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Cracking a smile can boost health–experts

And rather than wait for a reason to smile, just making the physical change of literally turning that frown upside down could impact emotions

globalnation.inquirer.net logo
Oct 26 • 9:20 AM EDT • Health • globalnation.inquirer.net
ATM stolen from business in Brighton Park, Chicago police say

Chicago police are looking for the people who stole an ATM from a convenience store Sunday morning on the city's Southwest Side.

abc7chicago.com logo
Oct 25 • 6:20 PM EDT • Business • abc7chicago.com
😐 Neutral (7%)
Molina Healthcare awards $15,000 grant to expand tribal cultural wellness initiative
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Oct 25 • 6:14 PM EDT • Health • upnorthlive.com
Bob on Business: For Fort Worth’s office market, the summer was hot

Also, aviation acquisition and Grapevine company plans big expansion.

fortworthreport.org logo
Oct 25 • 6:01 PM EDT • Business • fortworthreport.org
Over 300 students learn science and technology at CCSD Family STEM Day

KSNV NBC Las Vegas covers news, sports, weather and traffic for the Las Vegas, Nevada area including Paradise, Spring Valley, Henderson, North Las Vegas, Indian Springs, Sloan, Searchlight, Laughlin and Nellis AFB.

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Oct 25 • 6:00 PM EDT • Science • news3lv.com
Serbia’s strongman leader Vucic concedes defeat to student-led movement in seismic political shift

It was a seismic political shift in the Balkan country where Vucic led with virtually absolute power for 14 years.

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Oct 25 • 5:42 PM EDT • Politics • cnbc.com
Aleksandar Vucic concedes defeat in Serbia's parliamentary election, marking political shift

Aleksandar Vucic, who denounced the oppositional student movement as a foreign-led attempt to unseat him, led with virtually absolute power for 14 years.

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Oct 25 • 5:30 PM EDT • Politics • cbsnews.com
Deep dive High-Signal Publisher
😐 Neutral (1%)
wow
56%
love
44%
Everton’s five-game winning home run ended by Aston Villa

Everton’s five-match winning run at Goodison Park has come to an end with Aston Villa running out 3-2 winners on Merseyside this afternoon.Brian Sørensen enjoyed a successful return to his former c...

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Oct 25 • 5:10 PM EDT • Sports • sports.yahoo.com
🙂 Positive (50%)
Clemson’s Loss to Virginia Tech Puts the Program in Flux

Clemson’s loss to Virginia Tech puts the program in flux heading into November. The Tigers now find themselves on the outside looking in on the ACC Championship race after being defeated 20-16 by the Hokies. Dabo Swinney’s team played well in many spots, especially in the third quarter. The complementary football Clemson displayed to start the …

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Oct 25 • 5:05 PM EDT • Sports • sports.yahoo.com
T.J. Hockenson finds end zone in Week 7 vs. Colts

Minnesota Vikings tight end T.J. Hockenson posted four receptions for 35 yards and a touchdown on five targets in Week 7

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Oct 25 • 4:51 PM EDT • Sports • sports.yahoo.com
Bryce Young throws one TD, two INTs in Week 7

Panthers QB Bryce Young finishes with season-low 163 yards and doubles INT total

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Oct 25 • 4:45 PM EDT • Sports • sports.yahoo.com
Justin Jefferson limited to 44 yards in Week 7

Minnesota Vikings wide receiver Justin Jefferson had four receptions for a team-high 44 yards on seven targets in Week 7

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Oct 25 • 4:38 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-7%)
U.S. measles cases more than double what they were last year as outbreak spreads

Pennsylvania is the worst hit state, with at least 1,338 cases of measles confirmed in 44 counties so far this year, according to the Pennsylvania Department of Health.

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Oct 25 • 4:35 PM EDT • Health • npr.org
Deep dive High-Signal Publisher
😐 Neutral (19%)
wow
100%
Historic Texas theater sold to New York wellness business

Not everyone is happy about this development.

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Oct 25 • 4:31 PM EDT • Business • chron.com
Kyler Murray throws for 150 yards, TD in Week 7

Minnesota Vikings quarterback Kyler Murray completed 14 of 24 passes for 150 yards, one touchdown and no interceptions in Week 7

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Oct 25 • 4:16 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
When will Myles Garrett return to the Rams?

Here's the latest on Myles Garrett as he continues recovering from early-season knee surgery.

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Oct 25 • 4:06 PM EDT • Sports • sports.yahoo.com
🙂 Positive (80%)
love
100%
Is the Big 12 a two-bid CFP league? + 2-loss SEC playoff hopes + Lincoln Riley’s future at USC
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Oct 25 • 4:05 PM EDT • Sports • sports.yahoo.com
Germaphobe primates want to avoid getting sick, too

Some monkeys become significantly more cautious about food sources that appear contaminated after experiencing deadly outbreaks of disease.

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Oct 25 • 4:00 PM EDT • Science • seattletimes.com
Yankees Social Media Spotlight: The MA kids head to MSG

Cam Schlittler and Ben Rice head to Madison Square Garden to watch the Knicks raise a banner.

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Oct 25 • 4:00 PM EDT • Sports • sports.yahoo.com
French and Italian Retailers Tally Losses Ahead of Holiday Season

Retailers in France and Italy face financial losses and security concerns as protests disrupt business ahead of the holiday shopping season.

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Oct 25 • 3:57 PM EDT • Business • wwd.com
Ex-Spur Jeremy Sochan becomes a Legend

The Dallas Legends used the top pick in Saturday's G League draft on Sochan, who will look to salvage an NBA career that has not gone as expected for the former lottery selection.

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Oct 25 • 3:53 PM EDT • Sports • sports.yahoo.com
Two Georgia Bulldogs ranked among college football's top-25 players

Two Georgia Bulldogs earned top-15 spots on ESPN's midseason top 25 college football player rankings.

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Oct 25 • 3:33 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
wow
100%
Primark's Business Doesn't Make Sense

In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot

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Oct 25 • 3:31 PM EDT • Business • finance.yahoo.com
Big Las Vegas show closures mark a transitional time for Strip entertainment

The culture of Las Vegas is inextricably linked to the artists and technicians behind the Strip’s vibrant live entertainment industry, so any time a show closes

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Oct 25 • 3:30 PM EDT • Entertainment • cdcgaming.com
😐 Neutral (2%)
ahah
55%
wow
45%
Science 4 Everyone: How does sod and tall fescue work?

Science teacher and Storm Team4 Meteorologist Ryan Miller explains how to use sod in your yard to prepare for cooler weather.

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Oct 25 • 3:27 PM EDT • Science • nbcwashington.com
The Politics of Heaven ~ The Imaginative Conservative

The key to understanding Thomas More’s generous dedication to the real but limited good he could do on earth is, as Frank Mitjans makes clear, that More’s constant contemplation of God was the source of his boundless care for the souls surrounding him. Thomas More’s Vocation, by Frank Mitjans

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Oct 25 • 3:20 PM EDT • Politics • theimaginativeconservative.org
Mid-Hudson Valley business calendar for the week of Oct. 26, 2026

Mid-Hudson Valley business calendar

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Oct 25 • 3:20 PM EDT • Business • dailyfreeman.com
New heist movie starring Pete Davidson to finally hit theaters in November

Billed as ”Point Break" meets “Fast and Furious,” Davidson will share the silver screen with Nicholas Hoult and Zoë Kravitz.

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Oct 25 • 3:19 PM EDT • Entertainment • silive.com
New Braunfels Wurstfest ranks No. 1 in Southern Living list

Southern Living ranks this Texas Oktoberfest ahead of Fredericksburg.

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Oct 25 • 3:18 PM EDT • Entertainment • mysanantonio.com
USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again

Both the USC Trojans and the UCLA Bruins had their rankings in the Associated Press Top 25 poll following their results from Saturday. View this post on Instagram A post shared by LA Sports Report (@lasportsreport) What Happened to USC’s Ranking? Following their loss to Wisconsin on Saturday, USC dropped out of the Top 25. […] The post USC Drops Out of AP Top 25 Poll After Wisconsin Loss, UCLA Rises Again appeared first on LA Sports Report.

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Oct 25 • 3:07 PM EDT • Sports • sports.yahoo.com
Retire Your Old Fountain: The Alternative From Home Depot Perfect For Your Small Patio

The Teamson Solar Gray Stone Wall Fountain from Home Depot is a great fountain for small patios thanks to its compact size and solar powered design.

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Oct 25 • 3:00 PM EDT • Technology • housedigest.com
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center

The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.

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Oct 25 • 3:00 PM EDT • Health • loudountimes.com
🚨 Barcelona & Real Madrid name XIs for El Clásico

Barcelona and Real Madrid face off in El Clásico this evening. Hansi Flick's Barcelona top La Liga this season after winning all nine matches.Real Madrid will hope for improvements this evening as L...

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Oct 25 • 2:54 PM EDT • Sports • sports.yahoo.com
Who's running to be Oklahoma's next Commissioner of Labor?

Republican Kevin West, Libertarian Mike Hall and Democrat Kevin Dawson will face off in November to be the next Commissioner of Labor.

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Oct 25 • 2:46 PM EDT • Politics • kgou.org
“Business as usual” – PSG coach refuses to give his players an excuse after triple blow

PSG are missing some important players, but that’s not an excuse says manager Luis Enrique, who still expects the best.If you enjoy PSG Talk coverage and want to see more of it, add us as a preferre...

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Oct 25 • 2:42 PM EDT • Business • sports.yahoo.com
Cracking a smile regularly may be good not just for your mood but for your health

Reminding yourself to smile often can not only help you form more friendships but also make you feel better.

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Oct 25 • 2:40 PM EDT • Health • medicalxpress.com
Heidi Klum frightens fans, teases Halloween costume with bizarre close-up of strange prosthetic

The Queen of Halloween herself Heidi Klum is offering fans a first look at this year’s Halloween costume. As usual, it involves some pretty bizarre prosthetics.

ew.com logo
Oct 25 • 2:37 PM EDT • Entertainment • ew.com
Nintendo reveals why you don't actually fight Bowser in Super Mario Bros. 1

Nintendo’s Shigeru Miyamoto has shared some insight into why players don’t actually fight Bowser in the original Super Mario Bros. Miyamoto was present at a press conference at the end of the week to celebrate him becoming the first developer to win Japan’s Order of Culture award. During the event, he was asked to share behind-the-scenes stories about the making...

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Oct 25 • 2:15 PM EDT • Technology • nintendoeverything.com
Cracking a smile regularly may be good not just for your mood but for your health

Reminding yourself to smile often can not only make more friendships but it can also make you feel better.

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Oct 25 • 2:10 PM EDT • Health • wane.com
Olympiacos May Attempt to Sign Genoa Midfield Maestro This Winter

Olympiacos are poised to reignite their pursuit of Morten Frendrup, testing Genoa's resolve after a rejected summer bid for the consistent Danish engine room specialist.

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Oct 25 • 2:01 PM EDT • Sports • sports.yahoo.com
The Times' top 25 high school football rankings

A look at the top 25 high school football teams in the Southland after Week 9.

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Oct 25 • 2:00 PM EDT • Sports • sports.yahoo.com
Knicks Have Clear Advantage Over Magic With Lopsided Injury Report

The New York Knicks look for their first win of the season.

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Oct 25 • 1:36 PM EDT • Sports • sports.yahoo.com
College GameDay On-Site for Gophers vs Hoosiers

The Minnesota Gophers are coming off a big win over Iowa. And now College GameDay is going with the to Bloomington Saturday for the game @ Indiana.

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Oct 25 • 1:35 PM EDT • Sports • sports.yahoo.com
Professor Katherine McNeill Inducted Into Massachusetts Science Educators Hall of Fame

Katherine L. McNeill was inducted into the Massachusetts Science Educators Hall of Fame on Friday in recognition of her two decades of work in science education.

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Oct 25 • 1:33 PM EDT • Science • bcheights.com
Deep dive
😐 Neutral (21%)
wow
100%
COMMENTARY: Three reasons why Tennessee football imploded against South Carolina

Penalties, brain blips and a hangover conspire to doom Volunteers.

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Oct 25 • 1:33 PM EDT • Sports • sports.yahoo.com
Projections for Cleveland Guardians’ Arbitration Eligible Players

The Cleveland Guardians have several key players arbitration-eligible this offseason.

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Oct 25 • 1:30 PM EDT • Sports • sports.yahoo.com
Elon Musk’s Grok Releases First AI-Generated “Odyssey” Episode

Months after Elon Musk promised that Grok Imagine would make an entirely AI “Odyssey” film, the tech mogul has partially followed through.

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Oct 25 • 1:22 PM EDT • Technology • variety.com
Steelers Now Postgame: Steelers 16, Saints 10

Pittsburgh Steelers Postgame: Join Alan Saunders and Jobe Morrison after the Steelers’ Week 7 win over the Saints on YouTube, […]

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Oct 25 • 1:18 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
ahah
100%
Sunday Open Thread

There is no Jays news and I’ve got nothing to talk about, so lets have an open thread. We had the second great World Series game in a row last night. I like watching baseball (or any sport) when I have no rooting interest. After a season of caring about every Jays game, I like […]

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Oct 25 • 1:17 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-10%)
love
67%
wow
33%
Clatsop County health inspections for September

Clatsop County health inspectors recently completed a round of restaurant inspections that yielded overwhelmingly positive results for most local eateries. But one Seaside establishment received a temporary closure after receiving […]

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Oct 25 • 1:10 PM EDT • Health • dailyastorian.com
New Trump housing order targets mortgage and title insurers

A White House plan to pull private mortgage insurance off loans sooner, and to let refinancing borrowers skip the lender's title policy, affects two insurance lines that say they already help keep costs down

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Oct 25 • 1:09 PM EDT • Business • insurancebusinessmag.com
Hunter's Moon 2026: All About October's Full Moon And What To Expect Tonight

The title "Hunter's Moon" dates back generations, originating in the Northern Hemisphere because it typically follows the harvest season.

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Oct 25 • 1:09 PM EDT • Science • ndtv.com
Argentina Folk Sounds, Controversy: Milo J, Cazzu, Broke Carey

Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside and sharing their history with the world.

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Oct 25 • 1:09 PM EDT • Politics • rollingstone.com
How Argentina’s Folk Sounds Are Shaping a Generation’s Politics and National Pride

Milo J, Cazzu, and more stars are embracing music and traditions of the Argentine countryside, staving off pop homogenization and sharing their history with the world

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Oct 25 • 1:09 PM EDT • Politics • yahoo.com
Steelers beat Saints to win first NFL game in Paris

The Pittsburgh Steelers defeated the New Orleans Saints 16-10 on Sunday to win the first-ever NFL regular season game in Paris. The low-scoring game had only one touchdown for each team.

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Oct 25 • 1:03 PM EDT • Sports • sports.yahoo.com
Business People: Evereve names industry vet Sarah Clary to advise on creative

RETAIL Evereve, an Edina-based women’s fashion retailer, announced it has named Sarah Clary as advisory chief creative officer. Clary previously has led creative direction campaigns and brand strategy for Hill House Home, Veronica…

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Oct 25 • 1:01 PM EDT • Business • twincities.com
'Tokens Are Cheap': Open Source Subreddit Bans AI

“AI, as it exists today, is incongruent to this Open Source community.”

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Oct 25 • 1:00 PM EDT • Technology • gizmodo.com
'Sound of Music' star Julie Andrews spotted in rare Hamptons outing weeks after turning 91

Julie Andrews, 91, was photographed in the Hamptons wearing a purple raincoat and pink sunglasses in a rare public outing in the coastal city.

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Oct 25 • 1:00 PM EDT • Entertainment • yahoo.com
This Switch 2 sequel accessory was a few millimeters away from being good

The right stick gets in the way.

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Oct 25 • 1:00 PM EDT • Technology • theverge.com
Jaylen Warren surpasses 100-yard mark in Week 7

Steelers RB Jaylen Warren rushes for at least 100 yards for third time this season

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Oct 25 • 12:59 PM EDT • Sports • sports.yahoo.com
Warren, Steelers stiff-arm Saints for 16-10 Paris win

Jaylen Warren had another big day and the Pittsburgh Steelers overcame some red-zone inefficiency to beat the New Orleans Saints.

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Oct 25 • 12:42 PM EDT • Sports • sports.yahoo.com
Warriors honor Bay Area sports reporter Michael Wagaman

After Michael Wagaman passed away in early August, Dallas Braden took time to tribute him during his call of the Athletics’ game on NBC Sports Bay Area and California. Wagaman had covered Bay Area sports teams since 1996, including for the Associated Press, and freelanced for NBC Sports Bay Area and California at the time…

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Oct 25 • 12:30 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
Lakers 1st-Round Draft Pick Floated as Trade Piece

The Los Angeles Lakers are off to a fast start. Could it be time to weigh trading away some young pieces to boost the rotation? The post Lakers 1st-Round Draft Pick Floated as Trade Piece appeared first on HEAVY.

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Oct 25 • 12:29 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
'Not a one-person job:' Bernardsville explores exit from Bernards Health Department

BERNARDSVILLE - Concerns about costs have led borough officials to consider cutting off decades-long services from the Bernards Township Health Department and switching to the Somerset County Health Department.

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Oct 25 • 12:27 PM EDT • Health • newjerseyhills.com
One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie

Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.

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Oct 25 • 12:17 PM EDT • Entertainment • yahoo.com
Kings' Veterans Praise Rookie Acuff After 33-Point Showing

The Sacramento Kings are yet to get a win, but Darius Acuff Jr. looks like the high-octane guard that the franchise so desperately needs. Coming off a 33-point outburst, how will Acuff play against the Memphis Grizzlies?

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Oct 25 • 12:13 PM EDT • Sports • sports.yahoo.com
Lycia Lands a $317M IPO for Inflammation Drugs Based on Nobel Prize-Winning Science

Lycia Therapeutics’ protein-degrading drugs are based on the research of Carolyn Bertozzi, a Stanford chemistry professor and Nobel laureate. Lycia’s lead drug candidate is in development for food allergy, where it could compete against the blockbuster Roche drug Xolair.

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Oct 25 • 12:13 PM EDT • Science • medcitynews.com
Bloomington business continues to blossom

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Oct 25 • 12:11 PM EDT • Business • insideindianabusiness.com
😐 Neutral (0%)
MTSU named among Billboard's Top Music Business Schools for 12th year in a row

Middle Tennessee State University has been named a top music business school by Billboard for the 12th year in a row.MTSU's Department of Recording Industry mad

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Oct 25 • 12:10 PM EDT • Business • fox17.com
Buccaneers vs. Panthers Week 7 inactives: Baker Mayfield returns

The Tampa Bay Buccaneers are set to take on the Carolina Panthers Sunday afternoon in a crucial NFC South matchup at Bank of America Stadium in Charlotte. Tampa Bay received some encouraging news ahead of kickoff as quarterback Baker Mayfield is officially active and will start after missing the previous three games with a dislocated […]

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Oct 25 • 12:05 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
"It never was entertainment to us, ever. It was always something with a lot more importance and meaning." U2 reveal the unbroken promise that they made to one another as schoolboys in Ireland 50 years ago

"Music is not a matter of life and death, it’s something much more serious than that"

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Oct 25 • 12:00 PM EDT • Entertainment • loudersound.com
Americans have a grief problem we still call a mental health problem

OPINION — Americans have become much better at talking about mental health. We have learned words such as trauma, post-traumatic stress disorder, depression, anxiety, burnout, compassion fatigue and moral injury. That vocabulary matters.

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Oct 25 • 12:00 PM EDT • Health • yourvalley.net
Browns Week 7 inactives: Who's in, who's out?

The Browns are the healthiest they have been in some time as they take on the Titans in Week 7.

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Oct 25 • 11:59 AM EDT • Sports • sports.yahoo.com
2 political experts question Chicago Mayor Brandon Johnson's tax proposals for 2027 budget
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Oct 25 • 11:55 AM EDT • Politics • cbsnews.com
High-Signal Publisher
Cost of employer-sponsored health insurance rises again, survey finds

WASHINGTON — The cost of employer-sponsored health insurance increased again this year, as did the deductibles many people must pay before their plans begin covering most health care expenses, according

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Oct 25 • 11:40 AM EDT • Health • chronicleonline.com
How Braves should handle $42 million Jurickson Profar situation

This could be one solution for the Braves.

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Oct 25 • 11:36 AM EDT • Sports • sports.yahoo.com
How Nathan Fielder's cringe-comedy career led him to Elizabeth Holmes

Spoiler alert! We're discussing the themes and structure of the Elizabeth Holmes documentary "You Can See Everything" and touching on a surprising aspect of its second half, so turn away if you want to go in completely cold.

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Oct 25 • 11:34 AM EDT • Entertainment • thenewstribune.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Senator, former California Secretary of State Alex Padilla weighs in on voter roll fight

With one week left before the midterm elections, California is facing a federal lawsuit alleging that non-citizens were registered to vote, received mail-in ballots, and, in some cases, voted.

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Oct 25 • 11:25 AM EDT • Politics • kcra.com
Who can buy California's voter rolls and why?

Chris Micheli, an adjunct professor at McGeorge School of Law and longtime lobbyist, explained who is able to buy the voter rolls and why in an interview on California Politics 360.

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Oct 25 • 11:25 AM EDT • Politics • kcra.com
California Politics 360 full episode | Clash over voter rolls heads to court

On Tuesday, one week before the election, a federal judge will determine the next steps.

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Oct 25 • 11:25 AM EDT • Politics • kcra.com
South Texas Health System (@stxhealthsystem)

1 likes, 1 comments - stxhealthsystem on October 25, 2026: "Exceptional Care Starts With You: Nurses play a vital role in every patient journey, providing the compassionate, skilled care that helps make South Texas Health System’s 12 facilities a trusted healthcare resource for communities across the Rio Grande Valley. If you're passionate about making a difference and delivering exceptional patient care, now is your opportunity to join the largest integrated healthcare network in the region. STHS is seeking dedicated and compassionate registered nurses to join its team at four acute care hospitals, a behavioral health hospital and seven freestanding emergency departments. Become part of a team committed to clinical excellence, collaboration and compassionate care. To view current openings and apply, visit the STHS careers page at the link in our bio.".

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Oct 25 • 11:18 AM EDT • Health • instagram.com
Apple Stores Reportedly Rolling Out New Anti-Theft System for iPhones

Bloomberg's Mark Gurman today reported that Apple is facing a growing problem where some people will buy iPhones or other products and either remove accessories from the box, open up the device and remove components, and/or remove the entire device, and then attempt to return the box hoping that the employee will not notice.

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Oct 25 • 11:18 AM EDT • Technology • macrumors.com
Robinson, Baker have tough talk about the offense

Robinson, Baker have tough talk about the offense

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Oct 25 • 11:15 AM EDT • Sports • sports.yahoo.com
GO Health asks families to be lead-aware

BATAVIA — Area health departments are encouraging families to get the facts and get their children and homes tested for National Lead Poisoning Prevention Week.

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Oct 25 • 11:00 AM EDT • Health • thedailynewsonline.com
Little Rock health fair connects Arkansans with screenings and preventive care
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Oct 25 • 10:58 AM EDT • Health • katv.com
Brazil votes in a tense Lula vs. Bolsonaro runoff with U.S. influence over Latin America at stake

The election pits the left-of-center veteran politician Lula against Bolsonaro, an ally of U.S. President Donald Trump and the son of imprisoned former President Jair Bolsonaro.

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Oct 25 • 10:57 AM EDT • Politics • pbs.org
Evaluating DJ Herz After Bouncing Back from Injury with Nationals

After making his first MLB appearance in nearly two years, what should the Washington Nationals expect from DJ Herz in his third season with the organization?

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Oct 25 • 10:56 AM EDT • Sports • sports.yahoo.com
Scientists Find Chronic Back Pain Activates a Brain Network Linked to Personal Identity

A new UC San Diego brain imaging study involving 114 adults suggests that chronic back pain flare-ups affect brain networks involved in self-reflection and personal memories. The findings may help exp...

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Oct 25 • 10:49 AM EDT • Science • yahoo.com
University of Rochester Medicine Home Healthcare holds inaugural Hospice 5K

13WHAM ABC Rochester provides local news, weather forecasts, traffic updates, health reports, notices of events and items of interest in the community, local sports and entertainment programming for Rochester and nearby towns and communities including Greece, Victor, Pittsford, Penfield, Henrietta, Webster, Irondequoit, Fairport, Chili, Gates, Rush, Wheatland, Canandaigua, Farmington, Spencerport and Hilton.

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Oct 25 • 10:44 AM EDT • Health • 13wham.com
After Fighting in Gaza and Battling PTSD, Shahar Varon Seeks a Voice In Israel's Mental Health Future

Soldiers and others suffering from post-traumatic stress disorder […]

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Oct 25 • 10:41 AM EDT • Health • themedialine.org
Grading Iowa Football's Loss To Minnesota

This may have been Iowa's worst quarterback performance since the dreadful 2023 season.

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Oct 25 • 10:30 AM EDT • Sports • sports.yahoo.com
NFL Trade Deadline Could Dramatically Change The AFC South Landscape

With top stars from the Titans, Colts, and Jaguars hitting the trade block, Houston’s rivals could strip their rosters of veteran talent to fuel a mid-season rebuild.

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Oct 25 • 10:22 AM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
NC business co-owner kills man ‘acting irrationally’ outside Zumba class, police say

A man “acting irrationally” toward patrons of a Zumba fitness class was fatally shot when he turned his attention to an armed business co-owner at the scene, according to investigators in western North Carolina. The confrontation occ…

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Oct 25 • 10:20 AM EDT • Business • pilotonline.com
Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks

The Boston Celtics beat the New York Knicks 107-103 on Friday night at TD Garden. Jayson Tatum scored 36 points and closed the game with a run that sealed the win. The stat line told the obvious story.But after the game, the moment Tatum wanted to talk about was not one of his own. It […] The post Jayson Tatum Reacts to Encouraging Celtics Development Against Knicks appeared first on HEAVY.

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Oct 25 • 10:17 AM EDT • Sports • sports.yahoo.com
Some Thoughts About Ron Duguay

Dear, departed Ron Duguay was not anything like his playboy image.

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Oct 25 • 10:16 AM EDT • Sports • sports.yahoo.com
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Preview

The Men's First Team are back in Serie A action, this time heading south to face Lecce in Puglia.The Serie A Matchday 8 clash is set to take place at the Stadio Via del Mare at 18:00 CET on Sunday, Oc...

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Oct 25 • 10:15 AM EDT • Sports • sports.yahoo.com
Michigan's Jason Beck promised change, but numbers tell another story

Michigan football vowed to fix its perimeter run game or stop it, but the team continues to struggle on the edge.

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Oct 25 • 10:04 AM EDT • Sports • sports.yahoo.com
Can social media bans protect young people’s mental health? Early research suggests that bans aren’t the answer

About 20 countries are looking to ban minors from social media. But bans have not always worked as planned. Here are some other ideas to make platforms safer for kids.

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Oct 25 • 10:01 AM EDT • Health • inquirer.com
Halifax Health Sees 19 Biketoberfest-Related Injuries in 2026

With Biketoberfest 2026 having ended on October 18, Daytona Beach’s Halifax Health Medical Center announced the statistics on injuries related to the event. 19 patients were treated for injuries …

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Oct 25 • 10:00 AM EDT • Health • newsdaytonabeach.com