SCROLL NEWS / DISCOVERY

Search headlines

Find the stories shaping the conversation.

Search mode
Refine results
Active filters Keyword All time

Results for " list " 6,716 found 🔀 AI-powered Shuffle

America’s socialist surge and its hard limits

Socialism is gaining ground in the US, fuelled by anger over inequality and economic insecurity. But can its rising popularity translate into lasting political influence across the country? US author and academic Michael Kazin sheds light on the issue.

thinkchina.sg logo
Oct 23 • 4:07 AM EDT • Politics • thinkchina.sg
Government won’t put together ‘shopping list’ for public to stockpile for emergency

Ministers have repeated several warnings in the last 18 months about the threat of hybrid attacks from overseas

theguardian.com logo
Oct 23 • 4:01 AM EDT • Politics • theguardian.com
😐 Neutral (13%)
Jazz Chisholm Jr & Two Other Yankees Refused Analytics Help

The New York Yankees continue to find more reasons to make changes after the disappointing ALDS exit. Most MLB teams have analytics teams to help the players make changes, including the Yankees under General Manager Brian Cashman. Jazz Chisholm Jr was one of three players who reportedly refused to listen to these suggestions and ignore […] The post Jazz Chisholm Jr & Two Other Yankees Refused Analytics Help appeared first on HEAVY.

sports.yahoo.com logo
Oct 23 • 1:48 AM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
wow
75%
angry
25%
'Generational rage': Young Europeans fight to be heard

From blockaded schools in Rome to tent camps in Madrid and street protests in France, young people across Europe are turning their anger on a political class they say is not listening.- 'Inspiring oth...

yahoo.com logo
Oct 22 • 10:30 PM EDT • Politics • yahoo.com
George Pickens a limited participant Thursday

Cowboys WR George Pickens dealing with shoulder issue and listed as limited

sports.yahoo.com logo
Oct 22 • 6:22 PM EDT • Sports • sports.yahoo.com
Patriots Playmaker Named Potential Trade Chip by FOX Sports

The NFL trade deadline is approaching, and various writers are listing their top candidates who could be traded for their respective teams. For the New England Patriots, Fox Sports’ Henry McKenna had an interesting name. Running back TreVeyon Henderson was his choice for this article. Henderson has 49 carries for 194 yards and a touchdown […] The post Patriots Playmaker Named Potential Trade Chip by FOX Sports appeared first on HEAVY.

sports.yahoo.com logo
Oct 22 • 4:51 PM EDT • Sports • sports.yahoo.com
As AI transforms patient experience, clinicians see changes too

Panelists at the HIMSS AI in Healthcare Forum explored both sides of a new paradigm where artificial intelligence tools have the potential to both streamline and complexify care delivery, depending who's using them and how.

healthcareitnews.com logo
Oct 22 • 4:23 PM EDT • Health • healthcareitnews.com
Microsoft Diagnostic AI Outperforms Generalist Physicians in Science Study

Microsoft's MAI-DxO diagnostic system outperformed participating generalist physicians on complex diagnostic cases in a peer-reviewed study published October 22, 2026 in Science, which reported 83.2% accuracy for the sys...

unite.ai logo
Oct 22 • 3:13 PM EDT • Science • unite.ai
Josh Simmons set to miss at least four weeks

Chiefs OT Josh Simmons moved to the Reserve/Injured list but will not need back surgery

sports.yahoo.com logo
Oct 22 • 3:05 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-30%)
Tarik Skubal Rumors: Toronto Blue Jays Listed as Potential Suitor

Skubal is going to hit free agency this winter with a lot of questions around him.

sports.yahoo.com logo
Oct 22 • 3:00 PM EDT • Sports • sports.yahoo.com
Indiana men’s basketball listed as a top NIL spender ahead of 2026-27 season

Indiana, fresh off a transfer portal roster reload, was listed as a big spender by CBS Sports ahead of the season.

sports.yahoo.com logo
Oct 22 • 3:00 PM EDT • Sports • sports.yahoo.com
Microsoft’s Mustafa Suleyman says its AI outperforms doctors on hard cases as he chases ‘medical superintelligence’

Microsoft’s new AI diagnostic system beat generalist doctors on hard cases, according to a study in Science. But most of the improvement seems to come from the AI models underneath, not from Microsoft’s system itself.

techcrunch.com logo
Oct 22 • 2:43 PM EDT • Technology • techcrunch.com
‘Clear political stunt’: Beshear rejects Ball’s nominees for executive ethics commission

A day after submitting nominations for an appointment to the Executive Branch Ethics Commission, Republican Auditor Allison Ball says Democratic Gov. Andy Beshear rejected her list. A spokesperson for the governor said the list was “a clear political stunt.”

kentuckylantern.com logo
Oct 22 • 2:29 PM EDT • Politics • kentuckylantern.com
Best of Santa Cruz County entertainment, arts & food events this weekend, Oct. 22-25

With the weekend nearly here, check out things to do around Santa Cruz County, with a recommendation from Lily Belli and a specially curated list from Lookout's BOLO events calendar.

lookout.co logo
Oct 22 • 2:21 PM EDT • Entertainment • lookout.co
Politics: The Midterm Races You Aren’t Hearing About

In just a dozen days, voters across the country will cast their ballots in midterm elections that could shift the balance of power in Washington. A lot of focus has been devoted to the contested races for Congress, with billions of dollars being spent on critical statewide contests and referendums.From governors’ mansions to statehouses to local ballot initiatives, voters will make their voices heard.We gather a panel of experts and zero in on some midterm races that aren’t necessarily making national headlines.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.

npr.org logo
Oct 22 • 1:41 PM EDT • Politics • npr.org
High-Signal Publisher
How well have past GOTY winners sold?

We’re less than two months away from 2026’s The Game Awards, and what a year it’s been for fantastic games, including Resident Evil Requiem, Forza Horizon 6, Slay the Spire II, the Blood of Dawnwalker, and Control Resonant – just to name a few. So as we approach the end of the year, we thought we’d look back on our estimates for the GOTY winners of the past four years. In terms of revenue, Elden Ring (2022 winner), Baldur’s Gate 3 (2023), Astro Bot (2024), and Expedition 33 (2025) have generated a combined $3.8B via 73M copies sold: Let’s have a look, then. Elden Ring has generated $2B in revenue Elden Ring is a phenomenon in every sense. It’s sold a whopping 36.4M copies across Steam (50%), PS5 (35%), and Xbox (15% across console and PC). Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Elden Ring also just passed an astronomical milestone: $2B in revenue. While PlayStation and Xbox account for half of Elden Ring’s copies sold across these three platforms, they account for 57.5% of revenue. This – as ever – is due to regional pricing and the higher relative share of PC gamers in lower-priced markets. For example, around 17.4% of Elden Ring’s Steam copies sold were in China, where the game costs about 26% less than the price in the States. There’s an … interesting narrative going around these days that console gamers are only interested in ball-and-gun games and have the patience for little else. Well, Elden Ring’s impressive sales prove that is simply not true, and across all platforms. What’s more, over 9.8M people have played Elden Ring for over 100 hours, with nearly 3.5M people getting all of the achievements and trophies. For reference, 10.9% of Elden Ring’s PlayStation players have the platinum trophy, while 10.5% of players on Steam and 3.9% of Xbox players unlocked all the achievements. Git gud, Xbox players! Of the 1.5M people who played Elden Ring on PlayStation last month, 4% also played Dark Souls 3 last month, 4% played Bloodborne, and 3% played Sekiro. There’s those Soulsborne diehards for you. By many accounts, including my own, Elden Ring is one of the best games of all time. It’s an evergreen seller that will continue to be a cash cow for Bandai and FromSoftware for years to come. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Elden Ring has sold another 2M copies across Steam, PlayStation, and Xbox this year, generating almost $110M. This means it’s outperforming many of this year’s high-profile releases. Even Elden Ring’s standalone run-based PvE spinoff, 2025’s Nightreign, has sold 7.8M copies and generated $282M in revenue. Baldur’s Gate 3 is another billion-dollar-plus banger Another cross-platform phenomenon is Baldur’s Gate 3, which has sold 23.2M copies and generated over $1.2B in revenue. About 18.7M of these copies (80.6%) are via Steam, 2.9M via PS5 (12.7%), and 1.6M (6.8%) via Xbox. Around 1.3M folks on Steam bought BG3 before it hit 1.0. The PlayStation version launched about a month after the PC 1.0 release, while the Xbox version came four months later due to technical issues around developing local co-op on the Series S. Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Across platforms, Baldur’s Gate 3’s monthly active users have never dropped below 2M, including 2.2M MAUs last month (68.5% on Steam, 21.9% on PS5, and 9.6% on Xbox). And it still regularly brings in 280K to 400K players every day: About 1% of BG3’s Steam player base has played for over 500 hours! That’s a little under 200K people. Astro Bot is also an evergreen seller, albeit a more niche, family one Astro Bot, 2024’s winner, has now sold 4.7M copies and generated $291M in revenue. The budget, including marketing, is almost certainly under $100M, given the small Japan-based core team and three-year dev timeline. You can really see why the tides are changing toward less expensive hubs. Astro Bot is the only first-party winner on this list, but follows other first-party winners of The Last of Us Part II (2020’s winner), God of War (2018), and Breath of the Wild (2017). Around 46.6% of Astro Bot’s copies sold have been physical, which is far higher than the typical game. This makes sense for a couple of reasons: There’s a large family audience for this one, and physical boxes are an item to wrap when giving Astro as a gift. Astro has collector value for the PlayStation core (this is nostalgia-fueled platformer celebrating PlayStation’s history) Want more free estimates and insights in your inbox twice a week? Subscribe below! Subscribe Astro is another one of those games that continues selling over time, regularly selling more than 100K a month. It’s sold around 1M more copies this year ($60M in revenue) and is a popular title with families. We can see this using the Alinea platform’s MAU crossover tool: Astro Bot’s top #2, #3, and #4 games by crossover in any given month this year are Minecraft, Fortnite, and Roblox – without fail. The #1 title every month, though, is Astro’s Playroom, a pack-in with all PS5 consoles. For every month this year, between 20% and 30% of Astro Bot players also played Astro’s Playroom that month. So the free pack-in is a noice funnel for converting players to a full paid product. Expedition 33 sells 8.7M despite Game Pass cannibalisation Finally, we have last year’s winner – Expedition 33. The turn-based-RPG banger has generated $366M via 8.7M copies sold, with 58.8% on Steam, 35.7% on PS5, and 5.5% on Xbox. Xbox’s share of copies sold is this low due to Expedition 33 launching on Game Pass, where 4.3M people across console and PC accessed the game. A little under 700K Xbox players used their subscription to play Expedition 33 this year. That said, the game’s 1.5-year Game Pass deal ended last week on October 16, and we’re already beginning to see a positive trend on Expedition 33’s copies sold via Xbox (but the jury’s still out!). There’s understandably a lot of French pride behind this one, as France is the game’s #3 market on both Steam and PlayStation. Vive la France! One thing that stood out to me is that the GOTY winners aren’t $300M Hollywood productions made in the US. They’re mostly mid-budget studios outside the traditional AAA cost centres. Lots to think about there. Also, good games sell well; who’d have thunk it!? And there’s a whole load of them this year, with GTA 6 still to come, too. GTA just made the cutoff point for the VGAs this year. What a coincidence! Loading... Cool links and other stuff Our physical games newsletter from Tuesday was picked up by GameSpot, Eurogamer, TweakTown, and a bunch of others. We’re offering a free trial of our platform for games companies. Send us a message here, or reply right here on Substack/email, and we’ll set you up. Next week, we’ve got some exciting news regarding the future of our newsletter, so stay tuned! The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. Want to see why these companies (and many others) are subscribed to Alinea? Get a free platform trial! [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]

alineaanalytics.substack.com logo
Oct 22 • 1:02 PM EDT • Technology • alineaanalytics.substack.com
Two CVSS 9.0 Linux KSMBD RCE Flaws Disclosed on Public Mailing Lists Before Kernel Fixes

Two CVSS 9.0 flaws in Linux KSMBD could enable remote code execution; one needs no authentication, and neither has a mainline fix.

thehackernews.com logo
Oct 22 • 1:01 PM EDT • Technology • thehackernews.com
G-Shock's Affordable "CasiOak" Successor Is Here, and It Looks a Lot Like Another Bucket-List Sports Watch

G-Shock says the 2500 series takes after its original 1983 octagonal watch. Some excited fans are convinced about another horological icon.

gearpatrol.com logo
Oct 22 • 12:56 PM EDT • Technology • gearpatrol.com
Pullup Entertainment Q2 2027 Earnings Call Is Live

Pullup Entertainment's quarterly earnings call has just begun.Live earnings calls are not yet supported in the mobile app. To listen and follow along in real time, open TradingView website in your browser.

tradingview.com logo
Oct 22 • 12:12 PM EDT • Entertainment • tradingview.com
Latest threat to democracy: Politicians bullying journalists

When officials refuse to answer questions they aren’t simply disrespecting journalists. They are disrespecting the citizens those journalists serve.

seattletimes.com logo
Oct 22 • 11:15 AM EDT • Politics • seattletimes.com
Tennessee FFA member studies Hurricane Helene's lasting impact on farmer mental health

A National FFA agriscience fair finalist says the impacts of Hurricane Helene inspired her to take a closer look at farmer mental health. Abby Petterson from the Erwin FFA Chapter in Tennessee says her two-year research project focuses on supporting the next generation of agriculture. “There is a stigma, but more importantly, there is a […]

brownfieldagnews.com logo
Oct 22 • 11:03 AM EDT • Health • brownfieldagnews.com
Essentia Health-St. Joseph’s Brainerd Clinic welcomes Dr. Caehla McGeady to practice family Medicine

Dr. Caehla McGeady, a family medicine specialist, is thrilled to join the Essentia Health St. Joseph’s-Brainerd Clinic.

essentiahealth.org logo
Oct 22 • 11:00 AM EDT • Health • essentiahealth.org
Grading the Buffalo Bills Special Teams At The Bye Week

Tyler Bass’s perfection and a game-changing blocked kick anchor a dominant unit. From field position battles to return-game sparks, these specialists have earned their elite midseason marks.

sports.yahoo.com logo
Oct 22 • 10:09 AM EDT • Sports • sports.yahoo.com
Noteworthy Arms to Consider as Padres Offseason Acquisitions

The San Diego Padres' pitching staff was one of many highlights for the organization in 2026, headlined by a remarkable turnaround from the starters after the All-Star break. With the late-season returns of Nick Pivetta and Joe Musgrove from the injured list, San Diego's front office still remains focused on acquiring additional starting pitching for …

sports.yahoo.com logo
Oct 22 • 10:00 AM EDT • Sports • sports.yahoo.com
Michigan State Quarterback Listed as Questionable on Availability Report

Battered by injuries to Alessio Milivojevic and several defensive stars, the Spartans face a daunting road test against No. 9 UCLA while leaning heavily on their depth.

sports.yahoo.com logo
Oct 22 • 9:41 AM EDT • Sports • sports.yahoo.com
Cubs Listed As Potential Suitor For Tarik Skubal
sports.yahoo.com logo
Oct 22 • 9:35 AM EDT • Sports • sports.yahoo.com
5 Startups to Pitch at UToledo Business Incubator’s Tech419 Oct. 29

Three of this year’s five finalists have UToledo ties, with ventures spanning space research, orthopaedic surgery, manufacturing and facility maintenance.

news.utoledo.edu logo
Oct 22 • 9:34 AM EDT • Business • news.utoledo.edu
Henrico Business Watch: Business license filings Oct. 15-21, 2026

Henrico County reported the following business license filings with start dates during the week. The filings are listed alphabetically by business or trade name, followed by a registered address and business industry classification. Carlyle Temp Agency LLC, 4112 Townhouse Road, Apartment F, Henrico – Employment agency. MJ Henley Powerwashing LLC, 4048

henricocitizen.com logo
Oct 22 • 9:04 AM EDT • Business • henricocitizen.com
Vespexx Recognized as Finalist for the Digital Health Hub Foundation Digital Health & AI Awards 2026 at HLTH

Vespexx Inc., an AI-driven femtech company, today announced it has been named a Finalist for the Digital Health Hub Foundation's Digital Health & AI Awards 2026, held at HLTH. Competing in the Rising Star track under the Women's & Family Health category, Vespexx advanced from the Quarterfinalist stage announced earlier this fall, standing out among more than 1,300 submissions.

finance.yahoo.com logo
Oct 22 • 9:00 AM EDT • Health • finance.yahoo.com
Sheba sells ARC innovation arm to Redesign Health in deal valued at tens of millions of dollars

The deal transfers management of ARC’s global network and the rights to establish new hospital innovation centers to the U.S. healthcare venture builder, while Sheba retains its stakes in portfolio companies.

calcalistech.com logo
Oct 22 • 8:03 AM EDT • Health • calcalistech.com
Introspection required if EU Inc fails, says start-up lobbyist

European start-ups have a new voice in Brussels. Startups for Europe, created from the merger of lobby groups Allied for Startups and the European Startup Network, is hoping to harness the momentum behind EU-Inc, a campaign that united start-ups and investors behind demands for a new pan-European company regime.At a launch event for the new association in Brussels on October 1, the mood was remarkably upbeat compared to a typical Eurobubble gathering, more Silicon Valley than Schuman roundabout.When asked whether this reflects a feeling that Europe is on the right track, chief executive Serena Borbotti-Frison said it’s a “scary” moment as the continent looks to boost its competitiveness amid a new technological arms race.“What is at stake is quite intense, and the way we can answer is by delivering, but also with hope,” she told Science|Business. “It’s what our industry does. It’s not about identifying a pain point and then saying it’s too hard.”For many in the start-up community, that sense of hope is dwindling. In March, the European Commission presented its proposal for EU Inc, naming its initiative after the grassroots campaign.EU Inc was meant to be a gamechanger: the ability to incorporate within 48 hours for less than €100 and scale up across Europe; a harmonised stock option regime enabling start-ups to compete for talent; and simplified insolvency procedures for innovative start-ups to reduce the cost of failure.However, haggling by EU governments has raised concerns that EU Inc will be stripped of the very features, including stock option harmonisation, that are meant to make it attractive for companies.“I fear we are proving to ourselves that the model doesn’t work,” Borbotti-Frison said of the policymaking process. “Everyone agrees we should have EU Inc. Everyone agrees it’s hard to scale and we need to scale to answer the competitiveness [challenge], and still we cannot deliver? [. . .] What does that say about ourselves?”The Commission has made EU Inc a cornerstone of its single market reform, and has agreed with the European Parliament and the Council of the EU to target an agreement by the end of 2026. However, several points are currently holding up an agreement, including national rules around employee participation in management decisions, and the provision that employee stock options always be taxed at the point of sale. Some EU governments have reportedly pushed back on the Commission’s choice of legal basis, contending that anything related to taxation requires unanimity in the Council.Trade unions have also protested against EU Inc, fearing it will be exploited by companies looking to undermine workers’ rights.“If this doesn’t work, it’s introspection time, on the way our institutions work, maybe the way our lobbies work, and maybe the way the cooperation between them works,” Borbotti-Frison said.“Is it in the national interest? Is it a gap between political will and technical ability to operate? Is it speed? I don't know, but something needs to be fixed.”Ahead of last week’s European Council meeting, EU-Inc campaigners tried a new strategy: appealing directly to EU presidents and prime ministers. In an open letter, they urged EU leaders to “step in and give your negotiating teams a clear mandate to change course and reverse their objections to the Commission’s original proposal.”Lessons from EU-IncLike its predecessors, Startups for Europe will represent national start-up associations, but it is also targeting investors. The founding sponsors are venture capital firm Atomico and EQT, the investor selected earlier this year to manage the €5 billion Scaleup Europe Fund.It also wants to harness the knowledge and cross-border experience of European success stories. “Take the list of the 100 biggest unicorns in Europe. We are speaking to all of them,” Borbotti-Frison said. The association plans to publish a full list of supporters following the Slush tech conference in Helsinki in November.Andreas Klinger and Simon Schaefer, two key figures in the EU-Inc campaign, are both on the board of the new association, and Startups for Europe wants to take the lessons from their campaign.What was unprecedented about EU-Inc was “how rooted it was, and how strong it was in bringing everyone on board behind one clear pain point and solution to fix it,” Borbotti-Frison said. “This is an inspiration for us, and then we need to turn it into something more systematic, more bridged in Brussels, more connected to the policymaking game, and to scale it.”If it’s possible to unite such a broad coalition, it’s because the European start-up ecosystem is now mature, she said. “Maybe it was not ten years ago. Maybe it was not five years ago. But now, it’s mature to speak with one voice.”Open and liberal EuropeThe association plans to campaign on files related to three “pain points,” Borbotti-Frison said: “start and scale in Europe, fundraise and invest in Europe, and making Europe the most innovative continent.”As well as EU Inc, she cited public procurement, the EU’s simplification push, the Savings and Investments Union, and files related to AI adoption and technological sovereignty as priorities for the coming months.What these files have in common is that they relate not to subsidies but to the framework conditions influencing the availability of mostly private, or in the case of procurement, public, funding.Related articlesEmployee participation disagreement delays MEPs’ vote on EU IncCommission urges EU governments not to water down EU IncEU’s ‘ultra-fast’ €5B scale-up fund is set up to win, says its fund managerThe budget dispute over the next Horizon Europe programme will also impact start-ups, which are supported notably through the European Innovation Council. But EU innovation funding is a drop in the ocean compared to venture capital and public procurement budgets.“If competitiveness and innovation are a priority, then the [EU budget] should reflect it,” Borbotti-Frison said. However, she added that the main question is not how much public money is invested, but “how do we create the right conditions for the market to solve the problem?”The Scaleup Europe Fund mixes both approaches, using €1 billion in EU funding to crowd in private investors and address Europe’s lack of large-scale, late-stage growth funds. “It’s a proof of concept. Ideally, then the market will do it itself,” Borbotti-Frison said.Startups for Europe is also focused on bringing an alternative political narrative. Amid competing visions for open, global markets on the one side and a protectionist Europe on the other, it wants to offer “a third voice, to say we can be proudly European and build a strong continent in a liberal economy, open to the world, and global.”It can be tempting, when thinking about how Europe can better support innovation, to look across the Atlantic. But while it’s important to compare statistics to see where Europe needs to catch up, that’s where the comparison should stop, Borbotti-Frison said. “On everything else, we need to do it our own way. We don't have the same history. We don't have the same political model. We don't have the same way of life.”Many of the key files that could benefit the start-up community, including EU Inc and the Savings and Investments Union, rely on closer integration within Europe, making it easier to operate across borders.While the Commission has made deepening the single market a political priority, support at national level is more precarious. The coming months will see pivotal elections in Spain and France, while the German government has also been coming under pressure domestically. In each country, far-right parties have been gaining ground.When asked if she was concerned the political situation could jeopardise this progress, Borbotti-Frison responded: “Of course. I would be lying if I said I wasn’t.” However, she continues to believe that cooperation is the only way forward. “Doing it alone is not the solution. It’s also not who we are, it’s not the model we are building, and it’s not the scale we need.”

sciencebusiness.net logo
Oct 22 • 8:00 AM EDT • Science • sciencebusiness.net
Iowa businesses recognized as top 100 US small businesses

Three Iowa businesses were named to the U.S. Chamber of Commerce’s 2026 CO—100: America’s Top 100 Small Businesses list. The CO—100 recognizes small businesses for their growth, innovation and commitment to their customers, according to a news release. Original Group Holdings, a woodworking equipment manufacturer in Britt, was recognized as a community champion. The company…

businessrecord.com logo
Oct 22 • 8:00 AM EDT • Business • businessrecord.com
Several Linux Kernel Vulnerabilities Accidentally Posted To Public Kernel Mailing List

Seemingly as an accident, overnight several new Linux kernel vulnerability reports were posted to the public Linux kernel mailing list rather than the private security mailing list

phoronix.com logo
Oct 22 • 6:05 AM EDT • Technology • phoronix.com
Serbian Election Underscores the Region’s Long Political Limbo

Aleksandar Vucic, Serbia’s dominant political figure since 2012, may extend his grip, using the Balkans’ unresolved nationalist resentments.

nytimes.com logo
Oct 22 • 5:01 AM EDT • Politics • nytimes.com
Airbnb cracks down on checkout chore lists as hosts face new limits

Airbnb's new checkout rules bar hosts from asking guests to strip beds, wash dishes or do laundry, but some reasonable requests are still allowed.

foxbusiness.com logo
Oct 21 • 9:54 PM EDT • Business • foxbusiness.com
Lakers forwards Ziaire Williams and Matisse Thybulle grab final two starting spots

The veteran forwards are defensive specialists who join Luka Doncic, Austin Reaves and Walker Kessler against Golden State in season opener.

sports.yahoo.com logo
Oct 21 • 9:51 PM EDT • Sports • sports.yahoo.com
Northwestern Receives More Concerning Injury News Ahead of Rutgers

Northwestern faces more injury concerns ahead of Rutgers, with Luke Dehnicke ruled out and Robert Fitzgerald and Brendan Flakes listed as doubtful.

sports.yahoo.com logo
Oct 21 • 9:45 PM EDT • Sports • sports.yahoo.com
🙂 Positive (50%)
Panelist says immigration enforcement campaign adds challenges for Hispanic businesses

SPRINGDALE -- While any business can be affected by rising operating costs or tax burdens, Hispanic business owners in Northwest Arkansas are facing added challenges related to enhanced immigration enforcement efforts, according to Geovanny Sarmiento, constituent relations manager for the city of Rogers.

nwaonline.com logo
Oct 21 • 9:20 PM EDT • Business • nwaonline.com
Deep dive
😐 Neutral (3%)
wow
59%
ahah
41%
TENNESSEE VOLS FOOTBALL: Carter a Whitten semifinalist

For the second consecutive year, Tennessee senior linebacker Arion Carter has been named one of 20 semifinalists for the Jason Witten Collegiate Man of the Year award.

sports.yahoo.com logo
Oct 21 • 9:08 PM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
What to stream: Add best horror films of 2026 to your spooky...

Build your spooky-season watchlist with 2026 horror picks including “Obsession,” “Backrooms,” “Send Help” and “The Bride!,” now streaming or available to rent.

unionleader.com logo
Oct 21 • 9:00 PM EDT • Entertainment • unionleader.com
Lou Gramm to reunite with Foreigner for concerts, retire with a 'bang'

Former Foreigner vocalist Lou Gramm shared plans to retire: 'The second most important thing to putting your heart and your mind and your body into ... a great band is knowing when to walk away.'

latimes.com logo
Oct 21 • 8:08 PM EDT • Entertainment • latimes.com
Spurred by Pulitzer Prize-Winner’s Visit, Business Leaders Grapple With State’s Housing Crisis: Business NH Magazine

Brian Goldstone, journalist and author of the Pulitzer Prize-winning There Is No Place for Us: Working and Homeless in America, spoke during an Oct. 15 forum, hosted by the Greater Concord Chamber of Commerce and the Concord Coalition to End Homelessness.

businessnhmagazine.com logo
Oct 21 • 8:00 PM EDT • Business • businessnhmagazine.com
Northwestern's David Braun Earns National Coach of the Year Recognition

Northwestern head coach David Braun has earned a spot on the Paul “Bear” Bryant National Coach of the Year watch list following the Wildcats' impressive 5-1 start.

sports.yahoo.com logo
Oct 21 • 7:45 PM EDT • Sports • sports.yahoo.com
Brian Robinson Jr. listed as limited

Falcons RB Brian Robinson Jr. limited with hamstring injury in first practice of week

sports.yahoo.com logo
Oct 21 • 7:23 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-7%)
Rico Dowdle limited because of knee issue

Steelers RB Rico Dowdle dealing with new injury and was listed as limited

sports.yahoo.com logo
Oct 21 • 6:37 PM EDT • Sports • sports.yahoo.com
Trump’s growing list of campaign pledges: From the Politics Desk

Plus, Witkoff’s praise for Putin draws bipartisan backlash.

nbcnews.com logo
Oct 21 • 6:34 PM EDT • Politics • nbcnews.com
High-Signal Publisher
Jordan Love listed as limited with back injury on Wednesday
sports.yahoo.com logo
Oct 21 • 4:35 PM EDT • Sports • sports.yahoo.com
Bose Is Buying Skullcandy. It’s Not as Weird as It Sounds

By keeping Skullcandy in Park City, Utah, Bose is betting that skate cred and budget pricing will reach listeners it’s been missing.

wired.com logo
Oct 21 • 4:15 PM EDT • Technology • wired.com
Forge Nano to Trade on NASDAQ as NANO After Completing Business Combination with Archimedes Tech SPAC Partners II Co.

Forge Nano common stock and warrants expected to begin trading on NASDAQ on October 22, 2026 under the symbols “NANO” and “NANOW,” respectivelyPublic listing positions Forge Nano to accelerate growth across semiconductor manufacturing equipment and advanced battery technologies DENVER, Oct. 21, 2026 (GLOBE NEWSWIRE) -- Forge Nano, Inc., a leading U.S.-based semiconductor equipment and advanced materials company pioneering Atomic Layer Deposition (“ALD”) technology for artificial intelligence (“A

finance.yahoo.com logo
Oct 21 • 4:15 PM EDT • Business • finance.yahoo.com
Genenta Science receives Nasdaq minimum bid price deficiency notice

Content provided by Seeking Alpha is intended for information purposes only, and that Seeking Alpha does not offer any personalist investment advice and is not a licensed securities dealer, broker, US investment adviser or investment bank.

tradingview.com logo
Oct 21 • 4:10 PM EDT • Science • tradingview.com
Bucco Calls for Action to Support Small Businesses, Introduces Bill to Give Them a Voice in Trenton

While the Sherrill administration continues its ‘small business listening tour’, Senate Republican Leader Anthony M. Bucco (R-Morris, Passaic) is calling for immediate action to support Ne

senatenj.com logo
Oct 21 • 3:55 PM EDT • Business • senatenj.com
Bucs list Baker Mayfield as full participant on Wednesday
sports.yahoo.com logo
Oct 21 • 3:48 PM EDT • Sports • sports.yahoo.com
MTSU named to Billboard’s list of top music business schools for 12th straight year

Middle Tennessee State University’s Department of Recording Industry has been named among Billboard’s top music business schools for the 12th consecutive year, continuing a tradition of preparing students for careers across the music industry.

mtsunews.com logo
Oct 21 • 3:43 PM EDT • Entertainment • mtsunews.com
MTSU named to Billboard’s list of top music business schools for 12th straight year

Middle Tennessee State University’s Department of Recording Industry has been named among Billboard’s top music business schools for the 12th consecutive year, continuing a tradition of preparing students for careers across the music industry.

mtsunews.com logo
Oct 21 • 3:43 PM EDT • Business • mtsunews.com
Darren Waller listed as limited

Panthers TE Darren Waller starts week with a limited practice

sports.yahoo.com logo
Oct 21 • 3:28 PM EDT • Sports • sports.yahoo.com
Seneca begins $8.9M sports lounge project at Niagara casino

The Seneca Nation’s gaming enterprise, Seneca Resorts & Casinos, has begun construction on an $8.9 million Seneca Sports Lounge at its Niagara location, adding another major project to a growing list of capital investments across its properties. The venue is being built on the west concourse near the Bear’s Den Showroom, in the former Blues […]

tribalbusinessnews.com logo
Oct 21 • 3:06 PM EDT • Business • tribalbusinessnews.com
Michigan awards 12 drone projects state funding

The state of Michigan handed out another $1.7 million to drone startups statewide — and Detroit-based companies dominated the list.

crainsdetroit.com logo
Oct 21 • 2:19 PM EDT • Business • crainsdetroit.com
Longtime California punk band's guitarist reveals ‘fairly serious' health issue, steps away from touring

The announcement comes less than three weeks after The Offspring played Sacramento's Aftershock festival, with several more shows still listed on the band's calendar.

yahoo.com logo
Oct 21 • 1:57 PM EDT • Health • yahoo.com
Mayor Karen Bass fights for 2nd term against democratic socialist-backed Raman

Nearly three weeks into mail voting, only 5% of ballots have been returned, according to ballot tracking firm Political Data Inc.

spectrumnews1.com logo
Oct 21 • 1:39 PM EDT • Politics • spectrumnews1.com
Top Democrats join California immigrant, Nevada group to sue over federal election probes

The lawsuit accuses Trump and his administration of using “shoddily compiled lists of supposed noncitizens” and “coercive threats" against state officials to assert federal control over the midterms.

latimes.com logo
Oct 21 • 1:18 PM EDT • Politics • latimes.com
Making sense of America: Alumnus Astead Herndon's approach to political journalism

Nationally recognized journalist Astead Herndon, Comm ’15, discusses the values, experiences and reporting philosophy that guide his efforts to help Americans make sense of an increasingly complex political landscape.

today.marquette.edu logo
Oct 21 • 1:00 PM EDT • Politics • today.marquette.edu
T.J. Holmes and Amy Robach's exes announce engagement

Marilee Fiebig and actor Andrew Shue, former spouses of newly married journalists T.J. Holmes and Amy Robach, are engaged.

latimes.com logo
Oct 21 • 12:56 PM EDT • Entertainment • latimes.com
YouTube beats out TV as the top source for political news

Six in 10 Americans say they trust independent creators as much as professional journalists, a new survey finds.

futurity.org logo
Oct 21 • 12:25 PM EDT • Politics • futurity.org
Star Wars

Through A-list connections, Jaka Bizilj became a prominent humanitarian. His Ukrainian employees tell a different story.

van-magazine.com logo
Oct 21 • 11:01 AM EDT • Entertainment • van-magazine.com
Science News unveils its list of 10 scientists making an impact on our world

As a teenager, Gabriela Farfan became fascinated by the shapes and colors of minerals. Now, as curator of gems and minerals at the Smithsonian National Museum of Natural History, she studies what they can reveal about our planet.From corals that preserve chemical signatures of changing oceans to sparkling gemstones, Farfan uses crystal structures, chemistry and spectroscopy to uncover the information trapped inside minerals and show why they’re an essential part of natural history. WASHINGTON, O

finance.yahoo.com logo
Oct 21 • 9:05 AM EDT • Science • finance.yahoo.com
Ob Hospitalist Group Named Newsweek AI Impact Health Award Winner for Best Health System AI Transformation

/PRNewswire/ -- Ob Hospitalist Group (OBHG), the nation's largest and only dedicated provider of OB/GYN hospitalist services and a leader in comprehensive...

prnewswire.com logo
Oct 21 • 8:30 AM EDT • Health • prnewswire.com
Iowa basketball receiving votes in preseason AP Top 25 Poll

After a memorable trip to the Elite Eight last spring, Iowa basketball is among a list of programs receiving votes in the preseason AP Top 25 poll.

sports.yahoo.com logo
Oct 21 • 6:45 AM EDT • Sports • sports.yahoo.com
This week in Santa Cruz County business: Cruz Foam ceases operations; West Coast Community Bank celebrates Nasdaq listing

Santa Cruz-based Cruz Foam, which developed a biodegradable packaging made from shrimp shells and other natural materials, has closed and sold off its intellectual property, Jessica M. Pasko reports in her weekly look at local business. Meanwhile, Santa Cruz-based West Coast Community Bancorp has moved its stock listing to the Nasdaq Stock Market, a milestone executives say is more than two decades in the making.

lookout.co logo
Oct 21 • 6:29 AM EDT • Business • lookout.co
Cowboys waive underperforming CB, promote Juanyeh Thomas, add Heisman-finalist QB

In his return stint, Juanyeh Thomas replaces former 5th-round pick Caelen Carson on the active roster. QB Kyle Trask joins the practice squad.

sports.yahoo.com logo
Oct 21 • 5:13 AM EDT • Sports • sports.yahoo.com
15-Minute Lesson Plan: 100 Unanswered Questions in Science

What questions about ourselves, our world and our universe would you most like to have answered? Why?

nytimes.com logo
Oct 21 • 4:00 AM EDT • Science • nytimes.com
Alexis Mac Allister shines in Liverpool win over Villarreal

Alexis Mac Allister scored twice to guide Liverpool to a thrilling 4-3 victory against Villarreal in the Champions League on Tuesday.Manager Andoni Iraola made six changes to the team that defeated Br...

sports.yahoo.com logo
Oct 21 • 2:40 AM EDT • Sports • sports.yahoo.com
Paul

Picture a press room full of journalists, a new signing at the desk, and an executive stepping up to announce: 'I can confirm that this is not an Inter player yet. He will be in a few weeks, once we o...

sports.yahoo.com logo
Oct 21 • 2:00 AM EDT • Sports • sports.yahoo.com
Carolina Hurricanes Dealt Major Dylan Larkin Trade News Amid Rumors

Per reports from The Detroit Free Press, Dylam Larkin has extended his trade list to 10 NHL teams, expanding on what was a group of three teams. The Dylan Larkin trade saga has been in full swing since the Detroit Red Wings star requested a trade from the organization amid several different rumors. Now, it […] The post Carolina Hurricanes Dealt Major Dylan Larkin Trade News Amid Rumors appeared first on HEAVY.

sports.yahoo.com logo
Oct 21 • 12:44 AM EDT • Sports • sports.yahoo.com
Student-produced film captures Ireland sports experience | UNC Hussman School of Journalism and Media

The documentary created by a UNC Hussman School of Journalism and Media team premieres on campus Oct. 22 and Oct. 23. — This story, written by UNC Hussman alumnus Michael Lananna ’14, was originally published at unc.edu. — Carolina senior Anna Laible came up with the idea about a year ago. At the annual UNC Sports and Entertainment Summit, the journalism student walked up to then-athletic director Bubba Cunningham and took a chance. “Hi, Bubba, I’m not sure if you remember me, but I’m part of the student broadcast team from the Olympics,” Laible told him. “I have this idea to do an Ireland documentary on the football team.” Encouraged by the enthusiastic response to the proposal, Laible and a team of students from the UNC Hussman School of Journalism and Media worked diligently to turn that vision into reality. In August, Laible and seven peers traveled to Dublin, Ireland, with the Carolina football team and women’s soccer team. Equipped with video cameras, the student journalists covered both teams during their international games — both wins — and filmed scenes throughout Dublin, interviewing Irish locals, Tar Heel fans and key Carolina figures who helped make the trip possible. Back home, Laible’s team put the finishing touches on the documentary, with its first screening at 6:30 p.m. Oct. 22-23 in Carroll Hall room 111. The project is the latest in a long line of sports documentaries produced under the guidance of C.A. Tuggle, John H. Stembler Jr. Distinguished Professor. Since the 2008 Beijing Olympics, Tuggle and the Hussman school have sent journalism students to cover each of the Summer Games, and Tuggle’s students have also produced documentaries on Carolina teams that win national championships. But this Ireland excursion presented a new kind of opportunity. “This trip is really unique,” Tuggle said. “Bubba liked the idea, so we started working on it, and it’s all because Anna was forward-thinking and assertive.” Laible’s team worked to create a holistic depiction of the Dublin trip, billed as “Much More Than a Game.” The documentary’s 12 chapters cover Irish culture, music, trips to the Guiness Storehouse and the myriad connections between Tar Heels and Ireland. “Our main focus was to make sure we gave a whole encompassing idea of what this experience was like,” Laible said. “We wanted to show not just the student-athletes, but other students, other Carolina fans, Carolina alumni, the music and really incorporate that all in the documentary.” Joining Laible in Dublin were juniors Emily Brietz, Cooper Hall, Eliza Jennings and Katherine McCullough and seniors Molly Malek, May Proctor and Merrily Tew. Those students also traveled to Milan for the 2026 Olympic Winter Games in February. Those kinds of opportunities wouldn’t be possible without the support of UNC Hussman and, in the case of the Ireland trip, the Carolina athletic department. UNC Hussman students create Ireland trip documentary. (Submitted photo) “Never in a million years did I think I would have the opportunity to go to the Olympics or to the Aer Lingus College Football Classic, and now I’m even being presented with potential opportunities go to the Super Bowl,” said Malek, who served in a leadership role with Laible in Dublin. “I think that Carolina does a terrific job of connecting us to these opportunities that almost no other university does. This is a university where you have the opportunity to have an interdisciplinary education and to learn and experience a lot of things all at once.” With the support of UNC Hussman, Tuggle and fellow students like Malek, Laible turned a spur-of-the-moment idea into a documentary. When the film screens, Laible said she’s not quite sure what emotions to expect. “I’m a little worried that I might cry — not that crying is a bad thing,” Laible said, laughing. “But I’m really grateful for so many people helping, and I’m excited for everyone to see it.”

hussman.unc.edu logo
Oct 20 • 10:18 PM EDT • Sports • hussman.unc.edu
Trump pushes to evict the press from the White House

While moving the media out of the White House may be a relatively small debate considering Trump’s broader attacks on journalists, it would be highly symbolic.

seattletimes.com logo
Oct 20 • 9:04 PM EDT • Politics • seattletimes.com
Bears list Jonah Jackson as a limited practice participant
sports.yahoo.com logo
Oct 20 • 5:41 PM EDT • Sports • sports.yahoo.com
Sports Entertainment Gaming Global Received Notice of Delisting

On October 14, 2026, Nasdaq staff issued a determination to delist the company’s common stock and warrants after it failed to file its Q2 2026 Form 10-Q, violating Listing Rule 5250(c)(1). Trading would be suspended on October 23, 2026 absent a hearing request; the company has requested a hearing a…

tradingview.com logo
Oct 20 • 5:33 PM EDT • Entertainment • tradingview.com
Spurred by Pulitzer Prize-winner's visit, business leaders grapple with state's housing crisis

The capital of Georgia — a city of more than 500,000 people nearly 1,200 miles away, where African-Americans outnumber their white counterparts — bears a striking similarity to New Hampshire’s capital. In Atlanta, like in Concord and countless municipalities across the country, housing costs have far eclipsed what working people can afford. Brian Goldstone, journalist […]

concordmonitor.com logo
Oct 20 • 2:32 PM EDT • Business • concordmonitor.com
Why child sexual abuse is our biggest public health crisis

An estimated one in five children will experience some form of sexual abuse before the age of 18. In this episode of Settle In, Amna Nawaz speaks with clinical psychologist Elizabeth Letourneau and journalist Luke Malone, authors of “One in Five,” a book that explores child sexual abuse as a public health crisis, about how education and early prevention can help protect children before harm occurs.

pbs.org logo
Oct 20 • 2:22 PM EDT • Health • pbs.org
🙂 Positive (35%)
Sundar Pichai: Google’s Frontier Imperative, Compute Scarcity Dilemmas, Future AI Products and Businesses

Alphabet CEO Sundar Pichai has little patience for doubts about Google’s willingness or capacity to compete at the frontier of AI. His company’s latest Gemini 4 Argon model — long-promised and recently delivered — beats OpenAI and Anthropic’s latest public models on coding, math, science, and knowledge-work benchmarks and has placed Google’s AI back among the world’s best. Amid chatter that Google was fine with good-enough lightweight ‘Flash’ models, Pichai pushed back hard against any suggestion that company is limiting its research ambitions. “We won’t do it any other way,” he told me in a Big Technology Podcast interview recorded this week at Google’s Mountain View headquarters. Pursuing cutting-edge research is costly for Google, requiring compute and chips that otherwise could be sold at a high markup by its cloud business. But Pichai said allocating resources to frontier AI development is “ground zero” for Google. “Our cloud business is at any given moment in time forgoing short-term revenues because we are making compute trade-offs to support frontier AI development,” Pichai told me. In our conversation, we discussed Argon (which Pichai says processed three times as many tokens as Gemini 3 in the 72 hours after launch), AI’s role in developing better models, the AI interface of the future, competition with OpenAI, Google’s partnerships with Anthropic and Apple, data centers in space, and the nature of his optimism. You can read the full conversation, lightly edited for length and clarity, below, or listen to it on Apple Podcasts, Spotify, YouTube, or your podcast app of choice. Alex Kantrowitz: Google is back at the frontier with Gemini 4 Argon, which beats OpenAI’s and Anthropic’s public models on benchmarks spanning coding, math, science, and knowledge work. The conventional wisdom was that Google had given up on the frontier to focus on fast, good-enough models for its products. That was wrong? Sundar Pichai: Very wrong. Look, we are so committed to being at the frontier. It’s in our DNA. We won’t do it any other way. We’ve been thinking about the AI frontier for well over a decade now. The frontier is very dynamic. It’s very competitive. It’s very exciting. I couldn’t be more pleased with how Argon has come together. We took our time with it. We made sure we tested it safely and deployed it carefully. We took a bit longer than our other models, given its capabilities. Across the board, be it for agentic work, knowledge work, coding, creative tasks, Argon is one of the really good frontier models. The first 72 hours since we launched, it’s almost up to 25 trillion tokens used, which is about three times what Gemini 3.0 had in the first 72 hours. And we are capacity constrained as we are serving it. Excited, but there are always areas….. You know, the frontier is very dynamic, and you have to keep evolving the models. There are areas which we can see we need to improve as well. We’ll be at work on all of that as well. Which areas? On any given model, Argon would be across the board better at everything if you just look even two months back. But the space is so evolving. Even on coding, for example, there are pockets where we know we need to do better, and there’s clear feedback. We’ll make it better. The argument for standard models is that they’re already good enough to build great products, with the frontier valuable only for certain tasks. Meta built Muse with good models rather than the best, and Google could put standard models into Maps, Gmail, and Search. Why isn’t that sufficient? It’s definitely not how I have thought about it at all. We are deeply committed to driving the state of the art and actually pushing where this technology can go, all the way from transformers. That’s a journey we’ve been on. You will see us continue to do that. When you’re at the frontier, you get an earlier look into the emerging capabilities, earlier than others, which helps you better prepare for the future. We are fortunate to have a wide set of opportunities across consumer and enterprise. Some of our cloud customers, for sure, want the model at the frontier. The frontier models will be better at developing the next set of models in an era of recursive self-improvement. I would argue it matters there. Internally, we have definitely seen a steep point of inflection by deploying Argon to our developers. It definitely tackles problems which our previous models could not do. Being at the frontier puts you at the innovation frontier and helps you drive that as well. There is room for models of all sizes and capabilities. That’s why we did Flash, Flash-Lite, etc. I agree with you that you can develop very good product experiences with not necessarily the most frontier model, because they tend to be slower and more expensive too. But we care about the Pareto frontier, and we’re committed to doing all of that. You said developing frontier models gives you a look at what’s coming. What do you see on the horizon? What makes this moment so exciting is you build something which you think is a culmination of months of work, and you put it out. You already see clear headroom ahead. We’ve all been working on these agentic, long-horizon capabilities, but clearly the frontier is going to have multiple of these agents working together to do things. That’s an example of an exciting paradigm underway. It’s also clear to me that users, both in consumer and enterprise, will have access to some multi-agent framework for them, working all the time doing things. It feels like a moment of infinite possibilities. Sergey Brin said one of Argon’s core innovations was relying more on the model to help develop the model. Yet incidents involving OpenAI’s bots breaking containment and Google’s bots accessing a site they shouldn’t have suggest these systems still aren’t perfectly aligned. Isn’t there reasonable cause for concern about accelerating toward recursive self-improvement? There are three parts to your question. Let’s first talk about RSI itself. You’re right, Sergey mentioned RSI being a critical contributor as we are developing Argon. But to be very clear, today, in a continuum, we are pretty far from the end state of RSI or something like that. The right way to describe it is you have RSI loops along with AI researchers in various aspects of model development. You almost have agents helping AI researchers in some automated way work together to build these models. It’s good to at least understand where we are today, and it’s super exciting. I expect that continuum to keep making progress as we go into next year. The second question is around safety. Security comes from defense in depth. You’re talking about alignment, obviously. We all are doing a lot of work to make sure the models are as aligned as possible. But it’s an active area of research, and there are clear gaps. That’s not the only thing we rely on. You have the work you do on alignment, but beyond that, we put a lot of effort into real-time monitoring as these models are working. Making sure you have good telemetry into what’s happening so that you can intervene in real time if you see unexpected behaviors. How you do that, the architecture with which you do that, how you make sure it’s all sandboxed and isolated in a way that it can continue doing its job during real-time monitoring — these are all areas of investment. Obviously, when we deploy these models, giving customers, enterprises, control, both with real-time monitoring, but their ability to decide where they deploy, what type of data which models ever have access to, etc. All that work is very, very important, and we are doing a lot of that. As an industry, we need to constantly up our game and take the time to do all this stuff, including dedicating the compute required to make sure you can safely deploy these models. The third part is: Is it all enough? This is why there are a lot of conversations in the industry, and I think it’s reasonable to be worried. The right way to approach something you worry about is early on thinking about what more we can do. As an industry, you’re definitely seeing increased levels of work on alignment, testing for safety, etc., as we deploy these models. The next step would be developing better standards so there are cross-industry standards of how we do these things, including the ability to evaluate using independent evaluators. If you look at areas like financial controls, we have accounting standards, we have independent auditors. Those are all the next natural steps for us as an industry to work toward, and regulation will end up playing a role as we go through all of that as well. Google pursues both language models and world models, while some other AI companies like OpenAI have focused more heavily on LLMs as the path to AGI. Why is world-model research important to you? As humans, you obviously perceive the world around you, and you’re taking all those inputs. Making sure these models are able to understand the laws of physics, simulate the world in high fidelity. All that, I think, are key enabling blocks for intelligence. We are working across all possible applications of this. Take an area like robotics. It’s not an accident: If you look at embodied reasoning benchmarks, Argon is state of the art. That all comes from our experience building world models. Inherently, I would expect there will be architectures which will converge all of this in the future. But for us, we view this as, today, this jagged frontier that is intelligence. We want to be at the frontier of all the possible approaches, and that will help us both drive better research, better insights, and develop a much better AGI model, is how we think about it. Some people argue Google should focus on selling its computing resources rather than using them for AI research. Cloud wants to sell compute at a high markup, while researchers need a very big computer to build the best models. How do you balance those demands? Ground zero for us is making sure we are investing in the compute that’s needed to be at the AI frontier. In 2015, I set the company to be AI-first. AI is that key horizontal ingredient across everything we do, all the way from Search to Cloud to Waymo. That is ground zero for us, making sure both for research and developing the models that we have enough compute needed. Beyond that, we have these independent businesses which each have their own long-range plans. They’re using those long-range plans to project forward, and we plan for compute for all of them. The cloud team, they have a business and they have a projection and they have demand signals. They have committed contracts. With that help, we can plan on a long-term compute trajectory for them. We’re fortunate to have this wide set of opportunities. There’s no company in the world which isn’t making trade-offs at any given moment in time. But the first principles we operate on is making sure we have enough compute to invest in the frontier, and that’s non-negotiable, and everything else works on top. Remember, we are building our own compute, our own data centers. There are long lead times. The compute we have today is a function of decisions I made in 2024. Even if you think back to a year from today, last year the agentic coding takeoff hadn’t happened. Today, obviously, when you sit and look at anything, everyone is short—not just us, other companies—and everyone wishes you had two times what you had planned for. That comes with the territory. At any given moment in time, we are planning for what we would need two to three years out in the future. You’re going to find some decisions you make may look suboptimal two years out, depending on where the state of the art is. I don’t spend too much time thinking about it. The way I think about compute allocation is making sure Google DeepMind, both for research and frontier model development, is cutting edge in terms of compute access. After that, we plan for all our businesses. It’s great we can provide our compute to other people too, like we have done. It allows us to scale that up, get real tests for it in the widest application set possible, test it in the real world, and make sure we are at the cutting edge of technology at every layer of our AI stack as well. Ben Horowitz relayed on a podcast that Andy Jassy had said compute was sold out until 2028. Are you seeing the same thing? If today a customer is coming out and asking us for compute in ’27, that is incredibly difficult to do. Even last year we went out and leased some short-term compute to accommodate some customers and help them out. But yes, we are all dealing with similar timelines. Every major technology shift seems to involve overbuilding, from railroads to fiber. Do you think that’s happening here? It depends on the time frames you’re looking at. This level of build, if I take a long enough time frame, it makes complete sense to me. We are at early stages of the most consequential technology ever, and this is not like fiber. It’s not dark. We are using it. We are capacity constrained on a daily basis. The applications, the underlying technology is improving rapidly. But running a company, the way I work through the moment is you look at your demand signals. You look at your committed revenue opportunities that you’re getting in the form of contracts. You balance that with the underlying technical capability, or internally you balance how we are using it internally, the model trajectories. Based on all that, you take a disciplined approach—a confident, aggressive, but disciplined approach—to plan out compute. But when you talk about the broader economy as a whole, you’re having people operate with various levels of risk. I focus on what I can control as a company and plan through it. If your question is, can there be an overbuild? Yes, because you can have some constrained components. Remember, what matters is a set of everything you need to build out that compute. Memory, electricity, electricians…. Land. Like 2,000 components or more. You could get constrained at some point. There could be things which cause bottlenecks, and then you could have overbuilds. There could be external shocks to the economy. There are macro risks. All that is possible at any given time. But am I confident that the compute we are planning for, we will have uses for it given enough time? Absolutely, yes. I was in the room when you said AI would be as profound as fire and electricity. If you believe that, shouldn’t you give researchers the biggest possible computer, even at the expense of today’s cloud profits? We’re all doing some form of that. Our cloud business is at any given moment in time forgoing short-term revenues because we are making compute trade-offs to support frontier AI development. What you’re seeing is true already. But you want to be thoughtful. Even our AI researchers have some constraints, which are also good. That’s what inspires creativity. That’s what helps you come up with a more efficient algorithmic breakthrough, maybe to use less memory. What we are committed to is to invest what’s needed to stay at the frontier. OpenAI President Greg Brockman told me a few months ago that the ideal AI product might have no interface at all—just as natural as conversation. What do you think the interface looks like in the age of AI? Computing historically has been humans adapting to computing. With AI, it’ll be the other way around. The technology will adapt seamlessly to how humans live and go about their day-to-day life. You want to be able to speak to that AI when you want to. It has context. It can be persistently running somewhere, give you continuity. You’re not dealing with a lot of complexity. It’s natural. All that makes sense to me. That doesn’t mean it won’t have any interface, however. Nowadays, even on my phone, Gemini voice models are so good. I can just press the microphone button. I can just ramble. That’s why we call it Rambler. I can ramble. It intelligently corrects with my personal context. Even my friends’ names, weird names, it gets it right, even if it first guesses it wrong. It’s amazing. I’m not going in, backspacing, editing once I finish saying it. It’s remarkable how good it’s gotten. But there are going to be moments you will need an interface. You may want to entertain yourself. You may want to watch a video. You may ask your AI to create something, and you want to watch it, consume it. The way I think about it is, you want it to be as seamless and as natural as possible, and that you are not doing the hard work adapting to whatever the interface is. The technology is adapting to how you’re working at any given moment in time. When I asked Sam Altman about competition from Google, he argued that OpenAI was building AI-native products and implied Google was bolting AI onto existing ones. Do you accept that framing, and can a “bolt-on” compete with an AI-native product? First of all, it’s a very dynamic moment. We are all pushing each other. OpenAI has pushed us as a company too. This is not just we are doing something to them. Far from it. Yes, Google went into its own version of a code red too. In the AI moment, all of us have to respond with varying levels of urgency at any given moment in time. We are constantly building new products as well. Gemini was built from the ground up as a product—the Gemini app I’m talking about. Or tomorrow, as all of us are adapting to agents, are you bolting agents onto ChatGPT, or are they building it natively? How would you think about that? You can always put these questions back. I don’t think of it that way. I think of it as you want to build world-class product experiences that are AI-native and they are winning. Some of it is adapting products, some of it is rethinking new experiences. They will all be part of how you approach this moment. How do you expect to make money from these AI interfaces? If an agent recommends a product and I buy it, should it take a cut of the sale, even if that’s disclosed? I’m going to put enterprise aside. Consumers are going to increasingly value this technology. Take software developers today. Developers are willing to pay for these coding models because it really helps make them more productive. Nobody would want to code the way they were coding three years ago, or even the same time last year. When you’re delivering value, there’s value to be had. I’ve never seen examples where consumer products really scale to billions of users, where people are using it intensely, and haven’t had monetization to go along with it. If you’re providing value to people, there is inherent value to be had. The nature of it may change. You’re asking a scenario in which agents are doing stuff for you. At the end of the day, you will have commercial needs. The agents need to fulfill those commercial needs. The providers on the other side are going to see value in that. There’s going to be some mechanism by which it gets fleshed out. That’s what an efficient system does. But what matters is that you’re building those world-class consumer experiences. I promised myself one product feature request: Can you make Gemini-powered search in Gmail as good as searching Gmail through ChatGPT? What’s going on here? One of the exciting things we announced recently is the unified Gemini agent for enterprise, and we’re bringing that to consumers. These are persistent agents which run 24/7 in the cloud. We’re spinning up a micro VM effectively for every query, and from the runtime, the harness, the model—it’s all a headless service. It’ll work everywhere, and it has your context with you. You can address this agent whether you’re in Workspace, in Search, in Gemini. Agents are going to drive this unification from a customer experience, which people are looking for. When you have a broad product portfolio and you’re moving forward fast, there are always areas where you’re moving forward faster than some other areas. That’s valid feedback. But we are putting a lot of time and effort into making sure, as we build out our agentic experience, that unification and that capability works well across all these services. People have asked where Google’s equivalent of Muse or Dots is. Do you anticipate creating a new product to compete with them? Our goal with Gemini is to be a personal, proactive, and powerful assistant. That’s what we are working toward. You saw us describe the early versions of it at Google I/O this year with Spark. Effectively, already, if you open the Gemini app as a Pro or an Ultra user, you see Chat and Task, and they start giving you that agentic experience. With Argon now, that capability is dramatically accelerated. What we announced recently in our enterprise event, we are bringing that to consumers as well. Soon in Gemini, you will be able to ask something, and it’s a continuum. You don’t need to think about whether you’re asking a chat or an agentic task. It’ll just automatically do the right thing, and it can work persistently in the background securely and get things done for you. Already, empirically, when I look at what’s coming into Gemini in our app, last year you would have tagged them and most of them would have been chats. But a steadily growing percentage is already agentic tasks in Gemini. Yes, we are going to bring personal agents to our consumers. It’ll work in the Gemini app. It’ll work in Google Search. It’ll work in Gmail. You can address it, call it, etc. We want to make sure we’re getting it right. It’ll be powered by Argon, and we are very excited to bring it to our users. Google has invested and committed tens of billions of dollars to Anthropic. What do you see in Dario Amodei that makes you want such a deep investment and partnership? Very early on, when we looked at the founding team of Anthropic, it was very clear to us this was a world-class team which was involved in some of the earliest GPT models. We were quickly able to assess that they would be at the frontier. We’ve always tried to identify and partner with companies which would be at the cutting edge of technology. We’ve done that with SpaceX. We’ve done that with Anthropic. That’s what we saw, and we had a chance to partner. Is your partnership with Apple to license Gemini for Siri expanding, contracting, or standing still? For both us and Apple, that partnership was about translating the capabilities of AI into better experiences for users. I thought Apple has done a phenomenal job of incorporating—they customize these models and build it into Siri—and it’s been great to see the reception. We are committed to doing more. You’re going to do more with them? There’s nothing specific to comment, but it’s a partnership. It’s working well. What have you learned so far about the feasibility of data centers in space? It’s a very exciting project. Projects like this remind me—I still recall that moment in the desert for the DARPA Grand Challenge, watching the Stanley car compete in it, which ended up being the basis for Waymo. With all these technologies, you’re at a moment in time where it looks a bit like sci-fi, but 10 to 20 years down the line, it’s actually working in a meaningful way. I feel the same in space. We’ve always believed in betting big on these technologies. Quantum has been a great example of it. We’re probably 10 years into the journey. Waymo, we are almost 20 years into the journey. Space, we are two to three years into the journey. It’s clear to me that it’s an approach which will make a lot of sense in the future. Being in sub-synchronous orbits with 24/7 access to the most abundant form of energy we have access to will make a lot of sense for this exponential increase in compute that we are going to need. Having said that, this is a challenging project. The team has disciplined milestones. It was a super exciting milestone to send the TPUs up to space. Sometime, as we are speaking, we are expecting a “hello world” moment from them. I look forward to seeing that happen, and we’ll continue investing here too. You previously said 25% of the code written within Google was written by AI. What’s the number today? That number in our world today is meaningless in the sense that every part of what we now touch is influenced by AI deeply. What we are tracking with Argon, for example, it’s been a point of inflection. People are using Argon to really go tackle complex projects, including projects which affect millions of lines of code. In the four weeks since we have launched Argon, we have seen a 30% increase in CLs, and more importantly, almost a similar increase—a one-third decrease in rollbacks. People are writing code more productively and better code with it. We are tracking it with newer metrics now. How are you dealing with opposition to data centers? If you can’t build in the U.S. the way you want to, where else do you go? We’re very committed to building our data centers very responsibly. When I look at our largest data centers in some of the communities where we have been the longest, I visit them, I talk to people. There are people who come and tell us their kids have gone to college because of our investments in these communities, and we’ve grown in those communities. To me, this is about doing it right. Engaging with the communities early, doing it transparently. We are committed to making sure we are bringing incremental power, and we cover 100% of the cost of our power needs for these projects. It’s understanding the impact on neighborhoods and making sure you’re working thoroughly to address them. Done rightly, you can continue making progress. But we are constantly taking feedback into account. I do worry not everyone operates the same way. People have been surprised by data centers showing up in their backyard. Those are all important. As an industry, we should continue to do better. But part of the reason, in a 20-year time frame, we are thinking about things like data centers in space is making sure we are able to put these data centers where maybe the trade-offs will be different. What unproven area of AI is Google working hardest to crack? Is it continual learning—getting models to keep updating after release—or something else? There are multiple parallel paths. You saw with Argon we have a million output tokens. With our Gemini models early on, we had a one-million context window on the input side. These are all examples of breakthroughs we are constantly working on. How do you think about synthetic data? How do you think about continual learning? How do you think about more efficient architectures? We do dedicate a meaningful percentage of our compute to these research bets too. It always goes hand in hand, including our world models. Those are all bets we are placing. Sometimes, as part of these bets, there are ideas that emerge which just make their way into the mainline models. Maybe we don’t fully talk about it, but we have multiple steps in these areas. Working in technology requires optimism that building something will improve the world, but those bets can leave real consequences when they fail. I recently returned to a town in El Salvador where enthusiasm for Bitcoin had given way to unfinished construction and something resembling a ghost town. How do you maintain the optimism you spoke about in your Stanford commencement address while accounting for those risks? I genuinely have a deep conviction that improving technology and improving access to technology makes people’s lives better. It’s been my personal experience in my life, out of which comes that deep conviction, optimism. But with that, I’ve always felt humanity’s journey is always about working hard to harness that technology to make it work well for society. The optimism is not an optimism that you just build whatever you want, whenever. You work hard to make sure you’re building technology in the service of humanity, to make the human condition better. That’s got to be the defining goal as we are approaching it. With that framework, I’m very, very optimistic. We are in very early stages of the kind of progress that we are going to see on many areas. We’re all talking about areas like healthcare. A lot of the progress is ahead. The ability to make things in a fundamentally cheaper way on many things where things have been getting expensive for a long, long time, discovering new materials, etc., which really bend the curve—it’s tough to step today and understand the impact of all that, but they’re going to be very profound. I’m very optimistic, but we have to be rightfully concerned about all the ways this technology can go wrong. Sundar, I know you don’t do many of these. Thank you. Thanks, Alex. Appreciate it.

bigtechnology.com logo
Oct 20 • 1:47 PM EDT • Technology • bigtechnology.com
Nintendo announces Halloween 2026 sale for Switch 2 and Switch

Nintendo just started a new Halloween 2026 sale for Switch 2 and Switch, and here's the full list of deals.

nintendoeverything.com logo
Oct 20 • 12:38 PM EDT • Technology • nintendoeverything.com
Vanessa Kerry is the new WHO envoy for health resilience. What's on her to-do list?

A respected figure in the world of global health, Dr. Kerry takes on a new responsibility. She says it's challenging but not "daunting."

npr.org logo
Oct 20 • 12:27 PM EDT • Health • npr.org
High-Signal Publisher
Coming to XBOX Game Pass: Final Fantasy VII Remake Intergrade, The Séance of Blake Manor, and More

Ghosts to question and a planet to save. Sounds like a perfectly reasonable few weeks to me! We have another batch of games coming soon to Game Pass, so clear a little room in that “Play Next List” and let’s get to it!

news.xbox.com logo
Oct 20 • 12:00 PM EDT • Technology • news.xbox.com
Axena Health Named Finalist for the Digital Health Hub Foundation - Digital Health & AI Awards 2026 at HLTH

NEWTON, Mass., October 20, 2026--Axena Health, Inc. (Axena Health), a women’s health company redefining the standard of care for pelvic health conditions through clinically proven, non-invasive treatments, today announced it has been named a finalist for the Digital Health Hub Foundation – Digital Health & AI Awards 2026 at HLTH. Selected from a pool of more than 1,300 participating companies across all tracks and categories, Axena Health is recognized in the Best in Class Track for Women’s and

finance.yahoo.com logo
Oct 20 • 11:59 AM EDT • Health • finance.yahoo.com
Buzz of the Week: Do you feel like you have a political home in Utah?

Republican, Democrat, Democratic Socialist, Libertarian, Independent, something else entirely — do you feel like you have a political home in Utah? Let us know what you think.

sltrib.com logo
Oct 20 • 11:37 AM EDT • Politics • sltrib.com
5 things to do this week in Greenville

See our curated list of upcoming and ongoing arts, culture and entertainment events in the Greenville area. Send us your events at greenville@postandcourier.com.

postandcourier.com logo
Oct 20 • 11:00 AM EDT • Entertainment • postandcourier.com
Time at CSUSM Helps Computer Science Grad Make Forbes' List

Parents usually do anything they can to get their kids to take a break from playing video games. Emily Sorger’s parents took a different approach. “When I was younger, my dad would say, ‘No, you can't go outside and play until you finish this level’ or ‘You can't do your homework until you play this game and tell me if you like it or...

news.csusm.edu logo
Oct 20 • 11:00 AM EDT • Science • news.csusm.edu
Mandy Moore, Emmy Rossum among A-list speakers at WME's inaugural Women’s Health Summit in Malibu

Katie Couric — whose upcoming documentary “Hormonal!” covers a crisis in women’s health — made an appearance via video to reveal a stat that drew gasps.

pagesix.com logo
Oct 20 • 10:40 AM EDT • Health • pagesix.com
Paxton campaign showing ‘desperation’ with manufactured story: Political commentator

In the final days until election, President Trump is set to hold another rally in Texas for Republican Senate candidate Ken Paxton. MS NOW National Reporter Rosa Flores shares what she is hearing from voters there. MediasTouch Journalist Adam Mockler, Democratic Strategist Basil Smikle, Bloomberg Businessweek Journalist Max Chafkin, and Rolling Stone Magazine Politics Reporter Nikki McCann Ramirez join the Group Chat with Stephanie Ruhle to share their analysis.

ms.now logo
Oct 20 • 10:02 AM EDT • Politics • ms.now
Looted French goods are popping up on resale site Vinted

The second-hand online marketplace Vinted has removed listings of looted French goods and stepped up checks on “suspicious” adverts, as the country’s authorities seek to prevent goods stolen during riots from being sold online.

cnn.com logo
Oct 20 • 9:28 AM EDT • Business • cnn.com
Antigravity just halved the price of its drone — by swapping its headset for wristwatch control

$800 now buys you a follow-me drone instead of an FPV flight experience.

theverge.com logo
Oct 20 • 9:00 AM EDT • Technology • theverge.com
Docktober invites folks to join citizen scientists in peeking under docks

Oregon naturalist leads the global Docktober movement, encouraging citizen scientists to discover and document the marine life thriving beneath public docks.

klcc.org logo
Oct 20 • 9:00 AM EDT • Science • klcc.org
AI is Changing Science: Here’s What Journalists Need to Know

Researchers are rapidly adopting AI for everything from data analysis to planning and executing entire research studies. Journalists will need to keep up. That means learning the basic principles, strengths, and weaknesses of the diverse technologies labeled as “AI”—and how to tell when using AI in science is actually noteworthy. Luckily for science reporters, knowing your beat well can help you cut through the hype.

theopennotebook.com logo
Oct 20 • 8:00 AM EDT • Science • theopennotebook.com
Spotify launches paid podcast memberships with perks beyond bonus content

Spotify's new paid memberships let podcasters offer fans exclusive perks, including ad-free listening, early access, and bonus content, while keeping 90% of the revenue.

techcrunch.com logo
Oct 20 • 8:00 AM EDT • Technology • techcrunch.com
Post-Shanghai ATP Power Rankings: Alexander Zverev Takes Charge

As you already know, this is not the ATP rankings list; rather, these are ATP power rankings that combine 2026 results, recent form, performance against elite opposition, current fitness, and the level each player is realistically capable of producing during the final stretch of the season. The picture has changed considerably since our pre-Wimbledon rankings. …

sports.yahoo.com logo
Oct 20 • 7:30 AM EDT • Sports • sports.yahoo.com
A note to readers: Science, accountability and elections

Dear readers, As early voting begins, I wanted to share some news — and why it connects to the decisions we make at the ballot box. I’ve been selected for the inaugural cohort of the South Atlantic Climate Journalism Hub mentorship program, hosted by Covering Climate Now. I’m excited to join this group, learn from scientists and fellow journalists, and expand my science reporting. Science directly ties to governance. Local officials make decisions about where development goes, how infrastructure is maintained, what emergency preparations receive funding, and how communities rebuild after disasters. Understanding the evidence behind those decisions helps us evaluate whether our government is serving us well. Here in western North Carolina, those connections are all around us, in Lake Lure and beyond. Flood maps inform decisions about property and development. Engineering assessments help identify risks at dams and bridges. Rainfall forecasts guide emergency preparations. Geological information helps explain landslide hazards. Water testing gives communities information they need to assess conditions. Meteorologists’ knowledge and public perception of weather events shape public safety. Each involves scientific or technical knowledge. Each also raises questions about public responsibility: What did officials know? How did they use that information? What did they tell the public? What did taxpayers receive for their money? A study can identify a problem. Elected officials still have to decide what to do about it, how to pay for it, and how to explain their choices. Reporting should examine both the evidence and the response. That is where I want to strengthen my work. My reporting on Helene recovery, infrastructure, flooding, public safety, and public spending has repeatedly brought me to questions that require scientific expertise alongside public records. This mentorship may help me better understand the research, ask more precise questions, and explain the answers clearly. I also bring the perspective of someone living with these concerns. I live downstream of Lake Lure Dam, and landslides affected my property during Helene. Those experiences bring urgency to my questions. Careful reporting helps establish the answers. Readers deserve to know what the evidence shows, where uncertainty remains, and whether officials accurately describe the information guiding their decisions. You also deserve scrutiny of proposed solutions: what they cost, what they are expected to accomplish, and what risks remain. Access to that information matters. As a mostly deaf journalist who relies on written communication, I will continue pressing for written public warnings, records, and explanations that people can read and use in real time. As you consider the candidates seeking your vote, consider how they approach evidence, preparedness, and transparency. Do they support local journalism, even when it’s not parroting a press release? Do they explain weather events clearly in plain English and explain their decisions after them? Make supporting records available? Acknowledge uncertainty? Follow through when a report identifies a risk? Those are practical questions about governing. Thank you for supporting Cops & Congress and the work that makes these questions part of the public conversation. I’m grateful to David Dickson and the CC Now team for this opportunity, and I look forward to bringing what I learn back to you. Annie DanceEditor & Publisher, Cops & Congress — Learn more about this newsletter, ethics policy, how you can help shape this work, and support it. Follow on X and Facebook. Send constructive criticism, fan mail, and tips with public documents for future stories: CopsandCongress@gmail.com ICYMI: View the Cops & Congress archive — Annie Dance is the publisher of Cops & Congress, a newsletter that analyzes what happens when crime, courts, disaster, democracy, and small-town policies collide. Views expressed here are covered by the First Amendment. Dance has a Bachelor of Arts from Manhattan University in Communication with a focus in Journalism and Government. She has been a journalist for over 20 years. Share Upgrade now or give a gift subscription

anniedance.substack.com logo
Oct 20 • 6:56 AM EDT • Science • anniedance.substack.com
One of three Jensen Huang-signed RTX Spark laptops won at NVIDIA launch event is already listed for $17,150

An ASUS ProArt RTX Spark laptop bearing Jensen Huang's signature is reportedly being offered for $17,150. The asking price exceeds regular Turkish retail pricing by more than two times.

videocardz.com logo
Oct 20 • 6:36 AM EDT • Technology • videocardz.com
List of DVD release dates for Oct. 20 and beyond

Following is a partial schedule of coming movies on DVD. Release dates are subject to change: OCTOBER 20: Masters of the Universe 20: Hadestown: The Musical 20: One Night Only

recorderonline.com logo
Oct 20 • 5:45 AM EDT • Entertainment • recorderonline.com
France Protests Show Europe’s Shift Away From Centrist Politics

Europe’s centrist parties are losing ground among young people and workers, who are increasingly tempted by populist promises of radical change.

nytimes.com logo
Oct 20 • 5:01 AM EDT • Politics • nytimes.com
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain

Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)

fiercebiotech.com logo
Oct 20 • 3:59 AM EDT • Business • fiercebiotech.com