SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " location " 1,370 found 🔀 AI-powered Shuffle
Human echolocation step echo by step
Experts in echolocation use multiple clicks and echoes to sense objects, offering insight into how the brain builds perception.
Gene Editing Institute Receives $500K Federal Grant to Expand CRISPR Learning Lab
ChristianaCare’s Gene Editing Institute has received a $500,000 federal grant secured by Delaware’s congressional delegation to expand its Learning Lab, a hands-on program that introduces high school and college students to gene editing. The Learning Lab is powered by CRISPR in a Box™, a teaching toolkit developed by Institute scientists that lets students try gene […]
ACES at Factory 52 acquired by Tri-State’s booming pickleball business
Greater Cincinnati’s fast-growing pickleball business has acquired another location.
I quit my corporate job to start a pizza business with $20K
Chris Brady quit tech sales at 25 to start Timber Pizza Co. with $20,000. It has since grown to multiple locations and mobile units.
GMB Management Software for Multi Location Business
GBPPromote GBPPromote Indore, Madhya Pradesh, April 05, 2026 (GLOBE NEWSWIRE) -- GBPPromote, a fast-growing Google Business Profile (GBP) management software, is gaining strong traction among agencies, franchises, enterprises, and individual businesses looking for a simpler and more scalable way to manage their local presence on Google. Adopted widely by franchises, agencies, and enterprise teams for multi-location GMB management, the platform is built to handle the kind of operational work that
Iran’s World Cup participation depends on relocation from US, minister says
Iran awaits FIFA's response after requesting relocation of its games to Mexico amid the US-Israeli war.
Nell Nolan: Cowan deb, Ellott deb, Benzman deb brunch
At individual parties, three debutantes of the season were honored at special locations, two historic and one, a charming home. Today, another celebration occurs, Easter, when families will visit homes
LaunchPad Golf brings tech-driven golf entertainment to Prior Lake with its first U.S. location
What time is UConn vs South Carolina in Final Four? Start time, location, TV Channel
Everything you need to know to tune into No. 1 UConn Huskies vs No. 1 South Carolina Gamecocks including start time and streaming options for the Final Four
What time is UCLA vs Texas in Final Four today? Start time, location, TV Channel
Everything you need to know to tune into No. 1 UCLA Bruins vs 1 Texas Longhorns including start time and streaming options for the Final Four
Family-owned Maryland candy business set to close with plans for possible new location
Easter brings a rush of customers to Log Cabin Homemade Chocolates in Bel Air, Maryland, which has been in business for 66 years.
Exclusive: US upends global supply program for malaria and HIV amid warnings of gaps
The U.S. is upending the way it delivers medical supplies for diseases such as HIV and malaria to lower-income countries, according to seven sources and an internal email, risking a second dislocation of life-saving services in just over a year.
Celebrate Science Day Takes Off at New Location: Reading Regional Airport
From helicopters to birds and the principles that lift them skyward, guests of all ages will discover how things fly while also enjoying a wide range of interactive STEM activities beyond aviation.
Several people arrested for $50M health care fraud across Southern California
Federal authorities arrested eight people for defrauding Medicare and other insurance companies with many of them using hospices as a front to bilk millions of dollars, the Department of Justice (DOJ) announced Thursday. Collectively, the eight people are accused of stealing from $50 million dollars from different locations across Southern California from Anaheim to Simi Valley. Calling Southern California a…
Family-owned Maryland candy business set to close with plans for possible new location
Measles exposure location confirmed at Providence Portland Hospital ER waiting room
Health officials have identified a new measles exposure site in the Portland area.
Raising Cane's looks to add Sioux Falls location
Popular national chicken restaurant Raising Cane's Chicken Fingers is taking steps toward a Sioux Falls location.
KFF Health Tracking Poll: The Public’s View of Immigration Enforcement Activities in Health Care Settings
Amid reports of Immigration and Customs Enforcement (ICE) at hospitals and President Trump's reversal of policy protecting "sensitive locations" like hospitals, KFF's Health Tracking Poll finds that a majority of the public say they are concerned about the Trump administration's actions in health care settings.
Can Congress keep US sports teams from leaving their cities?
From Brooklyn to Oakland, relocations have left scars. US senators Bernie Sanders and Greg Casar now want to give communities a chance to fight back
Dallas Stars, Town of Northlake officially open Children's Health StarCenter Multisport Northlake
Children’s Health StarCenter Multisport Northlake becomes the 11th StarCenter location in the DFW Metroplex
Original local business closes Short North location
Homage's original store located in the Short North has permanently closed. A sign posted to the business's door confirmed this, without stating a reason "why"
iOS 27 Siri Update Will Let Users Make Multiple Requests at Once
The updated version of Siri that Apple plans to release in iOS 27 may be able to handle multiple commands in a single query, reports Bloomberg. With the feature, users would be able to make multi-step requests that Siri would carry out, such as getting directions to a location and then sending those directions to someone in a message. Siri has long been limited to a single command for most requests, and the personal assistant is not able to parse queries with multiple components.
Rush Funplex proposes third KC metro entertainment center in Lee’s Summit
The metro already has Rush Funplex locations, which feature laser tag, go-karts and other entertainment, in the Northland and in Shawnee.
Predicting spring bloom is an art
Do you ever wish you could predict the future? The National Park Service in Washington D.C. does it every year when they forecast when the Capitol’s cherry blossoms will reach peak bloom. People travel from all over the world to enjoy the annual National Cherry Blossom Festival and to glimpse these fragile flowers before they are gone. On this month’s Nature Quest, we learn the ins and outs of cherry tree blossoms, how scientists make that big prediction every year — and why all this focus on blooms can help scientists better understand climate change. This episode is part of Nature Quest, our monthly segment from listeners noticing a change in the world around them. To participate, send a voice memo to shortwave@npr.org with your name, location and your question about a change you're seeing in nature!Want to learn more about nature’s calendar? Check out our first Nature Quest episode on whether flowers are blooming early.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.
The Bull Case For PENN Entertainment (PENN) Could Change Following Aurora Casino Relocation And Expansion
PENN Entertainment has opened the new US$360 million land-based Hollywood Casino Aurora across from Chicago Premium Outlets, nearly doubling its local workforce to about 700 people and preparing to transfer operations from its older riverboat site pending final regulatory approvals and funding support from Gaming and Leisure Properties and the City of Aurora. This expansion deepens PENN’s presence in the competitive Chicagoland casino corridor while highlighting its asset-light funding model...
San Francisco making it easier for businesses to host block parties
Super Bowl sites: A look at future locations, including Las Vegas for 2029 game
Las Vegas will host its second Super Bowl in a five-year span.
Contractor lays off 250+ employed at various Beacon Health facilities
More than 250 contracted workers employed at various Beacon Hospital locations across Southwest Michigan will lose their jobs come July.
Naked man breaks into Bend business, faces multiple charges
BEND, Ore. (KTVZ) -- A 43-year-old man was arrested Saturday night after police say he broke into a business and smeared feces in two areas of the building. Jajay Allen Findley was identified as the suspect and was taken into custody. Officers responded to the location after a caller reported a naked man had forced
Earth formed from material exclusively from the inner solar system, planetary scientists show
Planetary scientists have long debated where the material that formed Earth comes from. Despite its location in the inner solar system, they consider it likely that 6–40% of this material must have come ...
Quantum physics can confirm where someone is located
The concept of entanglement links far-flung particles. That relationship can prove that someone is in the location they claim to be.
Efforts to rebrand César Chavez Day are fueled by emotion and duty
Renaming efforts also are underway for dozens of schools, streets and other locations across the United States that are named for Chávez.
Hyde Park reopens in Bath with steak menu, more seafood, entertainment
Hyde Park steakhouse returns to Bath Township location after $1.8 million in renovations.
What time is Michigan vs Tennessee in Elite Eight today? Start time, location, TV Channel
Everything you need to know to tune into No. 1 Michigan Wolverines vs 6 Tennessee Volunteers including start time and streaming options for the Elite Eight
Your Photos Are Probably Giving Away Your Location. Here’s How to Stop That
All your snaps come with metadata containing more information than you might realize.
Floyd Mayweather pumps brakes on rematch with Manny Pacquiao
Floyd Mayweather cast some doubt on details of his pending fight with Manny Pacquiao, saying the location has not be set and that the bout will actually just be an exhibition.
What time is Texas vs Kentucky in Sweet 16 today? Start time, location, TV Channel
Everything you need to know to tune into No. 1 Texas Longhorns vs 5 Kentucky Wildcats including start time and streaming options for the Sweet 16
What time is Michigan vs Louisville in Sweet 16 today? Start time, location, TV Channel
Everything you need to know to tune into No. 2 Michigan Wolverines vs 3 Louisville Cardinals including start time and streaming options for the Sweet 16
Stick & Hack Entertainment bringing golf and racing simulators to new Broad Ripple location
Stick & Hack Entertainment bringing golf and racing simulators to new Broad Ripple location
Broad Ripple is getting a new entertainment venue featuring golf and racing simulators. Stick & Hack Entertainment announced that its second location in the Indianapolis area will be located at East ...
Incoming women's sports bar The Sports Bra unveils downtown location
Incoming sports bar The Sports Bra — the Portland, Oregon-based eatery known for showing exclusively women’s sports — has a home downtown.
Jewish Family Service provides holistic care at new Addison location
The goal of the organization based in Addison is to provide holistic care and help people become healthier in every aspect.
Dartmouth Health adds 26 new providers from various disciplines across health system
Providers span 13 healthcare disciplines and practices across nine Dartmouth Health locations
A handful of US malls are defying the odds in the era of e-commerce. Lakeside is one of them.
Here’s how the Metairie ball is bucking the trend. “Retailers used to come to town to open three locations. Now, they’re looking to open one and it’s at Lakeside.”
Portland kayak business searching for alternative locations after devastating wharf fire
Portland's Custom House Wharf is still months away from being rebuilt after this winter's devastating fire.
Challenges for downtown Buffalo businesses continue
BUFFALO, N.Y. (WIVB) — Business in downtown Buffalo continues to be a big topic. On Wednesday, Public Espresso announced it is closing its cafes — including a Washington Street location…
LPD: Several businesses added to list of places people may have been recorded illegally
These locations include Kohl’s, TJ Maxx, Target, Plato’s Closet, Mission Thrift, Millie’s Café, and The Muse Coffee Company.
New Congressional bill targets sports team relocations
More than 40 years after the Colts left Baltimore for Indianapolis like thieves in the night, those in a profession that enjoys nearly the same level of respect are trying to prevent it from happening again.
Oscars to leave Hollywood's Dolby Theatre in 2029
In addition to the physical relocation, the Oscars will shift to YouTube, a major reset as the show looks to expand its reach after years of declining TV audiences.
Progressives on Capitol Hill want to rein in sports franchise relocations
U.S. Rep. Greg Casar and U.S. Sen. Bernie Sanders said their Home Team Act would stop rich owners from leveraging big taxpayer subsidies.
Proposed bill from Sen. Bernie Sanders targets pro sports team relocation. Here's how
Rep. Greg Casar and Sen. Bernie Sanders have introduced the "Home Team Act" to Congress, which would alter the process of sports team relocation.
Broad Ripple welcomes new sports, entertainment venue
BROAD RIPPLE, Ind. — The Broad Ripple neighborhood will soon be home to another place where people can enjoy fun and food. Stick & Hack Entertainment is opening its second location at 46th Stre…
Critically endangered hare spotted in surprising location for the first time in 40 years — but it was already dead
Scientists in China have announced the first confirmed sighting of the critically endangered Hainan hare in part of its native range in four decades, after spotting its completely flattened carcass on a roadside.
Amusement Entertainment Management Client Wins 2026 FEC of the Year
Star Lanes Polaris of Columbus, Ohio proudly accepted The American Amusement Machine Association’s (AAMA) 2026 Family Entertainment Center Location of the Year Award during the AAMA President…
Merlin joins forces with Sony Pictures Entertainment and Triotech to bring the world of Jumanji to life at Madame Tussauds
Merlin Entertainments – a world leader in branded entertainment destinations – today announces four new locations across its global estate where the World of Jumanjj is being crafted into…
ICE presence rising at Michigan health care facilities, rights groups say
The Michigan Immigrant Rights Center and the ACLU of Michigan have sent guidance to more than 400 hospitals and providers in the state to outline law enforcement changes to ‘sensitive locations’ policy.
Comella’s closes Melrose location after 13 years in business
The family-run Massachusetts Italian chain continues to operate its 10 other locations.
Business Notes: Rocco’s Smokehouse Grill to reopen in temporary location
Rocco’s Smokehouse Grill soon plans to operate out of the Shops at High Street in the space formerly occupied by Strangeways.
Why beloved gas station Buc-ee's got an F from Better Business Bureau
The first-ever Buc-ee's location is opening in Arizona, and the travel center just got an F rating from the Better Business Bureau. Here's why.
Health inspectors found thawed seafood, food stored in buckets leading to temporary closure of Mama Tina’s Gumbo
Houston health inspectors investigating a customer illness complaint after eating Mama Tina’s Gumbo at the Houston Livestock Show & Rodeo found thawed seafood labeled “keep frozen” and learned the gumbo had been moved to a freezer at an unlicensed off-site location without temperature logs before being served, according to Houston Health Department records obtained by KPRC 2 News.
Locally-based behavioral health group to open first Louisville office
The location will provide individual, couples and family therapy.
Business closed after new Ohio law banning intoxicating hemp products went into effect
Senate Bill 56 grants law enforcement the authority to remove intoxicating THC products from unlicensed retail locations,
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Why Buc-Ee's Received An 'F' Rating From Better Business Bureau
Buc-ee's is a beloved Texas-based gas/convenience store chain with dozens of locations across the U.S. So why did it get an F from the Better Business Bureau?
Skin therapy business opening with celebration next month in the Poconos
The new location will offer customized skin rejuvenation treatments, including advanced exfoliation, LED light therapy, and modern facial technologies.
Skin therapy business opening with celebration next month in the Poconos
The new location will offer customized skin rejuvenation treatments, including advanced exfoliation, LED light therapy, and modern facial technologies.
A Physicist Said Heaven Has a Literal Address. The Science World Is Reacting Just Like You’d Expect.
A former Harvard physics lecturer and science communicator has said that heaven could have a physical location. And he knows exactly where it is.
Google Messages is getting the one feature I’ve actually wanted for years
Google Messages has finally rolled out live location sharing, and I can't believe it took this long.
Google Messages Real-time Location Sharing rolls out (or: How to remove the ‘plus’ dot)
Following the announcement at the start of this month, Real-time Location Sharing in Google Messages for Android is more widely rolling out.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Google Maps could soon get a long-overdue upgrade that replaces WhatsApp and Google Messages for location ...
Sharing your location has never felt this simple and fast.
This Google Maps update could change how you share your location
The new method is simpler and more obvious.
Girl Scout Cookies booths are open for business
Girl Scout Cookies season is officially underway in Utah, and cookie booths are popping up outside grocery stores and community locations across the state.
Girl Scout cookie booths are open for business
Girl Scout cookie season is officially underway in Utah, and cookie booths are popping up outside grocery stores and community locations across the state.
What breaks first when your business scales to multiple locations
Stamps.com reports that multi-location growth reveals operational misalignments and that managing varied tools and vendors complicates efficiency and increases costs.
Milwaukee's Walker's Point gets new indie game store
Tabletop Bookshelf, a new indie game store specializing in unique role-playing games, opens its first physical location in Milwaukee.
Health officials flag two Salt Lake County locations for measles exposure as cases rise
Salt Lake County health officials have flagged two new locations for measle locations within the last the week
Utah aquarium, pediatric care facility among recent measles exposure sites, health officials say
Utah health officials issued a warning of new measles exposure locations on Friday.
Apple Kicks Off 50th Anniversary With Surprise Alicia Keys Concert in New York
Apple mysteriously shut down its Grand Central Terminal store in New York City today, and it turns out it was for an impromptu Alicia Keys concert to celebrate Apple's upcoming 50th anniversary. Apple quietly invited select YouTubers and members of the media (including MacRumors) to the store location, but kept the performer secret until Alicia Keys took the stage.
Five Iron Golf Indoor Entertainment Venue Coming to Forth Worth's Near Southside
Five Iron Golf’s Fort Worth location will be its first in Texas. Projected to add 40 jobs to the local economy, it will feature 12 Trackman simulators with multi-angle swing-capture technology and access to more than 300 famous courses around the world. The venue will feature a full-service bar and kitchen, along with flexible indoor event spaces including a private bay.
The Sports Bra to open new women's sports bar location in Maine
The sports bar chain dedicated to women's sports that started in Portland, Oregon, announced a location will be coming to Portland, Maine.
Buc-ee’s locations receive failing grades from Better Business Bureau over outstanding complaints
Buc-ee’s is known for its clean restrooms and snacks, but according to the Better Business Bureau (BBB), it fails in the customer response department.
Women’s sports bar coming to Maine
The Sports Bra, which kicked off a trend of bars dedicated to showing women's games, plans to open its fifth franchise location in Portland.
As Buc-ee's readies first Ohio store, 38 get 'F' rating from BBB
As Buc-ee's gets ready to open its first store in Ohio, locations in five states received an \
33 Buc-ee’s locations receive ‘F’ rating from Better Business Bureau
Nearly three dozen Buc-ee's locations have received an "F" rating from the Better Business Bureau.
Chain favorite replacing Wawa at Trexler Business Center in Lower Macungie
Qdoba Mexican Eats is launching its third location in the Lehigh Valley, operating by the same group running the Whitehall and Westgate Mall sites.
Google Maps Gets Chatty With a New Gemini-Powered Interface
“Ask Maps,” rolling out today to Google Maps on mobile, lets you ask Gemini questions about locations and even to plan trips on your behalf.
RadiusDC to Acquire PhoenixNAP's Phoenix Data Center and Colocation Business
/PRNewswire/ -- RadiusDC, a leading provider of highly connected, innovative and resilient data center solutions, today announced that it has entered into a...
Michigan reports 1st measles case of 2026: What you need to know
Health officials say an adult with measles exposed others to the virus between March 4-8 at multiple locations across two Michigan counties.
New vision for old Sunrise Mall could play 'catalytic role' as city leaders mull sports center
The Citrus Heights City Council will consider a proposal to transform the old Sunrise Mall location into a "first facility of its kind in California" as a home-to-sports complex, complete with full-size ice rinks, turf fields and a concert arena, according to organizers from The Mettle Shop.
38 Buc-ee's get 'F' rating from Better Business Bureau. Here's why
Buc-ee's locations in Alabama, Georgia, Kentucky, Tennessee and Texas received an \
UMass Memorial Health - Milford Regional Medical Center and Shields Health Announce New Partnership for MRI and PET/CT Services in Milford
UMass Memorial Health – Milford Regional Medical Center and Shields Health announced a new joint venture partnership to provide advanced imaging services at two locations in Milford. Magnetic Resonance Imaging (MRI) services are available at Milford Regional Medical Center, located at 14 Prospect Street, and both MRI and Positron Emission Tomography/Computed Tomography (PET/CT) services are offered at the Cancer Center at Milford Regional Medical Center, located at 20 Prospect Street.
Get Care Now | Virginia & West Virginia
With locations in Virginia and West Virginia, Valley Health is proud to provide innovative health services to local communities. Learn more.
Why Site Preparation Makes Sense as Public Investment
Funding for site preparation can support improvements that make Michigan's best business locations more attractive and draw investment and jobs to our state.
Lehigh Valley Mall bids farewell to 6 businesses, welcoming several others
The departure of a prominent clothing brand and the upcoming opening of a popular restaurant chain’s first Lehigh Valley location are just a couple of the updates at the Lehigh
A Sanford Health doctor takes to the skies to bridge the rural health care gap in South Dakota
Sanford Health uses its own aircraft to provide 60 different types of specialty outreach to more than 200 locations each year.
Choice Healthcare Services Announces Expansion of Children’s Choice Pediatric Dentistry Locations in California
Two Locations to Launch New, Enhanced Offices in 2026 for Greater Patient Comfort and AccessibilitySacramento, CA, March 09, 2026 (GLOBE NEWSWIRE) -- Choice Healthcare Services, the parent company of Children’s Choice Dental Care, announced today the expansion and relocation of two of its dental care locations in California. The initiative is aimed at enhancing comfort, accessibility, and modern dental care for families and children in San Diego and Stockton. Children’s Choice Pediatric Dentistr