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Will Congress Save America's Hemp Businesses Before It's Too Late?
With Nov.26 federal hemp ban looming, a $28B industry faces potential extinction. Here's what the new THC cap means for businesses, jobs, and the future of hemp.
Winwin, the Latest Member to Leave NCT and SM Entertainment, Pens Emotional Letter to Fans
“These past 10 years will remain one of the most precious chapters of my life."
Winwin, the Latest Member to Leave NCT and SM Entertainment, Pens Emotional Letter to Fans
“These past 10 years will remain one of the most precious chapters of my life,” the star said in a letter to fans.
New Science Says Training Your Nose Can Slow Brain Aging (Yes, Really)
Smell training is an easy but overlooked way to leverage your nose to improve your memory and cognitive function.
Chinese Artist WINWIN Parts Ways With SM Entertainment And NCT
Chinese artist WINWIN has parted ways with SM Entertainment, terminating his exclusive contract after 10 years. He's currently focused on his acting activities in China.
Oil prices rise after fresh US strikes on Iran and return of sanctions on Tehran
Almost all major Asian stock markets fall, with Samsung Electronics shares sliding for a second day
Why Netflix’s ‘Maternal Instinct’ left out Taylor Parker’s mental health diagnosis
Director Jessica Dimmock explained her reasoning to Netflix's Tudum.
Unique fossil record of marine mollusks helps scientists predict extinction risk—before it's too late
Scientists are increasingly worried we may be witnessing the start of the "sixth mass extinction"—the first to be caused by human activities.
Trump admin reimposes oil sanctions after Iran strikes ships near Strait of Hormuz
The Trump administration is reimposing sanctions on Iranian oil sales in retaliation for a series of attacks on commercial ships near the Strait of Hormuz.
Rahm Emanuel will assail Netanyahu in Tel Aviv speech as American politics shift against Israel
Emanuel argues changes are needed, including sanctions on Israelis who attack Palestinians.
Comcast’s Sky to Buy ITV’s Media & Entertainment Unit in $2.1 Billion Deal
ITV’s linear channels and ITVX streaming platform will remain free-to-air, while Sky News and ITV News will stay editorially distinct
Comcast’s Sky to Buy ITV’s Media & Entertainment Unit in $2.1 Billion Deal
ITV’s linear channels and ITVX streaming platform will remain free-to-air, while Sky News and ITV News will stay editorially distinct
Trump Intervention in FIFA World Cup Ignites Controversy
Though Article 27 grants FIFA's disciplinary committee discretion to suspend sanctions, its use in automatic World Cup suspension is unusual.
CBS Sports Names Alabama the Greatest College Football Program of Three Different Decades, and It's Hard to Argue
Spanning the 1930s to the 2010s, the Crimson Tide outpaced every other powerhouse to claim historic dominance across three distinct eras of gridiron excellence and consistency.
FULL SHOW: Inside INdiana Business 7/5/26
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Scientists discover the deep sleep circuit that builds muscle, burns fat, and boosts the brain
Researchers have identified the brain circuitry that links deep sleep with the release of growth hormone, revealing how the two regulate each other. The newly discovered feedback loop helps explain why poor sleep can interfere with growth, muscle repair, fat metabolism, and brain function. Understanding this system could pave the way for new therapies for sleep disorders and diseases tied to metabolism and the brain, including Alzheimer's and Parkinson's.
Why Circulation Health Supplements Are Gaining Attention for Supporting Healthy Vascular Function and Everyday Wellness, According to PureHealth Research
PureHealth Research is highlighting growing consumer interest in circulation wellness and the role of targeted nutritional supplementation in maintaining healthy blood flow, vascular function, and overall cardiovascular wellness.Circulation health supplements commonly feature ingredients such as Omega-3 Fatty Acids, Berberine and Butcher's Broom, which are frequently included in formulations designed to promote healthy circulation and vascular health.
Ukrainian drones target more Russian oil infrastructure as fuel crisis adds political pressure on Putin, who shrugs off attacks as ‘not critical’
Ukrainian President Volodymyr Zelenskyy described the attack as part of Ukraine’s “long-range sanctions” against Russia.
This toad exists only in Canada—and scientists have finally discovered why
Scientists have identified something that may be even more uniquely Canadian than the beaver or moose: a genetically distinct western toad population found only in Canada. The discovery, made by researchers from the University of Ottawa, points to a rare and previously unrecognized group of toads living in the Canadian Rockies and raises fresh questions about conservation, biodiversity, and how much wildlife still remains to be fully understood.
New adenomyosis atlas reveals lesion-specific signals that may spare healthy uterine tissue
Researchers at the University of Liverpool have identified distinctive biological characteristics within adenomyosis lesions that could help pave the way for more targeted, less invasive treatments. The ...
Scientists Uncover Fossil Teeth Showing How Early Mammals Adapted After the Dinosaur Extinction
Researchers analyzed 200 fossil teeth from ancient mammals in China, revealing how they adapted and diversified after the mass extinction
Long Reads for the Long Weekend
(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) Happy Fourth of July weekend! As has been a tradition of mine going back to the beginning of the EntStrategyGuy website, I’m sharing my favorite long reads of the last year, like I did in 2019, 2020, 2021, 2024, and 2025. Let’s dive right in! Subscribe “Different Prices for the Same Ride: How Uber and Lyft Use AI to Get More Money Out of You“ by Derek Kravitz in Consumer Reports I don’t think surveillance pricing, like the kind described in this brilliant Consumer Reports article, is long for the world—it’s toxically unpopular—but we’ll see if either party takes on this issue. If I ran a political party focused on affordability, I would focus on a few pro-consumer and pro-market policies: Banning non-compete agreements. Ending surveillance pricing Eliminating junk fees (read more here...) Ensuring “right to repair” for consumer (and military!) products Capping excessive app store fees Stopping digital/algorithmic price-fixing tools. Preventing automatic subscription price increases. And more. If you want to fight inflation, there are a lot of great ways to do it quickly. Speaking of higher prices... “Secret Documents Show Pepsi and Walmart Colluded to Raise Food Prices Across the Economy“ by Matt Stoller in BIG Again, I think a political party should focus on lowering prices for consumers. And deals like this—Walmart making a deal/forcing Pepsi to offer the lowest prices at its stores and nowhere else—hypothetically lower prices at Walmart...but raise them everywhere else. “15 DUIs, still driving: California’s failure to take repeat drunk drivers off the road“ by Robert Lewis and Lauren Hepler in CalMatters CalMatters does terrific reporting in California, something the Golden State desperately needs more of, and this article is a great example of that. “PugLips: The next insanely popular thing you’ve never heard of…” by Simon Carless in Game Discover Co I thought that this parody article (and yes, it’s a parody, but I was definitely unsure at first) was hilarious and totally nailed how much tech/business journalism feels these days. Actually, three of my favorite articles this year were on hype in the video game industry, including Georg Zoller’s “The Video Game Industries Very Dark Night”—which I linked to recently and wrote a follow-up here—and Owen Mahoney’s “Derek Zoolander, Videogame Exec”. In particular, I like Mahoney’s focus on user experience as a guide to what trends will actually grab hold of customers. “The Matrix Lies“ by Evan Shapiro in Media War & Peace Evan Shapiro’s first person account of his experience with AI was hilarious. I think LLMs capabilities have significantly grown from last summer, and yet...my editor/researcher just had an abysmal experience using an LLM to do a quite basic task (which our LLM normally does each week) and the LLM made a mistake on every single data entry...along with seven different mistakes affecting twelve of the twenty or so entries, including mistakes that are explicitly spelled out in the prompt. That’s a brutal failure rate. Again, if you use AI/LLM for data collection, you need to take a lot of extra steps to verify and check the data. “Ghosts in the Balcony: A Cross-Country Trip to 58 Theaters Fighting to Survive“ by Matthew Frank in The Ankler I thought Matthew Frank’s pitch to head across America to visit theaters sounded insane aggressive at the time—at least it felt that way to someone a decade older than him; man, to be in your twenties again, am I right?—but I knew the result would be great. And it was, a terrific feature by a great young writer. Also, I loved Matthew’s recent article on who’s getting the precious few entry level jobs in Hollywood. (Hint: nepotism.) “Disney erased FiveThirtyEight“ and “Did Las Vegas get too greedy?” by Nate Silver in Silver Bulletin I love media history and analysis, and there’s no one better to get the history of FiveThirtyEight than from Nate Silver, who wrote about his personal experience in one of my favorite pieces from this year. I also loved Nate’s breakdown of what’s causing Vegas’ woes, but I’ll offer one criticism, summarized as “Might I suggest antitrust?” Many centrists/center-right/libertarian thinkers (Nate is self-described as the latter) often don’t consider consolidation or antitrust as factors in policy issues like housing, America’s military readiness, or, in this case, Las Vegas. Even if libertarians want to debunk antitrust/consolidation concerns, I’d love to read that debunking. In this case, Vegas is incredibly consolidated (though it also has been for a long time) and I’d have loved to read Nate at least contending with this factor, since he addresses almost every other potential factor for Vegas’ decline. “Why Microsoft’s Carbon Removal Pullback Is Such a Big Deal“ by Robinson Meyer in Heatmap News I’m a big supporter of carbon removal efforts, but this nascent industry faces a lot of headwinds, including this big move most recently. I think it’s clear that solar panels and batteries should be able to get the world to its carbon footprint goals, but effective carbon renewal remains necessary to prevent the worst impacts of global warming. “AI is killing the cheap smartphone“ by David Oks LLMs and AI will impact the world in ways we’re not ready for, and already, third world countries are seeing the prices of cheap cellphones skyrocket due to the cost of chips skyrocketing. This article by David Oks is a terrific breakdown. “100 Days of Madness: Netflix, Paramount, Warner and the Future of Hollywood“ by Wade Major at Hollywood Heretic Wade Major dove deep into Hollywood/streaming’s financials in this must read piece. Not that I agree with everything in this article (read my take on Warner Bros./Paramount here) but the analysis is top notch. I think many people discount how quality thinking, regardless of the argument/conclusion, will make you a better thinker. “Erased by the UFC: Frank Shamrock, The MMA GOAT of the 20th Century“ by Nate Wilcox in The MMA Draw Newsletter Growing up playing the UFC fighting game on the Dreamcast, Frank Shamrock was my favorite MMA fighter, and this history/tribute to him was great. Other Fun Reads “The Hardest Part Of History To Tell Is How It Felt“ by Craig Fehrman at Defector “Unmasking the Sea Star Killer“ by Craig Welch at bioGraphic “What Could Save the Industry? Fin-Syn“ by Richard Rushfield in The Ankler Alex Rollins Berg in Underexposed on movie bumpers, pillow shots, Disney trash cinema, cult films, and Casablanca. David H. Montgomery in YouGov’s The Surveyor on punctuation marks, condiments, dinosaurs, and comic strips and kids media. “How Medium finally pivoted its way to profitability“ and “Why the best journalists on YouTube are all former Vox employees“ by Simon Owens in Simon Owens’s Media Newsletter “It’s Not Just You, Netflix Shows Have Gotten Slightly Shorter: Here’s What the Data Says“ by Kasey Moore at What’s on Netflix “Numlock Awards: How Diane Warren became the biggest loser in Oscar history“ by Nathaniel Rakich and “Numlock Awards: The Oscar Bait era is over. The Oscar Chum era is here.” by Walt Hickey & Michael Domanico at Numlock Awards
House Dems dodge questions on SCOTUS trans athlete ruling, shift blame to 'culture wars'
House Democrats mostly sidestepped questions on the Supreme Court transgender athletes ruling, pivoting to the economy and Washington dysfunction.
Oba Corporation Introduces Mega Sardines to Azerbaijan Market to Address Regional Health Trends
Mega Sardines, in its distinctive upright vertical can, is already appearing on Oba shelves BAKU, Azerbaijan, July 03, 2026 (GLOBE NEWSWIRE) -- ...
This slim camera has a transparent LCD screen for a viewfinder
The Godox C100 skips a color preview screen for a multi-function viewfinder that can double as a light meter.
Iran exploring oil sales to Japan, buyers seek longer sanctions waiver, sources
Iran has begun talks to sell oil to Japanese companies, though prospective buyers are seeking a longer U.S. sanctions waiver and reassurances on safe shipping conditions in the Gulf, three Iranian and Western sources said.
Science on a Sphere
ALPENA — Inside the Great Lakes Maritime Heritage Center is an incredible and powerful tool that is too often missed. This is your chance to receive an interactive presentation of Science on a Sphere. There are less than 200 of these in the United States and Thunder Bay National Marine Sanctuary (TBNMS) is home to […]
How Roberts led a fractured Supreme Court to wins for the right and defeats for Trump
In President Trump's second year back in the White House, Chief Justice John G. Roberts Jr. and the court punctured his claim to have power with no limits.
Scott Bessent goes after the top Mexican cartel’s new billion-dollar business: gas stations
Treasury sanctioned two men and nine firms tied to a Jalisco cartel fuel-theft ring that reportedly nets tens of millions a year across 21 Mexican states.
Team's prediction task compares GPT-4o with classic machine learning
Large language models have been functionally opaque. Seeking transparency, a team undertook a comparison with traditional machine learning.
A Strange Attempt To Revive The 3DO Is Already Dead
A long-defunct developer returned from the dead promising to revive the 3DO, but quickly pulled its pledge when it became apparent it didn't have the right to.
A Nation Larger Than Its Politics
As America approaches its 250th birthday, I find myself wondering whether we have lost sight of something that earlier generations understood instinctively.Americans have never agreed on politics.We have argued over wars, taxes, immigration, religion, civil rights, economic policy, and the proper ro...
Jessica Tarlov: Even if this is just politics, do better
‘The Five’ co-hosts discuss lawmakers clashing during a sanctuary city hearing.
Bayer Group to consolidate U.S. glyphosate business into distinct entity operating as Ruveon
Advances key component of Crop Science division’s Five-Year Framework strategy / Reinforces commitment to delivering trusted Roundup® brands and glyphosate products and services to U.S. customers
Study Reveals Biology Underlying Oral Health Issues in Down Syndrome
Low saliva from calcium signaling dysfunction, microbiome changes may contribute to high rates of gum disease
Garden City restaurant violations include black mold, unsafe foods
Wayne County health reports show violations at Garden City eateries, including improper food storage, equipment malfunctions and hygiene issues.
Amanda Gonzalez ahead in Democratic primary for Secretary of State
Amanda Gonzalez is leading Sen. Jessie Danielson in the Democratic primary for Secretary of State, according to the Secretary of State’s website. As of 8:15 p.m., Gonzalez had 62.72% of the vote, while Danielson had 37.28%. Gonzalez, an election attorney, currently serves as the Jefferson County clerk and as an adjunct professor of election law […]
Gonzales ahead in Democratic primary for Secretary of State
Amanda Gonzalez is leading Jessie Danielson in the Democratic primary for Secretary of State, based on early returns posted after polls closed Tuesday night. As of 7:20 p.m., Gonzalez had 63.61% of the vote, while Danielson had 36.39%. Gonzalez, an election attorney, currently serves as the Jefferson County clerk and as an adjunct professor of […]
Wilmington Small Business Coalition: Building Momentum in 2026 by Heather McWhorter
This article was contributed by Lydia Thomas, UNCW CIE Program Manager. North Carolina continues to be one of the best states to start a business and in 2025, Wilmington, North Carolina earned a spot on the GoDaddy list of the top 10 most entrepreneurial cities in the U.S. While many know Wilmington as small beach town with exceptional food, lots of coffee shops, and fun, vibrant summer activities, a closer look reveals a thriving innovation economy. You’ll find startups emerging across industries including software, healthtech, bluetech, and fintech. At the core of this entrepreneurial ecosystem is the Wilmington Small Business Coalition, with small business advocates and entrepreneur support organizations (ESOs) dedicated to helping founders grow, thrive, and succeed. “No Wrong Door” Established in 2016, the Coalition was designed to make it easier for individuals and small businesses to access resources most suited to their particular needs. The Coalition is designed to have a “no wrong door” entryway into the regional startup ecosystem. Whether you are exploring a new idea sketched on the back of a napkin or leading a more established, growth-stage company, Coalition members can help connect you with the programs, funding opportunities, mentors, and resources best suited to your needs. No matter where you are in your entrepreneurial journey, any Coalition organization can help point you in the right direction. Coalition Members and Leadership Coalition members include the UNCW Center for Innovation and Entrepreneurship (UNCW CIE), AARP, Brunswick Community College Small Business Center, Cape Fear Community College Small Business Center, Cape Fear Region SCORE, Genesis Block Foundation, Network for Entrepreneurs in Wilmington (NEW), Small Business & Technology Development Center (SBTDC), Greater Wilmington Chamber of Commerce, YWCA Living the Dream Center for Entrepreneurship, Carolina Community Impact Fund (CCI Fund), Partner Community Capital, 717mkt Office Collaborative, NC Biotech, and Institute NC. In May 2026, the Coalition held its leadership elections, resulting in the selection of a new executive team. The following officers were elected to serve two-year terms: Chair: Lydia Thomas, UNCW CIE Vice Chair: Diane Lantz, CCI Fund Secretary: Aariene Hansley, Genesis Block Foundation Treasurer: Gloria Monroe, SBTDC Vision for the Wilmington Small Business Coalition In 2026, the Wilmington Small Business Coalition continues its work as a collaborative network of organizations. By connecting programs, expertise, and services across partner organizations, entrepreneurs can more easily find the right support at the right time. Rather than operating in silos, the Coalition aims to function as a unified, cohesive system of support for small businesses and entrepreneurs, ensuring that resources and expertise across partner organizations are visible and accessible. Through stronger collaboration and shared pathways, entrepreneurs can move more seamlessly from idea to startup to growth. Looking to dive into the Wilmington entrepreneurial ecosystem? Connect with any of the Coalition partners to get started! Connect with CIE To learn more about CIE and our services, programs, and events, join the CIE newsletter. You can also follow us on social media: Instagram, Facebook, LinkedIn, TikTok, or YouTube. CIE’s website is uncw.edu/cie. Heather McWhorter is the director of the UNCW Center for Innovation and Entrepreneurship (CIE). CIE supports innovation-forward start-ups and helps to build a vibrant innovation economy for all in southeast NC.
WATCH: Angel mom turns tables on sanctuary politicians with basic question about their priorities
Jessica Gorman told lawmakers her daughter Sheridan “was not a talking point" as she accused sanctuary city leaders of failing to protect American citizens.
June research roundup: 6 cool science stories we almost missed
Also, the science of poop's distinctive shape, boron buckyballs, and the secret to a soccer feint.
U.S. lifts oil sanctions on Iran amid chaotic talks
This reverses years of pressure on Tehran
SCSU Athletics Features 21 Owls To Receive NE10 Presidents' Award for Sports Excellence
NEW HAVEN, Conn. - Southern Connecticut State University Athletics featured 21 graduating student-athletes to receive the Northeast 10 Conference's Presidents' Award, as announced by the conference on June 30, 2026.
Reaching communities close to hostilities in Ukraine
Primary health care teams in Ukraine are reaching 121 locations within 60 km from active hostilities. This is part of the largest primary health care intervention in frontline areas in the country. European Union (EU)-supported teams are delivering essential services to people trapped by constant shelling and severe security constraints in 7 regions where no pharmacies operate, no health facilities function and evacuation remains impossible for residents.
Science for Living: How acupuncture is earning its place in modern medicine
UMass Chan researchers discuss the growing evidence behind acupuncture’s role in modern integrative medicine and how it is helping to reduce chronic pain.
Takeaways from the Supreme Court’s decisions expanding Trump’s firing power but preserving Fed for now
The Supreme Court handed President Donald Trump a significant win Monday by allowing him to remove the leaders of once-independent federal agencies at will, toppling a 1935 precedent in the process that could reorder the way the government functions.
Colorado Supreme Court: Redistricting plans for 2028 election cannot proceed under state constitution
The Colorado Supreme Court blocked all attempts at redrawing congressional district boundaries for the 2028 election from reaching the ballot on Monday, concluding each of the proposed ballot measures violated the constitutional single-subject requirement. The court considered five distinct, but related, ballot measures. Three proposals would have redrawn U.S. House of Representatives districts to give […]
Kakao Entertainment Announces Genre-Spanning Lineup
Kakao Entertainment enjoyed a highly successful first half of the year, with its Netflix series “The WONDERfools” and “Boyfriend on Demand” hitting global home runs with their distinctive narratives. Also building on the recently released suspense drama “Notes from the Last Row,” Kakao Entertainment’s genre-spanning 2026 slate features the upcoming action-comedy “A Bona Fide Killer” and the thriller “Mousetrap,” cementing - Read our full Pop Culture on The Outerhaven .
Trump calls likely DC mayor Janeese Lewis George a 'communist' and vows to block her agenda
D.C. mayoral frontrunner Janeese Lewis George faces clash with President Trump over ICE enforcement, policing, cashless bail and sanctuary city policies.
Being broke costs you 13 IQ points, according to science. Here's the number that changes everything.
CreditNinja reports that saving your first $10,000 unlocks financial stability, improving decision-making and reducing stress, ultimately boosting cognitive function.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Civility advocates look for ways to restore 'Iowa Nice' to campaigns, public discourse
A group of former and current officeholders are looking to encourage civility by encouraging civic participation and civil interactions.
Master Inventor Hoffman Turns Chemistry Into Capability | Johns Hopkins University Applied Physics Laboratory
Christopher Hoffman has been recognized as a Johns Hopkins APL Master Inventor, a distinction earned through a career spent asking a simple question: What can chemistry can do to solve a real-world problem?
The Science Of Speed: How Mizuno’s Nanoalloy Face Changes What’s Possible In Driver Design
Mizuno is the first company to put a functional polymer layer in front of a driver face. The implications go well beyond ball speed. For most of the
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Trump’s fixation on election overhaul bill derails GOP agenda on Capitol Hill
A nasty feud over President Donald Trump’s elections overhaul push has further crippled an already-dysfunctional Congress, leaving Republicans unable to move on critical elements of their agenda.
Scientists find molecular-level evidence for two structures in liquid water
A study published in Nature Physics provides new molecular-level evidence from simulations that liquid water is not a single uniform substance, but a constantly shifting mixture of two distinct microscopic ...
How Caesars’ Expanded Tribal iGaming and Community Partnership Could Shape Caesars Entertainment (CZR) Investors’ Outlook
In June 2026, Caesars Entertainment Inc. announced that it had expanded its partnership with three Wabanaki Nations in Maine to cover online casino gaming, aiming to launch Caesars Palace Online Casino, Caesars Sportsbook & Casino and Horseshoe Online Casino in 2026, subject to regulatory approval and integrated with Caesars Rewards and a universal digital wallet. A distinctive element of this agreement is Caesars’ commitment to employ and train tribal members while providing financial...
Poor metabolic health can age the brain even in young people, finds new large-scale study
Two people of very different ages can have a similar level of biological aging in their brains. Such an occurrence is possible because aging and metabolic health follow two distinct pathways that influence ...
Venezuela's Devastating Earthquake Was a ‘Doublet’? Here's What This Means
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Cowboys news: Dallas receiver looks forward to playing freely
Here's the latest news surrounding the Dallas Cowboys!
Keiser's Paul Dodson Voted 2025-26 SUN Sports Information Director of the Year
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What to know about the entertainment district lawsuit from ORED, Norman residents
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Federal judge bars Trump from implementing proof of citizenship requirement to vote
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BIZNOTES: Three West Seattle business anniversaries
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New DNA study of Neanderthals bolsters suspicions of human-driven extinction
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Fire at Whiteaker business now being investigated as arson
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Burial site of all female extinct human relatives baffles scientists
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Girls Flag Football is Now OHSAA’s 29th Recognized Sport
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ORED sues city, county, and more for entertainment district injunction
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Why Healthy People Often Become The Problem In Unhealthy Systems
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The tea in your kombucha changes more than just the taste
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Oil prices fall after US waives Iran sanctions and peace talks in Switzerland progress
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Every Pontiac Firebird Generation Ranked By Top Speed
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New Orleans Summer Entertainment & The Omni Hotel Controversy
This week on The Get Down, John Stanton breaks down the week ahead in New Orleans, including the City Council's final vote on the controversial Omni Hotel redevelopment plan. googletag.cmd.push(function() { googletag.display('ad-1492300'); }); Jake Clapp shares some upcoming entertainment picks, including Ilana Glazer's tour stop at the Joy Theater, and we take a look at summer bucket list ideas in The Pearl for making the most of the season in New Orleans.Be sure to grab a copy of our latest issue of Gambit and stay tuned for the latest on all things New Orleans at bestofneworleans.com. .donate-gambit-article-module-container { text-align: center; padding: 10px; /* background-color: #24da6d; */ background-color: rgb(153, 0, 0); margin-bottom: 20px; } .donate-gambit-article-module-title { font-weight: bold; color: #fff; } .donate-gambit-article-module-copy { color: #fff !important; font-size: 16px; } .donate-gambit-article-module-button { background-color: black; width: 50%; border-color: black; font-size: 16px; } .donate-gambit-article-module-button:hover { background-color: black; } @media only screen and (max-width: 600px) { .donate-gambit-article-module-button { font-size: 14px; width: 100%; } .donate-gambit-article-module-copy { font-size: 14px; } } BECOME A GAMBIT MEMBER AND JOIN OUR KREWE TODAY For more than 40 years, Gambit has covered New Orleans, for New Orleans. We’ve stood up to city hall with you, cheered the Saints with you, danced in the streets with you and cried over our collective loss with you. And we’re plannin’ on being here for 40 more. To do that, we need your help. Become a Gambit member today and help us continue our mission SUPPORT GAMBIT
N.C. A&T College of Education Earns Top National Rating in Science of Reading Teacher Preparation
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Trump’s Iran agreement embraces sanctions relief, a policy he and his team once denounced
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Can a Community Move Beyond the Systemic Fractures of Mental Health Care? "All Access hosted by Andy Garcia" Explores the Coordinated Response in Kansas
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Zeiss Medical Technology Collaborates With Envision Health Technologies to Advance Glaucoma Care Using VR-Based Testing
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Growing Interest in Liver Wellness Leads Consumers to Explore PureHealth Research Liver Health Supplements
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One common fat may fuel type 2 diabetes while another helps fight it
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FULL SHOW: Inside INdiana Business 6/21/26
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This video game is making men want to be fathers. It started a viral conversation
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Fire crews respond to 2:30 a.m. blaze at Whiteaker business
KVAL CBS 13 is the news, sports and weather source for Eugene, Oregon and nearby communities, including Springfield, Santa Clara, Coburg, Pleasant Hill, Creswell, Churchill, Alvadore, Marcola, Dexter, Thurston, Junction City, Brownsville, Harrisburg, Alvadore, Veneta and Alpine.
Biden scores temporary court victory as Trump appointed judge delays release of Hur investigation materials
Former President Biden wins a three-week injunction blocking release of audio recordings from Special Counsel Hur's classified documents investigation.
Illinois GOP chair says Obama Center is political operation on public land
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Iranian Guards' business empire to win big if US sanctions lifted
Four senior Iranian sources described how the Islamic Revolutionary Guard Corps was uniquely positioned to capture a large share of any financial rewards that would accrue from sanctions relief.
Iranian Guard’s business empire to win big if U.S. sanctions lifted
As the two sides eye a deal to end the war that could unlock billions of dollars for Iran, the elite Revolutionary Guard is poised to be one of the biggest beneficiaries.
Los Alamos Faith & Science Forum Presents ‘Saved By The Spirits: Did Religion Rescue Paleolithic Humans From Extinction?’ June 24
Dr. Nels Hoffman/Courtesy photo LAF&S FORUM NEWS RELEASE The Los Alamos Faith and Science Forum 2026 Summer Series Presents ‘Saved by the Spirits: Did religion rescue paleolithic humans from ex…
Iranian Guards' business empire to win big if U.S. sanctions lifted
Emerging outlines of a deal between Washington and Tehran to end their war contain a stinging paradox: sweeteners to coax Iran into compliance may strengthen an adversarial force that the U.S. and its Western allies consider a terrorist organisation.
Honk-Key Lock and Safe Celebrates Grand Opening of Its Grand Junction Storefront, Establishing a Full-Service Locksmith Grand Junction Residents and Businesses Can Reach for Safe, Vault, and...
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First US patient enrolled in device study to reduce coronary microvascular dysfunction
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Fresno Fair Expands 2026 Grandstand Entertainment With Rodeo Derby, Monster Trucks
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Alogic Debuts New Touchscreen Monitors and Portable Displays With Mac Support
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