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Thomson Reuters to Sell Stake in Legal, Tax Business to KKR
Thomson Reuters Corp. agreed to sell a 51% stake in its legal and tax publishing business to investment firm KKR & Co. in a $500 million deal.
Leonard Spencer lands support from West Orange Political Alliance
Spencer touted his support for small businesses and investments in workforce development.
U.S. National Science Foundation Announces Transformational Award to Connecticut's Quantum Tech Sector
'NSF Engines investments in critical technologies and future industries will transform America’s innovation infrastructure for decades to come'
Governor Morrisey Announces $1.8M Investment to Address Critical Healthcare Workforce Shortages
Governor Patrick Morrisey announced a $1.8 million funding opportunity through the state's Rural Health Transformation Program (RHTP) to help address critical healthcare workforce shortages across West Virginia.
Heavy Metal Icon Iron Maiden Sells Stake in Music Rights to Sweden’s Pophouse
Swedish music investment firm Pophouse Entertainment Group AB is adding another high-profile name to its portfolio by acquiring a stake in the publishing and music rights of Iron Maiden.
JPMorgan Posts Record Revenue Across Every Business Line
JPMorgan Chase had record revenue for each of its businesses in the quarter, CEO Jamie Dimon said. Highlights include: Fees from investment banking were up 30% from a year earlier. Revenue from markets rose 35%. Revenue in Consumer and Community Banking rose 8% to $20.27 billion, boosted by
Vistria sells stake in specialty pharmacy company to Warburg Pincus
Revenue at the Pittsburgh, Penn.-based Pantherx Rare had grown to nearly $10 billion from $2 billion since Vistria's investment.
Loyola awarded nearly $1 million to expand forensic science training, research
Loyola University Maryland has received nearly $1 million in federal funding to establish a forensic science training center, an investment university and law enforcement leaders say will strengthen forensic science education, expand research opportunities and deepen partnerships that support criminal investigations across the region.
The Quintessential Trump-era Politician
In 2020, I wrote an article about collaboration and collaborators. The title was History Will Judge the Complicit, and it started with the story of two famous East Germans, Markus Wolf and Wolfgang Leonhard, who both landed in East Berlin just after the end of the war. Although they came from very similar backgrounds, the former stuck with the regime, eventually becoming its spy boss; the latter, horrified by the brutal reality of Soviet-style communism, escaped. By way of juxtaposition, I also wrote about Lyndsey Graham and Mitt Romney. These two men also made very different decisions when confronted by Donald Trump’s assault on the ideals that they had both grown up believing: A glance at their biographies would not have led many to predict what happened next. On paper, Graham would have seemed, in 2016, like the man with deeper ties to the military, to the rule of law, and to an old-fashioned idea of American patriotism and American responsibility in the world. Romney, by contrast, with his shifts between the center and the right, with his multiple careers in business and politics, would have seemed less deeply attached to those same old-fashioned patriotic ideals. Most of us register soldiers as loyal patriots, and management consultants as self-interested. We assume people from small towns in South Carolina are more likely to resist political pressure than people who have lived in many places. Intuitively, we think that loyalty to a particular place implies loyalty to a set of values. But in this case the clichés were wrong. It was Graham who made excuses for Trump’s abuse of power. It was Graham—a JAG Corps lawyer—who downplayed the evidence that the president had attempted to manipulate foreign courts and blackmail a foreign leader into launching a phony investigation into a political rival. It was Graham who abandoned his own stated support for bipartisanship and instead pushed for a hyperpartisan Senate Judiciary Committee investigation into former Vice President Joe Biden’s son. It was Graham who played golf with Trump, who made excuses for him on television, who supported the president even as he slowly destroyed the American alliances—with Europeans, with the Kurds—that Graham had defended all his life. By contrast, it was Romney who, in February, became the only Republican senator to break ranks with his colleagues, voting to impeach the president. “Corrupting an election to keep oneself in office,” he said, is “perhaps the most abusive and destructive violation of one’s oath of office that I can imagine.” In the wake of Graham’s unexpected death on Saturday, I wrote about him again. He was, in many ways, the quintessential politician of Trump’s Washington, a man who shifted 180 degrees. Graham had been a fervent American patriot, proud reserve officer and military lawyer; he became one of the most important defenders of a president who believes soldiers are “suckers and losers” and shows no respect for law of any kind. As his politics changed, his language grew coarser and his behavior grew worse: He urged Israel to “level the place” in Gaza, and insulted the Danish prime minister in Munich, prompting a colleague, Senator Elissa Slotkin, to issue an apology. Here’s an excerpt from the article, which you can read in The Atlantic (gift link here) Like his close friend John McCain, Graham believed that America should stand at the center of a broad democratic alliance. The few times I met him were in that context, at the Munich Security Conference or at other European-American gatherings, which he once attended with great regularity. He also took seriously the practice of American democracy at home. In a 2014 conversation with The Atlantic, he described himself as a pragmatic politician who eschewed populist slogans. “I know Washington is broken, but what’s broken about it is everybody yelling and nobody trying to fix it,” he said. “I’m trying.” When Donald Trump first appeared in U.S. politics, Graham recognized him immediately for what he was: the spokesman for an alien ideology, one radically different from the idealistic patriotism that Graham had practiced and preached since childhood. Trump privately mocked the military that Graham loved as nothing but “suckers and losers.” He put falsehoods, cynicism, and personal greed at the center of his politics, while expressing disdain for transparency, accountability, and democracy itself. In 2015, Graham described Trump as a “race-baiting, xenophobic, religious bigot” who should “go to hell.” Also as a “nutjob.” When Trump won, Graham understood, as did so many others, that he would have to make some important choices. For a while, he went silent. In the spring of 2016, I saw him at one of those conferences in Europe. He seemed too depressed to speak. But then, like many other Republicans—and, more important, like many other people who have lived under political occupation or experienced radical regime change—he made the decision to abandon his previous ideals, to bury the patriotism that was once so important to him, and to become, instead, a loud, opportunistic collaborator. As I wrote in 2020, it’s very hard to look in to anyone’s heart and to understand their motivations from the outside. But it does seem that Graham had a deep need to be relevant, to be in the game, to be a player, at any cost. And that, rather than any particular achievement, is what he will be remembered for. Continuing to monitor conflicts of interest, ostentatious emoluments, outright corruption and policy changes that will facilitate outright corruption. (Read my original article, Kleptocracy Inc and check out the SNF Agora Institute chart) June 27 Trump diverted funds from more than 900 projects nationwide—including safety upgrades at national parks—to finance beautification projects around Washington, including $700,000 used to fix a White House walkway. June 28 After a years-long Department of Justice investigation into Abbott Laboratories over its management of a baby formula facility where potentially deadly bacteria turned up enough evidence to criminally charge the firm, top department officials instead opted for a financial penalty—illustrating the department’s move away from strict corporate enforcement under the Trump administration. June 29 Defense Secretary Pete Hegseth stacked the Defense Policy Board—which is charged with providing independent national security recommendations to the Office of the Secretary of Defense—with Trump allies, including tech billionaire Marc Andreessen, who has invested in defense contractors like OpenAI and SpaceX, after purging the panel last year. Trump purchased between $1 million and $5 million worth of stock in Axon—which makes about 90% of US tasers—two weeks before ICE solicited bids for a $220 million taser contract. The White House unveiled limited-edition US passports for America’s 250th birthday, featuring a portrait of Trump overlaid on the Declaration of Independence. June 30 Trump made around $1.2 billion from his various crypto companies last year, including more than $500 million from World Liberty Financial and $600 million from sales of his meme coin. Trump is considering issuing 250 pardons to commemorate America’s 250th birthday. These are expected to be largely doled out through the Office of the Pardon Attorney’s informal network of intermediaries. White-collar defense attorneys say they can typically win pardons for clients for $2 million. Last year, Trump administration officials awarded a no-bid contract worth up to $500 million to Clark Construction for the White House ballroom—negotiations in which the president was directly involved. July 1 The Amazon MGM Studios documentary about Melania Trump earned the First Lady more than $10 million. Trump made hundreds of individual stock purchases worth as much as $12.8 million the day before his announcement pausing “Liberation Day” tariffs for 90 days sent the S&P 500 soaring nearly 10%—one of the largest single-day gains ever. Mar-a-Lago and Trump National Doral saw record surges in revenue during Trump’s first year in office, earning $77.5 million and $121.9 million respectively, compared to average annual revenues of $25 million and $75 million during Trump’s first term. Entities across the Persian Gulf paid more than $300 million to Trump’s businesses last year, including $263 million from the sale of half his stake in World Liberty Financial to a firm backed by Sheikh Tahnoon bin Zayed Al Nahyan, a top UAE royal and brother of the country’s president. Kash Patel failed to properly disclose his stock purchase of a Department of Justice contractor, MicroStrategy, worth up to $250,000 last year, despite laws requiring disclosure within 45 days of the trade. July 2 Trump has been directing administration officials to steer more government contracts—so far worth more than $2.4 billion—to Jeff Bezos’s Blue Origin aerospace firm, after Amazon gave $1 million to Trump’s inaugural fund, donated to the White House ballroom project, and reached a $40 million deal to license a Melania Trump documentary. Alongside the billions he made from cryptocurrency last year, Trump earned millions of dollars from real estate licensing fees, including $21 million from organizations in the UAE and $9.2 million in Saudi Arabia, along with smaller sums from merchandise sales, including $4.7 million from Trump Watches and $35,920 from 45 Guitar, a guitar brand endorsed by the president. House Democrats accused consultants tied to the Trump administration of financial fraud, alleging they gave prospective donors to America250—the bipartisan committee created by Congress to celebrate the nation’s semiquincentennial—the banking and routing numbers for Freedom 250, the White House’s fund for events like the UFC cage fight. Democrats also allege that Freedom 250’s CEO traveled to the World Economic Forum in Davos to solicit donations from foreign government officials and business leaders. The Trump administration’s proposed rollback of gun regulations would lift the prohibition on mailing handguns to individuals, a significant win for GrabAGun—the direct-to-consumer firearm retailer on whose board Donald Trump Jr. sits and in which he holds a 1.1% ownership stake. GrabAGun currently must rely on a middleman to transfer firearms to customers. Trump’s financial disclosure revealed that he made more than 21,000 securities trades during his first year back in office, growing his investment account to at least $858 million across stakes in around 1,600 companies, compared to the 13 total trades Joe Biden made during his entire presidency. July 4 Nearly 1 million people who bought the president’s meme coin—Trump Coin—collectively lost $3.8 billion on the token, while he walked away with $636 million. July 6 Shares of Dell closed up 4.4% after Trump recommended people buy the firm’s computers during a speech announcing the launch of Trump investment accounts for children, boosting the more than $1 million worth of shares the president owns in the company. July 9 Federal Reserve Chair Kevin Warsh named crypto investor and Trump ally Marc Andreessen to a task force aimed at modernizing the Federal Reserve, including rethinking its approach to inflation—a key factor keeping interest rates elevated. Palm Beach International Airport has officially changed its name to Trump International Airport—a move that will require Florida to pay royalties to the president’s family for licensing his name. I was there a few months ago, during a trip to Barcelona. The sculptures were a revelation, I’d never seen so many together before. Each one has its own personality. Enjoy the good weather, if you are lucky enough to have it. History Will Judge the Complicit The Quintessential Politician Autocracy Inc Open Letters, from Anne Applebaum is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
CIO: Digital transformation depends on strong foundations, unity of purpose
Endeavor Health Chief Information Officer Deb Anderson says lasting innovation requires infrastructure, governance and organizational agility – with technologies working holistically, not individually – before new IT investments can deliver value.
Wall Street goes bowling for profits, driving up the price of a middle-class pastime
Fueled by private equity investments, Lucky Strike Entertainment went on a buying spree and now owns more than 1 in 10 American bowling alleys.
Handover of Health Commodities
Joint Handover of Health Commodities Speech of Chargé d’Affaires Steve Bremner (…) Thank you for joining us. I am here today to demonstrate how U.S. foreign assistance under President Trump’s America First Global Health Strategy and our bilateral health MOU makes America safer and stronger while helping Madagascar build a more self-reliant health system. Through our bilateral Global Health Memorandum of Understanding (MOU) signed in December 2025 with the Ministry of Public Health, our two governments outlined shared priorities and responsibilities, including a strong focus on infectious disease threats and Madagascar’s increasing ownership and co-investment in its own health system. The MOU outlines the structure and terms of U.S. support to Madagascar’s health sector from 2026 through 2030, with a total commitment of $134,305,000 from the U.S. government and $41,216,252 from the Government of Madagascar to work jointly to address malaria, maternal and child health, polio and global health security issues. Stronger health systems help prevent instability and reduce the risk that infectious diseases reach the United States, making both our countries safer. America First foreign assistance is clear and disciplined: It is a tool of strategic engagement, not global charity. Every U.S. taxpayer dollar must show measurable results, reduce long-term dependence on U.S. taxpayer resources, and support greater self-reliance in recipient countries. Support must be efficient and targeted, with zero tolerance for fraud, waste, or abuse. This year, through the U.S.-funded Global Health Supply Chain Program – Procurement and Supply Management project, we are distributing: 989,250 long-lasting insecticide-treated nets, worth $2,000,000 to 63 districts and 1,661 Community Health Centers across Madagascar, with the third and final delivery of these nets having arrived in late June. Through the U.S.-funded Momentum Country and Global Leadership (MCGL) project, we are funding: The full cost of Starlink internet connectivity equipment procurement, installation, and one-year subscription for 31 priority District and Regional Health Offices. Through the U.S.-funded Strengthening Infectious Disease Detection Systems project, we are supplying: 908,523 pieces of critical medical equipment and a modernized digital surveillance system to the Ministry of Public Health. These materials will strengthen health systems, improve response capabilities, and help those most in need of protection from mosquito-borne diseases — particularly malaria, which continues to claim the lives of children and women at an unacceptable rate. Deployed effectively, they will contribute to reducing maternal and newborn mortality in rural and hard-to-reach communities where the need is greatest. In these same underserved areas, Starlink connectivity will play a critical role in enabling the rapid transmission of health data and information to central levels, ensuring that decision-makers receive timely, actionable intelligence and can mount swift, coordinated responses to protect populations. For Americans, this support delivers concrete benefits. Stronger health systems in Madagascar help detect and contain infectious diseases before they spread across borders, protecting American and Malagasy families. More stable, healthier countries can expand trade and economic cooperation with the United States. Our goal is not permanent support; it is temporary, targeted assistance that helps Madagascar save lives while achieving greater self-reliance and independence from foreign assistance. To the health workers and community health agents here that will use the products we’re delivering today: your dedication and skills save lives. Your work exemplifies the kind of local ownership that will enable Madagascar to reduce dependence on foreign assistance and manage the country’s health challenges. This targeted support delivers results today while helping Madagascar build toward a future where it can sustain and expand those health gains independently, ensuring that today’s U.S. support leads to Madagascar’s self-sufficiency. Thank you, Misaotra.
Metaverse Market Surge: Entertainment Industry Set to Quadruple by 2032
The global metaverse in entertainment market is experiencing rapid growth, with its market size expected to soar from over USD 30.6 billion in 2026 to more than USD 121.9 billion by 2032. This expansion is driven by increasing demand for interactive digital experiences and technological investments from gaming, media, and tech sectors. Mixed Reality (MR) devices are predicted to grow the fastest, enhancing digital interactions in gaming, concerts, and sports. North America is a key player, leadi
When regulation is good for business
By now, I think I have established both my view that I am a fan of ESG investing and the benefits of regulating what is and isn’t a sustainable investment, and my view that in Europe, ESG regulation has gone too far and become too costly. It almost feels like the old Aristotelian maxim of doing things in moderation that leads to the best outcomes is valid in regulatory efforts as well. To give you an example, let’s look at a study by the National Bank of Belgium on the impact of the EU’s Sustainable Finance Disclosure Regulation (SFDR) on fund flows of conventional and ESG funds. The SFDR was announced on 27 November 2019 and came into effect on 10 March 2021. It was implemented in several stages and split funds marketed in the EU into three broad categories: (i) Art. 6 funds that are basically conventional funds without any specific ESG integration, (ii) Art. 8 funds that ‘promote environmental or social characteristics’, which must provide additional reporting how they do that, and (iii) Art. 9 funds that are impact funds. The gaps between the announcement and the phased implementation give us an idea of how fund flows were affected by the regulation. It is clearly visible in the figure below that once the new regulation was announced and when it was initially implemented, fund flows in Art. 8 and Art. 9 funds increased significantly. Conventional Art. 6 funds also saw more inflows, but the increase was not statistically significant. I should add that the data below is pure fund flow, cleaned of performance effects and of any reclassified funds that moved from one classification to another. Note also that once the initial rush in ESG funds was over, additional, stricter regulatory requirements didn’t create that many new flows. This implies that with additional regulation, the funds incurred higher costs to comply but didn’t benefit in terms of new inflows and higher assets under management. Fund flows as the SFDR regulation was implemented in the EU Source: Emiris et al. (2026) When examining the drivers of these flows, the authors of the study found that institutional investors were more likely to switch to ESG funds and particularly so in countries where concerns about sustainability are culturally more accepted. In a society where buy-in into environmental and social risks is higher, private investors were shifting more of their assets into ESG funds as the regulation made it clear which funds are really green and which ones are not. And institutional investors in these countries did so as well, given the societal pressures and reputational risks of sticking with conventional funds. Meanwhile, fund managers reacted to the changing regulatory environment as well. Many funds that were mildly green before the regulation was announced became greener and more sustainable as the regulation was introduced to attract new assets and new investors. Cleverly, and unsurprisingly, these ESG funds also charge on average higher fees, which means that not only did fund managers gather fresh assets, but their profitability increased as well.
EDCMC celebrates with Salute to Business Awards on July 29th-DEADLINE for tickets is this Thursday 7/16-see below for details
MICHIGAN CITY, Ind. – The EDCMC team will be celebrating milestones, investments, impactful leaders and community-changing projects at the Salute to Business Awards July 29 at the Blue Chip Casino Hotel & Spa. The Economic Development Corporation Michigan City will be honoring businesses that are marking significant anniversaries, those that have invested in Michigan City and transformations of existing buildings that have led to a new chapter. Economic Development Leadership and Lifetime Achievement awards will spotlight individuals who are elevating economic development by sparking momentum and cultivating a strong foundation. “Our awards are a platform to celebrate our
Trump Accounts architect on auto-creating accounts for millions
Investor Brad Gerstner said Trump wants up to 70 million children auto-enrolled in the investment accounts "to make sure no child is left behind."
LSSU receives historic $30 million state investment to transform science center
SAULT STE. MARIE, Mich. – Lake Superior State University has received a $30 million capital outlay appropriation in the State of Michigan’s Fiscal Year 2027 budget to support the renovation and expansion of LSSU’s Center for Applied Science and Engineering Technology (CASET). The appropriation marks the largest capital outlay investment in LSSU history and a […]
Ohio ranked No. 1 state for business by CNBC in 2026
Ohio earned the top spot in CNBC's 2026 Top States for Business rankings, with the network citing the state's low business costs, strong infrastructure and workforce investments.
I traded investment banking for vacation rentals to be a good dad
A former banker explains why he left Wall Street — disappointing his immigrant parents — to build a vacation-rental business.
Health Investments Reverberate throughout Our Nation
Guest Opinion At the heart of the Cherokee story is an innate commitment to community. It’s the background rhythm that connects every Cherokee Nation citizen. Gadugi, our word for working together for the common good, is a part of our nature. Gadugi, itself, is unquantifiable. We can’t measure it directly. But when we look at […]
How Burry’s Prediction-Market Bet and New Products Will Impact Flutter Entertainment (FLUT) Investors
Recently, reports emerged that Michael Burry has taken positions in DraftKings and Flutter Entertainment, framing them as a regulatory-focused investment amid growing attention on prediction markets as competitors to traditional sportsbooks. Flutter Entertainment’s work on its own prediction-market products highlights how the company is actively preparing for possible shifts in how sports-related wagering and forecasting are regulated and offered. We’ll now examine how Flutter’s...
Virginia Climbs to No. 3 in CNBC's 2026 Top States for Business — Here's What Moved the Needle
Gov. Spanberger credits strategic investments and affordability gains, while a methodology change rewarding infrastructure does some of the heavy lifting.
New Mexico behavioral health committee signs off on $8M plan for northern region
The committee tasked with overseeing the repair of New Mexico's behavioral health system approved the second of 13 regional plans.
b1Bank acquires Baton Rouge-based financial consulting firm
American Planning Corporation will become a part of Smith Shellnut Wilson, Business First’s investment advising arm.
MAGA's attack on science is even worse than it looks
In my post on America’s 250-year anniversary, I argued that respect for the individual was the “secret sauce” in the U.S.’ long-lasting preeminence among nations. But it was certainly not the only factor. There were plenty of institutional innovations that helped the U.S. stay on top — economically, militarily, and in terms of the attractiveness of its society. One of these was American science. Today we take things like the modern research university, government grants for science, public-to-private research spinoffs, etc. for granted, but a lot of that infrastructure wasn’t there before World War 2. It was either invented or scaled up massively by the U.S. government in the postwar period, led by far-sighted scientist-bureaucrats like Vannevar Bush (pictured above). If you want to read about this history, a good place to start would be Jonathan Gruber and Simon Johnson’s excellent book Jump-Starting America. Those scientific institutions didn’t exist in a vacuum, however. They were backed by the U.S. government’s abiding faith in the power of science — and, even more fundamentally, by deep popular trust in the scientific enterprise. Science gave us radar and the atom bomb in wartime, and in peacetime it gave us plastics, vaccines, cheap food, and a thousand other things that made our lives easier. Science was also the driver behind American industry — chemicals, aerospace, telecommunications, computers, electronics, and so on. We owed science our jobs, our livelihoods, our comfortable living standards, and our greatness and power as a nation. It’s little wonder that both political parties, even as they fought viciously over other issues, were steadfast in their support of science. For a long time, the only people who distrusted science were a hippie fringe on the left who disliked modernity (or thought they did, anyway), who also disliked American industry and American power, and who subscribed to an early version of degrowth environmentalism. America’s scientific enterprise is still strong, especially compared to the systems in Europe, Japan, Korea, and other developed countries. It has lost a lot of ground to China in a relative sense, but a lot of that is because of China’s incredible growth; as China has poured untold amounts of money and talent into its research labs, spending and output have overtaken the U.S. by some measures. There are a few ways in which China’s rise creates problems for American science — for example, top scientists can choose to work in China instead of in the U.S. — and of course there’s the concern that China’s technological strength will help its military to reign supreme. But overall, China’s rise in science should be good for American science, since American scientists can use Chinese discoveries for free and build on them. The much bigger problem is that the scientific enterprise America built during and after World War 2 is now being threatened with absolute decline. The biggest problem, of course, is that much of the country — the Republican half — has basically lost faith in the scientific enterprise. To what degree this loss of faith is justified is an open question, and deserves to be discussed openly. But the larger point — that the system that powered American dominance is under threat — is true either way. Most Americans still trust science, but MAGA Republicans don’t There’s a myth, popular in right-wing circles, that scientists have lost the trust of regular Americans — either due to the increasingly left-wing composition of academic departments, or to misbehavior during Covid, or to DEI-related research taking over science, etc. This also fits with a wider narrative that Americans are losing trust in all of our institutions. But it just isn’t true. Poll after poll shows that on the whole, Americans still trust scientists and want to spend more on science. For example, here’s a Pew poll from late 2025 showing that although about a fifth of Republicans did lose confidence in science in 2020, two thirds still have at least “a fair amount” of confidence: That same poll found that scientists are among America’s most trusted groups — even better trusted than the military! In fact, Americans trust scientists more than people in most other countries do. Other polls show that although Republican trust in science has dropped somewhat, Republican support for spending more on science remains very strong: A Pew poll in 2023 found the exact same thing: So when MAGA types tell you about scientists losing their credibility, or a drop in trust in science, they’re only talking about themselves. Whatever left-wing politicization of science happened during the Biden administration — and there was definitely some of that — it was not enough to make most Republicans lose faith in the scientific enterprise, or favor research cuts in order to purge unwanted ideology from the system. That doesn’t mean I think progressives should continue down the path of politicizing scientific research. They should not, and Biden made real missteps in this area. Objectivity clearly matters for public trust of science in the long term. But as of right now, there’s no crisis of trust in science, except among the smallish minority of people who are running around screaming that there’s a crisis of trust in science. But despite science’s overwhelming popularity and public trust, Trump and his administration are launching an unprecedented and devastating attack on American science — cutting funding, and forcing science projects to undergo ideological review by government commissars. Trump’s comprehensive attack on science
Germany's lower house of parliament passes healthcare reform
Germany's lower house of parliament on Friday approved a bill to overhaul the creaking health insurance system that has drawn fierce opposition from drugs companies which fear tougher pricing measures will harm profitability and reduce investment.
Arkansas small business owners detail plans for growth, investment
U.S. Bank's fourth annual Small Business Perspective survey, released at the end of June, highlighted the resilience of Gen Z business owners and the industry's technology-driven future.
CNBC names Ohio the top state in America for business for the first time
Ohio has been named America’s Top State for Business in 2026, a first-time No. 1 finish that state leaders say reflects years of investment aimed at attracting
A 58-year-old Texan bet $430,000 of retirement funds on a golf franchise — and the business was profitable in one month
From boredom in retirement to the pursuit of higher investment returns, older Americans are launching businesses instead of settling into traditional retirement.
Globavend Expands Entertainment Business Through Strategic Investment in MAMAMOO 2026 WORLD TOUR <4WARD> Hong Kong, Securing Participation in Concert Economics
Investment strengthens company's live entertainment presence and advances its AI-powered digital entertainment strategy...
MLS’ Newest Billionaire Owner Thinks Investors Can Do Better Than Buying A Sports Team
Months after spending hundreds of millions of his own cash to buy Sporting Kansas City, wealth advisor Peter Mallouk says he still prefers stocks as an investment.
SKF eyes role in humanoid robotics business
SKF is looking to work its way into the expanding Chinese robotics market with a recently announced agreement with Leaderdrive (LD), a global manufacturer specializing in precision robotic components. The companies are working together on a venture in China focused on high-precision transmission components for robot joints. SKF officials said the investment is a step […]
NAVER D2SF Invests in 23i, a Virtual Entertainment Startup
NAVER D2SF, the corporate venture capital arm of NAVER, has made a new investment in 23i (CEO, Hyungmin Kim), a virtual entertainment startup. As the global virtual entertainment market continues to grow rapidly, particularly in Korea and Japan, NAVER D2SF decided to invest in the team based on its ability to create expanded entertainment IP through strong content production capabilities and an in-house technology pipeline designed to maximize the strengths of virtual artists.
State officials highlight housing investments following deadly Knights Inn fire
State Sen. Lea Webb and Assemblywoman Donna Lupardo on Wednesday discussed concerns with the housing issues in Broome County.
Holland packaging company buys former Howard Miller Clock facility for $15.9M
Coastal Container plans to use the facility to meet ongoing growth as it makes other investments.
Justin Ishbia’s Shore Capital buys employee benefits firm in healthcare push
Chicago-based Shore Capital has raised more than $2 billion for healthcare investments since 2024.
Illinois Surpasses 1,000 Certified Peer Professionals, Marking Major Milestone in Behavioral Health Workforce Growth
State’s peer workforce growth was supported by investments in peer recovery support services and the CRSS Success Program
HSBC opens review of Turkish retail and business banking operations
The assessment does not cover wholesale banking operations, including investment banking.
Apple to invest $30 billion in US chip manufacturing
Apple announced it is investing more than $30 billion in chip manufacturing in the U.S. that will produce a whopping 15 billion chips as part of its $600 billion long-term investment within America.
Ascension to buy Tennessee hospital as part of a $1B investment deal
One of the largest nonprofit health systems in the country is set to buy Williamson Health, a Tennessee-based regional hospital and provider network. If approved by regulators, the transaction could be finalized sometime next year.
Martin County and ECU Health celebrate progress toward re-establishing essential health care services in Martin County
Martin County and ECU Health are celebrating investments included in the State Budget to support access to essential health services in eastern North Carolina.
Explaining The Comcast and NBCUniversal Divorce
(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) I hope everyone had a happy Fourth of July in America, celebrating the country’s 250th birthday. Frankly, I am bummed the 250th wasn’t a bigger celebration, but that’s a different topic for a different Substack. While it was generally a quiet week on the entertainment/streaming/media business fronts, we still had some interesting news stories. Actually, that kinda undersells one of the stories, a huge, huge, huge divestment that could upend the entertainment landscape... So let’s get right to it. In today’s column, I’ll cover Comcast spinning off the rest of NBCUniversal, an entertainment company investing in an LLM company and an LLM-owner investing in a movie studio, the latest round of threats of digital tariffs, and more. Let’s dive in. Subscribe Most Important Story of the Week - Most: Comcast/NBCU Breakup!!!! If I had to describe my reaction to Comcast spinning out NBCUniversal, it feels like a relationship ending, either breaking up or divorcing. Comcast’s decision to spin off the rest of NBCUniversal, after spinning off some of its cable assets into Versant last year, really does feel like a family breaking up under “irreconcilable differences”. Of my stereotypes of the entertainment moguls, my go-to for Comcast CEO Brian Roberts—heir to the Comcast fortune, but a man who’s been at the helm for 24 years now, and president for twelve years before that—is that he likes building empires. He cut his teeth acquiring cable rivals in the 1990s and tried to buy Disney repeatedly, then settled for NBCUniversal after a long court battle. (Contrast this with Rupert Murdoch, a man who also loved to buy, but would also sell when the price is right. Murdoch made Fox out of nothing, but then sold 20th Century Fox to Disney, arguably at the top of the market. So I understood why he sold.) But I don’t understand Roberts’ motivation to sell now. I have some explanations but no single, super-satisfying explanation. Strategically, it would just make more sense to have kept NBCUniversal in-house, especially for a one-time empire builder like Comcast. Yet one powerful force—arguably the decider in modern capitalism—likely overwhelmed all other considerations. At first, I thought I’d arrange my thoughts as a “Five Why” analysis, digging through each layer of the puzzle. But instead, I found myself asking, “But…why?” (And I only ended up with four sections.) So let’s look at Comcast from that angle. Then, at the end, I’ll give my biggest strategic recommendation for every company in Hollywood. It’s obvious, but sometimes, the obvious strategy is the most ignored. But…Why? The Stock Market, Conglomerations, and Sum of the Parts Analysis We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… Why Comcast could never get a “tech company” valuation The not-so-secret motivation for Comcast What Versant has to do with all of this The key strategic advice I think every entertainment exec should follow (though it’s really obvious) Some big AI investment news… Whether we’ll see digital tariffs… And more… ...please subscribe! We can only keep doing this great work with your support.
Ask an Antelope: Sara Bruner helps students discover healthcare careers
"Investing in health science education is an investment in the future health and well-being of our state."
Rahm Emanuel to denounce Netanyahu during Tel Aviv speech as American politics shift against Israel
According to remarks obtained by The Associated Press, Emanuel on Wednesday will criticize Israeli Prime Minister Benjamin Netanyahu for leading Israel to a "dead end" and say unconditional U.S. support has been a mistake.
Make the Business Case for Your Sustainability Initiative
Sustainability proposals often stall not because they lack merit, but because they are framed in a language that does not match how senior leaders allocate capital. While CSOs tend to emphasize impact, materiality, and disclosure, CFOs and CEOs need to understand cash flow, risk, and return. External reporting frameworks are useful for accountability, but they are poorly suited to internal investment decisions, which require project-level comparisons rather than aggregated enterprise metrics. Sustainability investments should therefore be evaluated like any other investment: by showing how they reduce current costs, avoid future costs, generate new revenue, or protect existing revenue. Strong cases begin with a clear business story that links the proposed action to a specific business impact and cash-flow outcome, then quantify what can credibly be quantified while treating harder-to-measure benefits as either upside or an explicit strategic bet.
News | Live Nation buys land in Dublin Docklands for live entertainment venue
The near three-hectare site was purchased with Oak View Group and Gaiety Investments
Thousands of acres, billions in investment: What's next for RiverPlex MegaPark?
The RiverPlex MegaPark is still years away from reaching its full potential, but the foundation is being laid for what could become one of the Gulf Coast’s largest industrial hubs, according to Ascension Economic Development Corporation President and CEO Kate MacArthur. With roughly $10 billion in announced investment already committed and thousands of acres still […]
CaroMont Health Opens CaroMont Hematology & Oncology in Belmont
CaroMont Health has opened CaroMont Hematology & Oncology in Belmont, expanding access to cancer and blood disorder care across the region. Located in the CaroMont Health Medical Pavilion on the campus of CaroMont Regional Medical Center in Belmont, the practice offers physician visits, infusion therapy and laboratory services in one convenient location, along with comprehensive hematology and medical oncology care including chemotherapy, immunotherapy, targeted therapy, hormone therapy and survivorship support. The opening is part of CaroMont Health's $200 million investment in cancer care, the second largest investment in the health system's history, which will double its oncology capacity across the region.
Meet Naomi Osaka’s Business Partners Behind Her Wimbledon Comeback
Naomi Osaka has returned to IMG while continuing to build Hana Kuma, KINLÒ and an investment portfolio spanning sports and startups.
Safety Is Everybody's Business
Safe communities don't happen by chance. From business investment to neighborhood design, every sector has a role to play in creating places where people and economies thrive.
Molasky Family Gift Names Lee Business School's Department of Economics and Real Estate
UNLV’s first named academic department honors the Molasky family’s decades-long connection to the university; reflects investment in students, faculty, and region's future.
New disease threats follow Trump administration's health program cuts
The Trump administration has cut investments in programs and agencies that prevent, track, and respond to health hazards.
Opinion | Trade Uncertainty Is Bad for Business
The Trump administration’s failure to renew the U.S.-Mexico-Canada pact in its current form is a gift to lobbyists and will discourage investment.
How New York’s ‘summer camp kings’ left Israeli investors burned
Simad Holdings Simad leapfrogged over a long series of watchdogs without difficulty and won the confidence of some of Israel's biggest investment managers.
Ukraine recovery: International Coalition for Science, Research and Innovation signs Gdansk Declaration
On 26 June, the first-ever High-level Steering Committee of the International Coalition for Science, Research and Innovation in Ukraine signed the Gdansk Declaration during the Ukraine Recovery Conference in Poland. The Declaration outlines a shared ambition to support Ukraine in increasing its research and development investment to 3% of the GDP following the end of Russia’s full-scale war of aggression. This is in line with the European Research Area target. It also outlines various activities that Coalition members can implement to achieve this objective. The Declaration further provides a strategic framework for the Coalition’s work to support Ukraine’s modern and
Mubadala Opens $25 Billion Credit Business to Outside Investors
Abu Dhabi’s Mubadala Investment Co. is opening up one of its largest investment businesses to outside investors for the first time, betting on its ability to attract institutional capital as demand for alternative lending rises.
Free ‘Finding Financing for Your Small Business’ workshop coming to Carbondale July 16
Champion Community Investments will host a free workshop in Carbondale for entrepreneurs and small business owners on July 16.
Jaguars’ QB Lawrence Outperformed His Salary Last Season
An MVP finalist campaign and elite efficiency metrics prove Jacksonville’s $275 million investment is paying off as the star signal-caller climbs into the league’s upper echelon of quarterbacks.
EasyJet agrees to £5bn takeover by US investment firm
Agreement in principle with Castlelake follows several rejected offers and means UK’s biggest low-cost carrier will be taken private
Connections: Steve Toth appointed Thrilled Land company president
Cave Springs-based Thrilled Land Investments LLC, parent company of Leadership Properties and Thrilled Home Builders, recently named Fayetteville business leader Steve Toth as the company’s first president. Toth has more...
SoFi (SOFI) Launches AI Investing And Small Business Loans In Product Push
SoFi Technologies (NasdaqGS:SOFI) has launched Composer by SoFi, an AI-powered investing platform designed to help members build and automate customized investment strategies. The company has also introduced SoFi Small Business Loans, a digital-first lending product aimed at giving entrepreneurs faster access to capital with no fees. These product rollouts expand SoFi's presence in AI-driven investing tools and small business lending within its broader financial services platform. SoFi...
Booz Allen Hamilton (BAH) to Buy Ultra I&C Mission Solutions Business for $720 Million
Booz Allen Hamilton Holding Corp. (NYSE:BAH) is one of the 12 best industrial stocks with more than 50% upside. The company’s acquisitive growth strategy is making it a compelling investment case. On June 22, Booz Allen Hamilton Holding Corp. (NYSE:BAH) signed a definitive agreement with an Advent portfolio company, Cobham Ultra Group, to purchase its […]
89 Percent — And a Reminder of What Science Can Do When We Pay For It
A century of work, and finally a shot that protects against one of the world's great killers of children. That is not luck. That is investment. Every once
Watch Ebola Crisis Exposes Congo's Fragile Health System
Daniele Nyirandutiye, Senior Fellow at the Center for American Progress, discusses how the Ebola outbreak in Congo exposed critical weaknesses in healthcare and why long-term investment is essential.
Knicks Success Assert Madison Square Garden Sports Corp. (MSGS) as a Top Stock to Buy According to Ariel Investments
Madison Square Garden Sports Corp. (NYSE:MSGS) is one of the top stocks to buy according to Ariel Investments. On June 23, Susquehanna reiterated a Positive rating on Madison Square Garden Sports Corp. (NYSE:MSGS) and raised the price target to $430. The new price target represents significant upside as the stock is trading at about $403 […]
Solid Growth Prospects Assert Sphere Entertainment Co. (SPHR) as a Top Stock to Buy According to Ariel Investments
Sphere Entertainment Co. (NYSE:SPHR) is one of the top stocks to buy according to Ariel Investments. On June 18, Benchmark reiterated a Buy rating on Sphere Entertainment (NYSE:SPHR) and raised the price target to $175 from $155. The price target hike comes amid expectations that the company is well positioned to deliver a solid second […]
Madison Square Garden Entertainment Corp. (MSGE) To Remain Fully Operational Amid New York Penn Station Redevelopment
Madison Square Garden Entertainment Corp. (NYSE:MSGE) is one of the top stocks to buy according to Ariel Investments. On June 9, Madison Square Garden Entertainment Corp. (NYSE:MSGE) entered into a non-binding agreement with Penn Transformation Partners for the development of the New York Penn Station. Under the terms of the agreement, Madison Square Garden will […]
Securing a high-character goldmine preserves Cowboys draft investment
It is still unbelievable that Caleb Downs fell to the Cowboys.
Final State Budget Brings $5M for New Behavioral Health Pilot to Central Coast
The State budget includes a one-time $5 million investment for CenCal Health and the behavioral health departments of both Santa Barbara and San Luis
Microsoft launches AI-focused professional services business with $2.5B investment
Microsoft launches AI-focused professional services business with $2.5B investment - SiliconANGLE
What Makes Live Nation Entertainment (LYV) a Good Investment Bet?
TimesSquare Capital Management, an equity investment management company, released its “U.S. Mid Cap Growth Strategy” first-quarter 2026 investor letter. A copy of the letter can be downloaded here. The Strategy fell 7.72% (net) in the quarter compared to -6.35% for the Russell Midcap Growth Index. In the first quarter, markets navigated geopolitical tensions and economic resilience alongside […]
Microsoft Frontier Company: AI engineering that amplifies and protects your intelligence
The pace of AI adoption is moving incredibly fast. Customers have moved well beyond experimentation and understand the importance of adopting AI to transform their business. They are now concentrating on delivering measurable business outcomes and demonstrating a return on their AI investments, while ensuring their intelligence is amplified and their IP is protected. Today...
U.S. Healthcare Spending’s Meager Return On Investment
The U.S. spends a lot on healthcare — in terms of total and per capita expenditures and patient out-of-pocket costs — but gets a relatively poor return on its investment.
Why Norma Kamali Swapped Fashion Shows for Team Fitness
The New York-based designer says free exercise classes are an investment in her team’s mental health and her brand’s resilience.
4 tech stocks that can weather an upheaval in the AI trade
Ben McMillan, IDX Advisor's chief investment officer, said of his clients are growing wary of a sea change in the AI trade.
How Investors May Respond To PENN Entertainment (PENN) Aurora Casino Opening And Russell 2000 Shift
PENN Entertainment recently celebrated the grand opening of its new US$360 million Hollywood Casino and Hotel Aurora in Illinois, while also being moved from the Russell 1000 family of indices into the Russell 2000, Russell 2000 Value, and Russell 2000 Dynamic indices as part of the latest rebalancing. This combination of a large-scale brick-and-mortar investment and a shift toward small-cap and value-oriented index inclusion reshapes how both fundamental and index-tracking investors may...
BlueCrest warns UK is bad for business after losing £200mn tax battle
Investment firm says country ‘no longer a serious contender’
Halogen Ventures founder Jesse Draper shares her daily routine
Jesse Draper, founder of Halogen Ventures, shares her Santa Monica routine, managing investments and family while advocating for female entrepreneurs.
Xbox ends deal to fund and publish IO Interactive's Project Fantasy; redundancies expected
Developer says it must "adapt to new reality" as Xbox reshapes investment priorities
Trump made hundreds of millions from cryptocurrency ventures in first year back in office
President Donald Trump collected billions of dollars through an array of cryptocurrency holdings, royalty payments and property investments last year, according to his latest annual financial disclosure released on Tuesday.
South Fulton leaders hopeful new investment will address crucial healthcare gap on Atlanta's south side
For decades, residents and officials alike have raised the issue regarding limited access to hospitals and specialty care in South Fulton. Now, county leaders and health officials are earmarking funds to address the situation.
Private equity in youth sports draws bipartisan scrutiny in Congress
Democratic and Republican Congress members expressed alarm at the trend of private equity investment in youth sports.
FMOL Health pegs Cancer Institute investment at $70M, shares timeline
FMOL Health expects to invest roughly $70 million to transform the former Bone & Joint Clinic of Baton Rouge building into a new home for the Our Lady of the Lake Cancer Institute, according to E.… Already an INSIDER? Sign in. Already an INSIDER? Sign in
Jon and Mindy Gray Bet on AI Science Research to Prevent Cancer
Blackstone Inc. President Jon Gray has steered his firm to more artificial-intelligence investments, and the same is true with his science philanthropy.
Meitav Investment House Announces Immediate Report Concerning Selected Business Data for May 2026
/PRNewswire/ -- Meitav Investment House (TASE: MTAV) announced today that further to the Company's immediate report dated March 2, 2026 (Reference No....
RWJBarnabas Health Invests $1.7 Million to Support Community Health Initiatives in Hudson County
On June 16, 2026, RWJBarnabas Health announced a combined $1.7 million investment to support local organizations working to address barriers to care, food insecurity, and economic stability among underserved communities in Jersey City and Hudson County.
Gov. Laura Kelly surveys landscape as she exits government service, points to unfinished business
Term-limited Gov. Laura Kelly celebrates work on priorities of economic development, fiscal stewardship and investment in early-childhood development.
Talawar Therapeutics and JATT II Acquisition Corp. Announce Definitive Business Combination Agreement to Create Publicly Listed Biotechnology Company Developing Potentially Best-in-Class Bispecifics for I&I Diseases
Oversubscribed $225 million concurrent private investment in public equity ("PIPE") with available cash to the combined company at closing anticipated to fund...
Investor Clive Meanwell on designing biotechs for population health, and AI's role as a catalyst
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AI scientist company Edison Scientific tapped by team behind Metsera to create new biotechs
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India’s Yash Raj Films Backs Rusk Media in Vertical Entertainment Push (EXCLUSIVE)
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Meaningful Outcomes Determine the Winners of the Health AI Race
Global investment in healthcare AI exceeded $18 billion in 2025, yet health systems still lack a shared understanding of the outcomes that investment should deliver. This paper argues that success in the health AI race will be determined not by technological sophistication but by which systems first identify and pursue the outcomes that matter most to patients, professionals and health systems. Without a shared language for defining and measuring what healthcare AI should deliver, systems risk optimizing for what is easiest to count rather than what matters most. This paper provides a framework for ensuring AI investment translates into real value for healthcare systems and the populations they serve.
“Toy Story 5 ”soars past “Supergirl”'s bumpy $38 million takeoff at the box office
D.C. and Warner Bros. were hoping for a $50–55 million return on their $170 million investment into the standalone supheroine flick.
I Put Apple CarPlay In My Wife's 2006 Toyota 4Runner And I'm Never Looking Back
Despite its 300,000 miles we're not getting rid of the 4Runner anytime soon, so it was worth making a small investment to bring its infotainment into the 2020s.
Investment in Israeli health tech startups dove 40% in 2025
Data shows that while the global industry saw a resurgence in private funding, investments in Israeli startups hit a five-year low amid geopolitical uncertainty
Best investments over the past 100 years? Almost all are tech companies
Most of the top performers are tech companies, headed by Apple, Nvidia and Microsoft.
How PENN’s US$360 Million Aurora Resort Shift At PENN Entertainment (PENN) Has Changed Its Investment Story
PENN Entertainment has opened the US$360 million Hollywood Casino and Hotel Aurora, replacing its former Fox River riverboat with a 388,500-square-foot, 24/7 land-based resort featuring over 1,000 slots, 50 table games, a sportsbook, 226-room hotel, spa, event center, and extensive dining options. The Aurora project, which created around 700 permanent roles and mirrors PENN’s broader shift into higher-amenity land-based properties, highlights how the company is reinvesting heavily to refresh...
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
How to manage public investment in science with balance
Public debt is higher today and growing at a faster rate than before the pandemic in 80% of the world's economies. According to the latest fiscal report from the International Monetary Fund, global public ...
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.