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Lorde AI glasses criticism Sparks Privacy Debate

Lorde AI glasses criticism highlights public discomfort with smart glasses amid privacy concerns and celebrity endorsements at major music festivals.

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Jul 12 • 4:31 PM EDT • Technology • en.cryptonomist.ch
Quantum Computers Identify Nuclear Fusion Fuel Chemistry in Major First

Computing the future of fusion.

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Jul 12 • 4:00 PM EDT • Science • sciencealert.com
Gunfire near downtown entertainment district mistaken for fireworks by nearby neighbors

Downtown residents mistook the sound of rapid gunfire for late-night fireworks, waking up Sunday morning to a heavy police presence and a neighborhood cordoned off by crime scene tape.

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Jul 12 • 1:36 PM EDT • Entertainment • actionnewsjax.com
Gunfire near downtown entertainment district mistaken for fireworks by nearby neighbors

Downtown residents mistook the sound of rapid gunfire for late-night fireworks, waking up Sunday morning to a heavy police presence and a neighborhood cordoned off by crime scene tape.

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Jul 12 • 1:36 PM EDT • Entertainment • yahoo.com
At Family Science Night, Wonder Comes Before Answers.

BAR HARBOR—Family Science Night isn’t really about science. It’s about wonder. It’s about watching a five-year-old realize that the tiny creature under a microscope is a real living thing. It’s about a teenager discovering that the scientist explaining genetics or regeneration isn’t much older than they are. It’s about parents seeing curiosity spread across a child’s face the way excitement spreads across a crowd at a Fourth of July parade. For one evening, families realize that the laboratory isn’t some secretive place where knowledge is hidden behind white coats and closed doors. They learn that the lab is a place their neighbors work, their friends’ parents work, and it becomes a place where questions matter more than answers. It’s a place where wonder is the origin for knowledge. At the lab, children learn that it’s okay not to know. Adults remember that they once asked “Why?” about everything. Scientists are reminded why they fell in love with discovery in the first place. There are experiments, games, obstacle courses, and demonstrations, of course. But those are really just invitations—to touch, to explore, to laugh, to make mistakes, and to ask one more question. In a world that often rewards certainty, Family Science Night celebrates curiosity. And perhaps that’s its greatest gift. Long after the microscopes are packed away and the experiments are over, what families take home isn’t just a few new facts about biology. They take home the feeling that discovery belongs to everyone—that science isn’t something happening somewhere else by someone else. It’s simply what happens when people are given permission to wonder. A Family Science Night at the Mount Desert Island Biological Laboratory is one of those rare community events where children and adults can experience science as something they do, not just something they read about. Hands on discovery allows hands-on learning and joy. Real scientists, some local, some scientist-interns (but still scientists) just in college make science real, approachable, and exciting. And there, complex ideas like forever chemical-filtration, DNA and so much more become not complex. Instead, they become fun. Summer fellows are challenged to explain cutting-edge biomedical research in ways a first-grader—and their grandparent—can understand. Past activities have explored gene expression, kidney function, axolotl regeneration, worms, microplastics, and phytoplankton through games and creative demonstrations. Though it’s called family night, you can also see adults going from station to station, exploring, learning together across ages. Family Science Night reflects the laboratory’s broader mission of breaking down barriers between researchers and the public, helping people understand how scientific discoveries relate to everyday life and the health of Maine’s environment. Family Science Night transforms a world-class research laboratory into a giant interactive classroom, where curiosity is encouraged, questions are celebrated, and families discover that science isn’t just something that happens in a lab—it’s an adventure anyone can join. About MDI Biological Laboratory For more than 125 years, MDI Bio Lab has been a center for training and research in comparative biology. In the last two decades its biomedical research has focused on aging, regeneration, and environmental toxins. The Laboratory houses 11 research groups staffed by an international team of world-class scientists and graduate students. It also leads a statewide network of colleges, universities and research institutions that collaborate to provide training, research experiences and financial support to help young Mainers play a bigger role in today’s biomedical revolution. Located on Maine’s rugged coast, the Laboratory’s 100+ acre campus houses research facilities, cottages and dorms that house visiting scientists and students. It is also home to MDI Bioscience, a subsidiary working to design innovative techniques to speed the drug discovery process. LINKS TO LEARN MORE NIH INBRE MDI BIOLOGICAL LABORATORY Photos: Carrie Jones and Shaun Farrar/Bar Harbor Story HELP SUPPORT THE BAR HARBOR STORY When we started The Bar Harbor Story, we didn’t know if anyone would read it. But you showed up. You shared. You sent tips. Now—over 400,000 views every month later—it’s clear: people here care about their community and each other. We’ve kept everything free because news should never be out of reach, but every one of our stories takes time to write, and your support keeps The Bar Harbor Story going. If you value our work, please consider a paid subscription, a founding membership, or a sponsorship. It truly helps us cover one more meeting, tell one more story, shine one more light. Even $5 a month makes a difference. Click here to become a one-time supporter now. Thank you so much for being here. Founding member information can be found here. Have questions about sponsorships? Just send Shaun an email at sfarrar86@gmail.com, he’d love to hear from you. Subscribe Share Bar Harbor Story Share Leave a comment

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Jul 12 • 8:18 AM EDT • Science • barharborstory.substack.com
‘What a joke’: World Cup referee mistake sparks outrage

Sunday afternoon’s FIFA World Cup quarterfinal match between England and Norway was a hard-fought battle that took extra time to decide a victor. However, the match was marred by controversy after what appeared to be a clear referee mistake. On England’s equalizing goal late in the first half, the ball appeared to hit a camera…

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Jul 12 • 1:16 AM EDT • Sports • sports.yahoo.com
Embolo sent off as result of mistaken identity rule

Switzerland's Breel Embolo becomes first player to be sent off as a result of a new law for mistaken identity at the World Cup.

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Jul 12 • 12:23 AM EDT • Sports • sports.yahoo.com
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Florida Has Too Many Big Question Marks Surfacing Before Camp

A high-stakes quarterback battle and defensive depth concerns define Jon Sumrall’s debut, leaving the Florida Gators as a volatile wild card despite Steve Spurrier’s optimistic ten-win projection.

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Jul 11 • 5:55 PM EDT • Sports • sports.yahoo.com
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Syrians optimistic but cautious as sanctions removal revives economic hopes
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Jul 11 • 11:54 AM EDT • Politics • aljazeera.com
Is Melco Resorts & Entertainment (NasdaqGS:MLCO) A Bargain After Its Sri Lanka Launch?

Melco Resorts & Entertainment stock has had a difficult run over the past few years, yet its current valuation checks paint a more supportive picture for investors trying to judge whether the market has become too pessimistic. Over the past 5 years, the share price has declined 63.2%, which signals that sentiment around Melco Resorts & Entertainment has been weak for a prolonged period. The recent opening of City of Dreams Sri Lanka can support expectations for the company to grow its...

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Jul 11 • 10:44 AM EDT • Entertainment • simplywall.st
Legionnaires' outbreak hits New York as officials rush to test water towers

To date, 46 people have been infected from breathing mist from bacteria-filled water coolers on the Upper East side.

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Jul 10 • 9:37 PM EDT • Health • bbc.com
World Cup: After Thibaut Courtois’ injury, one mistake sent Belgium home and Spain through
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Jul 10 • 7:39 PM EDT • Sports • sports.yahoo.com
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Wildwood, NJ businesses see summer momentum after busy Fourth of July week

Businesses in the Wildwoods say activity picked up during holiday week and are optimistic the momentum will continue through the rest of the summer.

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Jul 10 • 5:31 PM EDT • Business • 6abc.com
Trump Administration Taps Climate Science Critic to Oversee National Climate Assessment

Matthew M. Wielicki has criticized the scientific consensus on global warming as alarmist. Now he’ll oversee a major federal report on the topic.

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Jul 10 • 2:07 PM EDT • Science • nytimes.com
MAGA's attack on science is even worse than it looks

In my post on America’s 250-year anniversary, I argued that respect for the individual was the “secret sauce” in the U.S.’ long-lasting preeminence among nations. But it was certainly not the only factor. There were plenty of institutional innovations that helped the U.S. stay on top — economically, militarily, and in terms of the attractiveness of its society. One of these was American science. Today we take things like the modern research university, government grants for science, public-to-private research spinoffs, etc. for granted, but a lot of that infrastructure wasn’t there before World War 2. It was either invented or scaled up massively by the U.S. government in the postwar period, led by far-sighted scientist-bureaucrats like Vannevar Bush (pictured above). If you want to read about this history, a good place to start would be Jonathan Gruber and Simon Johnson’s excellent book Jump-Starting America. Those scientific institutions didn’t exist in a vacuum, however. They were backed by the U.S. government’s abiding faith in the power of science — and, even more fundamentally, by deep popular trust in the scientific enterprise. Science gave us radar and the atom bomb in wartime, and in peacetime it gave us plastics, vaccines, cheap food, and a thousand other things that made our lives easier. Science was also the driver behind American industry — chemicals, aerospace, telecommunications, computers, electronics, and so on. We owed science our jobs, our livelihoods, our comfortable living standards, and our greatness and power as a nation. It’s little wonder that both political parties, even as they fought viciously over other issues, were steadfast in their support of science. For a long time, the only people who distrusted science were a hippie fringe on the left who disliked modernity (or thought they did, anyway), who also disliked American industry and American power, and who subscribed to an early version of degrowth environmentalism. America’s scientific enterprise is still strong, especially compared to the systems in Europe, Japan, Korea, and other developed countries. It has lost a lot of ground to China in a relative sense, but a lot of that is because of China’s incredible growth; as China has poured untold amounts of money and talent into its research labs, spending and output have overtaken the U.S. by some measures. There are a few ways in which China’s rise creates problems for American science — for example, top scientists can choose to work in China instead of in the U.S. — and of course there’s the concern that China’s technological strength will help its military to reign supreme. But overall, China’s rise in science should be good for American science, since American scientists can use Chinese discoveries for free and build on them. The much bigger problem is that the scientific enterprise America built during and after World War 2 is now being threatened with absolute decline. The biggest problem, of course, is that much of the country — the Republican half — has basically lost faith in the scientific enterprise. To what degree this loss of faith is justified is an open question, and deserves to be discussed openly. But the larger point — that the system that powered American dominance is under threat — is true either way. Most Americans still trust science, but MAGA Republicans don’t There’s a myth, popular in right-wing circles, that scientists have lost the trust of regular Americans — either due to the increasingly left-wing composition of academic departments, or to misbehavior during Covid, or to DEI-related research taking over science, etc. This also fits with a wider narrative that Americans are losing trust in all of our institutions. But it just isn’t true. Poll after poll shows that on the whole, Americans still trust scientists and want to spend more on science. For example, here’s a Pew poll from late 2025 showing that although about a fifth of Republicans did lose confidence in science in 2020, two thirds still have at least “a fair amount” of confidence: That same poll found that scientists are among America’s most trusted groups — even better trusted than the military! In fact, Americans trust scientists more than people in most other countries do. Other polls show that although Republican trust in science has dropped somewhat, Republican support for spending more on science remains very strong: A Pew poll in 2023 found the exact same thing: So when MAGA types tell you about scientists losing their credibility, or a drop in trust in science, they’re only talking about themselves. Whatever left-wing politicization of science happened during the Biden administration — and there was definitely some of that — it was not enough to make most Republicans lose faith in the scientific enterprise, or favor research cuts in order to purge unwanted ideology from the system. That doesn’t mean I think progressives should continue down the path of politicizing scientific research. They should not, and Biden made real missteps in this area. Objectivity clearly matters for public trust of science in the long term. But as of right now, there’s no crisis of trust in science, except among the smallish minority of people who are running around screaming that there’s a crisis of trust in science. But despite science’s overwhelming popularity and public trust, Trump and his administration are launching an unprecedented and devastating attack on American science — cutting funding, and forcing science projects to undergo ideological review by government commissars. Trump’s comprehensive attack on science

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Jul 10 • 11:23 AM EDT • Science • noahpinion.blog
New sodium metal battery design charges in just 4 minutes and retains its capacity for years

Chinese researchers say they have overcome one of the trickiest problems of battery chemistry by developing a special gel.

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Jul 10 • 9:00 AM EDT • Science • livescience.com
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Fed appoints task forces led by Marc Andreessen, Asha Sharma

Economists, researchers, and industry insiders like Marc Andreessen and Asha Sharma have joined Fed task forces to revamp economic policies.

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Jul 9 • 6:42 PM EDT • Business • businessinsider.com
Nobel-Winning U.S. Chemist Omar Yaghi Will Move to China to Lead A.I. Institute

Omar Yaghi of the University of California, Berkeley, will head an initiative to apply artificial intelligence to the discovery of new materials.

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Jul 9 • 5:15 PM EDT • Science • nytimes.com
Business

The world this week

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Jul 9 • 9:03 AM EDT • Business • economist.com
Politics

The world this week

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Jul 9 • 9:03 AM EDT • Politics • economist.com
The Ozempic and Wegovy mistake sending thousands to poison control

Poison control calls involving semaglutide (Ozempic and Wegovy) soared after the drug was approved for weight management, with researchers linking the increase to accidental dosing mistakes rather than intentional misuse. Simple education about proper weekly dosing and gradual dose increases could help prevent many of these avoidable incidents.

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Jul 8 • 8:00 PM EDT • Science • sciencedaily.com
How Attribution Science Uses Models to Uncover Climate Change’s Effects on Weather

Running climate model simulations with—and without—observed human influences can quantify how emissions changed the probability or intensity of a weather event.

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Jul 8 • 3:17 PM EDT • Science • blog.ucs.org
Harvard scientists turn a silicon chip into a DNA writing machine

Scientists have created a silicon chip that can write dozens of DNA sequences simultaneously using electricity and water-based enzymes, offering a cleaner alternative to conventional DNA manufacturing. The breakthrough could eventually support portable DNA-writing devices and even massive DNA data storage, although new chemistry will be needed to scale the technology further.

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Jul 8 • 8:00 AM EDT • Science • sciencedaily.com
Hungary moves to overhaul university models banned from Horizon Europe

Hungary’s new government is aiming to overhaul the governance model of the institutions and universities that lost access to Horizon Europe and Erasmus+ funds “in a short timeframe,” according to Péter Horváth, the new state secretary for science policy and innovation. “As of today, the two non-university foundation-controlled institutions under my remit have been transformed,” he told Science|Business. “We hope the universities will follow and that this will be enough to satisfy the EU’s demands.”Under the previous government, led by Viktor Orbán and his Fidesz party, many academic and scientific institutions were restructured and made into special public trust foundations, with members strongly linked to the government given lifelong mandates and significant decision-making powers with little oversight. The European Commission deemed that this undermined academic freedom and transparency in the country, leading to a ban on 34 institutions in 2022, including 21 universities, which saw academics in Hungary lose access to Horizon Europe grants. The new Hungarian government, elected in May and led by Péter Magyar and his Tisza Party, has promised to dismantle this governance model and restore the institutions to EU programmes. As a result, the European Commission has promised to return access to the Erasmus+ education mobility programme, but so far no concrete agreement has been made on the Horizon Europe programme for research and innovation. Hungary has already made legislative changes in June to allow the institutions to be reformed and set a timeline for the implementation.The non-university foundations, which are mainly cultural centres such as the Foundation for Hungarian Culture or the Makovecz Campus Foundation, will all be dissolved by August 31 this year, a date tied to EU-set milestones that Hungary must meet to unlock frozen funds, with control transferred to relevant ministries. Meanwhile, the universities will have until 31 August 2027. For each university foundation, the government will set the dissolution date and the body to take over operations. There is no final decision on a permanent new model for the universities, according to Hungarian MEP Eszter Lakos, who is shadow rapporteur for the Horizon Europe specific programme, a separate piece of legislation detailing implementation rules for the EU’s next research programme, due to start in 2028. “The aim of the transition year is to settle this with [the universities], not to impose a model, and not to put them under state control,” she told Science|Business. “The goal is to give academic independence back to universities.”There are three models that are most likely to be implemented. One would be a return to a traditional, state-run model. Another could be a newer, more self-standing public institution. A third option would be a reformed version of the foundation models that meet EU standards. According to Lakos, the dismantling of the system put in place by the Orbán government is well underway and if all goes according to plan, Hungary could regain access to EU research money by the start of the next academic year in 2027. “I believe that the Hungarian government is doing the necessary changes so the universities could return as beneficiaries to Horizon from the next school year,” she said. In the meantime, “the universities, institutes and cultural assets carry on under proper public stewardship rather than a handful of unaccountable trustees,” said Lakos. The laws passed in June impose new safeguards: board terms are capped at four years and renewable only once, appointments are made through open competitions and sitting politicians cannot join joining these boards.It remains unclear whether a domestic science funding programme set up as a back-up scheme by the former government following the EU funding ban, called HU-rizon, could be continued. “This programme should never have had to have been established in the first place, but it has proven to be quite popular,” he said. “I am considering continuing this programme with a refined focus on helping international collaborations.”Re-organising the research network One of the first priorities for Horváth and his cabinet is to resolve questions over the future of the Hungarian Research Network, Hun-Ren. The network of academic institutes was taken away from the Hungarian Academy of Sciences in 2019 and turned into a quasi-private organisation, with similarities in its governance to the public trust foundations.Horváth and his team have consulted over 5,000 representatives from the network and the conclusion is broad unhappiness with the directors of all the institutes involved. “We have presented the results to the president and the chief executive of the network and this is currently being discussed,” Horváth said. The plan is to re-integrate the network back into the Academy of Sciences but in an improved way, “learning from mistakes of the past,” he added. The government also wants to reintegrate four humanities and social science research centres into the network that the previous government had transferred to Eötvös Loránd University. The transfer brought sharp criticism from the academic community, with a group of Hungarian research heads, including European Research Council grant recipients, sending an open letter to Orbán warning that the transfer would “cause historically significant harm to the entirety of Hungarian scientific life.” The transfer was “one of the biggest shames in Hungarian research in the past 20 years,” Horváth said. “We want to immediately re-integrate them back into the research network and to regain the trust of these institutions, because the way they were treated was really unfair.”Another pressing issue is the Élvonal Excellence Research and Talent Development Foundation, led by Nobel laureate Ferenc Krausz. The foundation signed a financing agreement with the former government earlier this year for a budget of over €730 million over the next five years. The goal is to create a world-class centre to attract top talent from abroad and to develop local researchers. But there was little transparency about this foundation, and news of its huge budget, which is nearly as much as Hungary’s entire research budget, caused a stir in the media following the recent elections. Another issue is that, as with the foundation boards of the institutes banned from Horizon Europe, there was little-to-no oversight of decisions led by Krausz. “It was an excellent idea but an unacceptable execution,” Horváth said of the foundation. “The fact that this is out of the Hungarian funding scheme, mostly concentrating on one person who decides on the budget is unacceptable for us.”The government plans to merge the centre with the National Research, Development and Innovation Office, the country’s R&D funding agency, with a reduced budget. Horváth is hopeful that Krausz will still be involved. The new government’s R&D goalsA phrase that crops up regularly during the discussion with Horváth is “democratic process.” The new state secretary is determined to involve Hungary’s research community in shaping future policies. This marks a departure from the previous government’s approach, and several people in Hungary’s research community have commented on the openness of the new government. In terms of concrete goals, Horváth and his team already have plans. He wants to create a new science fund in Hungary, based on the best practices of other European countries. The fund would not be tied to annual government budgets and would provide long-term, stable financing. “If we were to succeed in creating this fund, then I think it would be one of the biggest achievements for me in this period of government,” Horváth said. On the innovation side, he is looking into how best to bring in the private sector. “We want to make sure that we are working with the private sector to support innovation,” Horváth said. One of his big aims is to introduce entrepreneurship teaching into high schools. Hungary already has a reputable national academy offering research and innovation training in the field of natural sciences, and Horváth wants to expand this to all disciplines and across the whole country. “One of the main ways to elevate our innovative businesses is to teach our children to be innovative,” he said. “This will probably need ten years to pay off, but this is what we should do. Our aim is to make Hungary strong in our region, and this is what is needed.” Related articlesHungary’s Horizon Europe performance in numbersCommission unlocks Erasmus+ cash for Hungary, Horizon could be next‘Academic Huxit.’ Hungarian researchers speak out on impact of EU ban A more difficult task will be funding. The new government is aiming to increase research spending to 2% of the GDP by 2030, and then increase it to 3% in line with EU objectives. Currently, spending sits around 1.3%. But according to Horváth, the current budget, inherited from the previous government, is “heavily in the negative,” so any plans to increase research spending will have to start next year. Achieving 2% by 2030 already needs a big push, almost doubling the research budget. “This is something we’d definitely like to reach, and something I can see us achieving,” he said. “From the 2030s, I’d like to see an innovative generation growing up that can help us reach the 3% target.” Positivity in the new governmentDespite the many challenges facing Horváth and his team, the mood is positive. “It feels a bit like a start-up right now. Everyone is working 24/7, day and night, trying to do as much as they can. There is a lot of energy,” he said. It is a big change for the state secretary who, like many in his cabinet, is coming from a background in research or business, and not in politics. “Six weeks ago, I was sitting with my microscope and my research PhDs, so it’s been a big change for me,” said the computer scientist, who was previously the director of the Institute of Biochemistry at the Hun-Ren Biological Research Centre in Hungary and worked at the Institute for AI for Health at Helmholtz Munich. But he is relishing the task to transform the country’s R&D landscape. “We feel enormous support from the Hungarian people, but also from Europe,” he said. “We’ve received a lot of letters of support from around Europe. There is big trust there, and huge responsibility on our side. We want to get everything back on track, and there’s a lot to do.”

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Jul 8 • 5:47 AM EDT • Science • sciencebusiness.net
Stockton businesses optimistic as new city hall opens on waterfront

Stockton's new city hall opened on the waterfront, bringing hundreds of employees to the area and raising hopes among nearby businesses for increased activity.

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Jul 7 • 9:39 PM EDT • Business • kcra.com
Argonne Team’s ChemGraph Unlocks AI for Chemistry and Materials Science

LEMONT, Ill., July 07, 2026--The framework uses large language models to help nonexperts access computational chemistry expertise

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Jul 7 • 4:00 PM EDT • Science • finance.yahoo.com
Rahm Emanuel to denounce Netanyahu during Tel Aviv speech as American politics shift against Israel

According to remarks obtained by The Associated Press, Emanuel on Wednesday will criticize Israeli Prime Minister Benjamin Netanyahu for leading Israel to a "dead end" and say unconditional U.S. support has been a mistake.

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Jul 7 • 1:51 PM EDT • Politics • pbs.org
New Faculty Research Lecturer Thuc-Quyen Nguyen reflects on science, mentorship and resilience

Nguyen, a distinguished professor of chemistry and biochemistry, will deliver her lecture during the 2026-2027 academic year

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Jul 7 • 9:00 AM EDT • Science • news.ucsb.edu
Argonne team’s ChemGraph unlocks AI for chemistry and materials science

Researchers at Argonne National Laboratory have developed a framework, ChemGraph, that uses artificial intelligence to help nonexperts access computational chemistry expertise.

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Jul 7 • 8:00 AM EDT • Science • anl.gov
Voters love rent freezes. Economists hate them. Except for this one.

Does rent control really backfire?

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Jul 7 • 6:00 AM EDT • Politics • vox.com
These 2 Renowned Financial Experts Have Opposing Views on Debt. So, Who's Right?

Entrepreneurs who understand the difference between predictable free cash flow and optimistic projections can use leverage to build wealth — while others quietly destroy their businesses with it.

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Jul 6 • 2:00 PM EDT • Business • entrepreneur.com
THE MAGIC OF SCIENCE | Texas A&M University Chemistry Road Show lights up the Expo Center with chemistry…not magic!

The Rusk County Library’s Summer Reading Program offered local lectiophiles (lovers of reading) a magical morning filled with ear-piercing explosions, dancing rainbow-colored flames, shattering roses, burning dollar bills that never […]

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Jul 6 • 8:30 AM EDT • Science • thehendersonnews.com
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The Talos Principle 3 creators are doing their best to stay hopeful in the tech apocalypse

The puzzle series' final installment is staying optimistic, even in the face of death and AI

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Jul 6 • 8:00 AM EDT • Technology • polygon.com
What Is The Biggest Mistake Founders Make When Building A Business?

She built a company with twenty employees and steady revenue. So why did her dream vacation turn into a seven-day phone call?

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Jul 6 • 8:00 AM EDT • Business • forbes.com
'Yes, this does suck': NYC health officials brace for new Medicaid work rules

The new city budget includes $3M for hiring community health workers to help people navigate the changes.

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Jul 6 • 6:30 AM EDT • Health • gothamist.com
“I Am an Unabashed Optimist About the Long-Term Future of Science.”

The new president of the National Academy of Sciences talks about learning to see as a scientist and communicating science in a noisy information landscape.

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Jul 6 • 6:00 AM EDT • Science • issues.org
NCAA president says it would be a ‘mistake’ to ‘walk away’ from Protect College Sports Act

Charlie Baker, the president of the NCAA, said the Protect College Sports Act effectively “deals with” many of the issues facing his industry. “What we’re really trying to achieve is some sor…

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Jul 5 • 11:13 PM EDT • Sports • thehill.com
Three Under-the-Radar Trade Targets for Philadelphia 76ers

To optimize a star-studded core, the Philadelphia 76ers must prioritize low-usage role players. These three players offer the chemistry and financial flexibility necessary for a deep postseason run.

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Jul 5 • 9:07 PM EDT • Sports • sports.yahoo.com
Biden-era illegal immigration drove up housing costs, Fed economists find

A Federal Reserve working paper finds unauthorized immigration during the Biden administration drove up home prices by 2.2% and rents by 1.4%.

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Jul 5 • 1:45 PM EDT • Business • foxbusiness.com
Opinion: Science Under Attack, But Undefeated

The latest Russian attack damaged the historic Palladin Institute of Biochemistry, but Ukrainian science will remain strong

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Jul 5 • 11:39 AM EDT • Science • kyivpost.com
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The 7 Biggest Mistakes People Make In Their Wills, According To Estate Lawyers

These attorneys have seen it all, and they want you to avoid these costly legal and financial problems for your family's sake.

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Jul 5 • 7:00 AM EDT • Technology • huffpost.com
Business as unusual for OPEC

Catch up quickly on the global stories that matter

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Jul 4 • 8:00 PM EDT • Business • economist.com
Heavy Periods? Signs It Could Be Uterine Fibroids

Signs of fibroids can be easy to dismiss or mistake for something else. Here’s what to watch for and when to talk to your doctor.

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Jul 4 • 3:11 PM EDT • Health • healthnewshub.org
Don't read too much into election results

It is a mistake to read too much into the success of Melat Kiros and her upset win over U.S. Rep. Diana DeGette.

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Jul 4 • 5:30 AM EDT • Politics • coloradonewsline.com
'Cautiously optimistic': Swing voters describe their view of America at 250

As America turns 250, voters from our Swing Shift project talk about the state of the country. Their views ranged from "uncertain" and "concerned" to "excited" and "cautiously optimistic."

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Jul 4 • 5:00 AM EDT • Politics • kgou.org
'Cautiously optimistic': Swing voters describe their view of America at 250

As America turns 250, voters from our Swing Shift project talk about the state of the country. Their views ranged from "uncertain" and "concerned" to "excited" and "cautiously optimistic."

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Jul 4 • 5:00 AM EDT • Politics • npr.org
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Liverpool can capitalise on £100m Tottenham mistake

Liverpool are now just a couple of weeks away from the start of their pre-season. A lot of change has already occurred at Anfield with Andoni Iraola and Victor Munoz both being brought in.This is obvi...

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Jul 4 • 4:35 AM EDT • Sports • sports.yahoo.com
Firework chemistry: the science behind firework colors

Different chemical compounds create the brilliant reds, blues, greens and golds you see bursting overhead.

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Jul 3 • 4:39 PM EDT • Science • wvlt.tv
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Long Reads for the Long Weekend

(Welcome to the Entertainment Strategy Guy, a newsletter on the entertainment industry and business strategy. I write a weekly Streaming Ratings Report and a bi-weekly strategy column, along with occasional deep dives into other topics, like today’s article. Please subscribe.) Happy Fourth of July weekend! As has been a tradition of mine going back to the beginning of the EntStrategyGuy website, I’m sharing my favorite long reads of the last year, like I did in 2019, 2020, 2021, 2024, and 2025. Let’s dive right in! Subscribe “Different Prices for the Same Ride: How Uber and Lyft Use AI to Get More Money Out of You“ by Derek Kravitz in Consumer Reports I don’t think surveillance pricing, like the kind described in this brilliant Consumer Reports article, is long for the world—it’s toxically unpopular—but we’ll see if either party takes on this issue. If I ran a political party focused on affordability, I would focus on a few pro-consumer and pro-market policies: Banning non-compete agreements. Ending surveillance pricing Eliminating junk fees (read more here...) Ensuring “right to repair” for consumer (and military!) products Capping excessive app store fees Stopping digital/algorithmic price-fixing tools. Preventing automatic subscription price increases. And more. If you want to fight inflation, there are a lot of great ways to do it quickly. Speaking of higher prices... “Secret Documents Show Pepsi and Walmart Colluded to Raise Food Prices Across the Economy“ by Matt Stoller in BIG Again, I think a political party should focus on lowering prices for consumers. And deals like this—Walmart making a deal/forcing Pepsi to offer the lowest prices at its stores and nowhere else—hypothetically lower prices at Walmart...but raise them everywhere else. “15 DUIs, still driving: California’s failure to take repeat drunk drivers off the road“ by Robert Lewis and Lauren Hepler in CalMatters CalMatters does terrific reporting in California, something the Golden State desperately needs more of, and this article is a great example of that. “PugLips: The next insanely popular thing you’ve never heard of…” by Simon Carless in Game Discover Co I thought that this parody article (and yes, it’s a parody, but I was definitely unsure at first) was hilarious and totally nailed how much tech/business journalism feels these days. Actually, three of my favorite articles this year were on hype in the video game industry, including Georg Zoller’s “The Video Game Industries Very Dark Night”—which I linked to recently and wrote a follow-up here—and Owen Mahoney’s “Derek Zoolander, Videogame Exec”. In particular, I like Mahoney’s focus on user experience as a guide to what trends will actually grab hold of customers. “The Matrix Lies“ by Evan Shapiro in Media War & Peace Evan Shapiro’s first person account of his experience with AI was hilarious. I think LLMs capabilities have significantly grown from last summer, and yet...my editor/researcher just had an abysmal experience using an LLM to do a quite basic task (which our LLM normally does each week) and the LLM made a mistake on every single data entry...along with seven different mistakes affecting twelve of the twenty or so entries, including mistakes that are explicitly spelled out in the prompt. That’s a brutal failure rate. Again, if you use AI/LLM for data collection, you need to take a lot of extra steps to verify and check the data. “Ghosts in the Balcony: A Cross-Country Trip to 58 Theaters Fighting to Survive“ by Matthew Frank in The Ankler I thought Matthew Frank’s pitch to head across America to visit theaters sounded insane aggressive at the time—at least it felt that way to someone a decade older than him; man, to be in your twenties again, am I right?—but I knew the result would be great. And it was, a terrific feature by a great young writer. Also, I loved Matthew’s recent article on who’s getting the precious few entry level jobs in Hollywood. (Hint: nepotism.) “Disney erased FiveThirtyEight“ and “Did Las Vegas get too greedy?” by Nate Silver in Silver Bulletin I love media history and analysis, and there’s no one better to get the history of FiveThirtyEight than from Nate Silver, who wrote about his personal experience in one of my favorite pieces from this year. I also loved Nate’s breakdown of what’s causing Vegas’ woes, but I’ll offer one criticism, summarized as “Might I suggest antitrust?” Many centrists/center-right/libertarian thinkers (Nate is self-described as the latter) often don’t consider consolidation or antitrust as factors in policy issues like housing, America’s military readiness, or, in this case, Las Vegas. Even if libertarians want to debunk antitrust/consolidation concerns, I’d love to read that debunking. In this case, Vegas is incredibly consolidated (though it also has been for a long time) and I’d have loved to read Nate at least contending with this factor, since he addresses almost every other potential factor for Vegas’ decline. “Why Microsoft’s Carbon Removal Pullback Is Such a Big Deal“ by Robinson Meyer in Heatmap News I’m a big supporter of carbon removal efforts, but this nascent industry faces a lot of headwinds, including this big move most recently. I think it’s clear that solar panels and batteries should be able to get the world to its carbon footprint goals, but effective carbon renewal remains necessary to prevent the worst impacts of global warming. “AI is killing the cheap smartphone“ by David Oks LLMs and AI will impact the world in ways we’re not ready for, and already, third world countries are seeing the prices of cheap cellphones skyrocket due to the cost of chips skyrocketing. This article by David Oks is a terrific breakdown. “100 Days of Madness: Netflix, Paramount, Warner and the Future of Hollywood“ by Wade Major at Hollywood Heretic Wade Major dove deep into Hollywood/streaming’s financials in this must read piece. Not that I agree with everything in this article (read my take on Warner Bros./Paramount here) but the analysis is top notch. I think many people discount how quality thinking, regardless of the argument/conclusion, will make you a better thinker. “Erased by the UFC: Frank Shamrock, The MMA GOAT of the 20th Century“ by Nate Wilcox in The MMA Draw Newsletter Growing up playing the UFC fighting game on the Dreamcast, Frank Shamrock was my favorite MMA fighter, and this history/tribute to him was great. Other Fun Reads “The Hardest Part Of History To Tell Is How It Felt“ by Craig Fehrman at Defector “Unmasking the Sea Star Killer“ by Craig Welch at bioGraphic “What Could Save the Industry? Fin-Syn“ by Richard Rushfield in The Ankler Alex Rollins Berg in Underexposed on movie bumpers, pillow shots, Disney trash cinema, cult films, and Casablanca. David H. Montgomery in YouGov’s The Surveyor on punctuation marks, condiments, dinosaurs, and comic strips and kids media. “How Medium finally pivoted its way to profitability“ and “Why the best journalists on YouTube are all former Vox employees“ by Simon Owens in Simon Owens’s Media Newsletter “It’s Not Just You, Netflix Shows Have Gotten Slightly Shorter: Here’s What the Data Says“ by Kasey Moore at What’s on Netflix “Numlock Awards: How Diane Warren became the biggest loser in Oscar history“ by Nathaniel Rakich and “Numlock Awards: The Oscar Bait era is over. The Oscar Chum era is here.” by Walt Hickey & Michael Domanico at Numlock Awards

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Jul 3 • 2:38 PM EDT • Entertainment • entertainment.substack.com
1 in 5 adults make health decisions based on what they see on social media despite widespread mistrust

Every few scrolls, another health expert appears on the screen. While some are genuinely qualified, others simply sound convincing enough to pass as one. With AI-generated content flooding feeds, avoiding ...

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Jul 3 • 12:20 PM EDT • Health • medicalxpress.com
Asking Eric: Spouse refuses to ever apologize

A spouse’s lifelong refusal to admit small mistakes leaves their partner feeling dismissed, resentful, and increasingly worn down by repeated blame-shifting behavior.

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Jul 3 • 7:00 AM EDT • Technology • al.com
Goldman Sachs economist predicts AI displacing 15 million jobs

Joseph Briggs of Goldman Sachs foresees AI displacing 15 million US jobs, but suggests new roles will emerge as adoption progresses.

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Jul 3 • 6:20 AM EDT • Business • businessinsider.com
From bamboo sticks to modern chemistry: A history of fireworks on display at the Science History Institute in Old City

“Flash! Bang! Boom! A History of Fireworks” tells the story of fireworks from the earliest Chinese inventions to today’s choreographed pyrotechnic displays.

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Jul 3 • 5:00 AM EDT • Science • whyy.org
Colorado business confidence improves but still pessimistic

Halfway into the year, business confidence across Colorado has improved but is still negative, a new report found. The Leeds Business Confidence Index, a measurement of how business leaders across Colorado feel about the future of the national and state economy, increased by one point to a score of 43, according to a report released […]

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Jul 2 • 2:26 PM EDT • Business • gazette.com
Colorado business confidence improves but still pessimistic

Halfway into the year, business confidence across Colorado has improved but is still negative, a new report found. The Leeds Business Confidence Index, a measurement of how business leaders across Colorado feel about the future of the national and state economy, increased by one point to a score of 43, according to a report released […]

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Jul 2 • 2:26 PM EDT • Business • coloradopolitics.com
Colorado business confidence improves but still pessimistic

Halfway into the year, business confidence across Colorado has improved but is still negative, a new report found. The Leeds Business Confidence Index, a measurement of how business leaders across Colorado feel about the future of the national and state economy, increased by one point to a score of 43, according to a report released […]

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Jul 2 • 2:26 PM EDT • Politics • coloradopolitics.com
Students gain hands-on research skills during ASSURE summer science program

Liberty University’s ASSURE program, an annual six-week summer intensive through the School of Health Sciences’ Department of Biology & Chemistry, concluded last month with its largest participation yet, with 36 students gaining research experience under the supervision of 16 faculty members....

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Jul 2 • 10:45 AM EDT • Science • liberty.edu
Politics

The world this week

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Jul 2 • 10:22 AM EDT • Politics • economist.com
Croatia criticised for ‘unambitious’ changes to 2022 science law

Croatia’s science ministry has been accused of a lack of ambition, and even incompetence, over proposed changes to the country’s 2022 science law. Critics say an opportunity has been missed to fix wider shortcomings in the research and universities system.“This law, like all the previous ones, will not significantly change the current state of science in Croatia,” Vlatko Silobrčić, a member of the Croatian Academy of Sciences, told Science Business. “A small shift here and there will not have a significant impact.”The 2022 law introduced multi-year block grant financing of research, based on results, and changes intended to boost employment and career progression for researchers and lecturers. But implementation of the law has been uneven. “It became apparent that certain of its provisions were subject to different interpretations by higher education institutions and scientific institutes,” the science ministry said in its proposal for change. “This caused legal uncertainty in the system, administrative difficulties in implementation and, in certain cases, unequal treatment of teachers, scientists and students.”Most of the proposed amendments deal with technicalities in hiring and promoting staff, such as extending the committee deadlines from 60 to 90 days, or allowing applicants to cite all of their achievements and not only those since their last appointment.Both the ministry and Croatian media highlighted changes that would raise the retirement age from 65 to 67 years and allow part-time students 15 year rather than 10 years to finish their studies.The change to retirement age has been criticised for reinforcing a weakness in the system. According to Matko Marušić, professor emeritus at the University of Split, this will “allow unproductive teachers to advance and work longer, while hindering and discouraging productive ones.”A longtime campaigner for excellence-based meritocracy, he sees little hope in the new legislation. “I am not optimistic that things will improve,” he told Science Business. “As recent changes to the law in Croatia show, the legal framework is becoming increasingly hypocritical and harmful.”For Marušić, who analyses Croatia's university system in a recently published book, the situation is “unfavourable and constantly deteriorating” due to the criteria used for academic advancement.“The key criterion for advancement should be scientific productivity,” he said. “In Croatia [. . .] scientific criteria are increasingly lowered, and ineffective and absurd criteria such as waiting times for promotion and age limits for remaining in a job are promoted.” He would also like to see better criteria for the quality of teaching at universities. “In practice, teaching is not monitored or evaluated,” he said, estimating that up to a third of teaching simply does not take place. “Under the guise of university autonomy and bad laws, universities and faculties are allowed to earn additional money by increasing enrolment quotas that have nothing to do with the needs of the labour market.” Lack of ambitionDora Kršul, a reporter at Telegram.hr who covers science policy in Croatia, finds the rationale for changes “bizarre.” “The ministry responsible for supervising the uniform application of the law is changing the law because it is being implemented unevenly,” she said. “This primarily speaks to the power relationship in the sphere of science and higher education in Croatia, that is, the question arises as to who actually manages this system.”Rather than raising quality, she continued, the changes appear to be designed to help vocational and applied universities who have not been complying with the law.The Independent Union of Research and Higher Education Employees of Croatia said that the changes were “unambitious” and represent a missed opportunity for more important changes. “We think some of the changes are even negative,” it said in its statement on June 25. One of these is introduction of an “assistant” job title that allows people to be hired only for the duration of a project. Related articles: Elections to top science bodies test Croatia’s gender equality in researchSlovakia revises R&D approach to increase focus on competitivenessLatvia pilots citizen engagement in research grant evaluationsThe union’s president, Tvrtko Smital, who was part of the 15-member working group tasked with drafting the changes, told the local media there was a “worrying lack of ambition” in the process, and “lack of competence” in terms of research experience and understanding the problems in the system.“There is no clear will to deal with the problems,” said Smital, an assistant professor of marine and environmental sciences at the Ruđer Bošković Institute in Zagreb. “It’s a combination of unambitiousness and incompetence,” he went on, expressing his “deep frustration” with the situation. “There is no strategy, no clear thinking, and money is not being spent optimally.”Croatia’s science ministry has not responded to requests for comment.

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Jul 2 • 8:00 AM EDT • Science • sciencebusiness.net
Exploding Colors: The Science Behind Fireworks

College of Charleston chemistry professor Kate Mullaugh explains how fireworks get their brilliant colors, brightening our skies every Fourth of July.

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Jul 1 • 3:17 PM EDT • Science • today.charleston.edu
3 reasons to like Wisconsin’s new AD hire

Why should Badgers fans be optimistic about their new Athletic Director?

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Jul 1 • 2:39 PM EDT • Sports • sports.yahoo.com
Scientists have built a cell in a lab from the ground up

What do you call an organism with no evolutionary ancestors? SpudCell, apparently

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Jul 1 • 1:47 PM EDT • Science • economist.com
Scientists have built a cell from the ground up

What do you call an organism with no evolutionary ancestors? SpudCell, apparently

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Jul 1 • 1:47 PM EDT • Science • economist.com
Scientists can now study the event horizons of black holes

They make the universe’s most extreme gravitational laboratories

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Jul 1 • 10:12 AM EDT • Science • economist.com
Private sector added 98,000 jobs in June, below expectations, ADP says

The figure reported on Wednesday is below economists’ estimates of an increase of 118,000 jobs. The prior month's reading was unrevised at 122,000.

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Jul 1 • 8:25 AM EDT • Business • foxbusiness.com
Scientists reveal what really happens when water is trapped in tiny spaces

A decades-old puzzle about water has finally been unraveled. Researchers found that water trapped in tiny nanoscale spaces is not inherently more reactive. Instead, the intense pressures created inside these microscopic gaps explain most of the effect, while the surrounding material can further enhance water's chemistry if it interacts with the reaction products.

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Jul 1 • 8:00 AM EDT • Science • sciencedaily.com
PlayStation PC Retreat Is A Mistake, As 18+ Months Late Ports Made Money Without Costing a Single Console Sale

Shawn Layden argues PlayStation’s PC port retreat is a mistake, proving late ports made cash without dropping PS5 sales

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Jun 30 • 11:03 AM EDT • Technology • wccftech.com
NATO joins exercises off US coast, even as it loses political fight in Trump's Washington

The warning came booming over the airwaves, in a voice unmistakably from the American south: "Warship! Get out of our waters!"

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Jun 30 • 6:04 AM EDT • Politics • reuters.com
El Boletín newsletter: An earthquake shakes Venezuela’s political reset

Our correspondent in Caracas reports on how disaster is testing an already fragile country

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Jun 30 • 4:08 AM EDT • Politics • economist.com
Radiology providers must pay $7M, modify policies after breast cancer miss

Radiologist Henry C. Lusane, MD, with Acumen Medical Imaging, interpreted the scans, reporting the mass as benign, a mistake later leading to a terminal cancer diagnosis.

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Jun 30 • 2:39 AM EDT • Business • radiologybusiness.com
Faculty in Politics, Chemistry, Biology and English Appointed to Endowed Professorships | Pomona College in Claremont, California

Four faculty members have been awarded endowed professorship positions. The Pomona College Board of Trustees voted to support these appointments during their meeting in May.

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Jun 29 • 1:19 PM EDT • Politics • pomona.edu
Supreme Court rules MSU economist Lisa Cook can remain as Fed governor

The Trump administration sought to remove Fed governor Lisa Cook amid a push to get the U.S. independent central bank to lower interest rates.

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Jun 29 • 12:24 PM EDT • Politics • detroitnews.com
Deep dive
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Amorepacific Highlights Science-Led K-Beauty Innovation at NYSCC

/PRNewswire/ -- Amorepacific is reinforcing its science-led approach to K-beauty in the U.S. through engagements with the New York Society of Cosmetic Chemists...

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Jun 29 • 10:00 AM EDT • Science • prnewswire.com
Bank of England chief economist warns against ‘complacency’ in fight against inflation

Rolling coverage of the latest economic and financial news

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Jun 29 • 2:43 AM EDT • Business • theguardian.com
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Secret Alchemist, Sarelly and Borntostandout Are Among the Winners of The Business of Beauty Global Awards 2026

From emerging challengers to established disruptors, this year’s Global Awards winners are setting a new benchmark for beauty entrepreneurship.

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Jun 29 • 12:30 AM EDT • Business • businessoffashion.com
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial

Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to

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Jun 28 • 3:45 PM EDT • Health • astrazeneca-us.com
3 Traps Health Systems Fall Into When Trying to Improve Their Culture

Cultivating a positive culture is a priority for hospital leaders, but many are making avoidable mistakes. Myra Gregorian, Seattle Children's chief people and transformation officer, outlined some of these common blunders — such as not involving frontline staff in decision making and assuming that simple communication methods are sufficient.

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Jun 28 • 9:44 AM EDT • Health • medcitynews.com
I tested my workout at Gatorade's sports lab: My 3 hydration mistakes

A sweat test at Gatorade's sports science lab for elite athletes revealed I wasn't consuming enough water, electrolytes, or carbs during workouts.

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Jun 27 • 5:17 AM EDT • Business • businessinsider.com
Asheville grants $855K to business accelerator, extends recovery program through 2028

Asheville grants $855,000 to Optimist Ventures, an accelerator for Asheville entrepreneurs affected by Hurricane Helene.

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Jun 26 • 10:14 PM EDT • Business • wlos.com
Seattle’s Pioneer Square lands a new retailer

A bespoke diamond jewelry company opened a store in Pioneer Square. The CEO is optimistic about its future in downtown Seattle.

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Jun 26 • 1:00 PM EDT • Business • seattletimes.com
Master Inventor Hoffman Turns Chemistry Into Capability | Johns Hopkins University Applied Physics Laboratory

Christopher Hoffman has been recognized as a Johns Hopkins APL Master Inventor, a distinction earned through a career spent asking a simple question: What can chemistry can do to solve a real-world problem?

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Jun 26 • 11:02 AM EDT • Science • jhuapl.edu
The Business of Beauty Global Awards 2026: Winners Announced

Wavy, Secret Alchemist, Sarelly, Dr. Diamond’s Metacine, Borntostandout and Suri are the winners of The Business of Beauty Global Awards 2026, honoured on Thursday at the Global Forum in Napa Valley, California.

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Jun 26 • 2:33 AM EDT • Business • businessoffashion.com
Smart voices in business react to Apple and Xbox price hikes

After Apple and Microsoft's Xbox raised prices due to a shortage of memory chips, tech observers are not optimistic about future prices.

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Jun 26 • 12:44 AM EDT • Business • businessinsider.com
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Distrust In Science Isn't New: We Mistook Silence For Trust

Distrust in medicine and science isn't a new crisis. Drawing on decades in communities, a physician explains the real source and how we earn trust.

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Jun 25 • 7:20 PM EDT • Science • forbes.com
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Making Our Own Luck

We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.

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Jun 25 • 4:48 PM EDT • Science • goodscience.substack.com
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How should European scientists respond to the US AI kill switch?

Earlier in June, Europe’s worst fears of technological dependence were confirmed when the White House ordered the AI firm Anthropic to stop non-US citizens using its leading models. This kill-switch moment crystalised anxieties in Brussels that the continent, lagging the US on the creation of leading-edge AI models, is now a technological of vassal of Washington. The shock has specific implications for European scientists and universities. Some governments are now worried that with AI being integrated into labs, Donald Trump now has his finger hovering over an off switch for European science. “Having restrictions on this tool, it can have an impact on our own research,” said France’s research minister, Philippe Baptiste, at the VivaTech conference in Paris on June 18.Baptiste, himself a former academic, said that colleagues in mathematics had recently warned him they were now cut off from leading-edge US models, risking their work. “This model is not available anymore now because of the US restriction, and for the first time this had an impact on mathematics,” a field where large language models (LLMs) are making a significant contribution, said Baptiste. So, should European scientists avoid relying on US models in the future? Or would this be a self-harming overreaction? And how is AI being used in science, anyway? What happened?On June 12, it emerged that Washington, citing cybersecurity concerns, had ordered Anthropic to stop non-US citizens using two models: Claude Mythos 5, and Claude Fable 5, a version of Mythos but with guardrails to prevent abuse. Anthropic said Washington’s concerns were overblown. But forced to follow the order, yet with no way to check who was using the models, the company suddenly shut down access for everyone, US citizens included. There’s still no agreement on how to restore broad access. But last week, Bloomberg reported that select US companies, and the US government, still had access to Mythos despite the ban, but the EU’s cybersecurity agency Enisa had been shut out. Class division of researchersIn the longer term, access outside the US should be restored, said Marcel Salathé, co-director of the AI centre at the Federal Polytechnic School of Lausanne (EPFL), because a permanent restriction would be financially ruinous to US AI firms. “Even Trump will eventually budge to economic pressure,” he said.However, US AI firms might end up operating rather like banks, doing due diligence on users of their leading-edge AI models, he went on.European scientists are unlikely to fall foul of such checks, he said. But having a Chinese postgraduate in their lab, or doing a type of research the US disapproved of, could potentially result in access being denied. “It will create a sort of class division of researchers,” he said. More than frontier modelsHowever, successfully deploying AI in science is about far more than just having access to leading LLMs such as Mythos.Instead, many science-specific tools, most famously Alphafold, which predicts protein folding structures, require “far less” computing power to train than frontier models, well within the capabilities of European supercomputers, according to a recent analysis by the Arq Foundation, a Brussel-based AI think tank. Instead, tools such as Alphafold are possible because certain fields, like protein folding, weather prediction or astronomy, have large, clean, standardised datasets that can be used to train predictive models. Rather than compute, “data is the central constraint for AI for science,” the report says. For example, a less powerful physics model trained on CERN’s data “will be more valuable than the best model without certain data,” said Bengüsu Özcan, author of the report. European advantage?Europe could therefore steal a march by using its scientific data and infrastructure to create models US digital giants cannot. “They might actually match or go even beyond what these big [US] companies are doing,” said Özcan.Indeed, some European start-ups hope to create automated testing labs to create the kind of standardised data that could speed up the discovery of new materials. Materials scientists say there’s currently too little data to train models. AI scientistsHowever, even if the bottleneck for AI in science is often data, rather than compute, being at the mercy of the US for LLM access could still become a problem for European scientists. A new class of “AI scientists” based on leading LLMs is also emerging, Özcan’s report says.Unlike domain-specific tools like Alphafold, these try to automate day-to-day scientific work, by providing an overarching tool that coordinates specific models to synthesise existing literature, generate hypotheses or run analysis of data. The problem for Europe, however, is that these tools are sometimes based on US leading models. Google Deepmind’s AI Co-Scientist, for example, is built on Google’s Gemini LLM. Systematic failureThese scientific automation tools are still in their early stages, and still exhibit “systematic failures on scientific tasks,” Özcan’s report says. One of the problems is that the messy, day-to-day process of scientific discovery is largely not documented, meaning LLMs don’t have a good source of data to learn how scientists actually work. Meanwhile, some tasks, such as literature synthesis, don’t typically require access to leading edge models.However, the performance of AI scientific assistants could improve as companies such as Google pour resources into developing them. Rely on US“Unfortunately, for scientific assistants, there is not much we can do right now except rely on US frontier AI,” said Antoine Bosselut, a natural language processing expert based at EPFL. Chinese-built open models, which can run on local computers, lessening the risk of a shutdown, are touted as one alternative to US dependence. There’s also Mistral, once seen as Europe’s main AI hope, but the Paris-based company has seen its recent models fall behind in performance. But the Chinese alternatives are generally not as capable as US frontier AI models, said Bosselut, unless paired with fiddly, custom tools that allows them to act as independent agents. “Most scientists do not have the time,” he said. Don’t jump ship yetAlthough the kill switch moment is seen a warning shot for European scientists, it doesn’t mean labs should abandon US AI tools immediately. “I do not think the right response is simply to abandon US-based models and systems under the banner of sovereignty or independence,” said Mattias Björnmalm, secretary general of the Cesaer university association. “That would be an overreaction.”Related articlesEuropean sovereignty in AI requires ‘ugly trade-offs,’ say experts Robotic lab start-up makes case for €500M EU-funded materials testing facilityAI in science: is it useful? Instead, European researchers need to ask themselves whether they’re becoming dependent on technology that could be turned off in Washington, said Özcan. “They might not see this today, but they should really start asking this question,” she said. European researchers need a plan B, said Salathé. “I would recommend to every researcher, very proactively explore alternatives.”Own toolsIn addition, Björnmalm and others want European research institutions to develop their own scientific AI tools.Instead of signing AI deals with US digital giants, European universities should be using this money to create their own models, which may end up being superior for research, said Sabine Leonelli, an expert on the use of AI in science at the Technical University of Munich. “Universities in Europe seem to be happy to sign commercial contracts with US companies on the assumption [their AI tools] are better,” she said. But US frontier LLMs are typically opaque, and have been developed without independent scientific input, she said. “This is not good enough for science.”Last year, Swiss researchers released Apertus, an LLM designed to be completely transparent, from its development methods to its training data. The idea is that this makes scientific tools built on top of the model far more reproducible than with closed, commercial alternatives.“Europe needs more of this: serious capacity-building that gives researchers, universities and companies credible options,” said Björnmalm.

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Jun 25 • 8:00 AM EDT • Science • sciencebusiness.net
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