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FDA Should Practice the Science It Preaches
The FDA has plenty of advice for pharmaceutical companies. It publishes guidance documents, establishes scientific expectations, and expects drug developers to explain themselves when they take a diff...
Ex-OpenAI science chief Kevin Weil launches Warp Sciences with $215M for drug chemistry
Ex-OpenAI science chief Kevin Weil launches Warp Sciences with $215M for drug chemistry - SiliconANGLE
Sen. Louise Lucas indicted on federal drug charges
Virginia Senate President pro tempore L. Louise Lucas was charged Thursday in connection with an alleged criminal enterprise.
FDA has finalized its guidance on apps related to drugs
In this edition of STAT Health Tech: FDA's guidance on prescription drug use-related software, and telehealth pushing GLP-1s for addiction.
Goodbye obesity, hello Ozempic: GLP-1 politics
The rise of Ozempic and GLP-1 drugs reveals how body politics, beauty standards, class and desirability shape ideas of the American body.
New US drug launches need price check to counter access impediments, ICER, West Health urge
As policies from the last two presidential administrations put heightened focus on drug affordability in the United States, a new report suggests much work remains to be done when it comes to the l | As policies from the last two presidential administrations put heightened focus on drug affordability in the United States, a new report suggests much work remains to be done when it comes to the launch prices of novel medicines.
HCA Healthcare to Host Eighth Annual “Crush the Crisis” National Prescription Drug Take Back Day - Florida Hospital News and Healthcare Report
October 21, 2026 – HCA Healthcare, Inc. (NYSE:HCA), one of the nation’s leading healthcare providers, today announced it will host its eighth annual “Crush the Crisis” national prescription drug take […]
Guns, drugs, AI, budget cuts join traditional maladies at public health forum
A daylong public health forum in Baltimore on Tuesday touched on health challenges that likely aren't found in any medical textbook: gun violence, artificial intelligence, social media and "the ravages of Washington" under the Trump administration.
Billionaire Mark Cuban’s 5-step plan to make healthcare affordable targets drug middlemen’s ‘contractual terrorism’
The Cost Plus Drugs cofounder told Texas lawmakers that insured patients are often better off paying cash—and laid out five fixes built around price transparency.
Would subsidizing weight-loss drugs make health care fairer?
GLP-1 medicines such as Ozempic, Wegovy and Mounjaro have transformed the treatment of obesity, but access to them in Australia increasingly depends on something much less medical: whether you can afford ...
Healthcare and Life Sciences Leaders Build on NVIDIA to Advance Drug Discovery and Expand Patient Care
NVIDIA today announced collaborations with leading global healthcare and research organizations to advance protein design — including through a newly released open model, RFD4-Proteina — accelerate drug discovery and bring greater precision to cancer care.
DEA serves search warrant at Cape Girardeau health clinic
The Drug Enforcement Administration served a search warrant at a health clinic in Cape Girardeau on Tuesday morning, October 20.
Harms of Public Health Measures Overlooked in COVID-19 Policy Reviews
Investigators link oversight with eroding trust in health authorities and call on future pandemic inquiries to weigh trade-offs.
No science background? AI does the lab work
Financial analysts used Anthropic’s Claude to design protein minibinders that bound scorpion toxins in lab tests—showing AI can compress drug discovery...
Tips for covering Medicare open enrollment
It's that time of year again when traditional Medicare enrollees can change their Part D prescription drug plan, move from a Medicare Advantage plan back to original Medicare, and in a handful of states, switch Medigap plans.
Judi Health launching employer Medicare Part D plan with a focus on transparency
Judi Health is launching a new Part D plan that aims to lean on its tech stack to drive transparency and outcomes. | Judi Health is launching a new Part D plan that aims to lean on its tech stack to drive transparency and outcomes.
Scientists finally uncover why statins can cause muscle pain
Scientists have uncovered a surprising reason why statins, the widely prescribed cholesterol-lowering drugs that help prevent heart attacks and strokes, can sometimes cause muscle pain, weakness, and even severe muscle damage. Using advanced imaging technology, researchers discovered that statins can attach to a crucial protein in muscle cells and force open a channel that normally controls calcium flow. This causes calcium to leak continuously, potentially damaging muscle tissue.
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain
Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)
GLP-1 drugs may protect kidney health in people with bipolar disorder
Mayo Clinic researchers found that GLP-1 receptor agonists, medications widely used for diabetes and weight management, were associated with a lower risk of dialysis or kidney transplantation in adults with bipolar disorder and chronic kidney disease.
GLP-1 Drugs and Mental Health: Effects on Depression and Anxiety
GLP-1 receptor agonists affect pathways involved in mood, appetite, and reward, prompting research into their potential benefits for depression, substance use disorders, and binge eating. Psychiatric treatment benefits remain unproven, while conflicting observational findings and reassuring trial evidence require careful interpretation.
Toppenish School District receives $7.5 million federal grant to expand mental health services for students
The BriefThe Toppenish School District has been awarded up to $7.5 million through Project AWARE (Advancing Wellness and Resiliency in Education), a federal grant administered by the Substance Abuse and Mental Health Services Administration (SAMHSA).The grant will provide up to $1.5 million annually over five years to expand mental health services, strengthen substance use prevention and intervention, and improve access to support for students.District officials say the funding will help address identified gaps in services, particularly drug and alcohol counseling at the high school level, and will allow the district to build capacity for long-term mental health support.TOPPENISH, WASHINGTON — The Toppenish School District has been awarded up to $7.5 million through Project AWARE (Advancing Wellness and Resiliency in Education), a federal grant administered by the Substance Abuse and Mental Health Services Administration (SAMHSA), to expand mental health services and substance use prevention for students.District officials said access to mental health resources has been limited, making it difficult for some students and families to get the support they need. The federal Project AWARE grant will help address those challenges by bringing schools and local healthcare providers together to better support students.The grant will provide up to $1.5 million annually over five years to expand mental health services, strengthen substance use prevention and intervention, and improve access to support for Toppenish students. Deputy Superintendent Dr. Jeff Camero said the district is focused on coordinating with service providers in the area to work as a unified team."We made the awareness with the grant. But looking at all the service providers in the area and how can we all together work as a team?" Camero said.Camero said the district wants to use those resources to reach students earlier and provide more support for those struggling with their mental health. The district plans to address a range of mental health challenges, from anxiety and depression to youth suicide risk. Camero emphasized the importance of supporting students in grades eight through twelve, where suicide rates are a particular concern."Making sure from anxiety to depression, making sure that we can help support our students at those levels, but also the youth suicide risk, looking at that as a top in this area, in our grades, you know, eight, for example, eight through 12, looking at suicide rate and looking at how whether we look at the ACES or whatever program we're looking at, that's federal, how that connects and how we can better serve our students with this extra funding," Camero said.The funding will allow the district to bring in additional staff, including mental health and substance use specialists, to work directly with students and connect families with community resources. The district is already posting positions, including a director role, with additional positions expected to follow.District officials are also thinking beyond the grant's five-year timeline. Brittany Kaple, Director of Public Relations for the Toppenish School District, said the intent is to build capacity and establish connections that will sustain mental health services even after the grant funding ends."We do have the director position already posted, with some of our other positions following really close behind that. But the intent is to, you know, it's a five-year grant, so those positions would be funded for that five years. But there's also the intent to build capacity and make those connections so that at the end of the grant, when that money, you know, if that money is not renewed," Kaple said.As student mental health needs continue to evolve, access to drug and alcohol counseling has become an important priority for the district. Kaple said teachers and staff have been raising concerns about the need for more support, especially at the high school level."And that was something that was also an identified need by our high school staff when the superintendent met with them last school year. They said that that was a really great need, something that they felt was a gap in services that we were providing for our students. And so this is going to be one way to help support that need," Kaple said.The Toppenish School District says its goal is to ensure students and families have access to the support they need, both now and in the years ahead. Additional positions, including drug and alcohol counselors and family engagement specialists, are expected to be posted in the coming weeks. News Sunnyside City Council navigates 2027 budget planning Monique Garcia News "Dancing with the Stars" champion J.R. Martinez shares message of resilience during Central Washington visit Tyler Wargo News Toppenish, Mattawa educators honored at state Educator of the Year Awards Erin Wencl News Kennewick educator named 2027 Washington Teacher of the Year Erin Wencl News Voters to decide the next Yakima County Sheriff Monique Garcia COPYRIGHT 2026 BY APPLE VALLEY NEWS NOW. ALL RIGHTS RESERVED. THIS MATERIAL MAY NOT BE PUBLISHED, BROADCAST, REWRITTEN OR REDISTRIBUTED.
Six Penn State Health locations to offer safe medication disposal on National Prescription Drug Take-Back Day
As part of a nationwide drug take-back effort, Penn State Health and local police departments will offer medication disposal sites across central Pennsylvania on Saturday, Oct. 24.
Fish product sold in Pennsylvania recalled for ‘possible health risk’
(WHMT) — The U.S. Food & Drug Administration (FDA) announced the recall of a fish product that was sold in six states, including Pennsylvania. According to the FDA, Krasnyi Oktyabr, Inc. …
Eric Dane’s drug addiction may have impacted the decision to write him off “Grey’s Anatomy”, new book reveals
The late actor writes about how his drug addiction may have impacted the decision to write him off the ABC series.
Researchers Discover a Blood-Pressure Drug May Stimulate “Healthy” Brown Fat
Losartan, a drug commonly prescribed for high blood pressure, boosts brown adipose tissue or “brown fat” activity and enhances its metabolism, according to a preclinical study by Weill Cornell Medicine, Rockefeller University and Memorial Sloan Kettering Cancer Center researchers.
Flu Clinics & Drug Take Back Day
Take part in upcoming public health events to help keep you and your family well this fall. Flu ClinicsThe Health Department is holding flu clinics in the coming weeks. Getting vaccinated for flu
Worried About Your Teen? Check Their Dental Exam Results For A Window Into Their Well-Being
By Dennis Thompson HealthDay ReporterMONDAY, Oct. 19, 2026 (HealthDay News) — You can tell a lot about your teen from their oral health, says a new American Academy of Pediatrics (AAP) report. Many teenage health problems — eating disorders, smoking, drug use, sexually transmitted diseases — can be ...
Microalgae could make a common antibiotic more effective
Scientists have turned microalgae into an unlikely drug-delivery vehicle, using it to boost the effectiveness of a common antibiotic.
LIFE-HEALTH-GLP-1S-ALCOHOL-FILEPIC-DMT
A Philadelphia Veterans Affairs doctor is leading a national trial testing whether GLP-1 drugs could help patients with alcohol use disorder.
San Francisco techie takes down zombie video game that let players kill homeless people: 'It showed poor judgment'
The creator said that he refunded all advertisers and made a donation to a drug treatment and recovery service equivalent to the revenue generated by the game.
Brown Fat Can Be Beneficial For The Body – And a Blood Pressure Drug Could Turn It On
Physical and mental health boosts.
Scientists Discover a Surprising New Effect of a Popular Blood Pressure Drug
A drug for high blood pressure could inspire future treatments for people with normal readings, thanks to an unexpected effect on the body’s energy-burning fat. Losartan already helps people control high blood pressure. New research suggests it could have a second use in activating brown fat, a tissue that burns energy to produce heat and
Qian Jiang, former Johns Hopkins’ eye institute expert, joins Chinese hospital
Chinese specialist leaves US for Sir Run Run Shaw Hospital to research eye transplants and work on virtual cells to test drug responses.
New drug reverses severe fatty liver disease by repairing the gut
Scientists have discovered that a potential new drug can reverse severe fatty liver disease in animal models by restoring gut health and blocking harmful substances from reaching the liver. The breakthrough could pave the way for new treatments for liver disease and potentially other serious conditions, including cardiovascular disease.
Democrats say Trump increased investments in drugmakers that were given Medicare exemptions
The report from congressional Democrats found that Trump’s pharmaceutical stock holdings grew from a maximum reported value of $1.7 million in 2024 to as much as $56.2 million at the end of 2025.
Brenda Vaccaro makes rare comment about ending engagement to Michael Douglas for Don Stroud
“I fell in love with somebody else, and I knew it,” the “Drugstore Cowboy” actress admits in a new interview.
RFK Jr. proposes FDA look the other way on unproven peptides, report says
FDA scientists said none of the popular drugs have been proven safe or effective.
Stand Up for Science Traces the Surprising Story Behind Ozempic and Related Drugs in the Latest 'Traces
Venom from a desert lizard, a hormone that vanishes in minutes & 40 years of persistence: the “overnight” weight loss drug revolution wasn’t overnight at all
Trump increased investments in drugmakers that benefited from Medicare exemptions, Democrats say
WASHINGTON (AP) — Investments in pharmaceutical companies made on behalf of President Donald Trump increased significantly after he returned to the White House last year, with his portfolio adding mil...
After stopping weight-loss drugs, people given a procedure kept about 80% of lost weight
In a post hoc analysis, 32% of Revita participants were weight-stable or lost more, versus 18% with sham; one-year results are anticipated in Q1 2027.
Closing surveillance detection gaps for emerging digital drug discourse with ontology-enhanced large language models
npj Digital Public Health - Closing surveillance detection gaps for emerging digital drug discourse with ontology-enhanced large language models
How BPC is Building Bipartisan Momentum on Youth Mental Health
America’s youth mental health crisis didn’t begin with COVID-19, but the pandemic dramatically accelerated it. More than 40% of teenagers reported persistent feelings of sadness or hopelessness. Youth suicide attempts, self-injury, and drug overdoses climbed to alarming levels. Meanwhile, the behavioral health system meant to catch these young people remains chronically understaffed and poorly designed … Continued
Who gets Alzheimer's drugs? Race, vulnerability and health status shape access
The first disease-modifying drugs for Alzheimer's disease offer patients the ability to slow cognitive decline by targeting amyloid plaques in the brain. But a new study suggests that not all patients ...
Why your health insurance is dropping GLP-1 coverage
Coverage for these anti-obesity drugs was finally becoming more common. Not anymore.
Trump administration advances plan for peptide drugs favored by RFK Jr.
Peptides are essentially unproven, unapproved, injectable drugs.
Weight-loss drugs may fight 7 serious health problems before the pounds even come off
GLP-1 medications like semaglutide and tirzepatide are repairing joints, calming inflammation, and protecting vital organs before any weight loss occurs.
AstraZeneca - How is AI helping scientists design the next generation of biologic medicines?
Learn how AstraZeneca combines AI drug discovery, laboratory automation and biology to refine biologic molecules and inform earlier decisions.
FAA Unveils New Tool to Gauge Fitness to Fly
MedGuide is an online, interactive resource that enables users to search medical conditions, prescriptions drugs and over-the-counter medications to determine whether a medication is acceptable for safety-related duties and whether an initial or subsequent-dose waiting period applies.
Ex-Florida congressman Matt Gaetz accused in suit of sex trafficking young women
The lawsuit alleges the two women were supplied with drugs, traveled across state lines and were paid to have sex with men, including Gaetz.
Par Health recalls 22 lots of IV blood thinner, its 3rd US product pull in a month
U.S.-based generic drugmaker Par Health has issued
Kurtis Carsch Selected as a 2026 Packard Fellow
The fellowship will fund research on materials with applications in energy, medicine and drug discovery.
DIY healthcare is on the rise – here’s why it’s so dangerous
DIY healthcare is booming – but fake pills, missed diagnoses and drug interactions are real risks.
Ozempic and Wegovy linked to rare risk of sudden vision loss
Popular diabetes and weight loss drugs such as Ozempic and Wegovy have been linked to a slightly increased risk of a rare condition that can cause sudden, potentially permanent vision loss. Although the risk remains very low, Rutgers researchers say the findings warrant attention as millions of people turn to GLP-1 medications.
Governor, health advocates push bill to lower drug prices for 23 medications
Under the proposed legislation, the state's Prescription Drug Affordability Board would have the authority to match the maximum fair price for prescriptions negotiated by the federal Medicare program.
Commonly prescribed blood-pressure drug may stimulate 'healthy' brown fat
Scientists have discovered that the drug losartan, commonly prescribed for high blood pressure, boosts brown adipose tissue activity in mice, enhancing their metabolism. This indicates that repurposing ...
Herpes ‘Remedies’ Sold On Amazon And Walmart Pose Public Health Risk, FDA Warns
WEDNESDAY, Oct. 14, 2026 (HealthDay News) — Creams, sprays and washes that promise relief from genital herpes are easy to order online, but none of them has been approved to treat the infection. The U.S. Food and Drug Administration (FDA) has sent warning letters to Amazon and Walmart over herpes
Finnish study finds poor oral health increases jawbone necrosis risks in breast cancer patients
Antiresorptive drugs, which reduce bone breakdown, are an important part of treatment for breast cancer that has spread to the bones. However, their use can be associated with osteonecrosis of the jaw (MRONJ), a condition in which bone tissue in the jaw dies.
AAPS names Patrick Sinko chief science officer
Drug Discovery and Development covers strategies and technologies related to pharmaceutical research and development and drug formulation.
Walmart adding new health care benefits for US workers
Walmart will expand its health benefits available to frontline workers, including a new no-cost prescription drug list.
This week in health care policy: October 5–9, 2026
Drug pricing and 340B PhRMA sues to block GLOBE. On October 7, PhRMA sued to block the most-favored-nation drug-pricing model CMS finalized last week. The suit argues GLOBE is a price control rather than a “test,” exceeds the Innovation Center’s authority, and fails the major questions doctrine. CEI commented on the GLOBE pilot earlier this […]
Meet Iris Shen, the 17-year-old Texas student who used clams as a model for testing blood-cancer drugs, found a drug combination that slowed tumor growth, and won a $150,000 Regeneron Science Talent Search prize
Iris Shen, a 17-year-old student from The Woodlands, Texas, has earned third place and a $150,000 award in the 2026 Regeneron Science Talent Search for an unusually creative approach to blood-cancer research. Instead of relying only on conventional laboratory models, Shen tested a potential cancer drug in clams to determine whether these animals could serve as an animal model for blood-cancer drug discovery.
Concept Life Sciences appoints Dr Adrijana Vinter as Chief Executive Officer
We are pleased to announce the appointment of Dr Adrijana Vinter as Chief Executive Officer. Dr Vinter brings more than 20 years of experience spanning medicinal chemistry research, commercial development and executive leadership in the pharmaceutical and contract research industry sectors.
After surging troops to the border, US Army showcases a quieter Rio Grande
The U.S. Army is deploying hundreds of soldiers to Texas' Rio Grande Valley in response to what it says are signs of elevated activity from Mexican drug cartels.
After surging troops to the border, US Army showcases a quieter Rio Grande
The U.S. Army is deploying hundreds of soldiers to Texas' Rio Grande Valley in response to what it says are signs of elevated activity from Mexican drug cartels.
After surging troops to the border, US Army showcases a quieter Rio Grande
The U.S. Army is deploying hundreds of soldiers to Texas' Rio Grande Valley in response to what it says are signs of elevated activity from Mexican drug cartels.
Great Women of Science: Ada Yonath, the Nobelist exemplifying perseverance
She was told she was chasing the impossible. She persisted through poverty, skepticism, and 25,000 failed attempts. In the end, Ada Yonath unlocked one of biology’s most elusive structures: the ribosome, transforming our understanding of how antibiotics work and paving the way for drugs that can overcome antibiotic resistance. Her story is not only one of scientific brilliance, but of extraordinary perseverance.
Weight-Loss Drugs for Kids Under 10? The World Health Organization Shares Its Recommendation
The World Health Organization (WHO) just released its first global guidelines on treating obesity in children and adolescents, and its stance on weight-loss drugs for children under 10 is a firm no. T...
NASA’s SpaceX CRS-35 Mission to Launch Health Research
NASA experiments focused on human and plant health and drug-resistant organisms will travel to the International Space Station aboard SpaceX’s 35th. This research supports astronaut health during long-duration missions through four investigations from the agency’s Biological and Physical Sciences division.
NASA’s SpaceX CRS-35 Mission to Launch Health Research
NASA experiments focused on human and plant health and drug-resistant organisms will travel to the International Space Station aboard SpaceX’s 35th. This research supports astronaut health during long-duration missions through four investigations from the agency’s Biological and Physical Sciences division.
Particle Engineering Takes Center Stage as Pharma Formulation Science Pushes Toward the Clinic
A forthcoming special issue of the Journal of Pharmaceutical Investigation will spotlight how particle engineering and formulation science are turning poorly soluble drug candidates into manufacturable medicines.
Particle Engineering Takes Center Stage as Formulation Science Pushes Drugs Toward the Clinic
A January 2027 special issue of the Journal of Pharmaceutical Investigation will spotlight how particle engineering and formulation science translate laboratory innovations into manufacturable drug dosage forms.
Particle Engineering Takes Center Stage as Journal Puts Drug Formulation Science in the Spotlight
The Journal of Pharmaceutical Investigation has announced a January 2027 special issue on translational particle engineering and formulation science, with submissions due June 30, 2026.
Scientists win chemistry Nobel for discoveries about mirrored molecules that led to many drugs
Portraits of Henri Kagan and Kenso Soai are shown on the screen as they are awarded the 2026 Nobel Prize in Chemistry, at the Royal Swedish Academy of Sciences in Stockholm, Sweden, on Oct. 7, 2026. Photo: (Fredrik Sandberg/TT News Agency via AP)By ADITHI RAMAKRISHNAN, KOSTYA MANENKOV and STEFANIE DAZIO STOCKHOLM (AP) — Scientists Henri B. Kagan and Kenso Soai...
Popular weight loss drugs linked to a surprising fingernail problem
Popular GLP-1 weight loss drugs, such as Ozempic and Wegovy, have been linked to unexpectedly high rates of nail detachment, hair loss, and scalp inflammation, with some problems occurring several times more frequently among users. Researchers found that weight loss alone could not fully explain the differences, suggesting there may be more to these overlooked symptoms.
How ‘people power’ and business transformed medicine, but created a whole new set of risks
We’re seeing what happens when consumer demand collides with commercial interests for drugs including GLP-1s, psychedelics and testosterone. It’s a huge shift.
Broncos Lineman Fined For Posting Drug Test Notice
Denver Broncos guard Quinn Meinerz is getting noticed for his ability to draw fines, which is not a good thing.
U.S. Department of Health and Human Services (HHS) Recommends Science-Based Thresholds to Target Dangerous Enhanced Kratom Products
Kratom products credit: CDPH DEA takes action based on updated recommendation from HHS October 11, 2026 - WASHINGTON - On Friday, the U.S. Department of Health and Human Services relesed the following: The U.S. Department of Health and Human Services (HHS) provided a new recommendation to the Drug Enforcement Administration (DEA) that establishes science-based thresholds for 7-hydroxymitragynine (7-OH) and mitragynine pseudoindoxyl (MGPI), potent opioid compounds associated with products marketed as kratom. The Department of Justice today announced that DEA issued new Notices of Intent reflecting HHS’ updated scientific analysis and recommendations, including a new Notice of Intent for 7-OH and MGPI incorporating HHS’ recommended concentration and ratio thresholds. Following a review of available scientific data and comments, HHS Assistant Secretary for Health Admiral Brian Christine, M.D., recommended that DEA use concentration or ratio-based thresholds to determine which products containing 7-OH and MGPI are subject to Schedule I control for purposes of temporary scheduling of these substances under the Controlled Substances Act. The recommendation is designed to target concentrated or chemically altered products while distinguishing them from natural botanical kratom products, which may contain trace amounts of 7-OH and MGPI. “We are drawing a clear line between natural kratom and dangerous, enhanced opioid products,” said HHS Secretary Robert F. Kennedy, Jr. “We listened to the public, followed the science, and developed a clear recommended threshold for temporary scheduling that targets concentrated 7-OH and MGPI without sweeping natural botanical kratom into Schedule I. The Trump Administration will continue taking decisive action against dangerous products that fuel addiction while making sure our policies are grounded in rigorous science.” Under the recommendation, 7-OH and MGPI would be controlled in Schedule I for purposes of temporary scheduling when either substance alone, or their combined amount when both are present: Exceeds 1 milligram per gram in solid powders, encapsulated material, or other solid forms, or exceeds 1 milligram per milliliter in liquid preparations; or When the mass of mitragynine present divided by the mass of 7-OH, or MGPI, or the combined amount of 7-OH and MGPI if both present, is less than 100. The ratio-based approach reflects the alkaloid composition of natural kratom products and provides a way to identify products intentionally enhanced or concentrated with 7-OH or MGPI. Available scientific data indicate that 7-OH occurs naturally in botanical kratom at relatively low or trace levels, while some evidence reviewed by FDA suggests MGPI may also occur at trace levels in some natural or kratom-derived products. FDA's scientific review found that 7-OH is substantially more potent than morphine in preclinical studies, with available data indicating approximately two to nine times greater potency depending on the study. FDA also identified evidence supporting a meaningful risk of opioid-like physical dependence and withdrawal from MGPI. “Our recommendation gives DEA a scientifically supportable framework to distinguish natural botanical kratom from products that have been concentrated or manipulated to deliver dangerous levels of potent opioid compounds,” said Assistant Secretary for Health Admiral Brian Christine, M.D. “This approach allows us to focus on the products that pose the greatest threat to public health.” In July 2025, following an FDA scientific and medical evaluation, HHS recommended that 7-OH above a specified threshold be placed in Schedule I of the Controlled Substances Act. In July 2026, DEA announced its intent to temporarily schedule 7-OH above a specified threshold, and HHS simultaneously sought public comment on the proposed threshold. DEA subsequently temporarily placed MGPI and two synthetic 7-OH derivatives, MGM-15 and MGM-16, in Schedule I. Since then, questions have emerged about how scheduling could affect natural botanical kratom products potentially containing trace amounts of MGPI. The new HHS recommendation responds to those concerns by providing DEA with a more precise threshold based on both the concentration of 7-OH and MGPI and their relationship to mitragynine, the predominant alkaloid in kratom. HHS and FDA will continue working with DEA to protect Americans from dangerous concentrated and synthetic opioid products while ensuring federal policy is grounded in the best available science. Source: HHS
Particle Engineering and Formulation Science Drive the Next Generation of Drug Delivery
The Journal of Pharmaceutical Investigation has announced a January 2027 special issue on translational advances in pharmaceutical dosage form development driven by particle engineering and formulation science.
Particle Engineering and Formulation Science Drive the Next Wave of Drug Delivery
A forthcoming special issue of the Journal of Pharmaceutical Investigation will gather research on how particle engineering and formulation science are transforming drug solubility, dosage form design, and pharmaceutical manufacturing.
Particle Engineering Takes Center Stage in Push to Translate Drug Formulation Science
The Journal of Pharmaceutical Investigation has announced a January 2027 special issue on translational advances in pharmaceutical dosage form development driven by particle engineering and formulation science, with submissions due by June 30, 2026.
A surprisingly simple way to relieve knee arthritis pain without pills or surgery
A surprisingly simple change in how you walk could help relieve knee arthritis pain and even slow joint damage. In a year-long clinical trial, researchers found that adjusting the angle of a person's foot while walking reduced osteoarthritis pain by an amount comparable to medication, without requiring drugs or surgery. Even more promising, MRI scans revealed that participants who adopted the personalized walking technique experienced slower deterioration in a marker of knee cartilage health.
Particle Engineering Takes Center Stage as Drug Formulation Science Enters Its Translational Era
The Journal of Pharmaceutical Investigation has announced a January 2027 special issue on translational advances in pharmaceutical dosage form development, covering particle engineering, solid-state control, QbD, and emerging manufacturing technologies, with submissions due June
Anthony Letai: The Science and Collaboration Behind Progress in RAS-Targeted Cancer Research
Anthony Letai: The Science and Collaboration Behind Progress in RAS-Targeted Cancer Research / Anthony Letai, cancer, Cancer research, Collaboration, drug
Stomach-turning sexually transmitted infection is on the rise — and standard medicines are failing
Shigella bacteria are becoming harder to treat as drug-resistant strains rise, and doctors warn Americans should be concerned but not panicked.
Ongoing lawsuits allege GLP-1s can cause serious harm. But we don't know how often
Scant data about serious adverse effects makes it harder to answer scientific and legal questions about how often the drugs might cause serious harm like blindness or pancreatitis.
Pacific Health voluntarily recalls Baby Magic Tea for containing alcohol
The company has not received reports of any adverse events associated with the product lot so far, according to the U.S. Food and Drug Administration.
Pacific Health voluntarily recalls Baby Magic Tea for alcohol
The company has not received reports of any adverse events associated with the product lot so far, according to the U.S. Food and Drug Administration.
HHS Recommends Science-Based Thresholds to Target Dangerous Enhanced Kratom Products
HHS provided a new recommendation to the Drug Enforcement Administration that establishes science-based thresholds.
Stanford Scientists Identify Enzyme That May Promote Cartilage Regeneration in Arthritis
Stanford researchers identified an enzyme that may restore cartilage repair signals in arthritic joints, offering a potential drug target backed by mouse and human tissue results.
"We are out of the rehabilitation business" - Rockets coach on former No. 1 pick's second failed drug test
Rockets coach drawed hard line on former No. 1 pick John Lucas after second failed drug test.
Second UK health body drops Israeli drug firm after activist pressure
Decision by Royal College of Pharmacy to end sponsorship comes after concerns over Teva Pharmaceuticals’ ‘activities’
Some People Taking Ozempic-Like Drugs Are Reporting Their Fingernails Detaching
An unexpected link worth investigating.
Trump bucks and the politics of mailing checks
The checks started going out last week, nearly one million of them, and mostly to battleground states. With a return address for the U.S. Treasury and a letter enclosed signed by President Donald Trump, these one-time checks for $500 were ostensibly government rebates for Obamacare enrollees who overpaid. In the accompanying letter, however, Trump attacks his predecessor and talks about his record in office on an important issue he’s not polling well on, which makes it seem more like the most expensive political mailer in U.S. history. The average piece of direct mail costs between 30 cents and $3, according to Mail Processing Associates, a print, mail, and fulfillment company. At $500 a pop plus roughly 50 cents each to issue the paper check, the cost of Trump’s healthcare mailer sent to more than 950,000 enrollees comes in at more than $475 million. Trump’s midterm healthcare message “For years, the Biden Administration overcharged you to fund the operation of HealthCare dot gov,” Trump wrote in the letter. “That money belongs to hard-working Americans, not the Government, and now, I am returning it to you!” In the letter, Trump makes false and misleading claims about his administration’s record on healthcare costs, an issue Democrats have a 20 point advantage on over Republicans, according to a recent poll from KFF, a nonpartisan health policy think tank. Trump touts his administration’s TrumpRX program, which he claims is “delivering massive discounts.” However, new research from KFF found that of a selection of drugs available on the TrumpRX platform, just five were the lowest price, while 13 were the highest price. Trump also falsely claims in the letter that he’s fighting to lower healthcare costs. In reality, average monthly premium payment costs for enrollees rose 58% under Trump while marketplace sign-ups declined 5%, per KFF. Under Trump’s One Big Beautiful Bill Act, it’s estimated 10 million more Americans will be uninsured by 2034. You get a check and you get a check and you get a check Trump’s long promised cash outs to his fans, from his days as a casino operator and gameshow host to his presidency. During the early days of the COVID-19 pandemic in 2020, the first Trump administration made the unprecedented move to put Trump’s name on checks that went out under the CARES Act (notably the $500 refund checks this time around don’t feature Trump’s name). Ever since, Trump’s been chasing that high. In his second term, Trump’s promised more stimulus that never arrived, like refund checks from DOGE cuts and tariffs, while he said at his party’s convention last month that he’d give out $5,000 checks to everyone if Republicans win in November. In reality, DOGE overstated its cost cutting and Trump’s government actually now spends more than former President Joe Biden’s, while Trump’s tariffs actually grew the trade deficit. His proposal for $5,000 checks would add about $1.2 trillion to the national debt. The problem is there’s no money to give. These $500 checks — plus $90 Medicare rebate checks also going out as well as $250 deposited this week in some Trump Accounts for kids courtesy Dell Technologies CEO Michael Dell and his wife Susan — represent the closest Trump’s going to get to making good on his promise to deliver cash fast. And the checks seem especially targeted. Though the $500 checks went out to enrollees in one of 30 states that use the federal HealthCare dot gov marketplace, a Reuters review found 71% of the payments, or $339 million, went to enrollees in 13 states that have the most competitive elections for governor and U.S. Senate. Most Americans don’t buy it Could Trump bucks sway the election? An Economist-YouGov poll found 57% of U.S. adults doubt Trump will deliver on his promise for $5,000 checks, compared to 21% who do. “I’m waiting on my DOGE check and I’m still waiting on my tariff check,” one 2024 Trump voter who’s since turned on him told a recent focus group. “It felt like kind of trying to buy people’s votes, which honestly felt like in elementary when the class president was like, hey we’re going to take you to the water park if you vote for me. It’s like, I don’t think it works like that.” But for voters in swing states who got a check, it could still matter. One survey published in 2022 found receiving a physically personalized check in the mail during the pandemic was associated with a much greater self-reported likelihood of voting for Trump in 2020, and those gains mainly came from out partisans. The issue for Trump comes if these checks are mostly going to Obamacare enrollees whose premiums have gone up by more than just $500 since he took office and who view the money as something like a bribe before the election rather than an actual long-term solution to lowering household costs. Spending $500.50 per mailer would be absurd as a normal campaign expenditure, but since Trump’s checks and letter are a government rebate, his campaign and super PAC didn’t have to spend a dime and he got out his message regardless. If enough voters in key states are swayed by the one-time payment, it could prove to be the best $0 the Trump campaign spent. 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