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Vieu Launches The World's First "Business Graph", Built For Agents And Humans

SEATTLE, July 14, 2026--Vieu's Business Graph maps global business relationships, powering enterprise scenarios like sales, marketing, talent, fundraising, and partnerships.

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Jul 14 • 2:09 PM EDT • Business • finance.yahoo.com
Christopher Nolan Fans Will Stop at Nothing to See ‘The Odyssey’ in Imax 70mm, From Cross-Country Trips to Delaying Pregnancy

Nothing is going to keep Amber Connaghan, a 29-year-old tech editor who lives in the California desert, from seeing Christopher Nolan’s “The Odyssey” on opening day. Connaghan bought her ticket over a...

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Jul 14 • 1:30 PM EDT • Entertainment • yahoo.com
Plans for large mortuary at city business park

Pure Cremation submits plans to build a mortuary in the Nether Poppleton area of York.

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Jul 14 • 1:17 PM EDT • Business • yahoo.com
Flutter Entertainment (FLUT) Faces Fresh Regulatory Focus, Is It Still 31% Below Fair Value?

Flutter Entertainment (NYSE:FLUT) is back in focus after two separate regulatory storylines put sports betting on investors’ radar, including a potential UK legal challenge to new affordability checks and fresh interest from investor Michael Burry. See our latest analysis for Flutter Entertainment. After a difficult stretch in which the year to date share price return is down 48.5% and the 1 year total shareholder return declined 61.91%, Flutter Entertainment has recently shown improving...

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Jul 14 • 1:12 PM EDT • Entertainment • finance.yahoo.com
Shedeur Sanders catches shade from Joe Flacco for visor choice

The third season of Netflix's 'Quarterback' series showed off the funny way Joe Flacco teased then-rookie Shedeur Sanders.

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Jul 14 • 11:43 AM EDT • Sports • sports.yahoo.com
Brick Pizzeria closes in Franklin; new 'entertainment experience' coming

Brick Pizzeria and Ristorante has closed at Ballpark Commons in Franklin after opening just over three years ago.

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Jul 14 • 10:13 AM EDT • Entertainment • yahoo.com
Pound marches higher as investors focus on UK politics

The pound rose against the dollar on Tuesday as investors took profits after the U.S. currency's recent climb to more than one-year highs ahead of ​key U.S. inflation data later in the day, while holding steady ‌against the euro.

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Jul 14 • 7:01 AM EDT • Politics • reuters.com
This sensor network could help predict bluff collapses along California's coast

Scientists at UC San Diego’s Scripps Institution of Oceanography found that it is possible to predict a coastal landslide hours, sometimes days, before it happens.

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Jul 14 • 6:00 AM EDT • Science • latimes.com
Building the tools behind the science

An industry application scientist reflects on the invisible labor behind widely used lab techniques, and how iterative testing, troubleshooting and cross-team collaboration turn new technologies into practical tools for the scientific community.

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Jul 13 • 8:00 PM EDT • Science • asbmb.org
Florida business establishment remains quiet on property tax amendment

Less than four months before Floridians vote on a proposal to phase out property taxes for homeowners, there’s no organized campaign seeking to move the measure past the 60% vote required for passage....

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Jul 13 • 2:30 PM EDT • Business • yahoo.com
From Brooklyn to the Biggest Names in Sports and Entertainment: Mitch Gould's Quintessential American Success Story

The creator of the Evolution of Distribution® who built Amazon's sports nutrition category from ground zero and placed brands with America's largest retailers, including Walmart, Costco, CVS, and Walgreens. BOCA RATON, FL / ACCESS Newswire / July ...

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Jul 13 • 9:00 AM EDT • Entertainment • finance.yahoo.com
WR Trent Taylor announces his retirement
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Jul 13 • 8:09 AM EDT • Sports • sports.yahoo.com
WOBAO SPORTS Expands Global Presence Through Triton Poker Montenegro 2026 International Project

Kuala Lumpur, Malaysia--(Newsfile Corp. - July 13, 2026) - WOBAO SPORTS has announced the completion of its international content production and brand exposure project at Triton Poker Montenegro 2026, where the company participated alongside SCORE8 during the internationally recognized poker event in Europe. WOBAO SPORTS supported content production and brand exposure initiatives during Triton Poker Montenegro 2026. To view an enhanced version of this graphic, please...

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Jul 13 • 3:36 AM EDT • Sports • finance.yahoo.com
Lakers have officially signed guard Collin Sexton

Guard Collin Sexton, an instant offense player and high-motor competitor, is now officially a member of the Lakers.

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Jul 12 • 10:31 PM EDT • Sports • sports.yahoo.com
Who’s more to blame for frustration at the pharmacy—insurers changing formularies or prescribers failing to keep up?

Patients increasingly wait for—or never receive—drug treatments deemed appropriate and timely by their doctors.

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Jul 12 • 8:09 PM EDT • Health • healthexec.com
Final day of Infinity Con brings more fans with entertainment for all ages

Sunday marked the final day of this year’s Infinity Con in Tallahassee, giving people a mix of pop culture, comic books, and anime.

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Jul 12 • 6:11 PM EDT • Entertainment • wctv.tv
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Retro Recap: All The Classic Gaming News From The Past Week (July 12th 2026)

Super Mario Bros. Special! Rhapsody: A Musical Adventure! Evercade price hike!

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Jul 12 • 1:30 PM EDT • Technology • timeextension.com
New York Giants add to secondary in 2027 mock draft by Yahoo! Sports

In a way-too-early mock draft by Yahoo! Sports, the New York Giants use their first-round pick to upgrade the secondary.

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Jul 12 • 7:55 AM EDT • Sports • sports.yahoo.com
Falcons training camp spotlight: WR Vinny Anthony II

Falcons training camp spotlight: Rookie WR Vinny Anthony can help in return game

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Jul 12 • 7:01 AM EDT • Sports • sports.yahoo.com
A 23-year-old from New Orleans is on the latest season of 'Project Runway'

Season 22 started Wednesday with the shows biggest number of contestants yet.

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Jul 12 • 7:00 AM EDT • Entertainment • nola.com
How Titans' Tony Pollard compares to other starting running backs?

Tony Pollard lands in the middle of PFF rankings as the Tennessee Titans prepare for the upcoming NFL season.

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Jul 12 • 6:04 AM EDT • Sports • sports.yahoo.com
First Baptist Church of Burlington celebrates pastor's 3rd anniversary

BURLINGTON, Ohio — On July 12, the First Baptist Church of Burlington will celebrate the third Pastoral Anniversary of Rev. LaShawn Kaigler with guest preachers Rev. Reginald Hill, Pastor Emeritus

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Jul 11 • 4:45 AM EDT • Entertainment • herald-dispatch.com
HOMETOWN ENTERTAINMENT: Erin Lunsford celebrates ‘Rhinestones’ album release with Roanoke show

Fincastle native Erin Lunsford brings her new album Rhinestones to Roanoke’s The Spot on Kirk Saturday night.

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Jul 10 • 3:00 PM EDT • Entertainment • wdbj7.com
Ohio business robbed of 33 guns as thieves smash through wall with stolen truck

Once inside, the group stole 27 handguns, five rifles, one shotgun, one short-barreled rifle, and four firearm suppressors, totaling 33 firearms.

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Jul 10 • 2:19 PM EDT • Business • whio.com
Random: The Internet Is Going Crazy For This Early 2000s Activision Surfing Game

The people yearn for Kelly Slater's Pro Surfer

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Jul 10 • 11:00 AM EDT • Technology • timeextension.com
Netflix in Talks to Buy Letterboxd: Report

Could Letterboxd, the popular film-review social network, end up in the clutches of Netflix or another big entertainment corporation? Letterboxd, founded in 2011, has been shopping itself to intereste...

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Jul 10 • 9:42 AM EDT • Entertainment • yahoo.com
MORNING BUSINESS REPORT: Grocery prices stress, Costco app

Families say grocery prices cause them the most financial stress and Costco allows customers to pay through its app. Here's the Morning Business Report for July 10.

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Jul 10 • 6:29 AM EDT • Business • wfsb.com
Great Lakes Sports & Entertainment Network to air Loons-Dragons Game 5

The Great Lakes Loons will play Game 5 of their series against the Dayton Dragons on Saturday, July 9, and there’s a new way to watch.

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Jul 9 • 4:48 PM EDT • Entertainment • wnem.com
SpaceX stock in focus as launch, Starlink business hit new milestones

SpaceX (SPCX) stock was in focus on Thursday after the company hit two major launch milestones, offering investors something positive to latch onto following a rough patch for the stock.

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Jul 9 • 11:32 AM EDT • Business • finance.yahoo.com
Pasadena Fire Department targets firefighter health following impacts of the Eaton Fire
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Jul 8 • 6:28 PM EDT • Health • cbsnews.com
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An introduction to Rock Chalk Talk

I look forward to what’s to come here at RCT!

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Jul 8 • 1:20 PM EDT • Sports • sports.yahoo.com
Sports creators Good Good, Dude Perfect team up on content, products

Two creator sports powerhouses, Good Good and Dude Perfect, are deepening their ties with an expansive partnership.

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Jul 8 • 7:00 AM EDT • Business • businessinsider.com
Accel Entertainment (ACEL) Leaves An Index, Is The Stock Still Undervalued?

Accel Entertainment (ACEL) was recently removed from the Russell 2000 Dynamic Index, a change that can affect how some index-linked funds treat the stock, as well as how investors think about liquidity and visibility. See our latest analysis for Accel Entertainment. The recent index removal comes as Accel Entertainment’s share price sits at $12.42, with a 90-day share price return of 6.61% and a 3-year total shareholder return of 16.07%. This suggests momentum has been building over the...

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Jul 8 • 1:09 AM EDT • Entertainment • finance.yahoo.com
Commanders make key front office hire after recent departure

Scott Fitterer, left the franchise to join the sports agency, Athletes First.

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Jul 8 • 12:51 AM EDT • Sports • sports.yahoo.com
AMC Entertainment (AMC) Stock Falls Amid Market Uptick: What Investors Need to Know

In the most recent trading session, AMC Entertainment (AMC) closed at $1.74, indicating a -7.94% shift from the previous trading day.

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Jul 6 • 5:45 PM EDT • Entertainment • finance.yahoo.com
Brad Stevens Press Conference: Celtics President Addresses Jaylen Brown Trade

Follow along right here for Brad Stevens' most notable comments from Monday's press conference.

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Jul 6 • 3:30 PM EDT • Sports • sports.yahoo.com
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Giannis Antetokounmpo's video will have Bucks fans sobbing
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Jul 6 • 1:46 PM EDT • Sports • sports.yahoo.com
Maliq Brown Snuffs One!

We didn't see this at Duke

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Jul 6 • 7:49 AM EDT • Sports • sports.yahoo.com
Prison health care lacks oversight, despite dedicated DE review board

A report analyzing the work of a state board tasked with monitoring the quality of health care in state prisons concluded the board isn't working.

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Jul 6 • 5:02 AM EDT • Health • delawareonline.com
Next American Sports Pro and QuickBuzz Announce Strategic Partnership to Build a Global Sports & Entertainment Digital Ecosystem

Ten-Year Collaboration Aims to Drive Subscriber Growth, Fan Engagement, and Long-Term Digital InnovationLondon, UK, July 06, 2026 (GLOBE NEWSWIRE) -- Next American Sports Pro (NASP), a rapidly expanding sports media and athlete development organization, today announced the signing of a strategic Memorandum of Understanding (MOU) with QuickBuzz to collaborate on creating one of the world's largest integrated sports and entertainment digital ecosystems. The partnership combines NASP's growing spor

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Jul 6 • 4:00 AM EDT • Sports • finance.yahoo.com
Colts Reacts Survey Results

The Horseshoe faithful have spoken!

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Jul 5 • 10:20 PM EDT • Sports • sports.yahoo.com
Padres Unsurprisingly Place Key Reliever In All-Star Game

The San Diego Padres will only have one player in the All-Star game, and it's closer Mason Miller.

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Jul 5 • 9:42 PM EDT • Sports • sports.yahoo.com
Three Under-the-Radar Trade Targets for Philadelphia 76ers

To optimize a star-studded core, the Philadelphia 76ers must prioritize low-usage role players. These three players offer the chemistry and financial flexibility necessary for a deep postseason run.

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Jul 5 • 9:07 PM EDT • Sports • sports.yahoo.com
SB Nation Reacts Results: Turner to Take the Next Step

That’s what our readers say

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Jul 5 • 7:39 PM EDT • Sports • sports.yahoo.com
Build the perfect Rams linebacker

If you could create the ideal “signal caller” for the defense, what would he look like?

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Jul 5 • 3:50 PM EDT • Sports • sports.yahoo.com
England's hopes crushed as Australia win T20 World Cup

England's T20 World Cup hopes are crush at the last as Australia clinch their seventh title with a comprehensive seven-wicket victory at Lord's.

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Jul 5 • 2:35 PM EDT • Sports • sports.yahoo.com
Billy G. Mills, among first Black politicians elected to L.A. City Council, dies

Billy Gene Mills was elected to the Los Angeles City Council in 1963 and served until 1974. He was also the first Black graduate of the UCLA Law School.

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Jul 5 • 10:53 AM EDT • Politics • latimes.com
Delivery firm Evri sues BBC for £1.2m over Panorama documentary

Company seeks redress for contracts it says it has lost as a result of programme’s claims about its business practices

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Jul 5 • 10:27 AM EDT • Business • theguardian.com
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Eagles News: Philadelphia’s defining number for 2026

Philadelphia Eagles news and links for 7/5/26.

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Jul 5 • 9:22 AM EDT • Sports • sports.yahoo.com
Yordan Alvarez blasts walk-off homer on July 4 for second time in career as Astros snap Rays' 9-game win streak

Just as he did in 2022, Alvarez brought the holiday fireworks, this time with a swing that capped a two-dinger, six-RBI performance.

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Jul 4 • 11:53 PM EDT • Sports • sports.yahoo.com
World Cup 2026: Jesse Marsch insists Canada was 'the better team' in loss to Morocco: 'I'd rather be us than them'
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Jul 4 • 9:27 PM EDT • Sports • sports.yahoo.com
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Oba Corporation Introduces Mega Sardines to Azerbaijan Market to Address Regional Health Trends

Mega Sardines, in its distinctive upright vertical can, is already appearing on Oba shelves BAKU, Azerbaijan, July 03, 2026 (GLOBE NEWSWIRE) -- ...

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Jul 3 • 12:00 PM EDT • Health • markets.businessinsider.com
Five Heart Podcast: The Band is Back Together

You’re seeing it all correctly. Do not adjust your antennae. Minnie is BACK! This week on the Five Heart Podcast, the unexplainable legal trouble of current and former Husker athletes. How does the distraction affect the Huskers? Will this provide some on-the-field clarity as far as who will be the designated number one RB in […]

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Jul 3 • 8:11 AM EDT • Sports • sports.yahoo.com
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Cavs announce 2026 NBA Summer League roster

Nae’Qwan Tomlin will be joining the group heading to Vegas.

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Jul 2 • 4:00 PM EDT • Sports • sports.yahoo.com
Anfernee Simons agrees to 2-year deal with Philadelphia 76ers

The Philadelphia 76ers agreed to a two-year, $12.3 million contract with guard Anfernee Simons. Simons averaged 14.3 points per game last season.

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Jul 2 • 3:19 PM EDT • Sports • sports.yahoo.com
McNeese SEED Center offering consultation services and small business growth roundtable

There are several upcoming opportunities for small businesses and entrepreneurs coming up at the McNeese SEED Center.

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Jul 2 • 9:04 AM EDT • Business • kplctv.com
Scientists fear cuts may shut radio telescope

The site is part of e-MERLIN, a globally significant group of seven radio telescopes across the UK.

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Jul 2 • 5:11 AM EDT • Science • yahoo.com
Photo Gallery: Dev Camp Roll Call Part Two

Witness top picks and hungry invitees from Sweden to Ontario as they hit the ice in Seattle, showcasing the next generation of talent fighting for a roster spot.

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Jul 2 • 4:25 AM EDT • Sports • sports.yahoo.com
Exploreum Science Center kicking off special appreciation week

The Exploreum is celebrating the people who make our community stronger from July 6th to the 11th.

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Jul 1 • 10:46 AM EDT • Science • fox10tv.com
How Investors May Respond To PENN Entertainment (PENN) Aurora Casino Opening And Russell 2000 Shift

PENN Entertainment recently celebrated the grand opening of its new US$360 million Hollywood Casino and Hotel Aurora in Illinois, while also being moved from the Russell 1000 family of indices into the Russell 2000, Russell 2000 Value, and Russell 2000 Dynamic indices as part of the latest rebalancing. This combination of a large-scale brick-and-mortar investment and a shift toward small-cap and value-oriented index inclusion reshapes how both fundamental and index-tracking investors may...

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Jul 1 • 10:16 AM EDT • Entertainment • finance.yahoo.com
What Norris Center in Naples offers 2 years after Playhouse exit

Two years after Gulfshore Playhouse's departure from the Norris Community Center, the venue's event calendar is full with broader entertainment offerings.

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Jun 30 • 5:07 AM EDT • Entertainment • naplesnews.com
Anti-migrant politics spark resurgence of racism, say some Britons of colour

After nearly four decades in Britain, Ali Haydor says there are now days when he wishes he could hide his brown skin.

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Jun 30 • 1:03 AM EDT • Politics • reuters.com
West Hartford business owner detained by ICE, elected officials call for his release

A West Hartford business owner was taken into ICE custody last weekend outside a Dunkin’ location on Park Road, sparking a response from elected officials who are calling for his release.

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Jun 29 • 3:58 PM EDT • Business • wfsb.com
Minneapolis City Council member Aisha Chughtai taking mental health leave for a month
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Jun 29 • 12:51 PM EDT • Health • cbsnews.com
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Xbox Expects The 'Component Crisis' To Get Worse For Consoles In 2027

Specifically for console storage and memory prices

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Jun 29 • 10:15 AM EDT • Technology • purexbox.com
30-Day Challenge: All-Time Favorite Bears Defensive Back

Each day in June, we’ll roll out a fresh topic to get Bears fans thinking in our 30 Day Challenge, and today we want to know your all-time favorite defensive back.

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Jun 28 • 9:00 AM EDT • Sports • sports.yahoo.com
Diamondbacks 2, Tampa 4: Fish House Blues

Even without a dismal Zac Gallen performance, the Diamondbacks couldn’t play competitive baseball….

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Jun 27 • 9:42 PM EDT • Sports • sports.yahoo.com
BET Awards: Druski to make history as youngest host as show honors Lauryn Hill and Teyana Taylor

Druski will make history as the youngest host of the BET Awards on Sunday.

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Jun 27 • 9:23 PM EDT • Entertainment • seattletimes.com
BET Awards: Druski to make history as youngest host as show honors Lauryn Hill and Teyana Taylor

Druski will make history as the youngest host of the BET Awards on Sunday

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Jun 27 • 9:22 PM EDT • Entertainment • abcnews.com
We almost had a smartphone in the 90s. Why did it fail?

In the early 90’s, a company called General Magic began working on a portable device that would allow people to check email, make phone calls, even play games. It was basically a smartphone. But it never caught on.On today’s show, a theory about why this device failed. General Magic had generous investors, world-class talent and creative freedom. But is it possible what they needed was constraints?Support:Planet Money+Read: Our book: Planet Money: A Guide to the Economic Forces That Shape Your Life Our weekly longform Planet Money newsletterOur weekly Indicator round-up newsletterFollow: InstagramTikTokYouTubeFacebookThis episode was hosted by Erika Beras and Emma Peaslee. It was produced by Emma Peaslee with help from Sam Yellowhorse Kesler and James Sneed. It was edited by Marianne McCune and fact-checked by Charlotte Isidore. It was engineered by Jimmy Keeley with help from Cena Loffredo. Alex Goldmark is Planet Money’s executive producer.

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Jun 26 • 5:30 PM EDT • Technology • npr.org
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Pacquiao and Mayweather rematch postponed indefinitely

The rematch between boxing greats Manny Pacquiao and Floyd Mayweather has been postponed indefinitely because of a host of reasons, with contract disputes the main factor.

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Jun 26 • 12:35 PM EDT • Sports • sports.yahoo.com
CRAWFORD | Kenny Klein, beloved longtime Louisville sports information director, dies at 66

Klein's career spanned nearly four decades and helped shape the public face of Cardinals athletics through some of its greatest triumphs and most difficult crises.

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Jun 25 • 10:45 PM EDT • Sports • wdrb.com
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Health Watch: Scientists say animal therapy helps critically ill patients, prompting new legislation
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Jun 25 • 5:50 PM EDT • Health • cbsnews.com
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Making Our Own Luck

We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.

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Jun 25 • 4:48 PM EDT • Science • goodscience.substack.com
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