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Scientists discover a hidden heart valve risk linked to gum disease
Researchers found that bacteria linked to gum disease may help drive the development of calcific aortic valve stenosis by triggering inflammation and calcium buildup in the heart valve. The early findings suggest that keeping gums healthy could play a role in reducing the risk of this serious heart condition.
Ohio officials approve co-responder program for behavioral health calls
A MetroHealth social worker will respond with Parma and Parma Heights police and firefighters to mental health, substance use, homelessness and other crisis calls
First Baptist Church of Burlington celebrates pastor's 3rd anniversary
BURLINGTON, Ohio — On July 12, the First Baptist Church of Burlington will celebrate the third Pastoral Anniversary of Rev. LaShawn Kaigler with guest preachers Rev. Reginald Hill, Pastor Emeritus
Patrick Dempsey for Senate? Pop culture colonized electoral politics long ago.
Patrick Dempsey won’t be running for the Maine Senate seat Graham Platner wanted. But had he entered the race, it wouldn’t have come as a shock: Pop culture colonized electoral politics long ago.
City adds Memorial Behavioral Health responders to some fire emergency calls
Crews were already a part of a number of police calls.
Register for the Michigan Mental Health Diversion Council 2026 Summit
The Michigan Mental Health Diversion Council (MMHDC) and the Center for Behavioral Health and Justice are hosting “A Decade of Progress: Advancing Diversion and Crisis Response in Michigan Counties” on Thursday, Sept. 24, from 9 a.m. to noon.
CT chief justice aims to pilot ‘behavioral health court’ in New Haven
The task force includes doctors, law enforcement, educators and addiction treatment specialists who will shape how the court works.
New Mexico behavioral health committee signs off on $8M plan for northern region
The committee tasked with overseeing the repair of New Mexico's behavioral health system approved the second of 13 regional plans.
Hospitals Help: Grand Traverse Mental Health Crisis and Access Center Advances Behavioral Healthcare in Northern Michigan - MHA | Michigan Health & Hospital Association
Michigan hospitals are working alongside community partners to remove barriers and ensure residents across the state have access to timely, lifesaving behavioral healthcare services. Located on the Munson Medical Center campus, the Grand Traverse Mental Health Crisis and Access Center is transforming care delivery across Northern Michigan by providing around-the-clock…
Older adults face greater risk of mental health hospitalizations during extreme heatwaves
As the US recovers from its 4 July heatwave, a new study in Nature Health warns of an impending uptick in people attending hospitals for mental health and behavioral disorders, according to the first multi-country study of heatwave-related mental health hospitalization, led by Monash University in Australia.
Healthcare leaders: It’s 2026. Do you know who your champions are?
The concept of the healthcare workplace champion may be ripe for developing and expanding in this time of protracted workforce shortages. Researchers make the case in a new study, suggesting star performers can help stretched provider organizations build resilience against demoralization in their ranks.
Can't believe 'moral depravity' of the Democratic Party, political commentator expresses
'Fox News @ Night' panelists Brianna Lyman and Shirin Yadegar discuss Graham Platner's withdrawal from the Maine Senate race following allegations against him.
Fort Bend County Fair Announces 2026 Entertainment Lineup Featuring Sawyer Brown, Pat Green
ROSENBERG, Texas (Covering Katy News) — The Fort Bend County Fair has announced its entertainment lineup for its 90th annual celebration, featuring a mix of Texas country stars, Tejano favorites and nationally recognized performers during Championship BBQ Weekend and the fair's 10-day run. The 2026 Fort Bend County Fair begins with Championship BBQ Weekend on Sept. 18-19, followed by the fair Sept. 25 through Oct. 4. The entertainment schedule opens Friday, Sept. 18, with Tejano group Los Morales, followed by Texas country artist Cole Phillips on Saturday, Sept. 19. Phillips has gained attention for his traditional country sound influenced by classic honky-tonk music. The fair officially opens Friday, Sept. 25, with Tyce Delk, a New Mexico native whose touring schedule has expanded across the country. Country music veterans Sawyer Brown will headline Saturday, Sept. 26. The band, whose career spans more than four decades, remains known for hits including "Some Girls Do," "The Race Is On" and "Thank God for You." Go Tejano Day on Sunday, Sept. 27, will feature Prófugos de Nuevo León, along with performances by Los Rinches and Grupo Zenio. The second week of the fair begins Wednesday, Sept. 30, with Bellville singer-songwriter David Lewis, a recent Texas Country Music Association Male Artist of the Year nominee. Oklahoma Red Dirt artist Josh Meloy will perform Thursday, Oct. 1. Texas country star Pat Green returns to the Fort Bend County Fair stage Friday, Oct. 2. Green, whose career includes three Grammy Award nominations, has sold more than 2 million albums and amassed more than 200 million career streams. He is best known for songs including "Wave on Wave" and "Carry On." Country newcomer Vincent Mason will perform Saturday, Oct. 3. Mason has accumulated more than 500 million career streams and was recently nominated for Academy of Country Music New Male Artist of the Year. The fair concludes Sunday, Oct. 4, with Texas music legend Gary P. Nunn, whose "London Homesick Blues" remains one of the state's most recognizable songs. Weekend visitors also can enjoy performances on Music Row by J Paul Jr. & the Zydeco Nubreeds, Southern County Line, Los Rangerz and Horizon. The Fort Bend County Fair Association, a nonprofit organization, supports youth, agriculture and education. According to the association, it has awarded more than $2 million in scholarships during the past decade and generated $1.4 million through its 2025 youth auctions. Tickets go on sale at 10 a.m. Friday, July 10. Guests are encouraged to purchase tickets in advance and select the specific day they plan to attend, as tickets are valid only for the date purchased. Admission includes entry to the fairgrounds, access to the carnival, shopping, exhibits, food vendors and, when scheduled, admission to the rodeo and that day's concert. Season passes and single-day tickets will be available. For tickets and additional information, visit fortbendcountyfair.com or call the Fair Office at 281-342-6171. The address of the Fairgrounds is 4310 Texas 36 S in Rosenberg. 2026 Fort Bend County Fair Entertainment Schedule Championship BBQ Weekend Friday, Sept. 18: Los Morales Saturday, Sept. 19: Cole Phillips Fair Entertainment Friday, Sept. 25: Tyce Delk Saturday, Sept. 26: Sawyer Brown Sunday, Sept. 27 (Go Tejano Day): Prófugos de Nuevo León, Los Rinches and Grupo Zenio Wednesday, Sept. 30: David Lewis Thursday, Oct. 1: Josh Meloy Friday, Oct. 2: Pat Green Saturday, Oct. 3: Vincent Mason Sunday, Oct. 4: Gary P. Nunn × Expand FBCF Fort Bend County Fair 2026 Artist Lineup
Pa. to join 38 states and D.C. in collaboration enabling counseling outside state lines
Pennsylvania residents will soon be able to access behavioral healthcare even if they’re out of state or move away, thanks to a bill that passed...
Structural Factors Impacting White Men’s Health
LDI Fellow Derek Griffith and a colleague theorize that structural factors that benefit white men also may contribute to their poorer behavioral health outcomes.
The Elder Scrolls 6 Heavily Impacted by Xbox Layoffs, Team Morale at Rock Bottom
Over 50 people working on the RPG now gone
Graduate of Doctor of Health Sciences Graduate Program has Research Published, Selected for National Presentation
University of New Haven DHSc graduate Nevila Bardhi ’26 DHSc, MPH achieved two major milestones as her doctoral research on mercury-exposure screening was published in Public Health Reports, and it was selected for presentation at the 2026 American Public Health Association Annual Meeting.
Black marine scientists fight for Florida's coral reefs
Marine life has been experiencing a prolonged heat wave with no end in sight. Divers with BIMS, a global nonprofit network of Black ocean scientists and marine enthusiasts, joined the University of Miami's Rescue a Reef program to plant nursery-grown corals along the Florida Reef Tract. But for them, this work is about more than corals; it's also about Black representation in marine science.
Anchorage behavioral health center funding approved despite Fairview representatives’ opposition
The $750,000 federal funding award follows two months of public discourse.
Court dedicated to behavioral health may be coming to New Haven
NEW HAVEN, Conn. (WTNH) — An initiative is underway to establish a specialized court dedicated to behavioral health in New Haven, according to a Wednesday release by the state’s chief justice…
International team says science alone won't save coral reefs
Coral reefs are disappearing at an unprecedented rate as climate change, marine heat waves, pollution and coastal development threaten one of Earth's richest ecosystems. While scientific research has ...
Illinois Surpasses 1,000 Certified Peer Professionals, Marking Major Milestone in Behavioral Health Workforce Growth
State’s peer workforce growth was supported by investments in peer recovery support services and the CRSS Success Program
Small Business Spotlight: Business blooms beyond bouquets
BUSINESS: The Busy Bloom OWNERS: Amanda and Walter Adkins ADDRESS: 708 S. 17th St., Wilmington EMAIL: thebusybloomco@gmail.com WEBSITE: thebusybloomco.com PHONE NUMBER: (910) 742-0790 YEAR FOUNDED: 2024 NO. OF EMPLOYEES: 4 WHAT IS THE BUSY BLOOM? AMANDA ADKINS: “The Busy Bloom is a flower shop with a spin – a creative experience shop located in Wilmington’s Cargo District. Founded in 2024 by husband-and-wife team Amanda and Walter Adkins, we offer fresh flowers, botanical teas, a build-your-own bouquet bar, candle-making experiences, gifts, workshops, wedding florals and event services. Our mission is simple: to make flowers accessible, approachable and enjoyable for everyone – not just for special occasions.” WHY DID YOU START THE BUSINESS? AMANDA ADKINS: “The Busy Bloom was born from a lifelong connection to flowers and a desire to create meaningful experiences for people. After doing my own wedding florals and after years of working in healthcare management, I found myself returning to gardening and floral design as a creative outlet and source of healing. The loss of my mother-in-law, who always shared flowers from her garden, inspired me to pursue floristry full-time. My husband encouraged me and built a small flower cart for us to grow, and fast forward to now, two years later, it has grown into a community-centered business focused on bringing joy, connection and creativity through flowers.” WHAT KIND OF GROWTH ARE YOU HOPING FOR? AMANDA ADKINS: “We’re focused on sustainable growth that allows us to continue serving our community while expanding creative experiences. We hope to grow our wedding and event services, expand our educational workshops and creative programming and become a destination where people can gather, create and connect. We’re also passionate about creating opportunities that showcase floral design as an art form, such as our Fleur Couture fashion show and other community collaborations.” WHAT PAST EXPERIENCE HAVE YOU HAD WITH STARTING/WORKING IN BUSINESS? AMANDA ADKINS: “Before opening The Busy Bloom, I worked as a clinical manager in healthcare and spent years building leadership, operations and customer service skills. I’ve also worked in education and nonprofit programming, teaching people about nature and local ecosystems. Along the way, I designed flowers for weddings and events on the side, gradually turning a passion into a business. Walter has years of welding and construction experience, combined with entrepreneurship and a drive to own his own company. …The Busy Bloom has been a journey of combining creativity with entrepreneurship alongside my husband ... learning every step of the way.”
New weight loss pill beats oral Ozempic in major trial
A new once-daily weight-loss pill called orforglipron delivered better weight loss and blood sugar improvements than the leading oral semaglutide in a major clinical trial. The tablet could offer a more convenient alternative to injectable drugs like Ozempic and Wegovy because it doesn't require refrigeration or special timing with meals. It's also cheaper to manufacture, which could expand access globally.
ACC takes on DOAC use with new scientific statement
Direct oral anticoagulants continue to be underutilized and inappropriately dosed. The American College of Cardiology hopes a new scientific statement can help address those issues and provide clinicians with an updated look at this important topic.
Duke Health’s Jonathan Posner named System Psychiatrist-in-Chief and Chair of the Department of Psychiatry and Behavioral Sciences
"I have been struck by the quality of the faculty, the strength of the institution, and the genuine warmth of the Vanderbilt community. I am thrilled to be joining Vanderbilt Health and look forward to the work ahead."
Research shows how behavioral science silently protects American consumers and patients
A new Proceedings of the National Academy of Sciences (PNAS) special feature highlights the critical role of behavioral and decision sciences in U.S. governance. The publications demonstrate how psychological ...
Business attorney and political newcomer starts mayoral campaign committee
An Evanston attorney and nonprofit leader filed paperwork last week to run for mayor in next year's special election, growing the potential field a few
Business attorney and political newcomer starts mayoral campaign committee
An Evanston attorney and nonprofit leader filed paperwork last week to run for mayor in next year's special election, growing the potential field a few
Marine Le Pen verdict live: France's far-right leader awaits appeal ruling with presidential race at stake
Marine Le Pen will learn from a Paris appeals court whether an electoral ban for illicit party financing will prevent her running in next year's presidential election.
UConn’s Innovations Institute Advances Behavioral Health Leadership Through New Partnership
The collaborative aims to elevate professional development standards, disseminate critical leadership resources, and build resilient systems of care for chi ...
Oral health tips for travelers
Discover essential oral health tips for travelers to keep up all the great habits you’ve worked hard to develop at home.
Labour asks Electoral Commission to investigate claims Farage broke electoral law by not disclosing gifts
Parliamentary authorities are already looking into a £5m donation to the Reform Uk leader from the crypto billionaire Christopher Harborne
Marine Le Pen’s political future at stake with ruling on electoral ban imminent
Leader of France’s far-right National Rally and a contender for the presidency to get appeal decision on Tuesday
Behavioral Health Art Show Celebrates Creativity and Personal Growth
County Behavioral Health Services brought creativity and community together on June 12 at the Southeastern Live Well Center for its annual Strengths Based Case Management Art Show. More than a showcase, the art show highlights how creativity can open doors to healing and give participants a chance to be seen for their talent, not their challenges.
Integrating Behavioral Health Into Value-Based Care
Learn how a primary care–anchored model can improve behavioral health access, outcomes and value-based care performance
Research Universities Are Admitting Fewer Ph.D.s, a Bad Sign for Science
Some of the nation’s top research universities are shrinking doctoral programs because of uncertain federal funding.
Areta Crowell: Behavioral Health Leader
In 1967, the California Legislature overwhelmingly approved the Lanterman Petris Short Act, which sped the emptying of state hospitals. Areta Crowell lived the origin story of that landmark law. Her job was to implement the law in Los
Parham Doctors' Hospital's new intensive outpatient program expands behavioral health continuum of care
Parham Doctors’ Hospital recently launched a new adult intensive outpatient program, expanding access to behavioral health services for people who need more support than traditional outpatient care but do not require an inpatient hospital stay. The new program is designed to serve adults experiencing mental health challenges such as depression,
Maui County’s fringe mayoral candidates add unique ideas, opinions, entertainment to race
"It's one of my favorite aspects of politics is the fact that all of these folks get to run no matter how realistic their candidacies are. And sometimes they bring up really important issues, and sometimes they help shift the nature of what the mainstream candidates are talking about," political scientist Colin Moore said. "And sometimes it's just really entertaining."
A New Report Just Revealed a Widening Gap in Corporate Leadership. It Points to a Massive Opportunity for Startups
Good business is just doing right by people. Customer focus is both a driver of business success and a reflection of morality in action.
Scientists may have finally found how Alzheimer's kills brain cells
Researchers have identified a previously overlooked mechanism of brain cell death that appears to play a major role in Alzheimer's disease and frontotemporal dementia. The finding could lead to new treatments aimed at slowing neuron loss by interrupting the process before cells are destroyed.
Universal Health Services (UHS) Is Up 8.7% After CMS Proposes Hospital Payment Increase and Analyst Support
In recent days, Universal Health Services received a boost after the Centers for Medicare & Medicaid Services proposed a 2.4% payment rate increase for hospitals, alongside supportive analyst commentary on its operating performance and upcoming second-quarter results. This regulatory tailwind for hospital reimbursement comes as UHS continues to expand its behavioral health footprint and prepare for its next earnings update, potentially influencing how investors assess its longer-term growth...
‘Moral and political blindness’: EU lawmaker savages FIFA over Russia - Live Updates
Lithuanian MEP Petras Auštrevičius explained why FIFA’s decision to allow Russia to play in the upcoming U-15 World Cup is bad news.
Will Bill Belichick prove everyone wrong during the 2026 season?
The roasting will continue until morale improves, so how will Belichick respond?
News of disease outbreaks can warp our brains in strange and subtle ways
The "behavioural immune system" can drive harsher moral judgement and may even contribute to xenophobia.
Could Matthew Stafford have multiple years left?
“It’s demoralizing,” says Stafford about his back issue
Final State Budget Brings $5M for New Behavioral Health Pilot to Central Coast
The State budget includes a one-time $5 million investment for CenCal Health and the behavioral health departments of both Santa Barbara and San Luis
How democratic socialist Melat Kiros stunned Colorado politics with congressional primary win
The Denver Democratic Socialists of America has now notched by far its biggest electoral victory to date, after years of downballot wins.
How Trump Is Trying to Change the Electoral Process to Help Republicans
Here’s how President Trump is using the powers of his office to try to reshape the rules governing the midterms and future elections.
UK business morale slumps as Iran war pushes up costs, survey shows
British business confidence fell to its lowest since 2022 as the Iran war, which pushed up costs, saps expectations for future sales, a survey of accountants showed on Thursday.
SC behavioral health agency cuts 47 jobs in administrative overhaul, workers say they had no warning
Nearly 50 people are now without jobs after layoffs within the South Carolina Department of Behavioral Health and Developmental Disabilities.
Godot bans "autonomous AI agent use or vibe coded" contributions
Godot has updated its contribution policy and "take[n] steps" to reduce "demoralizing" AI contributions.
Marion County warns Oregon behavioral health rules put staff, residents at greater risk
KATU ABC 2 offers coverage of news, weather, sports and community events for Portland, Oregon and surrounding towns, including Beaverton, Lake Oswego, Milwaukie, Happy Valley, Gresham, Vancouver, Hillsboro, Oregon City, Tualatin, West Linn, Woodburn, Tigard, Tualatin and Garden Home.
Krafton settles with Subnautica 2 developer after drawn-out dispute over $250 million
The battle is over.
Study Reveals Biology Underlying Oral Health Issues in Down Syndrome
Low saliva from calcium signaling dysfunction, microbiome changes may contribute to high rates of gum disease
ACCESS Model: behavioral health edition
A new value-based care program for chronic condition management begins July 5. | A new payment model is designed to pay digital health companies based on outcomes in chronic condition management. But where does behavioral health fit? This episode explores that question with SonderMind and Headspace, two companies participating in the model's behavioral health track.
Democratic socialist Melat Kiros defeats longtime House incumbent in Colorado primary
Kiros, a 29-year-old lawyer turned doctoral student, is the latest candidate to rise from the party's left flank and boot establishment-backed candidates.
Newsom Vowed To Transform Kids’ Mental Health. Many California Schools Are Still Waiting.
Gov. Gavin Newsom launched an ambitious initiative to make public schools the epicenter of mental health services for young people. Five years after he promised transformation, many schools have struggled to get the program up and running, and hundreds more have yet to try.
Kings County names Lisa Rogers as new behavioral health director
Kings County has appointed Dr. Lisa Rogers as its new behavioral health director, bringing more than 15 years of leadership experience.
Opinion | California Politics Is Bought With Donations
We won’t get true policy improvements until we break the connection between fundraising for campaigns and our electoral system.
Maine high court to hear appeal ballot initiative case
Oral arguments are set for 10 a.m. Wednesday at the Capital Judicial Center in Augusta.
Catholic Charities unveils behavioral health center
BUFFALO, N.Y. (WIVB) — Catholic Charities unveiled its behavioral health center on Monday with more amenities to serve the surrounding community. The work on the clinic, located on Rich Stree…
Building Community, Capacity, and Collaboration Through gmhCONNECT | Johns Hopkins Center for Global Mental Health
Doctoral trainee Yesenia Garcia shares her experience at gmhCONNECT, a training and mentoring program for global mental health researchers.
Trump calls likely DC mayor Janeese Lewis George a 'communist' and vows to block her agenda
D.C. mayoral frontrunner Janeese Lewis George faces clash with President Trump over ICE enforcement, policing, cashless bail and sanctuary city policies.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Inside California Politics: Former LA city councilmember weighs in on mayoral race
(Inside California Politics) — With Los Angeles Mayor Karen Bass now set for a tough reelection campaign against former ally turned rival Nithya Raman, a former member of the L.A. City Council spok…
Despite Mayor Brandon Johnson campaign promise, 911 mental health response team flounders
Throughout his 2023 mayoral campaign, Brandon Johnson championed a progressive vision of sending teams of mental health clinicians instead of police officers to help people suffering from psychiatric emergencies. But since he took office…
Marine biobanks: the science of 'stopping time' for an ecosystem under pressure
In labs around the world, the ocean is being kept in jars. Some of it is alive, bubbling in flasks, while some lies frozen in liquid nitrogen. These marine biobanks are collections of coral cells, algae,…
Trump ramps up attacks on Democrats as ‘godless Communists’ ahead of November’s midterms
President Donald Trump on Friday seized on the electoral success of several democratic socialist candidates to ramp up his attacks on the Democratic Party, claiming it was being taken over by “godless Communists” who pose an existential threat to the nation.
Senators call for military healthcare program to cover autism therapy as a basic benefit
A letter to Defense Secretary Pete Hegseth follows an NBC News investigation into the military healthcare program’s restrictions on applied behavioral therapy.
Jessica Plummer new deputy administrator of Behavioral Health Services
A founding department staff member, Jessica Plummer has stepped into the new role of deputy administrator for Larimer County Behavioral Health Services (BHS)
Registration open for 2026 Behavioral Health & Children and Family Services Conference | Health and Human Services North Dakota
Registration is now open for the sixth annual Behavioral Health & Children and Family Services Conference, scheduled for Sept. 14-17 at the Bismarck Event Center and online through a livestream option.The main conference will take place Sept. 15-17, with optional pre- and post-conference sessions offered Sept. 14 and Sept. 17.More than 1,400 in-person attendees and hundreds of virtual participants are expected to take part in keynote presentations, breakout sessions and networking opportunities focused on behavioral health, child welfare, suicide prevention and youth development.
Green Party returns inadmissible donation from Zack Polanski
Under UK electoral law parties can only accept money from people on the UK electoral register.
Medical Debt Bills Advance, House Hears Behavioral Health Testimony
Several healthcare-related bills advanced in the Michigan Legislature during the week of June 22, including legislation addressing medical debt collections and behavioral health screenings.
Behavioral Healthcare Close to Home: SRMC Services Available in Sandoval County
Sandoval County spans more than 3,000 square miles with a population of 160,000 residents. As one of New Mexico’s fastest growing counties, it’s crucial the people who live there have access to high quality healthcare, including behavioral health...
Granger family pledges largest gift in history of UM-Health Sparrow
The Granger family has pledged the largest gift in University of Michigan Health-Sparrow history for a new behavioral health hospital.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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Online violence against women in politics: what shapes political party responses to technology-facilitated gender-based violence?
Political parties have a primary role to play in tackling online violence against women and gender diverse politicians. While the prevalence and impact of TFGBV, such as coordinated disinformation campaigns, deepfake image-based sexual abuse or trolling are well documented, many parties are still building their knowledge on how to respond effectively and have not put in place internal practices and policies that respond to the rapidly evolving, poorly regulated digital ecosystem. About the ReportIn order to promote and protect fair and democratic participation in politics, this ALIGN Report explores what political parties are doing in response to TFGBV and what factors shape their action. The findings, based on existing literature and interviews with gender and politics professionals, indicate there are three sets of factors which donors, civil society and practitioners should consider when designing action to support political parties to respond to TFGBV internally. These are: (1) gender norms; (2) socio-political environment; and (3) internal party factors.Key messagesUnequal gender norms are ubiquitous across politics, shaping expectations of leaders to be strong and assertive, and practices of political parties to uphold masculinist values and sustain cultures of silence. These often lead to weak response to TFGBV against women politicians.The socio-political context can incentivise or disincentivise action, depending on the salience of gender issues, which are increasingly weaponised. Electoral competitiveness, domestic laws (i.e. quota requirements), and even the political system or global normative frameworks influence political will to act.Internal party factors that shape responses will vary across countries and contexts, but include: structures to enforce codes of conduct, policies and reporting mechanisms on (TF)GBV, political ideology, extent of centralisation of leadership, and crucially the meaningful participation of women in decision-making positions, not least through internal women’s wings.Party responses can be seen as a spectrum, with actions falling between active discouragement to address TFGBV to commitment to transform unequal norms and practices within the party.About the ToolkitTogether with the report, this ALIGN toolkit offers gender professionals and others working on democratic strengthening a set of guiding questions and reflection prompts to identify which responses could be most effective and suitable in different contexts. These actions can complement other solutions to TFGBV, such as regulations promoting safety by design. The assessment spans a broad range of factors including: (1) different manifestations of gender norms, (2) the socio-political environment and (3) internal party structures.Key messagesPolitical parties are duty-bound to take action internally to respond to the significant threats posed to women members and candidates, including from their own party colleagues, affiliates and political peers.Existing party approaches to TFGBV can be assessed along a spectrum which ranges from active discouragement and passive acceptance to minimal response and transformative change.To generate effective and context-appropriate solutions to TFGBV, it is important to consider how gender norms shape leadership expectations and internal party practices, while also analysing the impact of the socio-political environment. While actions to support women to stay safe online are very common, codes of conduct and measures to strengthen women’s voice and power in the parties are proposed as most transformative solutions.
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