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Cracking a smile can boost health–experts

And rather than wait for a reason to smile, just making the physical change of literally turning that frown upside down could impact emotions

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Oct 26 • 9:20 AM EDT • Health • globalnation.inquirer.net
Serbia’s strongman leader Vucic concedes defeat to student-led movement in seismic political shift

It was a seismic political shift in the Balkan country where Vucic led with virtually absolute power for 14 years.

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Oct 25 • 5:42 PM EDT • Politics • cnbc.com
Aleksandar Vucic concedes defeat in Serbia's parliamentary election, marking political shift

Aleksandar Vucic, who denounced the oppositional student movement as a foreign-led attempt to unseat him, led with virtually absolute power for 14 years.

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Oct 25 • 5:30 PM EDT • Politics • cbsnews.com
Deep dive High-Signal Publisher
😐 Neutral (1%)
wow
56%
love
44%
Everton’s five-game winning home run ended by Aston Villa

Everton’s five-match winning run at Goodison Park has come to an end with Aston Villa running out 3-2 winners on Merseyside this afternoon.Brian Sørensen enjoyed a successful return to his former c...

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Oct 25 • 5:10 PM EDT • Sports • sports.yahoo.com
🙂 Positive (50%)
Scientists trapped antimatter particle for months -- but studying it without blowing up lab was a challenge
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Oct 25 • 5:07 PM EDT • Science • nypost.com
Is an Academy of Natural Sciences divorce coming?

Hearings for the museum are coming Monday. Will it make a difference?

inquirer.com logo
Oct 25 • 5:01 PM EDT • Science • inquirer.com
Volkswagen Bet On Xpeng To Save Its China Business, But Buyers Aren't Showing Up

Volkswagen once dominated China’s automotive market, but the rise of domestic electric vehicle manufacturers has turned its fortunes upside down. Hoping to regain lost ground, the German automaker partnered with Chinese EV specialist Xpeng in ... Read more

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Oct 25 • 5:00 PM EDT • Business • finance.yahoo.com
Packers' top two centers are questionable to return
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Oct 25 • 4:59 PM EDT • Sports • sports.yahoo.com
British Columbia's new premier lucks into the job in unexpected political turn

An electoral gamble by the Canadian province's outgoing premier, David Eby, backfired as the provincial Conservatives take power for the first time since 1928.

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Oct 25 • 4:58 PM EDT • Politics • yahoo.com
BC's new premier lucked into the job in an unexpected political turn

An electoral gamble by the Canadian province's outgoing premier, David Eby, backfired as the provincial Conservatives take power for the first time since 1928.

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Oct 25 • 4:58 PM EDT • Politics • bbc.com
🎥 Kylian Mbappé's lucky goal against FC Barcelona

Kylian Mbappé opened the scoring against FC Barcelona this Saturday, October 25.A truly unexpected goal.With both teams looking sluggish from the start, it took until the 42nd minute for the deadlock...

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Oct 25 • 4:52 PM EDT • Sports • sports.yahoo.com
🙂 Positive (33%)
Vučić concedes defeat in Serbian elections, says student movement won

The election was seen as a referendum on Vučić’s political dominance and the political system that has been in place in Serbia for more than a decade.

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Oct 25 • 4:51 PM EDT • Politics • euronews.com
Kenilworth's David Brearley 2026 Homecoming Photo Album

KENILWORTH, NJ – The Homecoming Dance was held on Friday, Oct. 16, and students were filled with energy and excitement as they left for the annual occasion held at David Brearley.To preserve the...

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Oct 25 • 4:48 PM EDT • Entertainment • tapinto.net
Ravens surrender 35 unanswered points in stunning loss to Bengals

Baltimore squandered a 13-0 halftime lead as Joe Burrow threw four touchdown passes and Cincinnati handed the Ravens a 35-13 defeat

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Oct 25 • 4:33 PM EDT • Sports • sports.yahoo.com
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A YouTuber dissected an iPhone Duo and thinks he found the cause of crackgate

A weak spot in the hinge may be failing and cracking iPhone Duo screens.

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Oct 25 • 4:16 PM EDT • Technology • theverge.com
When will Myles Garrett return to the Rams?

Here's the latest on Myles Garrett as he continues recovering from early-season knee surgery.

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Oct 25 • 4:06 PM EDT • Sports • sports.yahoo.com
🙂 Positive (80%)
love
100%
Is the Big 12 a two-bid CFP league? + 2-loss SEC playoff hopes + Lincoln Riley’s future at USC
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Oct 25 • 4:05 PM EDT • Sports • sports.yahoo.com
Sharpen memory and fight brain fog with simple 60-second trick from a neurologist

Dr. Rhonda Voskuhl explains why crosswords and sudoku miss the mark for brain fog and which timed word games actually target verbal memory loss.

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Oct 25 • 4:02 PM EDT • Health • foxnews.com
Tampa technical institute expands bilingual health care career training

Aguilas International Technical Institute has opened a larger Tampa facility, expanding bilingual career training as health care demand grows locally.

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Oct 25 • 3:57 PM EDT • Health • baynews9.com
Ex-Spur Jeremy Sochan becomes a Legend

The Dallas Legends used the top pick in Saturday's G League draft on Sochan, who will look to salvage an NBA career that has not gone as expected for the former lottery selection.

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Oct 25 • 3:53 PM EDT • Sports • sports.yahoo.com
Photo: Jude Bellingham’s head-turning new boots for Barcelona showdown

Real Madrid star Jude Bellingham has on Sunday evening provided a look at the head-turning footwear that he is set to make use of in El Clásico.The latest edition of Spanish football’s most bitter ...

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Oct 25 • 3:45 PM EDT • Sports • sports.yahoo.com
Primark's Business Doesn't Make Sense

In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot

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Oct 25 • 3:31 PM EDT • Business • finance.yahoo.com
Big Las Vegas show closures mark a transitional time for Strip entertainment

The culture of Las Vegas is inextricably linked to the artists and technicians behind the Strip’s vibrant live entertainment industry, so any time a show closes

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Oct 25 • 3:30 PM EDT • Entertainment • cdcgaming.com
😐 Neutral (2%)
ahah
55%
wow
45%
When will Jeremiyah Love return to the Cardinals?

Here's the latest on Jeremiyah Love's status for the rebuilding Cardinals.

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Oct 25 • 3:20 PM EDT • Sports • sports.yahoo.com
‘I was doing all the right things': What one survivor's diagnosis reveals about breast cancer risk

A new survey and a survivor's experience reveal a gap between what women think puts them at risk and what actually does.

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Oct 25 • 3:20 PM EDT • Health • nbcmiami.com
USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again

Both the USC Trojans and the UCLA Bruins had their rankings in the Associated Press Top 25 poll following their results from Saturday. View this post on Instagram A post shared by LA Sports Report (@lasportsreport) What Happened to USC’s Ranking? Following their loss to Wisconsin on Saturday, USC dropped out of the Top 25. […] The post USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again appeared first on LA Sports Report.

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Oct 25 • 3:07 PM EDT • Sports • sports.yahoo.com
Halloween evolved as a Frankenstein of cultural celebrations

The holiday has origins in Celtic, Roman and Catholic festivals and feasts, and mixed with other traditions as it spread.

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Oct 25 • 3:00 PM EDT • Entertainment • theshorthorn.com
Christian McCaffrey able to return to Week 7 game

49ers RB Christian McCaffrey returns to Week 7 game after missing time with thigh issue

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Oct 25 • 2:56 PM EDT • Sports • sports.yahoo.com
After arts festival, San Francisco's Mid-Market businesses look for signs of a turnaround
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Oct 25 • 2:54 PM EDT • Business • cbsnews.com
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Elizabeth Holmes film puts up a fight against 'Clayface' at box office

A movie set in the world of Batman and a three-hour documentary about Elizabeth Holmes went head-to-head at the box office this weekend, and it turned out to be a closer contest than expected.

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Oct 25 • 2:50 PM EDT • Entertainment • bellinghamherald.com
Elizabeth Holmes film puts up a fight against 'Clayface' at box office

A movie set in the world of Batman and a three-hour documentary about Elizabeth Holmes went head-to-head at the box office this weekend, and it turned out to be a closer contest than expected.

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Oct 25 • 2:50 PM EDT • Entertainment • sacbee.com
Heidi Klum frightens fans, teases Halloween costume with bizarre close-up of strange prosthetic

The Queen of Halloween herself Heidi Klum is offering fans a first look at this year’s Halloween costume. As usual, it involves some pretty bizarre prosthetics.

ew.com logo
Oct 25 • 2:37 PM EDT • Entertainment • ew.com
Three Premier League talking points

Michael Carrick was pushed to the brink of the sack by Manchester United's latest debacle on Sunday.AFP Sport looks at three talking points from the weekend's action: Walls closing in on Carrick Michael Carrick's future as Manchester United boss was already hanging by a thread before Bournemouth inflicted what is likely to be a brutal last act for the former England midfielder at Old Trafford.

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Oct 25 • 2:36 PM EDT • Sports • sports.yahoo.com
Alaska Democratic Senate candidate Mary Peltola and her family suffer minor injuries in car crash

Alaska’s Democratic Senate candidate Mary Peltola and her family suffered minor injuries Saturday in a car crash while driving to a campaign stop, her campaign said.

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Oct 25 • 2:30 PM EDT • Politics • news4jax.com
Defender turns striker and scores in Bayern win

Bayern Munich beat Freiburg 3-1 away from home to reclaim top spot in the Bundesliga on Sunday (25).Dayot Upamecano was one of the standout performers, scoring the opener with a move in which he playe...

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Oct 25 • 2:27 PM EDT • Sports • sports.yahoo.com
Opening Odds: Separating the real from the fake

Mizzou returns to action this week, and we’ll learn more if they’re real or fake.

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Oct 25 • 2:23 PM EDT • Sports • sports.yahoo.com
The Future of IBD Treatment: 4 Promising Therapies to Know About

New treatments are in development for inflammatory bowel diseases like Crohn’s disease and ulcerative colitis. Find out what experts say you should know.

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Oct 25 • 2:21 PM EDT • Health • health.yahoo.com
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race

Blanche told CNN's “State of the Union” that President Donald Trump, who said Friday that he was "the one that said do it,” is not trying to overturn state election results “in any way, shape or form” on the cusp of the Nov. 3 election.

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Oct 25 • 2:19 PM EDT • Politics • pbs.org
Ramaswamy built his political career in NH. It's faltering in Ohio.

Many New Englanders remember Ramaswamy from his mad-dash presidential campaign in New Hampshire. Will his political career survive a tumultuous run for Ohio governor?

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Oct 25 • 2:13 PM EDT • Politics • bostonglobe.com
Trump on high gas prices: 'We're making a freaking fortune"

Americans, meanwhile, are paying record prices at the pump, according to AAA.

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Oct 25 • 2:04 PM EDT • Business • businessinsider.com
Inside 26-year-old’s club for million-dollar Chattanooga business owners

At 2nd American Restaurant on Thursday night, around 85 entrepreneurs who have scaled their businesses to at least $1 million in annual revenue sat to a family-style meal of beef cheek roast, airline chicken and the restaurant's signature bowl of mashed potatoes.

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Oct 25 • 2:01 PM EDT • Business • timesfreepress.com
Made in Tarrant: Family turns sports card hobby into baseball stadium business

Rebecca Gallagher and her family opened their business in Choctaw Stadium in Arlington a few weeks ago. They hope it can grow into a place for community.

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Oct 25 • 2:00 PM EDT • Sports • fortworthreport.org
Made in Tarrant: Family turns sports card hobby into baseball stadium business

Rebecca Gallagher and her family opened their business in Choctaw Stadium in Arlington a few weeks ago. They hope it can grow into a place for community.

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Oct 25 • 2:00 PM EDT • Business • fortworthreport.org
Navigating D1 pressure: how student-athletes balance their mental health

Mental health affects everyone, including athletes who have a really good way of hiding it. Research shows that mental health issues affect roughly 39-44% of Division I athletes. Behind game day, good game performance, and navigating life in college, D1 athletes are constantly trying to balance high expectations with their own well-being. It’s not...

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Oct 25 • 1:59 PM EDT • Health • nmsuroundup.com
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine

Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria contracted Ebola.

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Oct 25 • 1:45 PM EDT • Health • seattletimes.com
Uganda tightens Ebola border controls and requires returnees from Congo to pay for quarantine

Uganda is reinforcing existing border controls requiring citizens returning from Congo to undergo 21 days of quarantine at their own expense, the Health Ministry said Sunday, as investigators examine how a woman who traveled from Uganda to Nigeria cont...

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Oct 25 • 1:44 PM EDT • Health • abcnews.com
College GameDay On-Site for Gophers vs Hoosiers

The Minnesota Gophers are coming off a big win over Iowa. And now College GameDay is going with the to Bloomington Saturday for the game @ Indiana.

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Oct 25 • 1:35 PM EDT • Sports • sports.yahoo.com
Steelers Now Postgame: Steelers 16, Saints 10

Pittsburgh Steelers Postgame: Join Alan Saunders and Jobe Morrison after the Steelers’ Week 7 win over the Saints on YouTube, […]

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Oct 25 • 1:18 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
ahah
100%
‘You Can See Everything’ surges with $19.5M at box office; ‘Clayface’ takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

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Oct 25 • 1:17 PM EDT • Entertainment • seattletimes.com
How To Build A Cheap Home Server To Save Money On Subscriptions

You can turn an old laptop, a computer, or even a Raspberry Pi into a cheap media server, but it's best to run a Linux distribution for maximum compatibility.

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Oct 25 • 1:17 PM EDT • Technology • bgr.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KCBS All News 106.9FM and 740AM

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KNSS Radio

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Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

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Oct 25 • 1:16 PM EDT • Entertainment • clickorlando.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday | KMBZ

audacy.com logo
Oct 25 • 1:16 PM EDT • Entertainment • audacy.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday.

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Oct 25 • 1:16 PM EDT • Entertainment • news4jax.com
'You Can See Everything' surges with $19.5M at box office; 'Clayface' takes No. 1

DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s...

stamfordadvocate.com logo
Oct 25 • 1:16 PM EDT • Entertainment • stamfordadvocate.com
'You Can See Everything' Surges With $19.5M at Box Office; 'Clayface' Takes No. 1

NEW YORK (AP) — DC Studios scored a modest, R-rated win with “Clayface,” landing a $24 million opening weekend, according to studio estimates Sunday. But the biggest success story in theaters remained A24’s Elizabeth Holmes documentary “You Can See Everything,” which pulled in $19.5 million in its ...

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Oct 25 • 1:16 PM EDT • Entertainment • usnews.com
What Will It Take for Rockies to Make World Series?

It's been since 2007 for the Colorado Rockies to be a part of the World Series. Is there any hope for a return to the Fall Classic?

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Oct 25 • 1:14 PM EDT • Sports • sports.yahoo.com
Carrick ‘not expecting’ Man United crisis talks despite Bournemouth defeat

Michael Carrick said he is ‘not expecting’ imminent talks about his future despite Manchester United’s latest defeat.Carrick’s position as head coach looks under threat after Manchester United...

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Oct 25 • 1:08 PM EDT • Sports • sports.yahoo.com
Senate rivals seek support from Alaska Native voters

The major candidates in Alaska’s U.S. Senate race are both casting themselves as strong voices on Alaska Native issues as they seek support from the key constituency ahead of the Nov. 3 election

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Oct 25 • 1:03 PM EDT • Politics • latimes.com
'Sound of Music' star Julie Andrews spotted in rare Hamptons outing weeks after turning 91

Julie Andrews, 91, was photographed in the Hamptons wearing a purple raincoat and pink sunglasses in a rare public outing in the coastal city.

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Oct 25 • 1:00 PM EDT • Entertainment • yahoo.com
Oregon fires offensive coordinator Drew Mehringer after team scored just 10 points in loss to Illinois

Saturday's loss marked the third straight game in which Oregon scored under 20 points.

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Oct 25 • 12:57 PM EDT • Sports • sports.yahoo.com
Broncos Place Linebacker, Running Back On Injured Reserve

The Denver Broncos have a fluid injury situation, with Tyler Badie and Jonah Elliss being placed on injured reserve.

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Oct 25 • 12:57 PM EDT • Sports • sports.yahoo.com
Cattle Science Gets a $19.5 Million Upgrade as West Texas A and M Plans High-Tech Research Complex

West Texas A&M is building a $19.5M cattle research complex featuring AI technology, veterinary research and commercial-scale feedlot studies.

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Oct 25 • 12:45 PM EDT • Science • myvetcandy.com
Opposition leader María Machado returns to Venezuela

Machado had left the country just a month before the US government seized Venezuelan President Nicolás Maduro.

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Oct 25 • 12:21 PM EDT • Politics • bbc.com
Lakers’ Injury Report Rules Out Two Players for Jazz Game

Is Walker Kessler available in his return to Utah?

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Oct 25 • 12:21 PM EDT • Sports • sports.yahoo.com
One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie

Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.

yahoo.com logo
Oct 25 • 12:17 PM EDT • Entertainment • yahoo.com
Bloomington business continues to blossom

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Oct 25 • 12:11 PM EDT • Business • insideindianabusiness.com
😐 Neutral (0%)
3 comments | Progressive Democrats are closely watching four Senate...

Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.

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Oct 25 • 12:07 PM EDT • Politics • facebook.com
😐 Neutral (0%)
Buccaneers vs. Panthers Week 7 inactives: Baker Mayfield returns

The Tampa Bay Buccaneers are set to take on the Carolina Panthers Sunday afternoon in a crucial NFC South matchup at Bank of America Stadium in Charlotte. Tampa Bay received some encouraging news ahead of kickoff as quarterback Baker Mayfield is officially active and will start after missing the previous three games with a dislocated […]

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Oct 25 • 12:05 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
In West Maui, Democrat-turned-Republican defends House seat against Lahaina Strong organizer, local business advocate

Incumbent Rep. Elle Cochran, Green Party candidate Pā’ele Kiakona and Democratic nominee Sne Patel are battling to represent West Maui at a pivotal time in the fire recovery.

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Oct 25 • 12:01 PM EDT • Business • mauinow.com
"It never was entertainment to us, ever. It was always something with a lot more importance and meaning." U2 reveal the unbroken promise that they made to one another as schoolboys in Ireland 50 years ago

"Music is not a matter of life and death, it’s something much more serious than that"

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Oct 25 • 12:00 PM EDT • Entertainment • loudersound.com
Political cartoons for October 25

Sunday's political cartoons include increasing costs, the White House briefing room, and more

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Oct 25 • 12:00 PM EDT • Politics • theweek.com
Trick-or-treaters descend on Callow Avenue for Calloween

Photos from Charleston Business District's annual Calloween event on Saturday, Oct. 24. ·

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Oct 25 • 11:57 AM EDT • Business • kitsapsun.com
Liverpool 2, Brighton 0 – Match Recap: That Was Actually Fun

A look back at the key moments in Liverpool's great victory over Brighton in Premier League action.

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Oct 25 • 11:55 AM EDT • Sports • sports.yahoo.com
Selena Gomez's vaping admission highlights hidden health risks doctors say millions face daily

Selena Gomez called vaping "stupid" after it altered her voice, but doctors warn the health risks go beyond vocal cord damage for millions.

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Oct 25 • 11:48 AM EDT • Health • foxnews.com
#ESMO26: Merck and Moderna's cancer vaccine data were 'a triumph of science.' And now, the work begins

Merck and Moderna’s intismeran cut melanoma recurrence risk 42% at ESMO; experts weigh other tumors, manufacturing and boosters.

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Oct 25 • 11:46 AM EDT • Science • endpoints.news
Game Time Thread: Juventus vs. Lecce

MATCH INFO When: Sunday, Oct. 25, 2026. Where: Stadio Via del Mare, Lecce, Italy. Official kickoff time: 6 p.m. local time in Italy and across Europe, 8 p.m. in the United Kingdom, 1 p.m. Eastern time, 12 p.m. Central time, 10 a.m. Pacific time. (Please note that the fall time change in Italy goes into effect on Sunday, […]

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Oct 25 • 11:45 AM EDT • Sports • sports.yahoo.com
How Braves should handle $42 million Jurickson Profar situation

This could be one solution for the Braves.

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Oct 25 • 11:36 AM EDT • Sports • sports.yahoo.com
How Nathan Fielder's cringe-comedy career led him to Elizabeth Holmes

Spoiler alert! We're discussing the themes and structure of the Elizabeth Holmes documentary "You Can See Everything" and touching on a surprising aspect of its second half, so turn away if you want to go in completely cold.

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Oct 25 • 11:34 AM EDT • Entertainment • thenewstribune.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Texas Tech Leads 'Bad' Week 8 for Big 12 Unbeatens

The Red Raiders’ playoff dreams hit a wall in Cincinnati as sloppy play and missed opportunities ended their unbeaten run. The Big 12 race is now more open than ever after surprising finishes elsewhere.

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Oct 25 • 11:28 AM EDT • Sports • sports.yahoo.com
California Politics 360 full episode | Clash over voter rolls heads to court

On Tuesday, one week before the election, a federal judge will determine the next steps.

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Oct 25 • 11:25 AM EDT • Politics • kcra.com
South Texas Health System (@stxhealthsystem)

1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".

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Oct 25 • 11:18 AM EDT • Health • instagram.com
Apple Stores Reportedly Rolling Out New Anti-Theft System for iPhones

Bloomberg's Mark Gurman today reported that Apple is facing a growing problem where some people will buy iPhones or other products and either remove accessories from the box, open up the device and remove components, and/or remove the entire device, and then attempt to return the box hoping that the employee will not notice.

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Oct 25 • 11:18 AM EDT • Technology • macrumors.com
Syria’s Democratic Transition: Building Institutions Alongside Political Competition

Syria’s post-Assad transition has revived debate over when to legalize political parties. Parties are essential to political competition,

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Oct 25 • 11:16 AM EDT • Politics • fairobserver.com
Mystery Ohio news site boosting Ramaswamy's Amy Acton ad tied to California GOP non-profit

As Ohio Republican gubernatorial candidate Vivek Ramaswamy came under fire for releasing an attack ad featuring his Democratic competitor Amy Acton's estranged mother, a mysterious news site was runni...

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Oct 25 • 11:08 AM EDT • Politics • yahoo.com
Their friend died of cervical cancer in 2020. Now, they advocate for women’s health in N.S.

Following the death of their close friend from cervical cancer in 2020, two women in Nova Scotia were left wondering how things might have been different had she been diagnosed earlier. Six years later, they have raised over $4 million to improve technology and infrastructure for women's health.

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Oct 25 • 11:05 AM EDT • Health • cbc.ca
On Christ the King and the idolatry of politics

Editor’s note: This homily was preached on the feast of Christ the King (Extraordinary Form), October 25, 2026, at the Church of the Holy Innocents, New York City. In the calendar of the Usus Antiquior, […]

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Oct 25 • 11:00 AM EDT • Politics • catholicworldreport.com
Wrexham’s Summer Striker Decision Faces Fresh Scrutiny After Blackburn Defeat

Wrexham’s decision to back their current centre-forwards has become a renewed talking point after Saturday’s 2–0 defeat at Blackburn Rovers exposed the gap between attacking activity and a meaningful goal threat.

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Oct 25 • 11:00 AM EDT • Sports • sports.yahoo.com
Postpartum recovery window may play a critical role in maternal aging and long-term health

In many studies, it appears that women who have more children have a higher risk of heart disease and a shorter life span, but this effect is inconsistent across populations and no good explanation for ...

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Oct 25 • 11:00 AM EDT • Health • medicalxpress.com
Scientists Found One of The 'Chunkiest' Squid-Like Creatures Ever Known

A "thick and peculiar" cephalopod.

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Oct 25 • 11:00 AM EDT • Science • sciencealert.com
Campbell County health and food inspections (10/16/26–10/22/26)

GILLETTE, Wyo. — The Consumer Health Services Division of the Wyoming Department of Agriculture conducts inspections of retail food establishments throughout Wyoming (where there is not a local health department that does inspections) to help ensure safety of Wyoming residents. Campbell County establishments are inspected at least once a year by the WDA. All of […]

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Oct 25 • 11:00 AM EDT • Health • county17.com
Scientists Find Chronic Back Pain Activates a Brain Network Linked to Personal Identity

A new UC San Diego brain imaging study involving 114 adults suggests that chronic back pain flare-ups affect brain networks involved in self-reflection and personal memories. The findings may help exp...

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Oct 25 • 10:49 AM EDT • Science • yahoo.com
After Fighting in Gaza and Battling PTSD, Shahar Varon Seeks a Voice In Israel's Mental Health Future

Soldiers and others suffering from post-traumatic stress disorder […]

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Oct 25 • 10:41 AM EDT • Health • themedialine.org
World's Fastest Lawnmower Company Is Officially Going Out Of Business

Dixie Chopper made the world's raddest lawnmowers for almost half a century, but its story is now coming to an end.

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Oct 25 • 10:30 AM EDT • Business • carbuzz.com
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NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say

A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…

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Oct 25 • 10:20 AM EDT • Business • pilotonline.com
Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks

The Boston Celtics beat the New York Knicks 107-103 on Friday night at TD Garden. Jayson Tatum scored 36 points and closed the game with a run that sealed the win. The stat line told the obvious story.But after the game, the moment Tatum wanted to talk about was not one of his own. It […] The post Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks appeared first on HEAVY.

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Oct 25 • 10:17 AM EDT • Sports • sports.yahoo.com
Amid first 0-3 start since 2007, Giannis-led Heat searching for answers: ‘We’re not in panic mode’

The Heat’s Giannis Antetokounmpo era is off to a rough start.

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Oct 25 • 10:16 AM EDT • Sports • miamiherald.com
Preview

The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...

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Oct 25 • 10:15 AM EDT • Sports • sports.yahoo.com