SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " landscape " 2,744 found 🔀 AI-powered Shuffle
The lives of Idaho wilderness guides seem ideal but often hide pain
It’s an emotional let-down when the river runs end for the season and the wonderful people she met along the way are gone | Opinion
Company that pledged 200 jobs in Charlotte leaves town for SC, loses NC incentives
The company, known for brands like Dirt Devil, announced a $5 million investment in 2015.
Ralph Alvarado kept outside jobs while working as Tennessee health commissioner
Reports show that Alvarado, now a GOP congressional candidate, worked for Kentucky nursing homes and other facilities while in Tennessee.
Driver crashes through Bradenton business on Cortez Road, police say
Bradenton police said the crash happened Sunday afternoon.
Mapping the Global Health Landscape: Analysis of Fourteen International Organizations
The global health architecture includes a number of diverse international organizations with different mandates, governance models, financing structures, and operational approaches. This KFF resource looks across a range of variables to provide a descriptive mapping of 14 key global health and related international institutions. It is intended to inform discussions about synergies and coordination, duplication, comparative advantage, shared challenges, and architectural reform.
Sporting KC Weekly Schedule: Sept. 8-13, 2026
Sporting Kansas City II News: The official source for all SKC II news, photos, videos, highlights, and more.
How UC Davis Strengthens the Forensic Science Workforce
Meet UC Davis students and alumni using a forensic science degree to build careers analyzing DNA evidence and chemicals in crime labs.
Chrome is now shipping updates every 2 weeks as AI changes the security landscape
Google is speeding up Chrome’s release schedule to ship security patches and new features faster.
Are Irving, LaVine, Holiday realistic for Heat? And surprising Richards info
The Heat’s challenges in landing one more impactful player. And some notable data on new backup center Nick Richards.
In 12 years, Triangle man missed only 1 health insurance payment. He lost coverage
A mistake setting up autopay proved costly for this Morrisville family. Here’s what happened — and how you can avoid it.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Deconstructing LSD for Therapeutic Discoveries
UC Davis researchers have stripped down LSD to the base features responsible for its hallucinogenic and therapeutic effects.
Did California forget about its zero-emission school bus project?
“Considering the state’s requirement for all school buses to be zero-emission by 2035, more sustained statewide support is needed.”
Four Lake Norman hospitals seek approval for 3D body scanner. Only one will get it
Atrium, Duke Health, Novant and Southern Oncology compete to set up a 3D body scanner outside Charlotte.
NC Senate race sparks AI deepfake debate after mistake on Cabarrus County mailers
“The use of AI deepfake imagery and content deceives voters and violates their trust,” one candidate said.
Will this be year Dolphins get good guard play? And personnel chatter
Dolphins hoping for breakthrough at guard. And news and notes.
A whiplash election year enters its final stretch as Trump holds wild cards
As the final midterm of Donald Trump's presidency rapidly approaches, the landscape is proving especially volatile, with Trump often stirring the tumult.
The incongruity of caste and science
IIT-Mandi 'shudras' row: The human organism develops as its genes interact with its environment, and caste-based discrimination affects these environments
How Hope Florida scrutiny rattled the final years of the DeSantis administration
Here are the biggest impacts.
Michael Penix Jr. says he's 'really close' but not quite 100% healthy
Penix provided an update on his health and mindset after the Falcons named Tua Tagovailoa their starting quarterback for Week 1
Why CBS Sports Predicts Omarion Hampton Will Win NFL Rushing Title in 2026
The second-year running back should thrive in Mike McDaniel's system this season
'GMFB' predicts OPOY winner for 2026
"GMFB" predicts who will win Offensive Player of the Year for the 2026 season.
Dolphins’ Willie Gay hopes return to old role pays off. And more Willis feedback
A look at Dolphins linebacker Willie Gay Jr. and more feedback on Malik Willis.
Tim Schafer: "No one puts Double Fine out of business except me"
Studio boss discusses regaining independence after leaving Microsoft, and navigating the current industry landscape
Free concerts at ‘amazing venue’ aim to energize Moss Point’s Riverfront Park
The series opened Aug. 22, with hundreds attending the first concert.
Science Snapshots: September 6, 2026
Discover three groundbreaking research advancements: Saturn's decagonal wave, a new Zika detection method, and insights into inner speech.
From Academia to Industry: Hongbian Li on Wearable Electronics, AI, and the Changing Landscape of Materials Science
Hongbian Li shares her experience as a reviewer, shifting to industry, and on translating materials research into real-world applications.
Arctic Rivers Are Defying What Scientists Thought They Knew About Erosion
"We literally expected to see the opposite."
Vote by Vernon Health Board to remain independent marks shift in healthcare landscape for Viroqua, Vernon County
Sept. 5, 2026 VIROQUA, Wis. – The recent decision by the Vernon Health Board of Directors to not pursue an affiliation with Emplify Health was either a bold move to protect local independence for a small rural organization or a choice that sets up difficult challenges that could result in direct competition from an outside […]
Five Swing Factors That Will Define the Ravens’ Season
Lamar Jackson and Nnamdi Madubuike’s health, among other things, will be paramount in determining whether the Ravens can meet Super Bowl expectations in 2026.
In new ‘Lioness’ episode: YMCA, Masonic Temple, Fort Worth restaurant and more
The Paramount+ series airs on Sundays.
A whiplash election year enters its final stretch as Trump holds wild cards
The political landscape in the U.S. is volatile as the final midterm of President Donald Trump's presidency approaches
A whiplash election year enters its final stretch as Trump holds wild cards
The political landscape in the U.S. is volatile as the final midterm of President Donald Trump's presidency approaches. Trump often stirs the tumult, with issues such as redrawn congressional...
A whiplash election year enters its final stretch as Trump holds wild cards
The political landscape in the U.S. is volatile as the final midterm of President Donald Trump's presidency approaches.
A whiplash election year enters its final stretch as Trump holds wild cards
The political landscape in the U.S. is volatile as the final midterm of President Donald Trump's presidency approaches.
A whiplash election year enters its final stretch as Trump holds wild cards
The political landscape in the U.S. is volatile as the final midterm of President Donald Trump's presidency approaches. Trump often stirs the tumult, with issues such as redrawn congressional districts
JoCo woman sues Genesis Health Clubs, says personal trainer sexually abused her at 16
The suit, filed in Jackson County Circuit Court, accuses the trainer of abusing the teen — referred to in records as Jane Doe — during the time period of January 2021 and March 2021.
A South Carolina restaurant closed after a failed August health inspection. Here’s why
This South Carolina restaurant closed after a failed August health inspection. Here’s what to know.
An ‘albatross’ or a GOP turnout force: Trump’s role in Texas midterm elections
With a president down in the polls coming to Dallas for a convention, navigating the politics can be tricky for some midterm candidates.
Riverhead closer to taking over Long Island Science Center property
The vacant department store, officials said, threatens Riverhead's town square project.
49ers Prepare Educators to Build Positive Sports Culture Through Mental Wellness
49ers Flag presented by Visa, Positive Coaching Alliance, and USA Football hosted a coaches clinic with classroom learning and on-field instruction.
Cuba’s Raúl Castro reappears in public, dispelling rumors about his health
Rumors that Cuba’s nonagenarian ruler Raúl Castro was dead or severely ill had been spreading again on social media.
Frisco health inspectors find food safety issues in latest round of checks
The database compiled by the Star-Telegram includes data from Aug. 23 through Aug 29 and 52 inspections.
Three restaurants closed, roach infestation found in latest Tarrant health inspections
The inspection database compiled by the Star-Telegram contains data from Aug. 16 through Aug. 29 and 268 inspections.
North Hills, Hillsborough Street and Pittsboro restaurants go out of business
A burger spot near NC State is among the restaurants closing.
Player status report, presented by Orlando Health: Orlando City SC vs San Diego FC
Here is the Player Status Report, presented by Orlando Health, for Saturday's home match vs San Diego FC
Expert score prediction: Nebraska vs. Ohio
Another season opener that will provide the landscape for where Nebraska can go. Once again, this season is another crucial one for Matt Rhule.
Health officials issue strong warning to stay out of river water in Tri-Cities
Signs are being posted.
Mount Sinai health system will end gender-affirming care for youth, under agreement with Justice Department
The health system must also pay a fine and spend $2 million to help people who received gender-affirming care to "detransition," the government said.
Key moments in the Lindsay Clancy case: the 911 call, mental health care, mistrial
The judge has declared a mistrial in the Lindsay Clancy murder trial.
Player Availability Report: #DALvSKC
Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City is back on
Mecklenburg Public Health responds to West Nile Virus cases, anticipates more
West Nile virus cases generally peak in September, according to Mecklenburg Public Health.
Local spots fared well in the latest Merced County health inspections
The latest round of inspections was made from Aug. 27 to Sept. 2.
From country to pop: readers tell The Bee their favorite Dolly Parton songs
After the country singer’s death at the age of 80, The Bee’s readers revealed their favorite Dolly Parton tunes.
Beyoncé and Selena Quintanilla’s duet: New Spanish-language track blend their voices; Chris Pérez react
Latin music
Learning from the Trees
At a joint field school on Allen Island, Colby and UMaine researchers use dendrochronology, or tree-ring science, to unlock stories of climate, landscape, and human impact
Dissecting the Indiana Takes Arms Race in college football media
The sports media landscape is in the midst of a Cold War-style opinion race with Indiana football at its center.
Chiefs’ team representative on stadium authority board knows Kansas politics well
The Chiefs are the first NFL team with a representative who gets to vote on stadium-related decisions.
A good omen? Fort Lauderdale now allows more fortune tellers to set up shop
A zoning tweak opened up new areas of the city to entrepreneurial mystics.
How to balance soil health and wildlife conservation
Digging Deeper: Managing for diversity, whether it is aboveground or belowground, is crucial to building healthy rural landscapes and farms.
Ospreys and bunker, campaign politics, tax breaks for builders
Reader letters to Newsday.
Bad moves from the past plagued Bayern Munich’s summer
FC Bayern is doing what it can to compete in a tough landscape.
Five Things presented by Compass Minerals: Sporting travels to face FC Dallas
Sporting Kansas City hits the road this weekend to take on FC Dallas at Toyota Stadium down in Texas on Saturday night. Kickoff is set for 7:30 p.m. CT and will be available to stream on Apple TV, while the game will also be broadcast locally on the radio via
A judge expanded abortion access in Idaho last month. Another court paused his decision
Idaho Attorney General Raúl Labrador said the ruling “means unborn children and their mothers in our state are protected under Idaho law.”
A Grand Theft Auto marketing deal with Miami-Dade has a real-life foe: the sheriff
The mayor thinks a GTA deal could be a way to generate some money for Miami-Dade. Sheriff Cordero-Stutz: Not worth it.
EPA proposal could leave the public in the dark on data center plans
A plan by the Environmental Protection Agency could make it harder for the public to learn about and comment on proposed AI data centers that have sparked backlash in communities across the United States and transformed the midterm election landscape.
The business of the NFL: How Zach Harrison went from Falcons roster cut to returnee
Atlanta waived Harrison after claiming three players off waivers, knowing it could lose a defensive lineman who had made a strong impression on the organization.
Rooney and Kate Mara had to speak in unison in 'Bucking Fastard'
Werner Herzog's new film "Bucking Fastard" features sisters Rooney and Kate Mara playing siblings who speak in unison.
Tacoma brewery caught in controversy as owners’ political donations surface
A political organizer accused the businesses of being “anti-trans” after owners donated to a PAC. The owners say it was about tax reform.
Nuclear medicine physician-scientist Dr. Amir Iravani joins UCLA Health to lead Theranostics Program
Iravani will help advance the integration of theranostics into cancer care, expand clinical trials and research opportunities and develop new collaborations.
In KC’s River Market, business owners are ticked off about parking tickets
“What the city has done to this downtown area has been devastating to our businesses,” said Arthur Leduc, owner of Kansas City Taco Company.
Shane Strum appointed permanent CEO of Memorial Healthcare System in Broward
Under Strum, Broward Health and Memorial are aggressively expanding into areas where residents don’t have nearby access to care.
Florida Democrats call for attorney general’s impeachment over Hope Florida
Democrats have little power in Tallahassee.
Six Plano restaurants close over serious health violations, rodents and roaches
This inspection database compiled by the Star-Telegram contains results of 113 inspections from Aug. 16-22.
Olive oil shop in Overland Park to close after 15 years. Owner shares next venture
“Thank you for believing in a dream that started with a simple idea and grew into something none of us could have imagined,” the owner said in a message to customers.
It’s official: Cuba finally authorizes Cubans living abroad to own private businesses
The new legal framework published in the Official Gazette is the deepest overhaul of the island’s private sector since small and medium enterprises were legalized in 2021.
Missouri’s gerrymandered map faces final test as Supreme Court weighs referendum
The high-stakes decision could effectively decide the future of Kansas City’s representation in Congress.
MrBeast will try to survive ‘the planet’s most unforgiving landscapes’ using Gemini and Fitbit Air in deal with Google
Google has struck a deal with MrBeast, the most popular YouTuber, to promote Gemini and Google Health, with one of...
Everything to know about college football TV: Changes, plan for UM, new voices
What to know about college football on television this year. A full primer.
DeSantis throws support behind Donalds after contentious Republican primary
DeSantis made sure an event billed as a Florida GOP unity gathering was a celebration of his time as governor.
Yahoo Sports and Apple TV Team Up to Bring “The Cooligans” to a Live MLS Alternate Broadcast
NEW YORK (Wednesday, September 1, 2026) – Yahoo Sports and Apple TV are teaming up this season to deliver an alternate broadcast for select live Major League Soccer (MLS) matches, bringing fans a new way to experience the action with Yahoo Sports experts Alexis Guerreros and Christian Polanco of “The
NOAA announces priorities to promote science-based American seafood dominance
Today, NOAA announced priorities for advancing reforms within NOAA Fisheries to move towards regulations grounded in science that support American seafood dominance. These agency-level actions follow the Regional Priorities guidance that was released on July 2, 2026, to apply the same standard of accountability to NOAA’s own opera
Rhode Island could see a political wipeout next week
If Governor Dan McKee, Lieutenant Governor Sabina Matos, and Mayor Brett Smiley all were to fall, it would amount to an unprecedented upending of Rhode Island’s political establishment, and a massive rebuke that could signal a significant shift in the state’s political landscape.
Man charged in potential hate crime in Lexington. What to know about the case
Here’s what we know so far about the case.
Comings & Goings
Here’s a look at recent changes in the business landscape in the Sioux Falls area.
NYS Lyme disease cases jump 16%. 'Ticks are winning,' state health commissioner says.
"They're no longer just a nuisance, but ticks really are a rising threat," the state health commissioner said on Tuesday in Hampton Bays.
Science behind Grand Canyon floods
The Grand Canyon is one of the nation’s most visited natural wonders, but this week’s disaster is a stark reminder that extreme weather can transform its landscape in a matter of minutes. Victor Baker, regents' professor of Hydrology and Atmospheric Sciences, at University of Arizona, gives insight.
Broward’s Memorial Healthcare System board to vote on CEO position this week
During his tenure, interim CEO Shane Strum has pushed for Broward Health and Memorial to work together.
Quantum Science Researcher Receives Competitive Student Fellowship from UC Noyce
Nathan Gonzalez, a student studying scalable quantum technologies in the College of Engineering, has received a UC Noyce Graduate Student Fellowship for outstanding doctoral research. The program supports doctoral students at the forefront of computational health, quantum information science and cybersecurity.
Review | ‘Les Miz’ takes to the hills at Hudson Valley Shakespeare
For a show so preoccupied with God, death and redemption, there is something fitting about seeing “Les Miz” played against the actual landscape as daylight
Sports Editor for The Wall Street Journal Joshua Robinson joins 'GMFB'
Joshua Robinson, Sports Editor of the Wall Street Journal, joins "Good Morning Football" for an exclusive interview.
Fresno’s hot political month: ballot fiasco, racial slur fallout, DA stabbed, recall Bredefeld?
Here’s your guide to Fresno's chaotic August in politics. Each story and topic explained from dueling tax measures to why a senior DA was stabbed at a campaign ad shoot.
Bowling and beer: entertainment venue to move into Sacramento’s Downtown Commons
Located on J Street, the entertainment place will offer a variety of other games, as well as dining and drink options.
Vending machine brings free Narcan, health supplies to Raytown. How it works
Jackson County Public Health recently opened its second Bluebox outside of a Raytown business, offering free naloxone and other supplies.
Measles flagged at NC hotel and gas station, health department says
More than 20 cases of measles were recorded in the state in 2025 and 2026, but none have been reported since February.
Sporting KC Weekly Schedule: Sept. 1-5, 2026
Sporting Kansas City II News: The official source for all SKC II news, photos, videos, highlights, and more.
Massive KC entertainment center closes after 13 years. ‘So many memories’
“Celebrations, milestones, rainy-day adventures, and so many moments that we will carry with us long after the lights go out tonight,” the business wrote on social media.
Jeff Rehberger and the Business of Betting Big on Illinois
Jeff Rehberger looked at that landscape and saw something else: a regulated, scalable market that would reward whoever built the right infrastructure to operate inside it seriously.
We need more mega-science projects, says CERN Director-General
CERN's Director-General Mark Thomson advocates for more mega-science projects, highlighting the transformative Future Circular Collider during a Mumbai visit.
Centre County Sports Hall of Fame has 12 new inductees. Meet the 2026 class
The new members of the Hall of Fame include PIAA champions, storied coaches and more.