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Thunder guard Jalen Williams leaves Game 2 win over Suns with apparent hamstring injury
Jalen Williams missed extended time in the regular season with a separate hamstring injury, too.
WATCH: Leavitt says Trump has not set 'firm deadline' for Iranian proposal to extend ceasefire
“Ultimately, the timeline would be dictated by the commander in chief and the president of the United States,” Leavitt said.
Senators extend partnership with Aramark Sports + Entertainment
As part of the new agreement, Aramark will work with the Senators on improving the fan experience by upgrading some of the dining and concession areas inside the Canadian Tire Centre.
New York lawmakers pass sixth state budget extender that runs through April 27
The state budget was due on April 1.
Dustin Poirier: Zuffa Boxing not an option for UFC fighters
In recent years. several former or retired UFC fighters have extended their combat sports careers by transitioning to boxing. Former champions Tyron Woodley, Anderson Silva and Francis Ngannou have. Ben Askren, Nate Diaz, Jorge Masvial, Mike Perry and Darren Till also have, among others. Former ...
Why President Trump extended his ceasefire with Iran
President Donald Trump huddled with his national security team Tuesday afternoon at the White House facing a major decision: what to do next with Iran.
US oil prices rise as US-Iran peace talks remain uncertain
U.S. crude futures rose in early trade on Wednesday, despite Washington's announcement that it would indefinitely extend a ceasefire with Iran, as uncertainty over peace talks persisted and the Strait of Hormuz remained effectively closed.
New York lawmakers pass fifth state budget extender that runs through Wednesday
The state budget was due on April 1.
Caesars Entertainment gains on reports of status of M&A talks (update)
Caesars (CZR) stock rises after exclusive Fertitta talks extended due to family death.
CTS Eventim & Stage Entertainment Extend Ticketing Partnership
CTS Eventim, and Stage Entertainment, a leading global theatre production company founded in Germany, but producing musicals across Europe, have agreed to
Detroit Pistons home playoff losing streak now at 18 years
The Detroit Pistons extended their NBA-record home playoff losing streak to 11 games with a Game 1 loss to the Orlando Magic on Sunday, April 19.
New study reveals how maze-like magnetic patterns form and evolve in materials
Maze magnetic domains in soft magnetic materials strongly influence energy loss in electric motors, particularly at high temperatures. However, existing models struggle to explain their complex, temperature-dependent behavior. To address this gap, researchers developed an entropy-extended Ginzburg-Landau model combined with data-driven analysis to study these structures. The approach reveals how entropy and energy interactions drive magnetization reversal and increasing domain complexity, providing new insights into magnetic energy-loss mechanisms.
Mets extend losing streak to 11 in excruciating fashion with blown shutout by Devin Williams, loss to Cubs in extras
The Mets’ losing streak was on the ropes on Sunday. But a blown save spoiled a ninth-inning shutout, and the Cubs prevailed in extras to extend New York’s misery.
Opinion: Systemic failures in New Mexico health care oversight extend beyond Mark Erasmus case
A local attorney says one disgraced surgeon is a symptom of deeper corporate and oversight failures in New Mexico health care.
Trump signs bill extending controversial surveillance powers until April 30
President Donald Trump has signed a bill extending a controversial surveillance program until April 30 | 100.1 FM and AM 1020 KDKA
Trump signs bill extending controversial surveillance powers until April 30
President Donald Trump has signed a bill extending a controversial surveillance program until April 30 | WWJ Newsradio 950
Frank signaled that the Clippers would like to extend …
Frank signaled that the Clippers would like to extend …
🚨 Official: Juventus tie down one of their key men!
A deserved extension?It had been in the works for several weeks, and it is now official: Manuel Locatelli has extended his contract with Juventus until 2030.The Old Lady announced the news on Friday e...
Senate extends controversial surveillance program used by U.S. spy agencies
The Senate approved a short-term renewal until April 30. The measure cleared the Senate by voice vote, without a formal roll call, as Congress raced to meet a Monday deadline. It now heads to President Donald Trump, who had pushed for a clean 18-month extension, for his signature.
House approves short-term extension of surveillance law in blow to Republicans’ long-term plan
The decision to extend a warrantless security law until 30 April came after 20 Republicans worked with House Democrats to defeat attempts to pass five-year and 18-month renewals
House extends surveillance powers until April 30 after late-night revolt sinks GOP plan
President Donald Trump and his allies had lobbied aggressively all week for a clean 18-month renewal of the program.
House Votes to Extend Expiring Law on Warrantless Surveillance for 10 Days
The Senate would need to also approve the stopgap measure that passed the House early Friday. Libertarian-leaning House Republicans had balked at a long-term extension.
Delhi aim to extend good run vs Chennaiyin; Mohammedan Sporting look for first points in ISL double header day: Indian Sports LIVE, April 17
Here are all the updates from Indian sports on April 17, 2026.
New York lawmakers pass fourth state budget extender that runs through April 20
The state budget was due on April 1.
House considers bill to protect Haitian immigrants, in pushback against Trump administration
WASHINGTON (AP) — In a rare bipartisan moment, the House has agreed to consider legislation that would extend temporary protections for Haitian immigrants, pushing back against the Trump administration’s efforts to end the program. The bill expected for a vote Thursday would require the Trump administration to extend for three years Temporary Protected Status for Haiti, which would allow hundreds of thousands of qualifying immigrants to remain in the U.S. without fear of deportation. House
ChatGPT’s new ‘Thinking’ mode just hit a 94% reasoning score — 7 prompts it can solve that standard AI can’t
OpenAI's latest flagship model, GPT-5.4, introduces an "Extended Thinking" toggle — here is how to use its 94% reasoning power to solve "impossible" tasks
Blackhawks extend general manager Kyle Davidson's contract
The Chicago Blackhawks extended general manager Kyle Davidson's contract Wednesday without providing the length of the deal. “We are committing to Kyle to continue the plan he has put in place,” chairman and owner Danny Wirtz said before the team's season-ending game against San Jose. The Blackhawks are locked into 31st place in the 32-team NHL and haven’t made the Stanley Cup playoffs since the expanded COVID playoffs of 2020.
Trump urges extending FISA program as some lawmakers push for privacy protections for Americans
The program expires Monday, and critics want changes.
‘Marathon’ Testing A Battle Royale-ish Mode, An Offering To Casuals
Marathon is attempting to extend a hand to casuals by putting all players on the same page for a battle royale type mode where everyone starts on equal footing.
ECU Athletics Extends Partnership with adidas, Taps BSN SPORTS as Official Distributor - East Carolina University Athletics
GREENVILLE, N.C. – East Carolina Athletics has officially signed a multi-year extension with adidas, ensuring the global sportswear leader remains the offici...
Mocs, adidas Renew Partnership Through BSN SPORTS
The Chattanooga Mocs and adidas are extending a successful collaboration with new features that positively impact the athletics programs, University and Chattanooga community.
The Department of Justice’s investigation is the latest in Trump’s decades-long feud with the NFL
By targeting the NFL for allegedly forcing customers into expensive streaming options, Trump’s DOJ extends a long-running animosity
Dodgers’ Ohtani Chasing More Records With On-Base Streak
Los Angeles Dodgers superstar Shohei Ohtani extended his on-base streak to 46 games Sunday, and grew ever-closer to even more records. Ohtani broke the record for the longest on-base streak by a Japanese-born player in Friday’s game against the Texas…
Dr. Richard Finn recognized for advancing liver cancer treatments
Dr. Finn has been named a 2026 Blue Faery Award for Excellence in Liver Cancer Research honoree and will receive the Lifetime Impact Award.
49ers News: What a tremendous week to extend Trent Williams
Your daily San Francisco 49ers news for Monday, April 13th, 2026
Trump lambasts Pope Leo XIV, extending feud over Iran war with first American pontiff
President Donald Trump is sharply criticizing Pope Leo XIV, saying the U_S_-born pope is “not doing a very good job” and is “a very liberal person.”
Mamdani Embraces Socialist ‘Pothole Politics’ in Knockdown Center Barn Burner
The mayor marked his first 100 days on the job in an event aimed at celebrating city workers while extending the energy of his successful campaign — with a surprise appearance by Sen. Benie Sanders.
Will thrilling Scottish title race be decided on goal difference?
Rangers' 6-3 win over Falkirk extends the Ibrox side's advantage over leaders Heart of Midlothian and Celtic should the Scottish Premiership title be decided on goal difference.
SDFC's winless run extended, downed 2-1 by Minnesota United
San Diego FC’s winless streak continues to grow, falling in back-to-back matches after a 2-1 Saturday night loss to Minnesota United FC at Snapdragon Stadium.
'It was a cry for help' | Family mourns father killed in police shooting, says he struggled with mental health
The man's family asked that his identity, as well as their own, not be disclosed because they have not yet notified all of his extended family about what happened.
See How the Brewers Suffered Another Loss
The Milwaukee Brewers' skid has extended to four games, and a common theme continues to plague them.
ON THE JOB: “What is the Best Business Advice You’ve Ever Received?
Interviews by Deborah Jeanne Sergeant Sound advice can contribute to your success. We recently asked area business leaders, what was their best advice they’d ever received. Here’s what they said: “The best advice I ever received was from my then –boss, Gerry Church, Fulton plant manager at Miller Brewing Co. He told me that whenever I wanted to discuss a business problem or issue with him, I should also be prepared to offer possible solutions. It’s the difference between being proactive or reactive. It’s also the difference between being a leader or follower. That has served me well in any business relationship I have had since then.” — Stephen Chirello, Owner, Steve Chirello Advertising, Fulton “Someone will always do it for less; they will also take the most effort to service or satisfy and leave you for the next lower price.” — John M. Henry, Owner, Speedway Press, Mitchell Printing, Phoenix Press, Oswego “I’m going to answer this question by turning it around and giving my own advice that is, ‘Always treat every customer as if they were your only customer!’ We are celebrating our 50th anniversary in business this year. We started our business on March 25, 1976. My advice works.”” — Nick Chervinsky, President, Brewerton Pharmacy, Brewerton “’You need to toot your own horn, my grandfather, Howard D. Dice, told me.” — Beth Ann Dice, Women’s active aging and cancer recovery coach, Mission Movement Wellness Studio & Breast Cancer Recovery Studio, Fulton “In the micro enterprise class, they taught, ‘Get a good lawyer, accountant and bank.’ That was over 30 years ago and I still have those three today. I chose good people I could grow with.” — Tony Pauldine, Owner, Anthony M. Pauldine General Contractors Inc., Oswego “From my grandfather; ‘Listen to everyone! You never know where you will get the solution you need.’” — Kevin Dean, Executive director, Oswego County Opportunities, Fulton “‘Preparation is the mother of success.’ My dad always drilled that into my head growing up, and it has helped me avoid a lot of snags in both my personal and professional life. Thanks, Dad!” — Bekkah Frisch, Owner and president, iHeart Holdings, Inc., Fulton “If you don’t take a risk and try, you will never know.” — Justin Taber, Owner, Torbitt’s Service Center, Oswego “Be ready to take a loss.” — Cody Seymour, Manager, Damiano’s Eatery, Mexico “I’ve received so much good business advice over the years. When people are giving you advice, always be curious rather than judgmental. Follow your gut. Doing the right thing is never the wrong thing.” — Dana Decker, Principal owner/broker, Berkshire Hathaway Home Services, Oswego ’Do it and figure it out later.’ It hasn’t failed me yet. Too many people take time to think about doing this and this and this and then the opportunity is over with. If it’s somewhat reasonable — if it’s not something outrageous — do it and figure it out later.” — Jeremy Allen, Licensed real estate salesperson, Acropolis Realty Group, Syracuse “’Try to meet the needs of the customer. Treat them like you’d like to be treated.’ It’s like the Golden Rule says.” — Douglas Dickson, Physician and associate at CNY Foot Surgery and Podiatry Care, East Syracuse “The best piece of business advice I’ve ever received applies to life in general: always be honest. Never overstate your capabilities and always be willing to ask questions. The more specific you can be in any given topic will always lead to a better outcome.” — Tom Fernandez, President, Woodbine Hospitality, Syracuse “As a business owner, the advice would be ‘Don’t overextend yourself. Especially in agriculture, expect issues to come up.’ If something is going right, it’s not true agriculture. This last season, we scaled very hard to field another crew. We got more drones, crew and generators based on projections. This last season hit the ag community hard with a very wet spring. We did 15,000 to 20,000 acres for fungicide and the same for cover crop seeding in 2024. We scaled to 25,000 to 30,000 for 2025. We ended up doing 2,000 for fungicide and 3,000 for cover crop seeding. That’s why that advice was good.” — Rick Jordan, Operations manager, CNY Drove Services, Clinton “’Keep your head down, mind your own business and do the best for your clients that you can do.’ It has a lot to do with my success in working for Galloway Century 21.” — Ed Fayette, New York state licensed real estate agent, Century 21 Galloway, Oswego “’Expand in all ways, always.’ It just keeps you going and keeps you growing.” — Stephen Baier, Licensed real estate person, The Real Estate Agency & Bouck Commercial, Auburn “The best advice is, ‘Your biggest asset you won’t see on the books because it comes from your employees.’” — David Flickinger, Owner, Edible Arrangements, Syracuse “Don’t take things personally when you’re working with the public.” — Leeann Desimone, Manager, Annie’s Hallmark Shop, Auburn “‘Follow up.’ The customer knows that you care about what you are doing and that their opinion counts. Sometimes they might be on the fence about whether they want to use your company. If they’re asking your opinion on things, they feel you are concerned about what you’re doing. They like to be kept in the loop if they’re spending money with you.” — Dorothy Casper, Saslesperson, SweetWoods Memorials, Phoenix “The best business advice I received is ‘Never be the smartest person in the room. Surround yourself with people who are smarter than you.’ That’s how you learn.” — Debbie Bilello, Owner, Virtual Office Solutions, Central Square “’You need to grow your business but you can’t grow too big too fast.’ That’s what we’ve done at Pinnacle Maintenance. We’ve tried to grow but not too fast. Along those same lines, there’s another good piece of advice, ‘Don’t take on more than you can handle because it only leads to a bad name for your business and a bad experience for your customers.’ It goes along the same lines as growing your business slowly and carefully.” — David Wines, Owner, Pinnacle Maintenance, Central Square “Always be on time and do what you say you are going to do.’ I’ve done very well following that advice. Most of my work is referral and I don’t really do any advertising so I have a pretty good customer base. It’s mostly word-of-mouth from satisfied customers.” — Robert J. Fleming, Owner, Bob Fleming Windows & Doors, Brewerton “’Concentrate on your finances, always pay your taxes, and form a team you can depend on. Try to help the community you’re in as much as you can.’ We do all of these all the time here. We give and give and give to the community and the community gives back to us always.” — Susan Bonnet, Co-owner, Bonnet Sales and Service, Central Square “Keep smiling. It brings a positive attitude to the workplace.” — Karin Lindsley, Vice president, DTS Truck Service, Syracuse “‘Customer service above all.’ Following this advice has served us very well.’ — Guy Fox, Owner, Fox’s Discount Parts, West Monroe “The best thing to do is to make sure you’re taking in more money than you’re spending. I wish I could say I’m a good businessman but I have been in business since 1981. I’m not a bean counter but work well with my hands and its’s served me well all these years and I am still in business.” — Matt McGill, Owner, Matt McGill Collision, Brewerton
Seniors: Carol Watson, 72
Owner of Carol Watson Greenhouse and Landscaping in LaFayette enjoys her growing business — still puts in six-, seven-day weeks By Mary Beth Roach Carol Watson, the owner of Carol Watson Greenhouse and Landscaping, has been in gardens since she could walk. Literally. She said she learned to walk in her grandfather’s garden, which was next door to her current home and business in LaFayette. Today, at 72, she is running the business that her mother, Claire, opened in 1981 as Watson Greenhouse. Watson worked part-time for her mom until 1990, when she joined her full time. While she may not have had any formal horticultural experience, she said she learned so much about growing and raising plants from her mom, who had an abundance of energy and talent. Now, after 35 years in the business full time, Watson has no plans to retire, although she joked that she’d like a couple of days off a week. On her seven-acre site, complete with four greenhouses, Watson said her favorite parts of the job are working with and educating her customers; helping some of her young customers build terrariums; conducting occasional class field trips; and supporting local art by decorating the shop with an eclectic mix of pottery from at least four area craftspeople. A one-time employee of the former Dey Bros. department store in Syracuse, Watson said she loves merchandising and enjoys displaying unique pieces of art on shelves and even suspending from ceilings. “We’re creative. We also had top quality plants. We got a reputation of quality plants and unusual products,” she said. It’s tending to her customers and her plants, showcasing the unusual products, and hosting special events to benefit the community that keep her motivated to work six to seven days a week. “I just love it. I love taking care of the plants. I’m one of the few people that really enjoys watering,” she said. And while she has cultivated a solid customer base over the years, she remains savvy in her marketing efforts to draw in new customers. For example, she does a gardening segment on CNY Central television; her active Facebook page has thousands of followers; and she hosts a number of unique events and classes that not only introduce her shop to potential new clients, but some benefit nonprofits as well. About 13 years ago, when the local symphony orchestra was struggling, she said she wanted to help. So, partnering with the group, she began offering concerts, called Soirees, featuring the Syracuse Orchestra’s string quartet. Following up on a suggestion from a customer whose brother is a deejay in retirement, specializing in sock hops, she hosted the greenhouse’s first sock hop. Plants got moved back toward the walls to make room for dancing; a caterer was brought in, offering diner-like food; guests came in period outfits; and proceeds went to the Food Bank of CNY. She is excited about doing it again in October. Via her website, she promotes the greenhouse as an “oasis in the snow,” offering visitors the opportunity to pick up some decorating and gift ideas while taking in the floral and citrus scents. And she also caters to her four-legged friends. Over this past winter, she said, she came up with a “brilliant idea,” although at the time she didn’t appreciate just how brilliant it would become. Feeling it too cold outside to take her dog for a walk, she opted to bring it into the greenhouse. And before long, she was inviting people to bring their dogs into the big greenhouse as well. She looks forward to extending that invitation again this upcoming winter season. For Watson and her customers, the greenhouse is always in season.
Red Sea Military Hub Djibouti’s President Extends 27-Year Rule
Djiboutian President Ismaïl Omar Guelleh won elections by a landslide, extending his 27-year rule of the strategically located nation that’s an international military and maritime hub.
Vance meets Pakistan PM as US-Iran peace talks begin
Pakistan has emerged as a key player in efforts to extend a fragile ceasefire between the U.S. and Iran, hosting high-stakes talks involving Vice President JD Vance and senior advisers as both sides explore a path toward a more lasting agreement.
Federal judge extends restraining order on $6.2B merger Nexstar and Tegna
Nexstar's attorneys say the deal will lead to expanded local journalism and programming, not a reduction
Federal judge extends restraining order on $6.2B merger Nexstar and Tegna
Nexstar's attorneys say the deal will lead to expanded local journalism and programming, not a reduction
Borders Railway extension business case due by late 2027
It could ultimately pave the way for extending the rail line from Tweedbank to Carlisle.
15 things to do around the Seattle area this weekend
From taking advantage of an extended ski season to visiting a new art gallery in Pioneer Square, here are the latest local things to do around the Seattle area.
'Teacher crisis': Push to extend property tax to pay Duval County teachers continues
Homeowners may be asked to give a little more for a little longer.
Sky Sports and Kick It Out extend partnership to tackle discrimination and make football more welcoming
Sky Sports and Kick It Outs partnership is entering into a sixth year and will continue as a £1m investment in a mix of cash and value-in-kind support to help tackle discrimination and create career opportunities in football
A simple step to support Minnesota’s small businesses
To show a commitment to owners of small businesses, Minnesota should extend the pass-through entity tax election.
China's car sales extend declines in March
China's car sales fell for a sixth straight month in March, as rising fuel prices hit demand for gasoline models while electric vehicle sales still reeled from reduced incentives as the economic recovery is sputtering.
New York lawmakers pass state budget extender through April 14
The state budget was due on April 1.
S.F. Supervisor Jackie Fielder extends leave of absence to June 30
Fielder had already missed two weeks’ worth of board and committee meetings before news broke on March 27 that she was in the hospital amid an “acute personal health crisis.”
IRS extends Business Tax Accounts to partnerships, nonprofits and government entities
The Internal Revenue Service expanded its Business Tax Accounts to partnerships, tax-exempt organizations, and federal, state, local and tribal governments.
Hochul: Length of expected second state budget extender still being determined
The current extension, passed on March 31, runs through Tuesday.
City’s 2025/26 Premier League run-in
After an extended hiatus, City are back in Premier League action this Sunday when we face Chelsea. Men's Team City Magazine: April issue available to read now! Pep Guardiola’s side go to Stamford Br...
RSV is still spreading, prompting states to extend the immunization period
Respiratory syncytial virus is continuing to spread later into the spring than usual, driving most states to extend the window for RSV immunizations for eligible infants and toddlers.
49ers News: What a stunning week to extend Trent Williams
Your daily San Francisco 49ers news for Monday, April 6th, 2026
AI That Forecasts Hurricanes Years Ahead: Inside BU Research
At Boston University, research is the driving force behind innovation that spans industries and shapes the future. BU empowers faculty and students to tackle complex global challenges, producing thousands of publications each year and fueling breakthroughs that extend far beyond campus. Learn more about the innovators whose work powers discoveries on and off campus. Boston […]
NASA Shares Photos Shot on iPhone 17 Pro Max During Artemis II Mission to the Moon
NASA has shared three incredible photos shot on the iPhone 17 Pro Max by astronauts during the Artemis II mission to the Moon. In February, NASA announced that the iPhone had been fully qualified for extended use in orbit, with reports indicating that each of the four crew members aboard the Orion are equipped with an iPhone 17 Pro Max for personal photos and videos.
Bucs to talk with Tampa Sports Authority about Raymond James Stadium renovations
Discussions about needs and costs come as the NFL team nears a 2027 decision on extending its lease, and the Rays are seeking about $1.15 billion in public money for a new ballpark across the street.
Phil Mickelson to miss Masters over personal health matter
Phil Mickelson announced Thursday that he won't play in next week's Masters and will be out for an extended period as his family continues to "navigate a personal health matter."
Buffalo Bills and Kaleida Health aim to impact community health with an extended partnership
Kaleida Health will continue as the Official Healthcare Provider of the Buffalo Bills
Play every sport, try something new at Canlan Sports Camps
Kids ages 5-12 stay active at Canlan Sports Camps in Lake Barrington and Libertyville with sports, team games, pop-up activities and extended care options.
Deadline extended for DMV businesses to apply to work with NFL for 2027 draft
EventsDC extended the deadline for applications within the Washington DC, Maryland, Virginia (DMV) area to apply to help with the NFL draft in 2027.Events DC,
Slippery Rock extends with adidas, welcomes BSN SPORTS
Slippery Rock and adidas have announced an extension to their product and sponsorship agreement and The Rock Athletics Department has welcomed BSN SPORTS to be the exclusive supplier of uniforms, apparel, footwear, accessories and equipment.
Getty Images Extends Editorial Photography Internship Program for Emerging Talent in 2026
Getty Images Extends Editorial Photography Internship Program for Emerging Talent in 2026
New York lawmakers pass state budget extender through April 7
This will ensure the Legislature won’t have to return to Albany until after the Easter weekend.
Should the Twins extend Walker Jenkins before he debuts?
The Twins’ talented prospect has all the tools to succeed and early extensions are all the rage.
Wembanyama records fastest double-double in league history
San Antonio had six players score in double figures while extending its lead to 29 points in the third quarter.
Q&A: Getting services through TRICARE’s Extended Care Health Option
Military families can have a wide range of needs—and TRICARE has special programs to serve them. One of these programs is the Extended Care Health Option. ECHO is available to eligible active duty family members with special needs. It offers health care benefits beyond what other TRICARE plans offer.
Instagram is testing a feature that lets you watch Stories secretly
Other perks in testing for premium users include creating unlimited audience lists and extending a Story by an additional 24 hours.
Hochul tees up budget extender as Tier 6 talks percolate
Conversations have yet to fully lock in around countless issues that relate directly to spending, including pension reform.
Q&A: Getting services through TRICARE’s Extended Care Health Option
Military families can have a wide range of needs—and TRICARE has special programs to serve them. One of these programs is the Extended Care Health Option. ECHO is available to eligible active duty
When health data lives everywhere: Rethinking privacy outside the EHR
Health privacy risks now extend far beyond medical records governed by HIPAA.
Mount Sinai Health System Collaborates with OpenEvidence to Provide Evidence-Based Knowledge Within Electronic Medical Record
Collaboration extends access to all clinical users, including nurses and pharmacists
WhatsApp is working on a dedicated CarPlay app
The latest WhatsApp beta build on TestFlight introduces a native CarPlay app, extending the app’s utility beyond the current voice-based interface.
Navigating the social media minefield
Scientists and researchers seeking to announce promising findings, exchange ideas or contribute to policy discussions outside of academic circles may find social media an expedient tool.But increasingly, scientists and other professionals are discovering that online platforms can be a double-edged sword: while sharing their work and expertise is crucial for visibility and meeting funder expectations, it also exposes them to baseless criticism and even accusations of spreading false information."It is getting harder and harder for scientists, and researchers in general, to convey their findings without facing attacks on their legitimacy and accuracy of their research," says Valère Ndior, a professor of public law at the University of Western Brittany in Brest, France, who has spent more than a decade studying misinformation on social media. Researchers attempting to challenge deceptive online information may themselves be accused of political bias or not being objective in their research, he explains, adding that some scientists disengage because they feel overwhelmed and unable to sustain meaningful dialogue. "It is quite sad to see in some instances that researchers end up leaving social media altogether because they feel like the pressure is getting too intense or feel threatened," he says.Ndior, a past president of the Francophone Network of International Law, is also involved in European efforts to make science and research findings more accessible to the public. As an ambassador for the Science Comes to Town (SCTT) project, he has participated in recent discussions on public perceptions of science and online misinformation. The European Commission-funded initiative connects Brest and two other cities — Kiel in Germany and Split in Croatia — and aims to strengthen ties between communities, universities and research institutions to promote science awareness and cooperation across Europe.Coordinated campaigns around contentious topicsNdior draws a clear distinction between critical thinking and thoughtless criticism. Yet he sees online discussions being increasingly shaped by suspicious behaviour and coordinated information campaigns — including "raids" aimed at dominating discussions and "astroturfing," where small groups act as larger movements to sway debates. Tracking these patterns has become harder because some platforms have restricted data or charge for it, despite provisions of the European Union's Digital Securities Act aimed at ensuring researchers can have access to such data. According to Ndior, "platforms became more reluctant from the moment access to data became a legal requirement rather than a voluntary initiative."Unfounded claims and scepticism about science existed long before Internet chat groups. But the noticeable rise in online hostility has intensified around contentious topics, such as the coronavirus pandemic and climate change, alongside the weakening of gatekeepers to moderate content.For Ndior, dubious claims about pandemic countermeasures and vaccine safety highlighted the struggle between "balancing freedom of expression and the protection of public health and order." Efforts to remove social media content deemed false or risky for public health triggered accusations of censorship and the silencing of legitimate discussion, and in some cases, legal challenges.Concerns about attacks on the credibility of scientists and researchers have generated a flurry of academic papers in recent years and prompted professional communities to address ways to counter online attacks. Such unease extends to the generation that has grown up with digital media. Ndior points out that his students, some of whom research artificial intelligence regulation, hate speech, online surveillance and other controversial topics, hesitate to share their work or viewpoints online. "Many of them don't want to expose themselves too much because they don't feel ready to be faced with the backlash of other people criticising their research," he explains.Safer harbours for engagementLegal challenges against false or defamatory posts are not necessarily a solution — especially given the trans-jurisdictional nature of the Internet. Lawsuits also take time and money, and if they fail, can be counterproductive. Instead, Ndior advises scientists and researchers to be selective in how and where they communicate. Professional online platforms and moderated discussion spaces offer a better environment for engagement. He also highlights the value of more traditional formats, such as radio interviews and in-person discussions at schools, libraries and science fairs, which encourage dialogue with the public. "Personal contact makes a big difference," he says, while acknowledging that these approaches lack the global reach of social media.Ndior’s interest in digital law and online misinformation stems from his time as a doctoral student in international law in the early days of social media. He began analysing posts from governments and heads of state to determine if they could be considered official and thus used as evidence in litigation. His work attracted media attention and led to conference and speaking invitations. "This was not part of my plan," he says, "but this is what happens as a researcher — your interest is sparked by a certain event or phenomenon, and it suddenly becomes your focus."Ndior believes SCTT provides "a double benefit" for researchers, enabling them to connect with peers and interact with the public. "There is a wide community of people who are not in academia who are critical thinkers looking for opportunities to ask questions, to get information and contribute their ideas,” he says. "I really value that kind of feedback."Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
Navigating the social media minefield
Scientists and researchers seeking to announce promising findings, exchange ideas or contribute to policy discussions outside of academic circles may find social media an expedient tool.But increasingly, scientists and other professionals are discovering that online platforms can be a double-edged sword: while sharing their work and expertise is crucial for visibility and meeting funder expectations, it also exposes them to baseless criticism and even accusations of spreading false information."It is getting harder and harder for scientists, and researchers in general, to convey their findings without facing attacks on their legitimacy and accuracy of their research," says Valère Ndior, a professor of public law at the University of Western Brittany in Brest, France, who has spent more than a decade studying misinformation on social media. Researchers attempting to challenge deceptive online information may themselves be accused of political bias or not being objective in their research, he explains, adding that some scientists disengage because they feel overwhelmed and unable to sustain meaningful dialogue. "It is quite sad to see in some instances that researchers end up leaving social media altogether because they feel like the pressure is getting too intense or feel threatened," he says.Ndior, a past president of the Francophone Network of International Law, is also involved in European efforts to make science and research findings more accessible to the public. As an ambassador for the Science Comes to Town (SCTT) project, he has participated in recent discussions on public perceptions of science and online misinformation. The European Commission-funded initiative connects Brest and two other cities — Kiel in Germany and Split in Croatia — and aims to strengthen ties between communities, universities and research institutions to promote science awareness and cooperation across Europe.Coordinated campaigns around contentious topicsNdior draws a clear distinction between critical thinking and thoughtless criticism. Yet he sees online discussions being increasingly shaped by suspicious behaviour and coordinated information campaigns — including "raids" aimed at dominating discussions and "astroturfing," where small groups act as larger movements to sway debates. Tracking these patterns has become harder because some platforms have restricted data or charge for it, despite provisions of the European Union's Digital Securities Act aimed at ensuring researchers can have access to such data. According to Ndior, "platforms became more reluctant from the moment access to data became a legal requirement rather than a voluntary initiative."Unfounded claims and scepticism about science existed long before Internet chat groups. But the noticeable rise in online hostility has intensified around contentious topics, such as the coronavirus pandemic and climate change, alongside the weakening of gatekeepers to moderate content.For Ndior, dubious claims about pandemic countermeasures and vaccine safety highlighted the struggle between "balancing freedom of expression and the protection of public health and order." Efforts to remove social media content deemed false or risky for public health triggered accusations of censorship and the silencing of legitimate discussion, and in some cases, legal challenges.Concerns about attacks on the credibility of scientists and researchers have generated a flurry of academic papers in recent years and prompted professional communities to address ways to counter online attacks. Such unease extends to the generation that has grown up with digital media. Ndior points out that his students, some of whom research artificial intelligence regulation, hate speech, online surveillance and other controversial topics, hesitate to share their work or viewpoints online. "Many of them don't want to expose themselves too much because they don't feel ready to be faced with the backlash of other people criticising their research," he explains.Safer harbours for engagementLegal challenges against false or defamatory posts are not necessarily a solution — especially given the trans-jurisdictional nature of the Internet. Lawsuits also take time and money, and if they fail, can be counterproductive. Instead, Ndior advises scientists and researchers to be selective in how and where they communicate. Professional online platforms and moderated discussion spaces offer a better environment for engagement. He also highlights the value of more traditional formats, such as radio interviews and in-person discussions at schools, libraries and science fairs, which encourage dialogue with the public. "Personal contact makes a big difference," he says, while acknowledging that these approaches lack the global reach of social media.Ndior’s interest in digital law and online misinformation stems from his time as a doctoral student in international law in the early days of social media. He began analysing posts from governments and heads of state to determine if they could be considered official and thus used as evidence in litigation. His work attracted media attention and led to conference and speaking invitations. "This was not part of my plan," he says, "but this is what happens as a researcher — your interest is sparked by a certain event or phenomenon, and it suddenly becomes your focus."Ndior believes SCTT provides "a double benefit" for researchers, enabling them to connect with peers and interact with the public. "There is a wide community of people who are not in academia who are critical thinkers looking for opportunities to ask questions, to get information and contribute their ideas,” he says. "I really value that kind of feedback."Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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