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In House District 13, Two Political Newcomers Square Off
House District 13, the Lake County district that includes Polson, has been held by a Republican for more than a decade. This year, self-described moderate Democrat Dalton Bradford hopes he can change that. “I’m just a hometown guy,” Bradford said. “My wife would say I’m overly humble, but that truly is me. I don’t view […]
Eisenkot offers hawkish alternative to Netanyahu for Israeli PM
By Alexander Cornwell and Maayan Lubell JERUSALEM, Oct 23 (Reuters) - Reserved, media-shy, and a relative newcomer to Israeli politics, former military chief Gadi Eisenkot presents a clear contrast to
Illinois Freshman Quentin Coleman Ranked 8 in Newcomer Rankings
Illinois freshman Quentin Coleman continues to generate buzz after an impressive exhibition debut against Cincinnati.
Political newcomers De La Cruz and Garcia battle for redrawn Texas 35th Congressional District
On Nov. 3, Texas voters will choose a new U.S. representative for the newly redrawn 35th Congressional District. On the ballot are Republican Carlos De La Cruz and Democrat Johnny Garcia.
Sioux Falls native finds rewarding role connecting students to higher education
This week's Up-and-Comer is Regen Wiederrich, SDSU Connect coordinator at South Dakota State University.
Hammer and Rails Readers Reacts Survey: Purdue Men’s Basketball Newcomers
Which newcomer will make the biggest impact on Purdue basketball this season?
Oakridge mayor faces challenge from political newcomer who wants to rebuild
Mayor Bryan Cutchen says Oakridge is headed in the right direction and wants a second term to fix the ambulance deficit and failing pipes. Challenger Shawn Goddard, a first-time candidate, says the town needs a one-time, multimillion-dollar rebuild and a mayor who is a constant presence.
Tales of Eternia Remastered Review
I can safely call Tales of Eternia Remastered the definitive version for newcomers, so long as they don't mind a few dated gameplay mechanics.
K-Pop Newcomers A2O Lite and A2O Soul Make Their Debut
The multinational girl and boy groups are the latest project from Lee Soo-man, the former SM Entertainment producer.
Montana’s House battleground: Can 2 political newcomers overcome party politics?
The fight for Montana’s 1st District tests whether candidates can use their backgrounds to connect with voters and avoid being shaped by national politics
The record and the alternative
Elections involving incumbents offer voters something elections between newcomers cannot: evidence. Tom Sullivan need not tell Senate District 27 voters what kind of legislator he might be. After four years in the Colorado House and nearly four in the Senate, he has accumulated something more revealing than campaign promises. A record. Danielle Lammon offers something […]
Rep. Kevin Mannix faces political newcomer in fight to hold onto Oregon swing seat
A business law attorney and a safety professional with different levels of political experience are seeking to win an Oregon swing district.
Newcomer faces incumbent Zimmerman in 99th House District
Republican Dave Zimmerman has represented the 99th District in the Pennsylvania House for 12 years. This year, 23-year-old Democrat Ethan Gabrick, a teacher’s aide, hopes to take over as an
Accounting major turned orthodontist returns to provide care in hometown
This week's Up-and-Comer is Lauren Witte, an orthodontist at Barrow Orthodontics.
Republican US Rep. Glenn Grothman faces Democrat Brad Smith in race for Wisconsin's 6th Congressional District
Democrat Brad Smith of Mequon, a National Guard veteran and political newcomer, is trying to unseat Republican U.S. Rep. Glenn Grothman of Glenbeulah, who has represented Wisconsin’s 6th Congressional District for more than a decade.
Election 2026: Political newcomer Pierrette Farber running unopposed in Ulster County Legislature District 17
When New Paltz voters head to the polls, they will elect a political newcomer to represent them on the Ulster County Legislature.
Dem political newcomer Gray looks to unseat GOP freshman state Rep. Booth
District 35 in Orange and Osceola flipped from GOP to Democratic and back again in 2024.
Three Bucksport residents vie for two town council seats
Bucksport voters will have a choice of three candidates for two open town council seats on Nov. 3: Incumbent Mark Eastman and newcomers Jon Goss and Ralph Chapman.
Wisconsin women's basketball coach sees new players bond early
Badgers coach Robin Pingeton is reassembling the team with several newcomers and says they're already showing initiative.
Political newcomers vying for 51st District state House seat
The 51st District includes all or part of Barrington, Kildeer, Deer Park, Long Grove, Vernon Hills, Lake Zurich, Hawthorn Woods, Inverness, Palatine, Hoffman Estates, and Rolling Meadows.
Associate attorney grows career in hometown
This week's Up-and-Comer is Gabrielle Kauk, an associate attorney at Woods Fuller.
Escape From Tarkov’s New PvE Update Officially Makes the Game Easier for Newbies
Exfil Brothers rewards veterans for helping newcomers
Pistons Newcomer Sets Tone Early After Altercation With Suns Enforcer
A Pistons newcomer set the tone early after a heated altercation with Dillon Brooks led to a lengthy review and two penalties. The post Pistons Newcomer Sets Tone Early After Altercation With Suns Enforcer appeared first on HEAVY.
Michigan's largest banks after the Fifth Third-Comerica deal
Consolidation continues to shift the list of the largest players in Michigan's banking industry.
Quad-Cities comedy scene grows with a welcoming crowd of comics
Quad-Cities comedians foster a welcoming, growing scene where newcomers thrive, audiences grow and age cannot prevent reinvention.
Quad-Cities comedy scene grows with a welcoming crowd of comics
Quad-Cities comedians foster a welcoming, growing scene where newcomers thrive, audiences grow and age cannot prevent reinvention.
Retiring Tigers Star Justin Verlander Makes Financial MLB History
The Hall of Fame career for Detroit Tigers pitcher Justin Verlander came to a close late last month, as he made one final start wearing the Old English D in front of a packed house at Comerica Park. Verlander, who returned to the Tigers last offseason with a one-year contract, announced that the 2026 MLB […] The post Retiring Tigers Star Justin Verlander Makes Financial MLB History appeared first on HEAVY.
Pacers Coach Rick Carlisle Strongly Praises Newcomer Kelly Oubre Jr.
Indiana Pacers head coach Rick Carlisle praised new small forward Kelly Oubre Jr.
Bishop’s computer science chair says AI is eliminating ‘grunt work’ and reshaping digital jobs
Dr. Russell Butler, chair of Bishop’s University’s Department of Computer Science, says artificial intelligence is increasingly taking over routine digital “grunt work,” changing the skills students and workers may need in the years ahead. Photo courtesy of Bishop’s University. Click here to read our platform! Get local news like this every morning. Subscribe free below. Subscribe Pulse Newsroom Artificial intelligence is already taking over some of the routine digital work once performed by entry-level employees, according to Bishop’s University Computer Science chair Dr. Russell Butler — a shift he believes will make expertise, judgement and the ability to evaluate AI-generated work increasingly important. Butler described the change as automation reaching what he calls the “bottom of the cognitive pyramid” during an interview with The Pulse about AI, university education and the future of digital work. His argument is not that humans are disappearing from the workplace. Instead, he sees their role changing as AI becomes capable of handling more of the repetitive tasks involved in computer-based work. “Everything’s converging on just AI basically doing all the grunt work,” Butler said. The bottom of the cognitive pyramid Butler is from Lennoxville, completed his undergraduate studies at Bishop’s and later earned his PhD at the Université de Sherbrooke. He joined Bishop’s in 2019 and now chairs its Department of Computer Science. He uses AI in research, teaching and other creative work, and said the technology is increasingly capable of handling routine digital tasks that once required substantial human time. “You’ve got the grunt work, like moving things around in Excel, doing basic programming tasks,” Butler said. “That’s like the bottom grunt work that the entry-level worker would have done two or three years ago.” Butler went further, saying in his view that much of this type of work has already been absorbed by AI tools. He connected that change to a shift he sees taking place in computer science, where entry-level roles have declined while experienced workers can use AI to increase what they can produce. “A senior developer now has access to essentially an unlimited amount of junior developers on demand,” Butler said. He was describing AI systems metaphorically, not literal employees. His point was that one experienced developer can now ask AI tools to produce code or other technical work that might previously have been assigned to more junior workers. That raises a broader question for universities and employers. If some of the simpler work traditionally given to newcomers can now be done by machines, how do people gain the experience needed to become senior workers themselves? Students doing work that once required years of programming Butler said he is already seeing the change inside his classroom. He created a Bishop’s course called CS208, Coding in Plain English, to show students — including those without traditional programming backgrounds — what they can accomplish using AI. Some come from disciplines such as psychology or neuroscience with no previous programming experience. “What I’m finding is that students who have zero programming experience, they come in from another discipline like psychology or neuroscience or something, they are now able to get up and running with real data sets,” Butler said. Butler’s own doctoral work involved neuroimaging, and he said he has assigned students work he considers comparable to the kinds of analysis he performed during his PhD. He described giving students a real dataset, an expected result and instructions to use AI to complete the analysis. Butler said those students have been able to carry out work at a level he associates with tasks he once performed after years of programming experience. That does not mean a student using AI instantly acquires the same knowledge as an experienced computer scientist. But Butler sees it as evidence that AI can dramatically lower the technical barrier between having a problem to solve and producing a working result. The role of the person using the system then changes. They need to know what to ask for, understand enough about the subject to judge the answer and take responsibility for what is ultimately produced. What about AI hallucinations? One persistent concern surrounding generative AI is hallucination — when a system produces information that sounds convincing but is false or unsupported. Butler said that problem has improved substantially in newer systems and is not as severe as it was with earlier models. He pointed in particular to newer AI systems’ ability to search the web, consult scientific databases and return source links rather than simply generating a citation from their internal model. Butler nevertheless said users should verify what AI produces. “You should verify,” he said while discussing citations generated with AI. His position is that hallucinations have become less common in the systems he uses, not that incorrect AI output is impossible. Human checking remains part of the process. Hours of work compressed Butler offered another example from his administrative work at Bishop’s. The university has been comparing CEGEP courses with first-year Bishop’s courses to determine where students may qualify for advanced standing. Traditionally, Butler said, that means reviewing two sets of course descriptions and manually matching one institution’s courses with another’s. As department chair, that could require hours of reading and comparison. He said AI can now be given both sets of material and asked to generate an initial mapping automatically. “It saves me hours and hours of work,” Butler said. Butler said the AI-generated mapping can also produce a better result than he would produce himself. He sees similar opportunities in businesses. A company may receive specifications, drawings, emails or other digital material from customers and then have employees convert that information into an internal format before anything can be manufactured or delivered. AI can increasingly perform parts of that intermediate processing. In Butler’s view, the employee does not necessarily disappear. Instead, the job becomes more about checking the result. “The human is still there,” he said. Judgement could become more valuable That change is central to Butler’s view of where digital work may be headed. If AI can produce a first draft, write basic code, compare documents or process large amounts of information, he argues that knowledge and judgement become increasingly important. “The real scarce resource going forward is going to be domain knowledge, expertise, and… credentials, authority, the ability to work with other people,” Butler said. He is therefore encouraging students not only to learn AI tools but also to broaden their education. He mentioned acting, fine art and photography as examples of courses that can help develop what he described as taste and intuition — the ability to recognize what is good, what is not and what should be changed. “And that’s the skill that they need now because the grunt work has been automated and now it’s about evaluating what the AI produces and telling it how to improve or expand the output,” Butler said. That does not remove the need for technical knowledge. Butler’s argument is that the emphasis may shift away from manually completing every step of a task and toward directing, checking and improving work produced with AI assistance. He also stressed that humans remain responsible for final decisions. “At the end of the day, the human has to make the final call,” Butler said, pointing to the question of accountability. Physical work may be different Butler draws a distinction between digital work and jobs requiring people to manipulate the physical world. He expects AI to continue advancing quickly in tasks performed almost entirely on computers. He is more cautious about claims that humanoid robots will soon be able to replace workers such as plumbers or electricians. Butler said those trades would not be replaced “anytime soon” in his view and described some current robotics demonstrations as overhyped. He described the situation as counterintuitive. “It’s almost like we solved the highest level first,” he said, contrasting advances in digital AI with the harder problem of building robots capable of operating reliably in the physical world. Butler’s argument is that some digital occupations could face automation sooner than trades requiring complex physical work. The wider AI shift in the Townships Butler’s comments come as local institutions are increasingly grappling with how AI should be used. The federal government recently announced up to $162 million over five years for 10,000 AI-related placements through Mitacs. The Université de Sherbrooke told The Pulse that the number of its collaborative research and innovation projects supported through Mitacs has approximately doubled since 2018-19, while the number of placements has approximately tripled. UdeS also said it already has projects involving both AI adoption and the application of AI to other fields. At Bishop’s, Butler said part of his role involves building the Computer Science department’s local presence, connecting students with regional partners and strengthening relationships with the Sherbrooke technology ecosystem. Those developments put universities in a difficult position. They have to prepare students to use the tools employers increasingly have available while also making sure graduates understand enough to recognize when those tools are wrong, incomplete or being applied to the wrong problem. The risk of losing human skills Butler does not see AI as risk-free. Later in the interview, he raised a separate concern: as AI becomes better at reading, writing, programming and other cognitive tasks, people could lose some of the underlying skills that historically helped produce new ideas. “The other danger is that we’re going to lose the human skills,” Butler said. He specifically mentioned reading and writing and argued that people could lose some of the lower-level understanding that contributes to breakthroughs. Butler said AI systems are based on existing human knowledge and argued that they become much more powerful when paired with a capable person. That tension runs through his view of the technology. AI can remove hours of routine work. It can allow beginners to perform tasks that once required substantial technical training. It can give experienced workers significant leverage. But the more capable the technology becomes, the more important it may be for people to develop the judgement needed to decide what should be done in the first place. For Butler, that is where education may have to change. Students still need to understand their field. They still need to know when something is wrong. And they still need to be able to make the final decision. But if AI increasingly handles the bottom of the cognitive pyramid, the value of a worker may depend less on how quickly they can perform the grunt work and more on whether they understand what the work is supposed to accomplish. Don’t miss the next story that affects your community. Join thousands of readers getting The Pulse every morning—plus breaking news alerts when it matters most. If you value this kind of local journalism, consider supporting it. Subscribe, share and like! Subscribe Share
Who is Randy Villegas, the political newcomer trying to oust David Valadao from Congress and flip District 22 blue?
BAKERSFIELD, Calif. (KGET) – Although he’s relatively new to the political scene, Randy Villegas has been making waves in the legislative stage. Villegas, a self-described populist, is …
Who is Randy Villegas, the political newcomer trying to oust David Valadao from Congress and flip District 22 blue?
Committee led by Rep. James Comer seeks brain health study of naval aviators
The House Oversight Committee says the Navy isn’t doing enough to ensure it's protecting the long-term wellbeing of naval aviators.
Athletics' Zack Gelop sues Tigers, others over injury at Comerica Park
Athletics 3B Zack Gelof sued the Tigers and others, claiming a serious knee injury from colliding with an exposed metal fence at Comerica Park.
Lakers new players open up on significant of joining franchise
The expectations of being a Laker have already settled in for the team's newcomers.
The “Family Stone” sequel: Everything we know about the cast, plot, and more
The gang’s all here, along with an Emmy-winning newcomer.
Residents 'hopeful' as Manx election gives new politicians a chance
Isle of Man residents say they are optimistic for the future as a majority of newcomers are elected.
Pirates’ Kirby Yates announces retirement; ‘Completely at peace with it’
Kirby Yates is calling it a career. The 39-year-old confirmed after Saturday’s 4-3 loss to the Tigers at Comerica Park that the 2026 season will be his last.
Brentford's Summer Signings Graded After Unbeaten Premier League Start
Brentford brought in five senior players during the summer and remain unbeaten after five Premier League games. Some of the newcomers have already made a considerable impression.
Geiger, Byer Vie for Rockland Area House Seat
ROCKLAND — Residents of Rockland, North Haven, Matinicus, and part of Owls Head will decide whether to return Democrat Valli Geiger to the State House or elect political newcomer Melissa
Surprising Short-Notice Welterweight Bout Added to UFC 332
A surprising short-notice welterweight bout has been added to UFC 332, which takes place next Saturday night.As first reported by MMAMania.com, welterweight prospect Jacobe Smith will return to the Octagon to face UFC newcomer Bruce Whitehead in a surprising booking that has MMA fans scratching their heads.Heavy’s Marcel Dorff further confirmed that Smith vs. Whitehead […] The post Surprising Short-Notice Welterweight Bout Added to UFC 332 appeared first on HEAVY.
2nd Congressional District: Republican Kelley Dennison
The political newcomer, 27, said she wants more people from her generation, Gen Z, to join the political conversation.
Tigers Set Final Rotation Around Verlander’s Last Start
The Tigers set their final rotation, and Justin Verlander takes the mound one last time at Comerica. #Tigers
The NBA's 5 most interesting newcomers, starring LeBron James, LaMelo Ball and the Lakers' big swing
Tigers can seize series win on Wednesday afternoon against Nationals
The Detroit Tigers missed a chance to secure a series win over the visiting Washington Nationals on Tuesday night, dropping the second of the three-game series, 3-1. Despite tossing a quality start, Drew Anderson was saddled with the loss while the offense barely made a peep at Comerica Park. Making his final start of the […]
Longtime Davie mayor gets challenge from political newcomer
The incumbent mayor of Davie has held the seat for more than 15 years but her opponent in November’s election is a newcomer who says she has fresh eyes.
Florida State’s roster overhaul gets harsh early grade by 247 Sports
247Sports’ Cody Nagel gave Florida State the lowest grade among Power Four programs with 50-plus newcomers after a 1-2 start.
Tigers aim to clinch series vs Nationals on Tuesday night
The Detroit Tigers opened up the penultimate series of the 2026 campaign with a 9-2 victory at Comerica Park — soon to be Fifth Third Park — on Monday night. River Ryan looked good in his debut wearing the Olde English D, while home runs at the bottom of the batting order from Spencer Torkelson […]
When is “The Voice” season 30 on? Where to watch live and how voting works
Returning coaches Kelly Clarkson and Adam Levine are joined by two newcomers.
Opinion | Could a political newcomer reshape the Huntsville City Council?
With a low-turnout runoff on Tuesday, a single issue could be the difference in the Huntsville City Council race.
Detroit Tigers to Announce New Comerica Park Name
The Tigers and Fifth Third Bank will announce a new name for Comerica Park, with the rebranding expected to begin in 2027.
Incumbent, political newcomer to face off in race for Texas House District 91
Republican David Lowe and Democrat Yisak Worku are running to represent the northeast Tarrant district.
Detroit Free Press on Instagram: "Two teams from the Savannah Bananas traveling baseball tour came to Comerica Park for a pair of games on Sept. 18-19. Rivals the high-energy Party Animals and the stunt-performing Firefighters, brought their brand of baseball entertainment to Comerica Park on Friday and Saturday, turning America's pastime into a mix of sports, comedy, dancing and crowd interaction. Check the link in our bio for more. 📷 by Kimberly P. Mitchell @kpmitchellphoto, Detroit Free Press #detroit #michigan #comericapark #entertainment #bananaball @thefirefighters @thepartyanimals #baseball"
17 likes, 0 comments - detroitfreepress on September 20, 2026: "Two teams from the Savannah Bananas traveling baseball tour came to Comerica Park for a pair of games on Sept. 18-19. Rivals the high-energy Party Animals and the stunt-performing Firefighters, brought their brand of baseball entertainment to Comerica Park on Friday and Saturday, turning America's pastime into a mix of sports, comedy, dancing and crowd interaction. Check the link in our bio for more. 📷 by Kimberly P. Mitchell @kpmitchellphoto, Detroit Free Press #detroit #michigan #comericapark #entertainment #bananaball @thefirefighters @thepartyanimals #baseball".
2. Bundesliga Preview: Holstein Kiel vs. VfL Osnabrück
Holstein Kiel entertain Osnabrück on Saturday afternoon as they both hope to recover from last week’s defeats. The hosts conceded late against Heidenheim, while the newcomers were defeated at home ...
'SNL' locks in its Season 52 cast with 2 newcomers and these notable exits
'SNL' returns Sept. 26 with most of last season's cast, two newcomers and Kenan Thompson extending his record with a 24th season.
Genesis Needs “Compelling Business Case” for IMSA
WEC newcomer continue to monitor WeatherTech Championship entry, but no decisions made...
‘Resident Evil’ review: Zach Cregger’s masterful love letter to the games
The latest live-action film is a brilliant love letter to Capcom’s horror video game franchise that will delight (and terrify) fans and newcomers alike.
Political newcomers vie for Family Court bench
Attorney Patricia Marr and prosecutor Gwynneth Smith are hoping to fill the Clark County Family Court Dept. D vacancy resulting from Judge Bob Teuton’s decision not to seek reelection. Marr moved to Las Vegas from Ohio in 1985. She worked in the hospitality industry, and as a single parent, obtained a psychology degree from UNLV. […]
Isaiah Likely Named Giants' Newcomer Who Shined in Week 1
Isaiah Likely is named the New York Giants' newcomer who shined in Week 1.
'Stuffed' review: Jodie Comer and Harry Melling shine in a macabre musical romance
This one's for the weirdos who love a grisly musical.
Tigers seek second straight series win against Rockies on Saturday
The Detroit Tigers won their second game in a row for the first time since early August with a 6-2 victory over the Colorado Rockies at Comerica Park on Friday night. Riley Greene’s 3-for-4 performance fueled the good guys on offense and dodged danger on several occasions for a quality start while earning his 10th […]
Vikings’ Justin Jefferson Gets Blunt Over Kyler Murray Captain Decision
On Sept. 3, the Minnesota Vikings announced their captains for the 2026 NFL season, with one of them being Kyler Murray. Despite being a newcomer to the Vikings after the Arizona Cardinals cut ties with him this past offseason, the former No. 1 pick is transitioning well to Minnesota. Ahead of the Week 1 game […] The post Vikings’ Justin Jefferson Gets Blunt Over Kyler Murray Captain Decision appeared first on HEAVY.
5 Players to Watch as Rockets Open Preseason vs. Mavericks
Witness veteran stars returning from injury and elite newcomers debuting in Macao as Houston tests a revamped rotation against conference rivals in a high-stakes preseason tip-off.
Nine Years Since Brighton's First Ever Premier League Win
Relive the historic afternoon a Pascal Groß masterclass dismantled West Brom, sparking a transformative journey from top-flight newcomers to European contenders under the lights of the Amex.
Undefeated Anthony Wint Books Second UFC Fight in 43 Days
Former NFL player Anthony Wint has booked his second UFC fight in 43 days. The undefeated athlete out of Homestead, Florida, fights on the UFC 332 card on October 3 in Salt Lake City, Utah. He takes on promotional newcomer Lucas Armand in the heavyweight division. The UFC announced the fight on the Dana White’s […] The post Undefeated Anthony Wint Books Second UFC Fight in 43 Days appeared first on HEAVY.
Charlie’s Beat: Creating an experience in Madison
I love talking with newcomer folks like Ally and Chad Fife, owners of the Book Haven store on Main Street. They came to Madison just over three years ago, and
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Combat and socially agonised teens impress in Persona 4 Revival, the RPG that series director Kazuhisa Wada feels a "duty" to make
As a newcomer to the series, Persona 4 Revival looks to offer a good entry point. Though the developers are aiming it at their faithful.
The bioinformatics escape room where guests become genetic detectives
A Northeastern professor created a bioinformatics escape room to introduce newcomers to a growing career field.
Burcum: Sanford offers blueprint for Minnesota health care newcomers
As consolidation looms, the South Dakota-based system’s North Memorial deal sets a strong standard for others that may move into Minnesota.
Antoine Griezmann's scoring form lifts Orlando City
By Tyler SnipesWhen superstar summer newcomer Antoine Griezmann scores, Orlando City get points.It's a trend Lions fans will love to continue cheering on. Saturday’s 1-0 win at Inter.co Stadium ov...
Ten Ravens newcomers who could make an immediate impact
Ten additions who could play significant roles for Baltimore during the 2026 season.
UFC Paris Results: Hooker vs. Parnasse
Dan Hooker looks to get back on track against newcomer Salahdine Parnasse
Comer indicates McConnell staffers aiming for lawmaker to return to Senate later this month
Rep. James Comer indicated that he has spoken with McConnell staffers who indicated they are aiming for the senator will return later this month.
Cowboys’ All-Pro Newcomer Reveals Personal ‘Dream’ Career Move
The Dallas Cowboys signed Von Miller earlier this month, and he foresees himself sticking around a long time in a different role. The post Cowboys’ All-Pro Newcomer Reveals Personal ‘Dream’ Career Move appeared first on HEAVY.
GOP lawmaker says he expects McConnell will return to Capitol Hill later this month after lengthy absence
House Oversight Chair James Comer of Kentucky said Thursday that Sen. Mitch McConnell’s staff have told him they are hoping the senator – who has had an extended absence from Washington due to health issues – will return when the Senate comes back into session on September 14.
Neal, longtime incumbent, beats Whalen, an educator, political newcomer
He held off challenger Jeromie Whalen with less than 10% of the vote.
Neal, longtime incumbent, beats Whalen, an educator, political newcomer
U.S. Rep. Richard Neal has retained his seat as the congressman for the 1st Hampden District. He beat out school teacher Jeromie Whalen.
Business owner turned positive experience with childcare into school for others
This week's Up-and-Comer is Paige Berg, franchise owner of Primrose School of Sioux Falls at Heather Ridge.
Hanover volleyball looks to build defense after losing key seniors
Hanover Coach: Avery Kretschmar (1) League: NHIAA Division II Last Year: 12-5; loss in the quarterfinals Top Returners: Seniors — Sage Fargher (Setter), Bella Poisson (Outside), Casey Wilkinson (Libero), Esther Skogerboe (Middle) Newcomers: Juniors — Nour Tannous (Outside), Laila Sundred (Defensive Specialist), Amelia McGinnis (Right Side) Coach’s Analysis: “With the matriculation of seasoned front row […]
Draft picks, free agents: Recapping newcomers to Saints' 2026 roster
Recapping the rookies, free agents, and other new players that made the initial New Orleans Saints 53-man roster to begin the 2026 season.
Dodgers’ Tarik Skubal Gets Honest About Comerica Park Return
Tarik Skubal’s return to Comerica Park is officially in the books. The left-hander spoke about it with SportsNet LA’s Kirsten Watson after the Los Angeles Dodgers defeated the Detroit Tigers 2-1.“I think a good job of keeping baseball, baseball,” said Skubal. “Trying to compete and give my team a chance to win, I think you […] The post Dodgers’ Tarik Skubal Gets Honest About Comerica Park Return appeared first on HEAVY.
San Ramon swim coach Ntatsos dives into city politics
Longtime San Ramon swim coach Paschalis Ntatsos is testing the waters of city politics this year, with the political newcomer's first-ever campaign for public office now underway as a three-way race for mayor ramps up ahead of the November election.
Tigers can clinch series win vs Rays on Wednesday afternoon
The Detroit Tigers snapped their six-game losing streak on Tuesday night with a 4-1 victory over the Tampa Bay Rays at Comerica Park. Jackson Jobe was not incredibly sharp, but combined with the bullpen, the pitching staff stymied the visitors’ bats while a two-run homer from Max Clark helped power the good guys to the […]
Political newcomer Darline Graham wins South Carolina’s GOP Senate runoff
Her win in the snap primary to replace her late brother Lindsey Graham comes after President Donald Trump significantly boosted her campaign.
Why politicians are punchlines at the Edinburgh Fringe
There was a time when satire had an easier gig. Politicians said something ridiculous, comedians made fun of them, audiences laughed, and everyone went home. Subscribe Now the joke is often the headline. In a world where the unbelievable regularly makes the news, where politics can veer into parody before the comedians have had time to write the punchline, you might reasonably wonder: is satire running out of material? Not in Edinburgh. At the Fringe, I can confirm satire has a pulse, even in a relentless and rapid news cycle. Politicians as punchlines Take NewsRevue, the world’s longest-running live sketch show, where politicians are turned into punchlines at industrial speed. Its latest target? Andy Burnham - or, more accurately, his doppelganger, pictured below in the middle. The joke, he tells us, is that there have been so many politicians coming and going that even satire risks suffering from political fatigue. But perhaps that revolving door is precisely why comedy matters. When the news cycle moves faster than our ability to process it, comedians can hold up a mirror - and make us think twice. Small talk Take Ayoade Bamgboye, the Saturday Night Live UK star who won the Best Newcomer prize at last year’s Edinburgh Comedy Awards. Her Fringe debut was critically acclaimed; this year she is turning her attention to one of Britain’s most baffling social rituals: small talk. Share It’s a reminder that satire doesn’t always need a politician in its sights. Sometimes the target is simply us civilians - the strange little rules and rituals we have collectively agreed to pretend are normal. Politics and Palestinian identity For British-Palestinian comedian Sami Abu Wardeh, pictured below, comedy has a more urgent job. His new show, Sami Abu Wardeh Hates You, asks who gets to hate, and whether anger belongs to everyone, not just the far right. His comedy confronts politics and Palestinian identity while refusing to surrender the simple business of making people laugh. Shakespeare meets climate crisis And then there is HAM: an “eco-hijacking” of Hamlet, which its creators describe as “a sordid wrestle between a vegan and a sausage-lover”. Shakespeare meets the climate crisis. Meat meets moral panic. The end result? You’ll leave promising to become vegan and swiftly bulk buying Linda McCartney sausages. HAM was created by theatre company Hotter Project, aka Ell Potter and Mary Higgins, pictured below. They say comedy helped them avoid the preachiness sometimes associated with climate activism - using Shakespeare as a vessel for uncomfortable questions about the planet, politics and the way we live. Perhaps that is satire’s secret weapon. It doesn’t necessarily make the world less absurd. It makes the absurdity crystal clear. And at a moment when reality increasingly feels like it has been written by a sketch writer, the Fringe is proving there is still plenty to laugh and cry at. Satire isn’t dead. It’s alive, subletting and having the time of its life at the Fringe. Subscribe Share Channel 4 News Leave a comment
Miyazaki explains how The Duskbloods plans to protect newcomers from its best players
Hidetaka Miyazaki details how The Duskbloods will use ranked matchmaking to separate strong and new players.
Darline Graham’s Debate Misstep Tests South Carolina’s Appetite for a Political Newcomer
Senator Darline Graham has argued that her lack of political experience is a strength as she runs to succeed her brother, Lindsey Graham. But a debate misstep has rattled some of her supporters.
Nonprofit business development leader helps impact lives of young adults
This week's Up-and-Comer is Isaiah Neve, director of business development for tre Ministries.
Florida football's most intriguing newcomer for the 2026 season
The Athletic names Florida football offensive coordinator Buster Faulkner as the program's most intriguing newcomer.
Deals: Pixel 11 series goes on pre-order, Galaxy Z8 foldables and S26 models drop prices
The new Pixels will be available from August 20, but Samsung is already trying to undercut the newcomers. Google launched its new Pixel 11 series earlier...
See the most intriguing newcomer on Florida State's roster
Florida State is hoping newcomers to the program will bring new energy, some that is sorely needed after going 2-10 and 5-7 in the last two years.
At FAMU & Crawfordville, Gwen Graham, Byron Donalds preview campaigns
Gwen Graham voted at FAMU to honor FAMU's legacy of activism, while Byron Donalds campaigned in Crawfordville ahead of Florida's governor race.
Tigers Show Fight But Come Up Short in Loss
Spencer Torkelson’s clutch hitting and Gleyber Torres’s solo blast couldn't overcome Riley Greene’s injury absence and a shaky bullpen in a gritty divisional battle at Comerica Park.
Celtics Newcomer Named X-Factor After Blockbuster Jaylen Brown Trade
The Celtics’ return for Jaylen Brown enters next season carrying an X-factor label and the pressure to keep Boston among the East’s elite. The post Celtics Newcomer Named X-Factor After Blockbuster Jaylen Brown Trade appeared first on HEAVY.
Northwood students explore Midland in Go MAD March
As Midland prepares to welcome students to Northwood University’s campus in a few weeks, some of the city’s small businesses will get face time with newcomers on Aug. 21 for a welcome-back...
Congressional probe promised answers on Epstein. A year later, frustrations are mounting
Last summer, when lawmakers launched their Jeffrey Epstein investigation, it came with an ambitious promise: to pull back the curtain on decades of failed federal probes, secure the full release of long-withheld files and provide a public accounting of how the late pedophile evaded accountability for so long.
Marketing specialist adds real estate license for new challenge
This week's Up-and-Comer is Sydnie Fiala McGreevy, senior brand marketing specialist with Macurco/DwyerOmega.
WR Romeo Doubs shares unique way he memorizes Patriots' offense
Patriots newcomer Romeo Doubs explains how he memorizes the offense in his first year in the system.
Cowboys Newcomer Logs First Injury Concern of Training Camp
New Cowboys safety PJ Locke suffered the first injury of this training camp for the team, but the severity is in question. The post Cowboys Newcomer Logs First Injury Concern of Training Camp appeared first on HEAVY.