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🚨 No Calafiori, here's Arsenal's starting XI against Everton

Arsenal are hoping to capitalise today on a possible slip-up by Manchester City against Everton, who have drawn all their away league games.Here are today's line-ups at the Emirates Stadium: Arsenal: ...

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Oct 24 • 8:56 AM EDT • Sports • sports.yahoo.com
Iain Armitage cried while shooting the “Young Sheldon” pilot

“They were quiet tears, which made it all the more heartbreaking.”

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Oct 24 • 8:30 AM EDT • Entertainment • yahoo.com
Dodgers notes: Janet Marie Smith, Todd Benzinger, Dave Roberts

Joe Posnanski at his Joe Blogs newsletter wrote about 10 people he would immediately put into the National Baseball Hall of Fame today. Vin Scully, who topped the list, won the Ford C. Frick Award in 1982 and was inducted into Cooperstown, but Posnanski explains the Hall of Fame as an institution does not recognize […]

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Oct 24 • 8:04 AM EDT • Sports • sports.yahoo.com
Arsenal Fear Bukayo Saka Injury Could Be Worse Than First Feared

Arsenal could be about to lose one of their most important players for a significant stretch of the season. Bukayo Saka will miss Saturday’s Premier League match against Everton after suffering a thigh injury against Bayern Munich, and the early signs have left Mikel Arteta concerned that the problem could be more serious than first […] The post Arsenal Fear Bukayo Saka Injury Could Be Worse Than First Feared appeared first on HEAVY.

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Oct 24 • 7:30 AM EDT • Sports • sports.yahoo.com
Sixers vs. Bucks preview: How to watch, lineups, broadcast info

The Philadelphia 76ers will play host to the Milwaukee Bucks on Saturday to begin a back-to-back.

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Oct 24 • 7:03 AM EDT • Sports • sports.yahoo.com
Referee named for El Clásico between Barcelona and Real Madrid

The Spanish Football Federation have appointed Juan Martínez Munuera as the man in charge of Sunday’s decisive El Clásico between FC Barcelona and Real Madrid, which will be played at the Camp Nou. This will be the fifth time that the 44-year-old Juan Martínez Munuera officiates a Clásico in his 14 seasons in the First […]

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Oct 24 • 6:41 AM EDT • Sports • sports.yahoo.com
Cleveland Browns news: Titans preview, trade babble, and more!

The latest Cleveland Browns news and notes from around the NFL in the October 24 edition of the Saturday Dawg Chow.

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Oct 24 • 6:30 AM EDT • Sports • sports.yahoo.com
I bought a house in Japan at 23 with 7 college friends for under $20k

A recent college graduate teamed with friends to buy and renovate an abandoned home in Hiroshima, Japan. They're using it as an escape from city life.

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Oct 24 • 6:29 AM EDT • Business • businessinsider.com
Sean Sweeney did not provide much information …

Sean Sweeney did not provide much information …

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Oct 24 • 4:51 AM EDT • Sports • sports.yahoo.com
Illinois mortgage business will shut down, employees to be laid off

The permanent layoffs will affect 21 Illinois employees as well as 100 remote workers who report to the headquarters in Illinois.

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Oct 24 • 4:03 AM EDT • Business • finance.yahoo.com
Deion Sanders Must Change the Recruiting Strategy at Colorado

Coach Prime’s refusal to visit high schools or homes is backfiring. To survive the post-Shedeur era, Colorado must abandon transfer-portal reliance and rebuild traditional recruiting foundations.

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Oct 24 • 1:06 AM EDT • Sports • sports.yahoo.com
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Blazers Look to Build on Opening Night

Fresh off a dominant rout of Phoenix, Damian Lillard and Ja Morant lead Portland into Sacramento to test their elite ball movement against a struggling Kings backcourt.

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Oct 23 • 9:03 PM EDT • Sports • sports.yahoo.com
Witney Carson and Mark Ballas refused ‘to be in the same room’ during “DWTS” season 21 feud, PenaVegas claim

The professional dancers were once so close that Ballas cast Carson in one of his music videos and even planned her 21st birthday party.

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Oct 23 • 8:43 PM EDT • Entertainment • yahoo.com
Alabama’s first ‘Mom and Baby Mobile Health Center’ coming to Lowndes County

The “Mom and Baby Mobile Health Center” will start serving Lowndes County in November.

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Oct 23 • 7:04 PM EDT • Health • wsfa.com
Abandoned Popcorn Time apps had to be disabled to prevent a zombie army

What old and vulnerable software might be running on your PC right now?

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Oct 23 • 3:35 PM EDT • Technology • theverge.com
“Yaga”, “Clayface”, and stop-motion fantasy film “Wildwood ”top this week’s Must List

A “Baby-Sitters Club” podcast and a new stage production of “The Curious Case of Benjamin Button” round out our picks for the weekend of Oct. 23.

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Oct 23 • 3:00 PM EDT • Entertainment • yahoo.com
Omaha students learn health hazards of smoking, vaping

Some Omaha students got a hands-on lesson on the health hazards of smoking and vaping.

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Oct 23 • 2:39 PM EDT • Health • wowt.com
Anne Frank Exhibit at the Griffin Museum of Science & Industry
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Oct 23 • 12:34 PM EDT • Science • fox11online.com
Selig Argues for MLB Salary Cap: ‘You Have to Make Adjustments’

Selig unsuccessfully sought a cap while he was the Brewers owner.

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Oct 23 • 10:17 AM EDT • Sports • sports.yahoo.com
Cook Political Report shifts AL-2 race rating towards Democrats

The Cook Political Report shifted Alabama's 2nd Congressional District race from likely Republican to lean Republican.

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Oct 23 • 9:46 AM EDT • Politics • aldailynews.com
Closely watched US House race shifts in favor of Alabama Democrat, political forecaster says

Several other organizations still rate the district in Republicans’ favor, but say it’s close to a tossup.

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Oct 23 • 9:42 AM EDT • Politics • al.com
There’s a Reason That Netflix’s Ad Business Has Underwhelmed

Somewhat lost in the company’s slew of firings and engagement warnings over the past few weeks was the fact that Netflix is scaling back its ad forecast for 2026 from $3 billion to $2.7 billion. That’s despite the fact that: CTV is growing by 14-15% this year This year saw a monster upfront Netflix is the biggest streamer out there this side of YouTube, and was the platform that for years brands were supposedly dying to be a part of In other words, that’s an alarming pull-back from Netflix. A Wall Street analyst I spoke with last week was blunt, calling Netflix’s ad business “disappointing.” To me, a red flag on the ad front is that Netflix has never revealed how many ad-supported subscribers it has. Because if I know anything about how big companies work, if they have a positive number that makes them look really good - they tend to share it. (How many subs does go90 have right now? We’re not saying just yet. How are ads going on ChatGPT? Oh, a billion run rate - I see). Yes, to date Netflix has shared some fuzzy ad numbers, such as the idea that the company’s ad tier ‘reaches’ 250 million users globally.’ Here’s why that figure gives me pause: a)they lead with global, and b) they don’t explain how they are calculated. (Are they based on average people in each room? Surveys of some kind?). Regardless, some insiders say that Netflix’s ad tier is scaling nicely - others not so much. Either way, one of Netflix’s biggest challenge on the ad front appears to have been its starting point. Remember, when Netflix launched ads in 2022, it had 73 million subs in the US and Canada. That’s 73 million people who were used to Netflix with zero ads. And when the ad product rolled out, the company clearly was going after new users - a limited pool of potential subscribers by default. That focus seems to have changed over time, as Netflix has tried to convert longtime subscribers to the ad tier. Historically Netflix subscribers are very sticky. But is the company’s low churn a problem? Not necessarily, according to Antenna data. Rather, Netflix’s consumer loyalty is a bit of a double-edged sword. “Netflix is the one streamer which actually has seen substantial “trade downs” but has much lower ‘win backs,’ said Antenna founder Jonathan Carson (win-backs being people who were on the ad-free plan, cancelled, then rejoined on the ad plan). “Netflix has lower churn and so has less opportunity to win back old subs with a lower cost plan option.” This all might explain why Netflix has been so slow to roll out all of these table stakes targeting options until just this week. It likely didn’t have enough users to carve up into various targets. etc. However, what really hit Netflix’s ad business was Amazon’s move a few years ago to turn on advertising for Prime Video by default. Suddenly the market was awash in premium inventory, and Netflix was playing catch-up on multiple fronts. Thus, the streaming giant appears to still be figuring out if if wants lead in ‘programmatic TV,’ or premium ‘upfront’ TV sales. “The CTV market now sorts into three businesses, and Netflix is not the leader of any of them,” wrote analyst Jack Myers. Ouch. So how does Netflix ratchet up its ads business? Get the next NFL package You’re gonna have to wait until 2030 unless one of the bigger media companies like Skydance opts out, but the easiest (not cheapest) way for Netflix to become a huge TV ads contender is to get one of the regular NFL packages, ideally Sunday afternoons. That way it can sell ads to its whole U.S. subs base overnight. Go FAST This one is risky, because to program a compelling FAST channel, you’d likely have to take some older Netflix exclusive shows and make them available for free to non-subscribers. But FASTs, for better or worse, are ad-inventory machines. Go full UGC I’m not sure I see this happening. There is something already off about Netflix carrying podcasts and shows for creators. The experience sticks out in what is such a produced, and generally non-communal environment. But Netflix could open up its platform by allowing creators to upload videos without having to be approved by the service. But that opens a whole other can of worms (policing brand safety, copyright infringement, overall quality). Make a huge RMN Deal I was going to suggest something crazy, such as ‘instead of buying Warner Brothers, Netflix should buy Target. But the company doesn’t want to be in the brick and mortar business. Yet for Netflix’s ad business to compete in an Amazon world, it needs to be able to connect ad exposures to shopping. What if, instead of letting Amazon target Netflix viewers with its DSP, Netflix inked a deal with Target, or even took control of Roundel, and created its version of the Amazon full-funnel for brands? Price us out. I hope they don’t do this, but Netflix’s price increases - while significant - haven’t been enough to push long-term customers out of the ad-free tier. But if they made those prices so prohibitive, it could push large swaths of consumers to trade down. Then again, that could also dent engagement - as binging becomes much less appealing once you bring ads into the equation. Or, they could just launch a bunch of hit shows and maybe everyone will quickly forget all this angst. More from Amazon unBoxed A few weeks ago, I recorded two podcasts live at Amazon’s unBoxed event in San Francisco. I was able to go really deep with several brand partners about how Amazon’s various data and ad products work - particularly the under appreciated Amazon Marketing Cloud. First, I talked with Laura Abadias Velilla, of the Amazon specialty agency Amerge, along with Amazon’s own Charlotte Maines, Vice President, Devices Content & Advertising, about how the two partners helped a very specific printer company Epson launch into a brand new category - high end projectors. It’s a great example of how brands connect audience data across platforms to make budget deployment decisions. Next, I chatted with Monks VP Head of Digital Investment for North America Tom Burchill about how the agency actually brought in data from Linkedin to help target B2B customers across various Amazon properties for the brand Quicken. Check it out: Check these out, or just listen:

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Oct 23 • 8:52 AM EDT • Business • mikeshields.substack.com
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Alabama Football 2026 vs Texas A&M: Previewing the Aggie Defense

A Mike Elko defense may not be the best thing for a “get right” game for the Alabama offense.

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Oct 23 • 8:26 AM EDT • Sports • sports.yahoo.com
☹️ Negative (-25%)
Prince Harry shares rare 2-word health update on father King Charles
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Oct 23 • 5:35 AM EDT • Health • yahoo.com
Eisenkot offers hawkish alternative to Netanyahu for Israeli PM

By Alexander Cornwell and Maayan Lubell JERUSALEM, Oct 23 (Reuters) - Reserved, media-shy, and a relative newcomer to Israeli politics, former military chief Gadi Eisenkot presents a clear contrast to

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Oct 23 • 3:04 AM EDT • Politics • yahoo.com
WEARING PINK WITH PRIDE

SENTINEL SNAPSHOT: WEARING PINK WITH PRIDE

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Oct 23 • 3:00 AM EDT • Entertainment • romesentinel.com
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What is going on at 'chaotic' Newcastle?

Will the alarm bells be ringing at Newcastle United if they lose to struggling Crystal Palace on Sunday?

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Oct 23 • 2:37 AM EDT • Sports • sports.yahoo.com
World Snow Leopard Day: Community action and new science foster coexistence with humans

Snow leopards range across Asia’s rugged mountains, where they face mounting threats from climate change, declining wild prey, and retaliatory killings from local herders. Today, on Oct. 23, International Snow Leopard Day, we look back at recent Mongabay reporting highlighting how innovative science, climate-ready habitat, and community-centered conservation are helping these big cats share mountain […]

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Oct 23 • 2:21 AM EDT • Science • news.mongabay.com
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Thursday Night Football: Bears fend off Patriots 30-24
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Oct 22 • 11:31 PM EDT • Sports • sports.yahoo.com
Laurel Sports Hall of Fame holds ceremony for inaugural class

After making waves through the streets of the City Beautiful, former athletic stars had their names etched in Laurel history.

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Oct 22 • 11:16 PM EDT • Sports • wdam.com
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RWJBarnabas Health Celebrates the 10th Anniversary of The Beth Greenhouse and 50,000 Pounds of Fresh Produce in Newark

Newark Beth Israel Medical Center celebrated the 10th anniversary of The Beth Greenhouse, a hydroponic greenhouse that has provided more than 50,000 pounds of fresh produce to Newark residents and patients while promoting nutrition, wellness and food security throughout the community.

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Oct 22 • 11:05 PM EDT • Health • newswise.com
NC 3rd District candidates say rural health care is a priority, but differ on solutions
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Oct 22 • 8:22 PM EDT • Health • wcti12.com
Mark Andrews posts another full practice

Ravens TE Mark Andrews a full participant for second straight day

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Oct 22 • 7:55 PM EDT • Sports • sports.yahoo.com
Actor Tom Skerritt of ‘Steel Magnolias,' 'Top Gun,' dies at 93

NEW YORK — Prolific actor Tom Skerritt died Wednesday from natural causes. He was 93. Skerritf’s “heartbroken” family said, though fans knew him for his work on films including “Alien,”

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Oct 22 • 4:19 PM EDT • Entertainment • recorderonline.com
RWJBarnabas Health Celebrates the 10th Anniversary of The Beth Greenhouse and 50,000 Pounds of Fresh Produce in Newark

Newark Beth Israel Medical Center (NBIMC), an RWJBarnabas Health facility today celebrated the 10th Anniversary of the Beth Greenhouse, RWJBarnabas Health’s first hydroponic greenhouse and a pioneering community health initiative that has provided more than 50,000 pounds of fresh, locally grown produce to Newark residents and patients while advancing nutrition, wellness and food security throughout the city.

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Oct 22 • 3:17 PM EDT • Health • rwjbh.org
Environmental engineers awarded $2.4M to study how abandoned wells impact health

A multi-institutional team of researchers, led by an engineer from Penn State, has been awarded a five-year, $2.4 million grant from the Pennsylvania Department of Energy to study the impacts that orphaned natural gas wells might have on the surrounding environment or communities.

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Oct 22 • 1:01 PM EDT • Health • psu.edu
Alabama governor’s race could be surprisingly competitive, prominent political forecaster says

Sabato's Crystal Ball shifted Alabama's governor's race from "Safe Republican" to "Likely Republican."

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Oct 22 • 9:17 AM EDT • Politics • al.com
Every player from Alabama to play for the Boston Celtics

Our focus in this article is Al Butler.

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Oct 22 • 9:00 AM EDT • Sports • sports.yahoo.com
Islanders Gameday: Darche speaks as slumping Kings arrive

The Islanders try to extend their first win streak of the season as the sad-sack Kings come to town. This one is a ESPN/Hulu/Disney/whatever broadcast, so your viewing access may be affected. Leave First Islanders Goal picks here. Islanders News Elsewhere

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Oct 22 • 6:00 AM EDT • Sports • sports.yahoo.com
Trump’s billion-dollar grant cuts jeopardize Tulane public health research

President Donald Trump has terminated billions in federal science and research grants since 2025. As a result, global health research and job stability at Tulane University’s Celia Scott Weatherhead School of Public Health and Tropical Medicine are in jeopardy. Since 2025, the Trump administration has frozen or terminated $177 billion in grants on health equity,...

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Oct 21 • 11:27 PM EDT • Health • tulanehullabaloo.com
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NFL Playoff Picture Week 7: All 4 NFC North teams are in the field for now
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Oct 21 • 6:43 PM EDT • Sports • sports.yahoo.com
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Rotary Salute to Business October 27

10/11 News at 4

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Oct 21 • 6:02 PM EDT • Business • 1011now.com
Trump administration wants to reconsider permit for Massachusetts offshore wind project

The Trump administration is asking a federal judge to let it reconsider a major federal permit granted for a large offshore wind farm, making it the fourth project the Republican

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Oct 21 • 5:29 PM EDT • Politics • lancasteronline.com
Bob Huggins' family discloses health battle for college basketball legend

Former college basketball coach Bob Huggins' family released a statement that he's dealing with a progressive cognitive condition. What to know:

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Oct 21 • 5:03 PM EDT • Health • usatoday.com
Maryland Fires Mike Locksley, Opening a Big Ten Job

Mike Locksley is out at Maryland, and the Big Ten's first coaching vacancy is open. #BigTen

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Oct 21 • 2:45 PM EDT • Sports • sports.yahoo.com
Baba nabs $40M series A, backed by FirstMark Capital and CVS Health Ventures, for AI-powered Medicare patient navigation

Applied artificial intelligence company Baba

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Oct 21 • 1:15 PM EDT • Health • fiercehealthcare.com
Alabama HC Kalen DeBoer is Suddenly in Danger Yet Again

Alabama Crimson Tide head coach Kalen DeBoer desperately needs a win this week.

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Oct 21 • 9:31 AM EDT • Sports • sports.yahoo.com
HOMETOWN ENTERTAINMENT: Smith Mountain Lake Center to stage Zombie Prom at Westlake Cinema

Zombie Prom takes the stage at Westlake Cinema starting this week.

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Oct 21 • 9:00 AM EDT • Entertainment • wdbj7.com
Tuberville blasts Alabama pastors for not speaking out on politics: ‘Quit trying to keep your jobs’

“We are not winning in the pulpit and getting up and saying ‘this is what we stand for.’"

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Oct 21 • 7:00 AM EDT • Politics • al.com
25 Shortfalls Cruise Entertainment Teams See on Formal Evenings Among Guests on Almost Every Voyage

Formal night is supposed to be the glamorous peak of a cruise: gowns on the staircase, blazers at the bar, photographers waiting under a chandelier. Then the lobby fills up, and the same slip-ups show up sail after sail. A bathing suit at the dining room door. A perfect gown with beach flip-flops peeking out ...

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Oct 21 • 6:59 AM EDT • Entertainment • travel.yahoo.com
“We were told…”: Why Dortmund stars fled before showering

After their narrow 2–1 win over Azerbaijani champions FK Sabah, Borussia Dortmund’s players left the Olympic Stadium in Baku without showering. The immediate departure on the BVB team bus was appa...

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Oct 21 • 4:13 AM EDT • Sports • sports.yahoo.com
“When he did it, obviously there was a different feel …

“When he did it, obviously there was a different feel …

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Oct 21 • 3:37 AM EDT • Sports • sports.yahoo.com
Exploring tactile senses with the Orlando Science Center

Watch to see if meteorologist Victoria Wisniewski can guess what is in these stereognostic boxes

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Oct 20 • 11:48 PM EDT • Science • wesh.com
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Analyst predicts when the Browns may bench Deshaun Watson

Could the Browns bench Deshaun Watson at some point despite early season success.

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Oct 20 • 11:02 PM EDT • Sports • sports.yahoo.com
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Lena Waithe says Hollywood feels like "Walmart"

Actor, writer and producer Lena Waithe is questioning Hollywood's pursuit of mass-market entertainment as consolidation leaves creators with fewer places to sell original projects.

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Oct 20 • 6:22 PM EDT • Entertainment • yahoo.com
Paul George Sets Celtics Franchise Record During Loss to Pistons

Detroit spent three quarters getting torched by Paul George, then flipped the opener in one run. #Pistons

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Oct 20 • 6:20 PM EDT • Sports • sports.yahoo.com
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What happened to Ben Kindel? NHL player suffers 'medical episode' on plane

Pittsburgh Penguins forward Ben Kindel was taken to a Utah hospital Tuesday after suffering a "medical episode" on the team plane.

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Oct 20 • 5:21 PM EDT • Sports • sports.yahoo.com
Packers OC Makes Feelings Clear on Josh Jacobs Return

Green Bay Packers OC Adam Stenavich didn't mince words when asked about RB Josh Jacobs' return. The post Packers OC Makes Feelings Clear on Josh Jacobs Return appeared first on HEAVY.

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Oct 20 • 5:12 PM EDT • Sports • sports.yahoo.com
TENNESSEE VOLS FOOTBALL: Neyland hits 130 decibels in Alabama game

The Neyland Effect was full tilt during Tennessee's 26-10 victory over Alabama on the Third Saturday in October.

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Oct 20 • 5:02 PM EDT • Sports • sports.yahoo.com
Northwestern's Robert Fitzgerald Earns Multiple All-American Honors

Northwestern safety Robert Fitzgerald earns first-team midseason All-American honors from On3 and AP as the Wildcats await their defensive leader's return from injury.

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Oct 20 • 4:00 PM EDT • Sports • sports.yahoo.com
Judi Dench still hasn’t seen “Cats”, calls it a ‘waste’ of talent in new memoir: ‘I can’t bear it’

She confessed that she “didn’t feel right” in her role as Old Deuteronomy.

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Oct 20 • 3:07 PM EDT • Entertainment • yahoo.com
Phillies Mentioned as Possible Landing Spot for Teruaki Sato

The Philadelphia Phillies could look to add a power hitter to the lineup.

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Oct 20 • 2:49 PM EDT • Sports • sports.yahoo.com
Athletics, CBA and everything MLB in between

Cardinals on My Time is back for the winter in a little different capacity! With the offseason and winter looking questionable at best and the Cardinals sitting in an awkward spot, I decided to take the opportunity to expand my podcast a little bit. Since writing all things St. Louis Cardinals for the past few […]

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Oct 20 • 1:30 PM EDT • Sports • sports.yahoo.com
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Harms of Public Health Measures Overlooked in COVID-19 Policy Reviews

Investigators link oversight with eroding trust in health authorities and call on future pandemic inquiries to weigh trade-offs.

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Oct 20 • 12:51 PM EDT • Health • drugtopics.com
Former Alabama running back reportedly released by NFL team

The former Alabama running back and national champion will now be looking for his third NFL team in the last two seasons.

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Oct 20 • 12:50 PM EDT • Sports • sports.yahoo.com
TENNESSEE VOLS FOOTBALL: Bishop captures national weekly honors

Tennessee senior DeSean Bishop earned two national weekly award honors on Tuesday following his standout performance in the Volunteers' Third Saturday in October rivalry win over No. 6/7 Alabama last Saturday.

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Oct 20 • 12:46 PM EDT • Sports • sports.yahoo.com
Man arrested after unlawfully entering Alabama School of Math and Science Property, police say

A 44-year-old man was arrested Monday afternoon after unlawfully entering the grounds and a building at the Alabama School of Math and Science, according to the Mobile Police Department.

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Oct 20 • 11:44 AM EDT • Science • fox10tv.com
Who is Tommy Tuberville? Auburn coach turned governor candidate

From the Auburn sidelines to the U.S. Senate, Tommy Tuberville is now seeking Alabama's top office. Here's what voters should know.

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Oct 20 • 10:22 AM EDT • Politics • montgomeryadvertiser.com
Abbott, Big 10 Conference, Rutgers Athletics, and RWJBarnabas Health Seek to Boost National Blood Supplies

Diego Orozco knows firsthand that every blood donation offers new hope for blood cancer patients like him. After battling leukemia and enduring three stem cell transplants, the 34-year-old North Plainfield resident has relied on countless blood transfusions to survive some of the most difficult moments of his cancer journey.

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Oct 20 • 10:17 AM EDT • Health • rwjbh.org
“Among a lot of the more serious problems with Donald, …

“Among a lot of the more serious problems with Donald, …

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Oct 20 • 8:47 AM EDT • Sports • sports.yahoo.com
Western Way Entertainment brings trick riding, mounted shooting to ABAC PCA Pro Rodeo

When the PCA Pro Rodeo returns to Abraham Baldwin Agricultural College Nov. 13-14, the competition inside the arena won’t be the only thing keeping fans on the edge of their seats.

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Oct 20 • 8:32 AM EDT • Entertainment • tiftongazette.com
Green Bay Packers add former first-round pick amid defensive line injury concerns

The Green Bay Packers are searching for defensive line help after injuries weakened their options up front. With starting nose tackle Javon Hargrave out, veteran Chris McClellan is expected to fill the role, but Green Bay has limited depth behind him. To strengthen the rotation, the Packers have signed a former first round pick to [...]

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Oct 20 • 6:30 AM EDT • Sports • sports.yahoo.com
Pfizer makes ‘business decision’ to end phase 2 trial of autoimmune drug as program’s future uncertain

Pfizer has called time on a phase 2 trial of its CXCR5 antibody in an autoimmune blood disorder, with the company tight-lipped on whether this marks the end of the road for the asset. The Big Pharma had been evaluating the therapy, dubbed PF-06835375, in a phase 2 study of 61 patients with primary immune thrombocytopenia (ITP) that kicked off in 2022, according to the federal trials register. However, Pfizer confirmed to Fierce on Monday that this study had been terminated “due to a business decision.” “The decision to terminate the trial was not based on any safety concerns,” a spokesperson pointed out. At time of publication, PF-06835375 remained listed on Pfizer’s website for both ITP and lupus. A phase 1 study in lupus wrapped up in 2022, according to the trials database. ITP is an autoimmune disorder characterized by a low platelet count. Novartis was at one point evaluating its B-cell-depleting antibody ianalumab—recently approved as Fabhalta to treat immunoglobulin A nephropathy—as a potential treatment ITP. But the therapy struggled to demonstrate a benefit in the clinic for this indication. When contacted by Fierce, Pfizer wouldn’t confirm whether all work on PF-06835375 has been halted, and whether the company has any other plans to explore C-X-C chemokine receptor type 5 (CXCR5) as a mechanism. CXCR5 is found in blood cancers such as diffuse large B-cell lymphoma and mantle cell lymphoma chemokine receptor. However, there is little expression in normal tissue, which has led some drug developers to explore its potential. Vincerx Pharma had at one point been planning to take an anti-CXCR5 ADC into the clinic to treat B-cell malignancies, but that ambition was scrapped due to cash constraints. Where Big Pharma is placing its bets is one of the hot topics being discussed at Fierce Biotech's high-impact event in London next month. Find out more information and register by clicking on the banner below: [ ](https://qtxasset.com/quartz/qcloud5/media/image/where_big_pharma_is_placing_its_bets.png?VersionId=B8JrRbJ.pFUSK1pJgjeWHLGm_18RdLAy)

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Oct 20 • 3:59 AM EDT • Business • fiercebiotech.com
New-to-science seahorse is one of three long-misidentified species

Scientists have identified a new-to-science seahorse species from the Indian waters, which has helped resolve the taxonomy of a group misidentified for over a century. In 1856, zoologist Johann Jakob Kaup described the thorny or spiny seahorse, Hippocampus histrix, based on samples from Japan. Since then, this seahorse has been thought to be a single, […]

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Oct 20 • 3:09 AM EDT • Science • india.mongabay.com
Political hate speech can have real-word fallout. After the alleged attack on Helen Haines, our leaders must act

Social media amplify the worst excesses of what passes for public discourse, while some media outlets foment polarisation

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Oct 19 • 9:18 PM EDT • Politics • theguardian.com
Four goal 2nd half leads Belleville boys soccer over Newark Data Science in ECIT 2nd round

Belleville (9-6-1) advanced to the quarterfinals and host the winner between 10th-seeded Shabazz at seventh-seeded Newark Tech on Thursday, Oct.22.

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Oct 19 • 8:55 PM EDT • Science • nj.com
Gamethread: Penguins @ Mammoth

Talk about the game with Pens fans here!

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Oct 19 • 8:45 PM EDT • Sports • sports.yahoo.com
Tuskegee University Targets First Aviation Science Cohort Graduation in May 2027

Alabama, USA – Tuskegee University, a historically Black university operating an FAA-certificated...

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Oct 19 • 8:00 PM EDT • Science • afm.aero
RWJBarnabas Health Honored with New Jersey Business Magazine’s Community Service Award

RWJBarnabas Health has been recognized with New Jersey Business Magazine’s 2026 Community Service Award for Excellence for its Our Healthy Communities initiative, which addresses health disparities and strengthens communities across New Jersey through expanded access to health care, healthy food, housing, and economic opportunities.

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Oct 19 • 7:35 PM EDT • Health • newswise.com
RWJBarnabas Health Honored with New Jersey Business Magazine’s Community Service Award

RWJBarnabas Health has been recognized with New Jersey Business Magazine’s 2026 Community Service Award for Excellence for its Our Healthy Communities initiative, which addresses health disparities and strengthens communities across New Jersey through expanded access to health care, healthy food, housing, and economic opportunities.

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Oct 19 • 7:35 PM EDT • Business • newswise.com
Packers 23 Cowboys 13: Green Bay Cages Dak and Dallas

The Green Bay Packers (4-2) have now won three straight, with back-to-back convincing victories over their NFC opponents.

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Oct 19 • 5:48 PM EDT • Sports • sports.yahoo.com
Seating supplier Lear names finance VP as its next CFO

Lear tapped a 23-year company veteran to serve as its next CFO

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Oct 19 • 5:18 PM EDT • Business • crainsdetroit.com
Biggest Risers and Fallers From Warriors’ Six Preseason Games

Warriors head coach Steve Kerr doesn't think his team is where it needs to be right now, but playtime is over and meaningful basketball is just around the corner.

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Oct 19 • 3:54 PM EDT • Sports • sports.yahoo.com
Nick Saban recalls kind gesture from Jalen Hurts amid ex-Alabama football QB health concerns

Nick Saban will remember his former Alabama football QB Jalen Hurts as a \

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Oct 19 • 3:40 PM EDT • Health • tuscaloosanews.com
How a controversial lift on 'Dancing With the Stars' and a reference to Will Smith's Oscars slap led to pro dancer Val Chmerkovskiy's suspension

The controversy began when judge Carrie Ann Inaba told Harry Shum Jr. and Jenna Johnson that their routine included a move that is not allowed in traditional samba.

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Oct 19 • 3:25 PM EDT • Entertainment • yahoo.com
New murder trial ordered over juror's mental health crisis in 9th Circuit

A man's convictions for a killing on the waters off California's coast were vacated by the 9th U.S. Circuit Court of Appeals at San Francisco on Thursday…

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Oct 19 • 11:19 AM EDT • Health • abajournal.com
Alabama's CFP Hopes Smacked With Jarring Reality Check

The Alabama Crimson Tide are in danger of missing the CFP.

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Oct 19 • 11:00 AM EDT • Sports • sports.yahoo.com
Pakistan suspends Iran border trade, amid violence on both sides

Islamabad cites security concerns, while Tehran points to technical issues as Pakistan mediates between Iran and the US.

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Oct 19 • 10:43 AM EDT • Politics • aljazeera.com
39 homers should force the Yankees to rethink third base

Hanshin has agreed to let Teruaki Sato pursue a move to Major League Baseball through the posting system. For the […]

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Oct 19 • 9:56 AM EDT • Sports • sports.yahoo.com
Daily Bean: Maple Leafs Trade Talk; Matt Poitras; Hellebuyck Rumors

The Boston Bruins had the day off yesterday but are back to work today as they look to sweep their […]

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Oct 19 • 8:59 AM EDT • Sports • sports.yahoo.com
Sacha Baron Cohen Talks New Ali G Movie with Howard Stern

This week, Jimmy Kimmel Live! is broadcasting from the Brooklyn Academy of Music (BAM) in New York City.

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Oct 19 • 8:00 AM EDT • Entertainment • siriusxm.com
Here are some of the ways LSU’s Student Health Center supports students during the semester

The LSU Health Center has various resources to help you with your physical and mental health. From student check-ups to therapy, here are some services available to LSU students at the Student Health Center. Physical health LSU’s primary care clinic is what most LSU’s are aware of. Students are encouraged to make an appointment, but...

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Oct 19 • 7:00 AM EDT • Health • lsureveille.com
DoJ’s Ilhan Omar Probe Reeks of Politics

The department has done institutional damage to itself by targeting a congresswoman just weeks before the midterms.

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Oct 19 • 6:00 AM EDT • Politics • nymag.com
Commentary: What do we need after Nov. 3? Political imagination.

If we're going to have governments that respond to our problems, we have to abandon the idea that the only answers are in the free market.

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Oct 19 • 5:59 AM EDT • Politics • alabamareflector.com
Vanderbilt, Carnegie Mellon show Florida business range

Eight months ago, billionaires Stephen Ross and Ken Griffin spoke to a group of business executives gathered at the Norton Museum of Art in West Palm Beach. The February event was billed as a global finance and policy discussion, but at times speakers talked about South Florida's growing economy.

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Oct 19 • 5:03 AM EDT • Business • miamiherald.com
Vanderbilt, Carnegie Mellon show Florida business range

Eight months ago, billionaires Stephen Ross and Ken Griffin spoke to a group of business executives gathered at the Norton Museum of Art in West Palm Beach. The February event was billed as a global finance and policy discussion, but at times speakers talked about South Florida's growing economy.

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Oct 19 • 5:03 AM EDT • Business • bradenton.com
Lamprey Health Care and Gather launch food bus partnership

Gather's fresh food bus, known as Gus the Bus, is now making regular visits to Lamprey Health Care in Newmarket.

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Oct 19 • 5:02 AM EDT • Health • yahoo.com
Lee Child knows exactly how he'd end his bestselling Jack Reacher series

NEW YORK – Like Jack Reacher in one of his bestselling thriller books, Lee Child is coming to the rescue.

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Oct 19 • 4:25 AM EDT • Entertainment • centraloregondaily.com
Farmworkers’ health matters: South Africa looks to alternatives for chemical pesticides

Insects like fall armyworm or mealybugs can decimate food and commercial crops; like their counterparts elsewhere in the world, South Africa’s small and large farmers alike use synthetic chemical pesticides to control these and other pests. But about 385 million cases of unintentional acute pesticide poisoning are reported worldwide each year, according to the Pesticide […]

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Oct 19 • 2:22 AM EDT • Health • news.mongabay.com
Two new-to-science subterranean fishes reveal a hidden world underneath

A decade ago, Wimarithy K. Marak, a resident of Assam’s Goalpara district, often used to encounter a small pink creature in her neighbourhood’s wells. She simply thought of it as a worm infesting her locality. In 2021, after she became a researcher, she stumbled upon the creature again while drawing water from a well. “This […]

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Oct 19 • 2:05 AM EDT • Science • india.mongabay.com