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What to know about recent dire AI predictions and calls for safeguards
New warnings from within the artificial intelligence industry have revived a long-running debate over whether advanced AI could escape human control and ultimately threaten humanity’s survival, and whether the companies developing the technology are doing enough to prevent such a scenario.
See how Delaware's maternal health landscape compares with other states
In the wake of the Lindsay Clancy case, many parents have shared their mental health struggles. See how Delaware supports maternal mental health.
Pandemic-born Wichita business expands to two new states and debuts new product
After expanding across Kansas, Troy Brooks now has expanded his Greatness Vodka into Oklahoma and Missouri.
New warnings about the risks of AI to humanity revive a long-running debate
New warnings from the artificial-intelligence industry have revived debate over whether advanced AI models could escape human control and threaten humanity.
An Early Look at Fall Color in Canada
Reds, yellows, and oranges are already sweeping across tundra landscapes in Nunavut.
Between The Lines: Vikings 39, Packers 22
Vikings Entertainment Network's Tatum Everett was joined by Ben Leber to break down the Minnesota Vikings 39-22 win over the Green Bay Packer during Week 1 of the 2026 NFL season.
Yankee Stadium cooling tower positive for Legionnaires' disease, city health department says
The city health department advised anyone who has been in or around Yankee Stadium since late August to get tested for Legionnaires' disease.
Scientists Discovered a Bizarre 'Devil Flower' That Doesn't Need Sunlight
It looks like it escaped from a horror movie.
Scientists Discovered a Bizarre 'Devil Flower' That Doesn't Need Sunlight
It looks like it escaped from a horror movie.
3 Plano restaurants closed for serious health violations, roaches seen at others
Three Plano restaurants were temporarily closed for serious health violations, according to the latest city health inspections.
Wisconsin congressman survives emergency plane landing, swims to safety
Wisconsin Congressman Tom Tiffany escaped a sinking plane and swam to shallow water after an emergency landing in a lake. Tiffany and the pilot called 911 from on top of the plane.
Faith-based film productions are thriving in Sacramento. It’s part of a trend
The Sacramento region has long sought to attract film productions. One genre that is thriving in the region: Faith-based films.
The end times fascists are plotting their escape from our world. Our mission is clear
An unholy alliance is working toward an apocalyptic future from which only a chosen few will emerge unscathed. It’s becoming clear how we stop them
Little Mercury may be shrinking faster than scientists expected
This composite image provided by NASA/Johns Hopkins University Applied Physics Laboratory/Carnegie Institution of Washington on Oct. 22, 2013, shows Mercury as it appeared to the Messenger spacecraft following a flyby of the planet. (NASA/Johns Hopkins University Applied Physics Laboratory/Carnegie Institution of Washington via AP)By MARCIA DUNN CAPE CANAVERAL, Fla. (AP) — A new study shows that little, wrinkly Mercury may be shrinking faster...
Hawkeye Football: The Morning After Iowa State vs Iowa
Iowa’s passing game helps the Hawks cement the victory as they escape with a 16-13 win over ISU
Tj Regional Health to host capes and crowns
T.J. Regional Health will host its "Capes & Crowns" family fundraiser on Sunday, Sept. 27, at the T.J. Health Pavilion in Glasgow.
Science Snapshots: September 13, 2026
Explore groundbreaking discoveries in human drug use, sleep regulation, and the surprising effects of charged water on Teflon.
T.J. Regional Health to host ‘Capes & Crowns’ Fundraiser for WHAS Crusade for Children
Superheroes and princesses are invited to suit up for a good cause this month as T.J. Regional Health’s Rehabilitation Services department hosts Capes & Crowns, a family fundraiser benefiting the WHAS Crusade for Children.
Do Texas Rangers Have Enough Talent?
The Texas Rangers have some nice roster pieces, but is the team good enough to escape an average cycle of play?
South Florida family adds their love of tea to growing side-hustle ranks in U.S.
A survey found 28% of Americans have other gigs.
How burnt coconut helped discover new to science endemic species in Sri Lanka
COLOMBO — As dusk settled over the paddy fields at Puwakpitiya, a village on the northern edge of Knuckles Mountain Range locally known as Dumbara mountains in Central Sri Lanka, researchers began laying traps along the uneasy boundary between farmland and forest. They were targeting small terrestrial mammals moving through the landscape. On the ground, […]
Qualcomm Lost Apple’s Modem Business. Amazon Just Offered a $60 Billion Escape Route.
Qualcomm is watching Apple walk out the door with its modem business, but a surprise Amazon partnership promises a $60 billion lifeline built on unproven silicon in a market already owned by rivals. Whether that door holds the weight is the real question.
World Congress on Nursing and Health Care
The World Congress on Nursing and Health Care is a premier international gathering dedicated to advancing the science, practice, and future direction of nursing and healthcare. Scheduled for April 05-06, 2027, in Singapore, this distinguished event will convene a global community of nursing professionals, healthcare specialists, researchers, educators, clinicians, policymakers, and industry experts to exchange knowledge, share groundbreaking insights, and foster collaborations that shape the future of healthcare.Driven by the theme “Navigating the Future of Nursing through Research, Resilience, and Innovation,” the congress will explore the evolving landscape of nursing and its critical contribution to transforming healthcare delivery. The event will highlight pioneering research, evidence-based practices, innovative care models, and resilient approaches that empower nurses to address emerging healthcare challenges and enhance patient outcomes across diverse populations.
Stand-up comic Ali Saddiq talks storytelling and return to Tower District in Fresno
The stand-up comic was on the phone with The Bee in advance two performances, 5 p.m. and 8 p.m. Saturday at the Tower Theatre.
GTA 6 Officially Details Open-World Features
Rockstar Games details some of the open-world features players will enjoy in the upcoming release of GTA 6.
Player Availability Report: #SKCvLAFC
Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City returns home this
Grammy-winning singer Victoria Monét to make hometown Sacramento tour stop
The award-winning R&B and soul singer will bring her tour to Memorial Auditorium this winter.
Is running good for cyclists? Here's what the science says
Running is a convenient form of cross-training; here's how to get the biggest benefit on the bike, and what might have an even bigger effect.
2-Minute Drill: Colts healthy, secondary set for debut against Ravens
Matt Taylor looks ahead to Sunday's season opener against the Baltimore Ravens, with the Colts entering the season with a clean bill of health, including wide receiver Alec Pierce. Sunday will also be our first look at ent Colts' fully formed secondary, w
Dead and live roaches, egg sacs were found at this Sacramento eatery. Where?
Sacramento County health inspectors closed three dining facilities and cited 10 others this week.
Las Vegas Raiders and Team México announce strategic partnership in Mexico
Team México becomes an Official Sports Betting Partner of the Las Vegas Raiders in Mexico.
Kylian Mbappé says AI dictator memes show lack of political awareness
Kylian Mbappé didn't fully enjoy the flurry of AI memes depicting him as a dictator on social media during the World Cup.
Player availability report, presented by Orlando Health Jewett Orthopedic Institute: Orlando Pride at the Kansas City Current
Here is this week's player availability report, presented by Orlando Health Jewett Orthopedic Institute, for Friday's away match at the Kansas City Current
Renaming of Lake Ontario shows how names are political tools
“President Trump’s enthusiasm for renaming reveals that naming is a game of power and control.”
How Jeremy Gosch is refocusing Hy-Vee
Jeremy Gosch, in his fourth year as Hy-Vee’s CEO, is steering the large, Midwest regional grocery chain through a competitive landscape unlike any faced by his predecessors. The four Hy-Vee CEOs who preceded Gosch helped transform a small Iowa grocery chain into a regional retailer with more than $14 billion in annual sales. Along the…
Cape Cod musician honors Dolly Parton with tribute show in Cotuit
Musician Sara Bleything Sneed honors Dolly Parton with a new tribute show at the Cotuit Center for the Arts.
‘Widow’s Bay’ is the perfect escape in this absurd era
A perfect marriage of horror and comedy, 'Widow's Bay' reminds us that ignoring monsters won't make them go away.
Miami-area hospital to get new kids’ cancer center. How Palace founders are involved
The new center, made possible by a $15 million donation from Palace founders Helen and Jacob Shaham, will serve as a one-stop shop for care.
Vantiva delivers immersive sound and advanced entertainment with its new Soundscape Mini
, Sept. 11, 2026 (GLOBE NEWSWIRE) -- Press Release Vantiva delivers immersive sound and advanced entertainment with its new Soundscape Mini The compact...
The surprising reason one of science’s most famous creations was named after Dolly Parton
scientific history
2025-26 Record Fundraising Year for Life Sciences at UC Davis
The University of California, Davis, raised more than $676 million in philanthropic support during fiscal year 2025–26, more than doubling the university's previous giving record and marking the strongest fundraising year in its history.Donors’ unprecedented level of investment in UC Davis will expand opportunities for students, strengthen faculty excellence, accelerate discoveries that improve lives, and support new facilities and programs that elevate the university’s impact across California and beyond.
Inside the Republican Midterm Convention, Where It Was ‘Trump-a-Palooza’
Amid the glitz, glamour and party atmosphere of an unusual midterm convention in Dallas, the president boasted of his accomplishments, predicted Republican victories and all but ignored the daunting political landscape his party faces this fall.
NC’s Small Business Center Network Startup Showdown has local finalists
WILMINGTON — Voting is open for NC’s first Small Business Center Network Startup Showdown until Sept 15, with married finalists Kevin Roberts and Anna Barrett representing Cape Fear Community College…
Five Things presented by Compass Minerals: Sporting set to host LAFC
Sporting Kansas City returns home to host LAFC at Sporting Park on Saturday night. Kickoff is set for 7:30 p.m. CT and will be available to stream on Apple TV, while the game will also be broadcast locally on the radio via Sports Radio 810 WHB and La Grande 1340
Multi-generational business expertise: How legacies in local businesses find sustained success
Join us Sept. 29 for our third Power Breakfast of 2026 as business leaders share how they leverage decades of institutional wisdom. The Greater Fayetteville Business Journal invites you to join us for our third quarterly Power Breakfast, The Family Business Advantage: How Third-Generation Leaders Drive Longevity and Innovation, where business owners, executives and community leaders will come together to explore how multi-generational leadership creates lasting success. We are proud to welcome CEO of Holmes Security Systems, Stephen Wheeler; Director of Communications for Copiers Plus, Drew Smith; Inside Sales at Hubbard Supplyhouse, Mary Grace Hurley; and Managing Partner of Luigi’s Italian Chophouse & Bar, Nate Ernst, as our featured panelists. Representing the third generation of leadership within their family businesses, each brings a unique perspective on honoring decades of tradition while embracing new ideas, technologies and strategies that drive long-term growth. Together, with moderator Lauren Willets, Director of the Family Enterprise Center at UNC’s Kenan-Flagler Business School, they will share the challenges, opportunities and lessons learned from leading established organizations into the future.“Growing up in a family business gave me a unique perspective on what business can be. I saw the pride my grandfather and father took in knowing someone was a Copiers Plus customer, and the deep responsibility they felt to support our employees and the families who depended on the business. Seeing that sense of connection firsthand is what drew me to the business, and the legacy they built continues to drive me today. I’m excited to be part of the conversation about how family businesses can honor what previous generations built while continuing to grow and evolve for the future,” shared panelist Drew Smith. “We are so excited to welcome our panelists highlighting long-standing Fayetteville family businesses. This theme has certainly piqued the interest of the business community even beyond Fayetteville. I’m excited to pass the moderator baton over to Lauren Willets. With her background and expertise in the subject, she’s sure to unlock some great talking points and perspectives that will keep the conversation fresh and interesting to our guests. “We are so excited to welcome our panelists highlighting long-standing Fayetteville family businesses. This theme has certainly piqued the interest of the business community A third-generation family business is quite an impressive accomplishment, and we look forward to examining their secrets to a successful succession at this upcoming Power Breakfast!” shared Greater Fayetteville Business Journal Publisher Faith Hatton. Join us at the Cape Fear Botanical Garden for an inspiring morning of networking, thought-provoking discussion and actionable insights into the power of continuity, strategic evolution and visionary leadership. Whether your organization is family-owned or simply focused on creating a lasting legacy, you’ll leave with ideas that can strengthen your business for generations to come.To learn about becoming a Power Breakfast sponsor, contact the Greater Fayetteville Business Journal at 910.240.9697 or marketing@bizfayetteville.com. Tickets are on sale now. Reserve your seat by going to fayettevillepowerbreakfast.com.
Downtown Apex businesses feel construction strain as Salem Street project stretches
Months into the $4.7 million Salem Streetscape project, downtown Apex businesses say construction continues to deter customers as the town's timeline extends through December.
Michigan Free Falls Out of CBS Sports Top 30
CBS Sports put a number on how far Michigan fell after the Western Michigan escape. #GoBlue
Mike Macdonald On Seattle Sports 710AM: Test On Sam Darnold’s Hip Shows ‘Really Good News’
Seahawks coach Mike Macdonald gave a positive update on quarterback Sam Darnold on his weekly show on Seattle Sports 710AM.
Science Lab: Christian Parker’s task is tall, Cowboys' window is small
The 2026 season arrives with lots of pressure for the Cowboys, and that includes Christian Parker's defense being up against a shrinking offensive window in Dallas.
Tepper Sports & Entertainment and Charlotte Area Transit System team up to launch the Game Day Express, an extended Express Service for Gamedays
Along with recent traffic pattern updates, this extended express service aims to improve the flow of traffic and overall fan experience at Bank of America Stadium
U.S. Supreme Court again blocks Republican-backed Missouri congressional map
The SCOTUS decision is the latest in a whirlwind of legal decisions shifting the lines of Missouri’s congressional districts.
Little Mercury may be shrinking faster than scientists expected
CAPE CANAVERAL, Fla. (AP) — A new study shows that little, wrinkly Mercury may be shrinking faster than expected, the cosmos’ version of a grape shriveling into
Robert Kraft Elected to Sports Broadcasting Hall of Fame
Patriots Chairman and CEO recognized for decades of leadership that helped reshape the NFL's media landscape.
Little Mercury may be shrinking faster than scientists expected
CAPE CANAVERAL, Fla. (AP) — A new study shows that little, wrinkly Mercury may be shrinking faster than expected, the cosmos’ version of a grape shriveling into a raisin under the sun.
Little Mercury may be shrinking faster than scientists expected
CAPE CANAVERAL, Fla. (AP) — A new study shows that little, wrinkly Mercury may be shrinking faster than expected, the cosmos’ version of a grape shriveling into a raisin under the sun. Scientists f…
For these Midwest farmers, regenerative agriculture is about more than soil health. It's spiritual
A farmer in Minnesota has transformed a conventional farm using both formal agricultural education and the Indigenous wisdom he learned as a youth growing up in the Guatemalan rainforest.
After 9/11, Hollywood stars were the healers we didn't know we needed
From “SNL” to “Friends,” see how TV, music and pop culture gave Americans space to grieve, escape and eventually laugh again after 9/11.
Exclusive: How politics in Miami and Cuba killed secret negotiations, U.S. energy deal
The agreement would have given the United States significant sway over Cuba as its main oil provider.
What public records of local elections meeting texts show + tax limits opposition
Read our Under the Dome politics newsletter to stay up to date, including what public records of elections meeting texts show.
Want to buy an iconic piece of Wichita? This bar with 1935 roots is for sale.
Sabrina Parker, the longtime owner of Merle’s Place at 440 N. Seneca, wants to sell the business and its 1935 building.
2027 Infield Landscape Ever Changing
At one time, Leo De Vries was on such a fast track that it seemed inevitable that he would be a big factor by the 2027 season. One torn labrum later (shoulder surgery scheduled this weekend) and he won’t even be back on a minor league field until mid-May. So the presumptive starters along side […]
Missouri health agency warns of possible measles exposure at Sedalia train station
A resident of Missouri, who is confirmed to have measles, reportedly boarded a Chicago-bound train last month at the station in Sedalia.
Rhode Island could see a political wipeout next week
If Governor Dan McKee, Lieutenant Governor Sabina Matos, and Mayor Brett Smiley all were to fall, it would amount to an unprecedented upending of Rhode Island’s political establishment, and a massive rebuke that could signal a significant shift in the state’s political landscape.
Downtown Watertown’s business landscape changing
See how one eatery in downtown Watertown will reopen under new ownership, while others have shut their doors.
Lauren Oto advocates for Sacramento’s small businesses and diversity in leadership
Oto is one of the 2026 Change Makers, an award from The Sacramento Bee and the Nehemiah Leaders Programs.
KCK-area school fired employee for talking politics with state rep, lawsuit claims
The employee allegedly told the rep that “trans rights are human rights” and “diverting taxpayer $ to private schools is not right,” the suit says.
Appeals court declines to block ruling in favor of Missouri’s gerrymandered map
The decision marked another salvo in Missouri’s chaotic redistricting saga that has drawn national attention.
Fort Worth ISD earns grant to create, expand business and entrepreneur classrooms
The Texas Trust Gives Foundation awarded Fort Worth ISD its full grant to build business classrooms at World Language Institute.
Inside look: Bonaire Park, Summerville’s first-of-its-kind entertainment development
DOWNTOWN SUMMERVILLE, S.C. (WCBD) – Construction is underway on a major new venue in Summerville that local leaders say could transform the town’s entertainment and business landscape. The project, lo...
Inside look: Bonaire Park, Summerville’s first-of-its-kind entertainment development
DOWNTOWN SUMMERVILLE, S.C. (WCBD) – Construction is underway on a major new venue in Summerville that local leaders say could transform the town’s entertainment and business landscape. The pr…
Zay Flowers on His Health, Declan Doyle's Offense
WR Zay Flowers shares a positive health update despite being limited in Wednesday's practice, discusses his feelings about the season, and more.
See how gerrymandering in 2025 changed Missouri’s congressional map
It was chaos in Missouri politics Tuesday as the fight for what map voters will use during the November 2026 election and beyond continues.
Sacramento drive-in hosts free movie night with kid-friendly options. What to know
Discounts on nachos, bounce houses and other activities will accompany six free movies at the West Wind theater’s movie night.
Netflix orders new series based on Larry McMurtry’s ‘Lonesome Dove’
The book originally published in 1985.
Is it healthy for a child to play one sport all year? There’s a warning
Parents should take note of the medical concerns.
HSBC Premier checking gets an overhaul: Up to $3,000 bonus and enhanced travel, health, and wealth benefits
The HSBC Premier checking has been under the knife, receiving some major updates to its catalog of benefits—making it more compelling than ever.
Buffalo Museum of Science Unveils $3 Million Science Stadium Permanent Exhibit in Partnership with the Bills, Sabres, and Bandits
Transformative, interactive exhibit merges Western New York’s deep passion for sports with STEM learning; Ribbon-cutting ceremony set for September 24 before September 26 public opening.
Buffalo Museum of Science Unveils $3 Million Science Stadium Permanent Exhibit in Partnership with the Bills, Sabres, and Bandits
Transformative, interactive exhibit merges Western New York’s deep passion for sports with STEM learning; Ribbon-cutting ceremony set for September 24 before September 26 public opening.
In a forest where Jews fought the Nazis, a German military base and Lithuanian politics encroach on memory
Under German occupation, some 400 Jews escaped the Vilnius ghetto to Lithuania’s Rūdninkai Forest, created forts and organized attacks against the Nazis. Now, construction of a new German military base in the area is throwing into question …
Scientists Recreated Chirps of Jurassic Insects, Simulating a 165 Million-yo Soundscape (Listen)
It wasn't just the roars of the dinosaurs that made up the soundscape of the animal world during the Jurassic period.
Two Whatcom County businesses opened last month; two others closed permanently
Check out Bellingham’s latest business news. We’re keeping track of openings and closings.
New Anita Earls campaign ad + protest outside NC Supreme Court
Read our Under the Dome newsletter to stay up to date on North Carolina politics, delivered to your inbox.
Giants Now: CBS Sports' Preseason All-Rookie Team
The news of the day for Giants fans on Wednesday, September 9, 2026.
The lives of Idaho wilderness guides seem ideal but often hide pain
It’s an emotional let-down when the river runs end for the season and the wonderful people she met along the way are gone | Opinion
Company that pledged 200 jobs in Charlotte leaves town for SC, loses NC incentives
The company, known for brands like Dirt Devil, announced a $5 million investment in 2015.
Ralph Alvarado kept outside jobs while working as Tennessee health commissioner
Reports show that Alvarado, now a GOP congressional candidate, worked for Kentucky nursing homes and other facilities while in Tennessee.
Seagulls must learn from slow start
It's been a busy start to the 2026-27 campaign for Brighton and Fabian Hurzeler must now begin to prepare for a packed schedule of domestic and European football. Although the Seagulls will wait until October for their Conference League league phase to start, Hurzeler's side has endured a flurry of mixed results in their opening five games of the season. After a bruising 4-3 loss at Stamford Bridge to transfer-foes Chelsea, Brighton were lucky to escape with a 1-1 draw at home to Leeds.
Repairman snares alleged air-conditioner vandal above Houston business
A repairman was able to block the escape route.
Tiafoe escapes Michelsen to reach US Open semi-finals
Frances Tiafoe rallied from two sets down -- and 3-0 down in the fifth set -- to edge 22-year-old Alex Michelsen 5-7, 3-6, 7-5, 6-3, 7-6 (10/6) and reach the US Open semi-finals on Tuesday.But in a match of swinging momentum shifts, Tiafoe battled back from 5-3 down in the third set and recovered an early break in the fifth to reach his third US Open semi-final in five years.
Michigan Fans Split On Bryce Underwood Ahead Of Oklahoma
Michigan fans are split on Bryce Underwood after the Western Michigan escape, with Oklahoma next. #GoBlue
Driver crashes through Bradenton business on Cortez Road, police say
Bradenton police said the crash happened Sunday afternoon.
Mapping the Global Health Landscape: Analysis of Fourteen International Organizations
The global health architecture includes a number of diverse international organizations with different mandates, governance models, financing structures, and operational approaches. This KFF resource looks across a range of variables to provide a descriptive mapping of 14 key global health and related international institutions. It is intended to inform discussions about synergies and coordination, duplication, comparative advantage, shared challenges, and architectural reform.
Sporting KC Weekly Schedule: Sept. 8-13, 2026
Sporting Kansas City II News: The official source for all SKC II news, photos, videos, highlights, and more.
How UC Davis Strengthens the Forensic Science Workforce
Meet UC Davis students and alumni using a forensic science degree to build careers analyzing DNA evidence and chemicals in crime labs.
Michigan Football Film Room: Fixing the Run Game
Michigan Football escaped Western Michigan, but serious offensive concerns remain. We break down the Wolverines’ run-game struggles and what must improve in this week’s film study:
Chrome is now shipping updates every 2 weeks as AI changes the security landscape
Google is speeding up Chrome’s release schedule to ship security patches and new features faster.
Are Irving, LaVine, Holiday realistic for Heat? And surprising Richards info
The Heat’s challenges in landing one more impactful player. And some notable data on new backup center Nick Richards.
In 12 years, Triangle man missed only 1 health insurance payment. He lost coverage
A mistake setting up autopay proved costly for this Morrisville family. Here’s what happened — and how you can avoid it.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Deconstructing LSD for Therapeutic Discoveries
UC Davis researchers have stripped down LSD to the base features responsible for its hallucinogenic and therapeutic effects.