy S26 ‘Now Nudge’ is basically Google Pixel’s Magic Cue, but you’re forced to use Samsung Keyboard
Samsung is completely changing directions this year, and among moves like adding Perplexity as an AI assistant instead of relying...
Why People Don’t Like Talking About Politics
Political discussions are tense and rarely informative.
Seahawks GM 'catching up' after Super Bowl, clears air on Kenneth Walker
A little more than two weeks since winning Super Bowl 60, the Seattle Seahawks' general manager can bask in the glory. But barely bask.
Never eat the candy on your pillow: reentry politics
Your circumstances rarely change with reentry no matter who’s president, and it’s easy to forget that there is power in the political
Winter sports' future hinges on the climate
Expert says winter sports' growth will rely on climate change.
Hims & Hers Health, Inc. Reports Fourth Quarter and Full Year 2025 Financial Results
Revenue of approximately $2.35 billion, up 59% year-over-year in 2025 Net income of $128 million; Adjusted EBITDA of $318 million in 2025 Subscribers grew to over 2.5 million, up 13% year-over-year in 2025 Provides Q1 and full year 2026 guidance1, with full year 2026 revenue in the range of $2.7 billion to $2.9 billion and Adjusted EBITDA in the range of $300 million to $375 million Hims Hers Health, Inc. (“Hims Hers” or the “Company”, NYSE: HIMS), the leading health and wellness platform, today announced financial results for the fourth quarter and full year ended December 31, 2025 in a shareholder letter that is posted at investors.hims.com. “More than 2.5 million subscribers now rely on us for a healthcare experience that is both accessible and deeply personal – and we believe we’re well on our way to becoming the global leader in consumer health,” said Andrew Dudum, co-founder and CEO. “In 2025, we made it possible for more customers across the world to depend on us
How 3 business owners train their AI agents to be better employees
Three founders who rely mostly on AI share how they've built workflows and prompts to train their AI tools to push back and challenge their ideas.
Now's the time to celebrate Acadiana's Lee Allen Zeno, a musician who creates in the shadows
Zeno is a sideman, a musician who makes the stars sound great but rarely gets the spotlight.
Netflix Will Soon Stop Working on Some Streaming Players & Smart TVs
In a move that signals the ongoing evolution of streaming technology, Netflix has announced it will end support for its application on the PlayStation 3 console and several other older devices effective March 2, 2026. This decision affects a niche but dedicated group of users who continue to rely on these aging platforms for accessing […]
McCord: Run Huntington Beach Like a Service Business
Run Huntington Beach like a service business—not a political stage. Demand accounting on the 25-year Pacific Airshow deal, stop “balanced” budgets that rely on reserve raids and one-time patches, and tackle deferred maintenance and real hazard risks. November 2026: vote for competence, not drama.
I'm 40 and have the same health issues as my superager grandmother
My grandmother is 95 years old, and I'm 40, but we have the same medical issues. We rely on each other for support as our bodies change.
Five Berkeley Lab Scientists Receive DOE Early Career Research Awards
Five scientists from Lawrence Berkeley National Laboratory (Berkeley Lab) have received Early Career Research Program (ECRP) awards from the Department of Energy. The ECRP program, now in its 16th year, was established to bolster the nation’s scientific workforce by supporting exceptional researchers at the outset of their careers, when many scientists do their most formative work. Recipients use the funding to pursue projects that have the potential to solve scientific challenges and advance the country’s STEM capabilities. To be eligible for the program, a researcher must be an untenured, tenure-track assistant or associate professor at a U.S. academic institution, or a full-time employee at a DOE national laboratory or Office of Science user facility, who is within 10 years of having earned their doctorate. Awards to an institution of higher education will be approximately $875,000 over five years, and awards to a DOE national laboratory or Office of Science user facility will be approximately $2,750,000 over five years. This year’s Berkeley Lab awardees and their projects are listed below: Timon Heim: Better detectors for more powerful particle colliders Timon Heim is a staff scientist in the Physics Division. His ECRP project will develop a new type of detector that can track the particles generated by collisions in particle colliders with high spatial and temporal resolution. Current detectors in use at high-energy colliders, like the ATLAS detector at the Large Hadron Collider (LHC) at CERN, can track the trajectory and measure momentum of particles, but they can’t track a particle’s time of arrival with sufficient precision to discern from which of the many particle interactions they originate. Heim’s proposed technology — called a 4D tracking detector, because it captures data about particles’ positions in space and time — aims to solve this challenge, allowing researchers to glean more precise data from collision experiments to uncover new insights into fundamental forces and potentially discover new particles. The enhanced capabilities of 4D detectors will be a necessity for experiments at future colliders, such as the Muon Collider or Future Circular Collider. The project will develop custom microelectronics that process the signal of a pixelated silicon sensor that can register charged particles passing through it in an extreme radiation environment that these colliders produce during operation. The goal is to measure individual particles’ position with 50-micro-meter spatial and 50 pico-second (one trillionth of a second) temporal precision, for an incoming flux of around 1 billion particles per second per square centimeter. Harrison Lisabeth: Studying underground processes to unleash abundant energy Harrison Lisabeth is a research scientist in the Energy Geoscience Division focused on combining real-world experiments and AI to guide development of geothermal energy systems. His project will explore how deep underground rock formations – where geothermal wells are dug – are stressed by chemical reactions of the minerals and mechanical strain from movements in the Earth. A better understanding of subsurface stresses is essential to engineer safe and reliable geothermal wells that access the heat of deep rocks to produce electricity. It is estimated that the U.S. could generate ten times the amount of energy needed to power the grid using geothermal sources. Lisabeth plans to simulate how minerals grow, dissolve, and influence the behavior of surrounding rock in geothermal reservoirs by tracking chemical changes in rock samples under pressure in the lab. The project will also develop machine learning models to predict geologic strain based on field measurements and refine existing models that describe how common rock types deform under stress. Combining these approaches, Lisabeth hopes to develop a framework to predict stress to improve stability and longevity of geothermal wells. Daniel Carney: Pushing the quantum boundaries of particle measurement Daniel Carney is a staff scientist in the Physics Division who uses quantum information science to study particle physics and gravity. At very small scales, “quantum noise” — random fluctuations from the act of measurement — can drown out faint signals from rare processes. Carney’s ECRP project, “Fundamental Physics at the Quantum Limits of Measurement,” aims to build a new mechanical quantum sensor that can measure extremely small particle interactions below the limits of that quantum noise. The approach uses lasers to hold a tiny bead containing radioactive atoms; when one decays, the system measures the bead’s motion and the energy of any particles emitted. The experiment’s initial goal is to search for heavy sterile neutrinos, hypothetical particles predicted by some extensions of the Standard Model. The system could also help measure the mass of the neutrino, study the way particles interact through the electromagnetic and weak forces, and hunt for low-mass dark matter — all unsolved mysteries in particle physics. Callum Wilkinson: Using machine learning to demystify neutrinos Callum Wilkinson is a staff scientist in the Physics Division and part of the international Deep Underground Neutrino Experiment (DUNE) hosted by Fermi National Accelerator Laboratory. DUNE will create an intense beam of neutrinos that interact in detectors in Illinois and, after an 800-mile journey through the earth, in massive detectors in South Dakota. By precisely measuring neutrinos and how they change, researchers will get a better understanding of their fundamental properties and whether they are responsible for why there is so much more matter than antimatter in our universe. Wilkinson’s ECRP project will apply two machine learning techniques to improve the analysis of DUNE’s data and enhance the experiment’s precision. One approach will look for hidden patterns in how neutrinos interact and produce low-energy particles, while the other will help correct for distortions in what the detectors record. The methods will be tested on one of DUNE’s prototype detectors and could be used in other neutrino experiments, improving their measurements and helping scientists build better models. Aditi Krishnapriyan: Machine learning methods that scale as datasets grow Aditi Krishnapriyan is a faculty scientist in Berkeley Lab’s Applied Mathematics and Computational Research Division (AMCR) and assistant professor at UC Berkeley. Her project, awarded through UC Berkeley, will develop machine learning methods that scale with dataset size for modeling complex, multi-scale phenomena. The resulting tools can be applied in a wide range of research, including the study of new electrolytes for batteries or the examination of molecular interactions. ### Lawrence Berkeley National Laboratory (Berkeley Lab) is committed to groundbreaking research focused on discovery science and solutions for abundant and reliable energy supplies. The lab’s expertise spans materials, chemistry, physics, biology, earth and environmental science, mathematics, and computing. Researchers from around the world rely on the lab’s world-class scientific facilities for their own pioneering research. Founded in 1931 on the belief that the biggest problems are best addressed by teams, Berkeley Lab and its scientists have been recognized with 17 Nobel Prizes. Berkeley Lab is a multiprogram national laboratory managed by the University of California for the U.S. Department of Energy’s Office of Science. DOE’s Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit energy.gov/science.
Whoops, Scientists May Have Severely Miscalculated the Number of Species on Earth
A new study focused on cryptic species—animals that look the same but are genetically different—found that they’re more widespread among vertebrates than we previously thought.
She built a career in Japan and says one thing is non-negotiable
Lauren Rose Kocher never worked full-time in the US, so her understanding of corporate culture was formed almost entirely in Japan.
Ilia Malinin admits he was not 'ready to handle' Olympic pressure
Malinin entered the 2026 Winter Games under an intense spotlight. He was heavily expected to win a gold medal but a shocking performance left him off the podium entirely.